☆ 4.7 Review

The significance of glycolysis in tumor progression and its relationship with the tumor microenvironment

FRONTIERS IN PHARMACOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Gastroenterology & Hepatology

Single-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment

Liwen Wang et al.

Summary: This study explores the heterogeneity and pro-tumour mechanisms of neutrophils in pancreatic ductal adenocarcinoma (PDAC). The researchers discovered different subpopulations of tumour-associated neutrophils (TANs) associated with prognosis, as well as the glycolytic switch of TANs and the key regulatory factor in polarisation of neutrophils towards a pro-tumour phenotype. Importantly, immunohistochemistry analysis revealed the unfavorable prognostic value of BHLHE40(+) neutrophils in PDAC patients.

GUT (2023)

添加到收藏夹

Article Oncology

Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

Shogo Kumagai et al.

Summary: In highly glycolytic tumors, regulatory T (Treg) cells have higher PD-1 expression compared to effector T cells. Under low-glucose conditions, Treg cells actively absorb lactic acid through monocarboxylate transporter 1 (MCT1), promoting the expression of PD-1, while PD-1 expression by effector T cells is dampened. PD-1 blockade invigorates PD-1-expressing Treg cells, resulting in treatment failure.

CANCER CELL (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

PD-L1 blockade liberates intrinsic antitumourigenic properties of glycolytic macrophages in hepatocellular carcinoma

Li-Gong Lu et al.

Summary: In hepatocellular carcinoma (HCC), PD-L1(+) host macrophages are a major cellular source of PD-L1 in tumors, displaying a glycolytic phenotype and producing antitumor IL-12p70. The regulation of these macrophages involves fibronectin 1-induced PKM2, controlling both antitumor properties and inflammation-mediated PD-L1 expression. Modulating the context of glycolytic macrophages in HCC tumors may restore their antitumor properties and offer a precise strategy for anticancer therapy.

GUT (2022)

添加到收藏夹

Article Oncology

Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 A Systematic Analysis for the Global Burden of Disease Study 2019

Jonathan M. Kocarnik et al.

Summary: The global burden of cancer is substantial and growing, with differences in burden based on Sociodemographic Index (SDI). The largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles from 2010 to 2019.

JAMA ONCOLOGY (2022)

添加到收藏夹

Article Oncology

LINC01605 promotes aerobic glycolysis through lactate dehydrogenase A in triple-negative breast cancer

Wei Wang et al.

Summary: This study explores the role of long noncoding RNA LINC01605 in triple-negative breast cancer (TNBC). The findings suggest that high expression of LINC01605 is associated with poor survival prognosis in TNBC patients. Silencing of LINC01605 significantly inhibits proliferation, migration, and invasion of TNBC cell lines.

CANCER SCIENCE (2022)

添加到收藏夹

Article Environmental Sciences

Global burden of lung cancer attributable to ambient fine particulate matter pollution in 204 countries and territories, 1990-2019

Xiaorong Yang et al.

Summary: According to the Global Burden of Disease Study, the number of lung cancer deaths and DALYs attributable to ambient PM2.5 pollution significantly increased in 2019, with China ranking first globally. High SDI regions showed a rapid decrease in ASMR, while in low to middle SDI regions, the mortality rate or DALY rate increased in all age groups from 1990 to 2019.

ENVIRONMENTAL RESEARCH (2022)

添加到收藏夹

Article Cell Biology

Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage polarization in breast cancer

Huimin Jiang et al.

Summary: This study identifies a Zeb1-dependent mechanism that drives breast cancer progression by stimulating tumor-macrophage interplay, which could be a potential therapeutic target for the treatment of advanced cancers.

CELL DEATH & DISEASE (2022)

添加到收藏夹

Article Oncology

IRAK2-NF-κB signaling promotes glycolysis-dependent tumor growth in pancreatic cancer

Jian Yang et al.

Summary: The gene IRAK2 is highly expressed in pancreatic ductal adenocarcinoma (PDAC) and is associated with poor prognosis. IRAK2 promotes PDAC cell proliferation and metabolic reprogramming by regulating the activation of transcription factors. Targeting IRAK2 may serve as a novel therapeutic approach for PDAC.

