期刊
FRONTIERS IN PHARMACOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.1036423
关键词
kidney calculi; osteopontin; macrophages; T helper cells; dendritic cells; mast cells
资金
- National Natural Science Foundation of China [82260155]
- Yunnan Province Zhangqun Ye expert's workstation [202105AF150063]
- Yunnan Provincial Science and Technology Department/Kunming Medical University Joint Project of Basic Research [2019FE001(-149), 202001AY070001-062]
- Yunnan Medical Science Specialist Training Project [H-2017045]
The study highlights the important role of osteopontin in the formation of kidney stones and suggests it may be a crucial target for drug therapy of kidney stones.
The incidence of kidney stones averages 10%, and the recurrence rate of kidney stones is approximately 10% at 1 year, 35% at 5 years, 50% at 10 years, and 75% at 20 years. However, there is currently a lack of good medicines for the prevention and treatment of kidney stones. Osteopontin (OPN) is an important protein in kidney stone formation, but its role is controversial, with some studies suggesting that it inhibits stone formation, while other studies suggest that it can promote stone formation. OPN is a highly phosphorylated protein, and with the deepening of research, there is growing evidence that it promotes stone formation, and the phosphorylated protein is believed to have adhesion effect, promote stone aggregation and nucleation. In addition, OPN is closely related to immune cell infiltration, such as OPN as a pro-inflammatory factor, which can activate mast cells (degranulate to release various inflammatory factors), macrophages (differentiated into M1 macrophages), and T cells (differentiated into T1 cells) etc., and these inflammatory cells play a role in kidney damage and stone formation. In short, OPN mainly exists in the phosphorylated form in kidney stones, plays an important role in the formation of stones, and may be an important target for drug therapy of kidney stones.
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