CELLULAR ONCOLOGY (2022)

添加到收藏夹

Review Oncology

The Role of Metabolic Plasticity of Tumor-Associated Macrophages in Shaping the Tumor Microenvironment Immunity

Md Nabiul Hasan et al.

Summary: Tumor-associated macrophages support tumor progression and inhibit immune function by rewiring their metabolism. Understanding the metabolic changes of macrophages in the tumor microenvironment is essential for developing novel immune cell metabolism-targeted therapies.

CANCERS (2022)

添加到收藏夹

Article Cell Biology

Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of I?Ba

Dong Guo et al.

Summary: High glucose promotes PD-L1 expression in tumor cells, leading to tumor immune evasion. Inhibition of HK2 and PD-1 can eliminate tumor immune evasion and enhance the anti-tumor effect of immune checkpoint blockade.

CELL METABOLISM (2022)

添加到收藏夹

Article Oncology

Tumor associated macrophages-derived exosomes facilitate hepatocellular carcinoma malignance by transferring lncMMPA to tumor cells and activating glycolysis pathway

Minghao Xu et al.

Summary: This study found that tumor-associated macrophages enhance aerobic glycolysis and proliferation in hepatocellular carcinoma cells by transmitting a long non-coding RNA called lncMMPA through exosomes. Furthermore, lncMMPA increases the proliferation of HCC cells by interacting with miR-548s. Clinically, lncMMPA expression is associated with glycolysis in TAMs and reduced survival of HCC patients.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Tumor Microenvironment and its Implications for Antitumor Immunity in Cholangiocarcinoma: Future Perspectives for Novel Therapies

Hengsong Cao et al.

Summary: The incidence of cholangiocarcinoma is increasing and conventional treatments are not as effective as expected. Immunotherapy has become a cutting-edge research in cancer treatment. The tumor microenvironment of cholangiocarcinoma plays a significant role in tumor progression, and understanding the interactions between immune cells and stromal cells in the microenvironment is crucial for the development of immunotherapy.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

IL-6/STAT3 Axis Activates Glut5 to Regulate Fructose Metabolism and Tumorigenesis

Xiaoke Huang et al.

Summary: This study demonstrates that treatment with IL-6 activates fructose uptake and fructolysis in oral squamous cell carcinoma (OSCC) cells and prostate cancer cells. Mechanistically, the transcription factor STAT3 associates with the Glut5 promoter region and enhances Glut5 transcription in response to IL-6 treatment. Knockdown of Glut5 attenuates IL-6-induced tumor cell proliferation.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Potential of Novel Methyl Jasmonate Analogs as Anticancer Agents to Metabolically Target HK-2 Activity in Glioblastoma Cells

Damla Uludag et al.

Summary: The change in energy metabolism of cancer cells, particularly the inhibition of hexokinase-II (HK-II) activity, has the potential to be a target for cancer therapy. A newly developed compound, C-10, shows significant therapeutic efficacy against glioblastoma (GBM) cells through different cell death mechanisms.

FRONTIERS IN PHARMACOLOGY (2022)

添加到收藏夹

Review Medicine, Research & Experimental

Digging deeper through glucose metabolism and its regulators in cancer and metastasis

Majid Ghanavat et al.

Summary: Glucose metabolism enzymes and transporters play a significant role in cancer development and metastasis. Aerobic glycolysis is observed as the most favorable mechanism for glucose metabolism in cancer cells. Lactate, lactate dehydrogenase, and monocarboxylic transporter serve as potential biomarkers, therapeutic targets, and diagnostic tools for cancer and metastasis.

LIFE SCIENCES (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Salidroside Induces Apoptosis in Human Gastric Cancer Cells via the Downregulation of ENO1/PKM2/GLUT1 Expression

Ziying Dai et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2021)

添加到收藏夹

Article Cell Biology

RNAi-mediated knockdown of PFK1 decreases the invasive capability and metastasis of nasopharyngeal carcinoma cell line, CNE-2

Shuo Li et al.

Summary: This study demonstrates the importance of targeting PFK1 in NPC treatment by suppressing cell growth and invasive capability. It provides a new perspective for finding novel therapeutic strategies for NPC.

CELL CYCLE (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Targeting the tumor microenvironment in cholangiocarcinoma: implications for therapy

Juan Wang et al.

Summary: Cholangiocarcinomas (CCAs) are biliary epithelial tumors with increasing incidence, often diagnosed at an advanced stage due to the challenging early diagnosis. Current standard systemic therapy options are limited in their effectiveness, and immune checkpoint inhibition (ICI) has shown relatively disappointing response rates in CCAs due to their desmoplastic tumor microenvironment. Effective therapeutic strategies targeting the tumor microenvironment (TME) are needed for better treatment outcomes.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Zinc-Dependent Regulation of ZEB1 and YAP1 Coactivation Promotes Epithelial-Mesenchymal Transition Plasticity and Metastasis in Pancreatic Cancer

Mingyang Liu et al.

Summary: The study revealed that ZIP4 activates ZEB1 and YAP1 to regulate pancreatic cancer metastasis and EMT plasticity, with significant impact on tumor progression and spread.

GASTROENTEROLOGY (2021)

添加到收藏夹

Article Cell Biology

Emodin Induced Necroptosis and Inhibited Glycolysis in the Renal Cancer Cells by Enhancing ROS

Ke-jie Wang et al.

Summary: The study found that emodin effectively kills renal cancer cells by inducing necroptosis instead of apoptosis, through ROS-mediated activation of the JNK signaling pathway and inhibition of glycolysis. These findings may provide potential mechanisms for developing novel therapeutic approaches for patients with JNK- or PI3K/AKT-dysregulated renal cancer cells.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Silencing of ISLR inhibits tumour progression and glycolysis by inactivating the IL-6/JAK/STAT3 pathway in non-small cell lung cancer

Peng Zhang et al.

Summary: The study uncovered that overexpression of ISLR gene in non-small cell lung cancer was associated with lower survival rates in patients. Elevated ISLR expression levels promoted proliferation, migration, invasion, and glycolysis of tumor cells while inhibiting apoptosis, suggesting ISLR may serve as a potential molecular target for the diagnosis and treatment of NSCLC.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

添加到收藏夹

Review Cell Biology

Compartmentalization and metabolic regulation of glycolysis

Gregory G. Fuller et al.

Summary: Under hypoxic conditions, glycolysis becomes the primary metabolic pathway due to TCA cycle inhibition, but mechanisms compensating for the resulting decrease in energy production are not well understood. Recent studies show dynamic compartmentalization of glycolysis enzymes in response to hypoxic stress in yeast, C. elegans, and mammalian cells. Concentrating glycolysis enzymes into condensates may enhance glucose utilization and energy production.

JOURNAL OF CELL SCIENCE (2021)

添加到收藏夹

Article Oncology

The IRF2/CENP-N/AKT signaling axis promotes proliferation, cell cycling and apoptosis resistance in nasopharyngeal carcinoma cells by increasing aerobic glycolysis

Cheng-Lin Qi et al.

Summary: CENP-N is highly expressed in NPC and is associated with poor prognosis. The IRF2/CENP-N/AKT axis regulates glucose metabolism and cell cycle, promoting proliferation and anti-apoptotic abilities in NPC cells.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

添加到收藏夹

Article Cell Biology

Monocarboxylate transporter 1 promotes proliferation and invasion of renal cancer cells by mediating acetate transport

Minghua Li et al.

Summary: The study revealed that MCT1 is abnormally high in ccRCC and promotes cancer development. The regulatory effect of MCT1 on cell proliferation and invasion may be mediated by acetate transport.

CELL BIOLOGY INTERNATIONAL (2021)

添加到收藏夹

Review Immunology

Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy

Xin Peng et al.

Summary: Dendritic cells (DCs) play a crucial role in capturing antigens from pathogens or tumors and presenting them to T cells for immune response. However, the immune activity of DCs is generally inhibited in the tumor microenvironment (TME) due to abnormal metabolism of tumor cells causing metabolic changes in TME, limiting the function of DCs and leading to tumor immune escape.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Neurosciences

Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration

Atsuhito Uneda et al.

Summary: DGCs play a crucial role in GBM by promoting macrophage infiltration through secretion of CCN1, shaping a mesenchymal microenvironment and driving tumor progression.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)

添加到收藏夹

Article Oncology

Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo

Tiago De Oliveira et al.

Summary: The PFKFB3 inhibitor KAN0438757 significantly reduced CRC cell migration, invasion and survival, and showed significant effects on growth in patient-derived cancer organoids, while sparing normal colon organoids and healthy mice from high toxicity. These findings support further translational studies to evaluate KAN0438757 in CRC therapy.

CANCERS (2021)

添加到收藏夹

Article Oncology

Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics

Susi Zhu et al.

Summary: PKM2 plays a crucial role in tumor metabolism and its dysregulation is associated with cancer development and progression. Researchers are investigating the function and therapeutic potential of PKM2 in cancer, particularly its interactions with lncRNAs. The role of PKM2 in the tumor microenvironment (TME) is also being studied for its implications in cancer therapy.

CANCER LETTERS (2021)

添加到收藏夹

Article Immunology

Interleukin-1β Promotes Lung Adenocarcinoma Growth and Invasion Through Promoting Glycolysis via p38 Pathway

Qi Tan et al.

Summary: The study revealed that IL-1 beta promotes glycolysis of LUAD cells through the p38 signaling pathway, enhancing tumor-cell migration and invasion. Targeting IL-1 beta and the glycolysis pathway may be a potential therapeutic strategy for lung cancer.

JOURNAL OF INFLAMMATION RESEARCH (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Tumor microenvironment as a therapeutic target in cancer

Yi Xiao et al.

Summary: This article summarizes the current progress in targeting the tumor microenvironment in both drug development and clinical trials, emphasizing the challenges in intervening in the tumor microenvironment and discussing strategies to maximize therapeutic benefits. New technologies and approaches to better understand the tumor microenvironment are explored in this context.

PHARMACOLOGY & THERAPEUTICS (2021)

添加到收藏夹

Editorial Material Cell Biology

Glycolysis

Navdeep S. Chandel

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2021)

添加到收藏夹

Article Oncology

Hypoxia-Driven HIF-1α Activation Reprograms Pre-Activated NK Cells towards Highly Potent Effector Phenotypes via ERK/STAT3 Pathways

Seon Ah Lim et al.

Summary: In patients with advanced cancer, hypoxic stress shapes NK cells towards tumor-resistant and immunosuppressive phenotypes. Restoring NK cell function within hypoxia is crucial for successful tumor immunotherapy. Manipulating pO(2) exposure to naive vs. pre-activated NK cells, HIF-1 alpha-dependent metabolic reprogramming proved key to overcoming hypoxia-induced NK cell impairment, generating functionally robust NK cells for adoptive therapy and clinical evaluation.

CANCERS (2021)

添加到收藏夹

Article Cell Biology

Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming

Samantha M. Morrissey et al.

Summary: The study reveals that tumor-derived exosomes can polarize macrophages towards an immunosuppressive phenotype through NF-kB and glycolytic reprogramming, and are associated with lactate, GLUT-1, and YKT6 factors, further promoting tumor metastasis.

CELL METABOLISM (2021)

添加到收藏夹

Article Toxicology

Autophagy and glycolysis independently attenuate silibinin-induced apoptosis in human hepatocarcinoma HepG2 and Hep3B cells

J. Yang et al.

Summary: The study found that silibinin-induced apoptosis in HCC cells was incomplete, as up-regulated autophagy and reduced glycolysis were involved. Inhibiting autophagy or AMP-activated protein kinase activation enhanced the cytotoxicity of silibinin, suggesting that blockage of autophagy and glycolysis can lead to complete apoptosis of HCC cells treated with silibinin.

HUMAN & EXPERIMENTAL TOXICOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cancer Cell Metabolism in Hypoxia: Role of HIF-1 as Key Regulator and Therapeutic Target

Vittoria Infantino et al.

Summary: In cancer cells, metabolic reprogramming under low-oxygen conditions is crucial for tumor survival, with HIF-1 playing a pivotal role. Mitochondria are key players in regulating cellular energy and closely interact with HIF-1 to drive metabolic and functional changes in cancer cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Establishment of a novel glycolysis-related prognostic gene signature for ovarian cancer and its relationships with immune infiltration of the tumor microenvironment

Jianlei Bi et al.

Summary: This study constructed a prognostic model related to glycolysis for ovarian cancer, identifying 8 prognostic genes that effectively predicted patient survival. The results showed a close relationship between these glycolysis-related genes and immune cell infiltration in the tumor microenvironment.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Article Cell Biology

STAT3/LINC00671 axis regulates papillary thyroid tumor growth and metastasis via LDHA-mediated glycolysis

Nan Huo et al.

Summary: A novel lncRNA LINC00671 was found to be negatively correlated with LDHA, downregulating LDHA expression and predicting a good clinical outcome in thyroid cancer. The STAT3/LINC00671/LDHA axis was established as critical in regulating PTC growth and progression, suggesting potential therapeutic strategies in thyroid cancer.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Hexokinase 3 dysfunction promotes tumorigenesis and immune escape by upregulating monocyte/macrophage infiltration into the clear cell renal cell carcinoma microenvironment

Wenhao Xu et al.

Summary: This study identified the significant upregulation of HK3 in ccRCC tissues, which can predict tumor progression and poor prognosis. HK3 is a potential prognostic marker that can independently predict the survival of ccRCC patients. Additionally, HK3 can modulate glycolysis and malignant behaviors in ccRCC cells.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

The enhancement of glycolysis regulates pancreatic cancer metastasis

Jinshou Yang et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents

B. Pajak et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Comprehensive analysis of the association between tumor glycolysis and immune/inflammation function in breast cancer

Wenhui Li et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

添加到收藏夹

Article Medicine, Research & Experimental

PI3K-Akt-mTOR/PFKFB3 pathway mediated lung fibroblast aerobic glycolysis and collagen synthesis in lipopolysaccharide-induced pulmonary fibrosis

Xiaoting Hu et al.

LABORATORY INVESTIGATION (2020)

添加到收藏夹

Review Medicine, General & Internal

Tumor Microenvironment

Borros Arneth

MEDICINA-LITHUANIA (2020)

添加到收藏夹

Article Oncology

Exosome-delivered circRNA promotes glycolysis to induce chemoresistance through the miR-122-PKM2 axis in colorectal cancer

Xinyi Wang et al.

MOLECULAR ONCOLOGY (2020)

添加到收藏夹

Review Oncology

Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis

Kulsoom Zahra et al.

FRONTIERS IN ONCOLOGY (2020)

添加到收藏夹

Article Oncology

Tumor-associated macrophage interleukin-β promotes glycerol-3-phosphate dehydrogenase activation, glycolysis and tumorigenesis in glioma cells

Jian Lu et al.

CANCER SCIENCE (2020)

添加到收藏夹

Review Chemistry, Medicinal

Monocarboxylate transporter 1 and 4 inhibitors as potential therapeutics for treating solid tumours: A review with structure-activity relationship insights

Sachin Puri et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

添加到收藏夹

Article Cell & Tissue Engineering

Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity

Huang Zhu et al.

CELL STEM CELL (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

The tumor microenvironment

Nicole M. Anderson et al.

CURRENT BIOLOGY (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Biodegradable pH-responsive micelles loaded with 8-hydroxyquinoline glycoconjugates for Warburg effect based tumor targeting

Adrian Dominski et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

添加到收藏夹

Review Oncology

Cancer Acidity and Hypertonicity Contribute to Dysfunction of Tumor-Associated Dendritic Cells: Potential Impact on Antigen Cross-Presentation Machinery

Sven Burgdorf et al.

CANCERS (2020)

添加到收藏夹

Review Oncology

The Crosstalk Between Tumor-Associated Macrophages (TAMs) and Tumor Cells and the Corresponding Targeted Therapy

Zhe Ge et al.

FRONTIERS IN ONCOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

The updated landscape of tumor microenvironment and drug repurposing

Ming-Zhu Jin et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Endoplasmic Reticulum stress-dependent expression of ERO1L promotes aerobic glycolysis in Pancreatic Cancer

Junfeng Zhang et al.

THERANOSTICS (2020)

添加到收藏夹

Article Oncology

Blocking IL-6/GP130 Signaling Inhibits Cell Viability/Proliferation, Glycolysis, and Colony Forming Activity in Human Pancreatic Cancer Cells

Xiang Chen et al.

CURRENT CANCER DRUG TARGETS (2019)

添加到收藏夹

Review Biology

The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression

Peter Vaupel et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Lactate: A Metabolic Driver in the Tumour Landscape

Luigi Ippolito et al.

TRENDS IN BIOCHEMICAL SCIENCES (2019)

添加到收藏夹

Article Medicine, General & Internal

Increased glycolysis correlates with elevated immune activity in tumor immune microenvironment

Zehang Jiang et al.

EBIOMEDICINE (2019)

添加到收藏夹

Review Oncology

Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment

Tengjiao Fan et al.

CANCERS (2019)

添加到收藏夹

Article Gastroenterology & Hepatology

Glycolytic activation of peritumoral monocytes fosters immune privilege via the PFKFB3-PD-L1 axis in human hepatocellular carcinoma

Dong-Ping Chen et al.

JOURNAL OF HEPATOLOGY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Quercetin Inhibits the Proliferation of Glycolysis-Addicted HCC Cells by Reducing Hexokinase 2 and Akt-mTOR Pathway

Hongyan Wu et al.

MOLECULES (2019)

添加到收藏夹

Review Immunology

T Regulatory Cells and Priming the Suppressive Tumor Microenvironment

Christina M. Paluskievicz et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Oncology

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

Karen G. de la Cruz-Lopez et al.

FRONTIERS IN ONCOLOGY (2019)

添加到收藏夹

Article Oncology

Tumor microenvironment dictates regulatory T cell phenotype: Upregulated immune checkpoints reinforce suppressive function

Hye Ryun Kim et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Tumor-secreted dickkopf2 accelerates aerobic glycolysis and promotes angiogenesis in clorectal cancer

Fengliu Deng et al.

THERANOSTICS (2019)

添加到收藏夹

Review Immunology

Macrophages as regulators of tumour immunity and immunotherapy

David G. DeNardo et al.

NATURE REVIEWS IMMUNOLOGY (2019)

添加到收藏夹

Article Endocrinology & Metabolism

GLUT1 regulates cell glycolysis and proliferation in prostate cancer

Hengjun Xiao et al.

PROSTATE (2018)

添加到收藏夹

Article Cell Biology

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy

Tina Cascone et al.

CELL METABOLISM (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis

Yajuan Zhang et al.

MOLECULAR CELL (2018)

添加到收藏夹

Article Cell Biology

Tumor-associated macrophages promote progression and the Warburg effect via CCL18/NF-kB/VCAM-1 pathway in pancreatic ductal adenocarcinoma

Huilin Ye et al.

CELL DEATH & DISEASE (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Four Key Steps Control Glycolytic Flux in Mammalian Cells

Lukas Bahati Tanner et al.

CELL SYSTEMS (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Potential roles of IL-1 subfamily members in glycolysis in disease

Qi Tan et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2018)

添加到收藏夹

Article Pharmacology & Pharmacy

Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells

Marcella Manerba et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

添加到收藏夹

Article Cell Biology

PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis

Fabao Liu et al.

NATURE CELL BIOLOGY (2017)

添加到收藏夹

Article Genetics & Heredity

Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

Oliver G. McDonald et al.

NATURE GENETICS (2017)

添加到收藏夹

Review Oncology

Taming Tumor Glycolysis and Potential implications for immunotherapy

Shanmugasundaram Ganapathy-Kanniappan

FRONTIERS IN ONCOLOGY (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Dysfunctional T cell metabolism in the tumor microenvironment

Kathryn E. Beckermann et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2017)

添加到收藏夹

Review Clinical Neurology

The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor

Cara J. Valvona et al.

BRAIN PATHOLOGY (2016)

添加到收藏夹

Review Oncology

HIF-1 at the crossroads of hypoxia, inflammation, and cancer

Kuppusamy Balamurugan

INTERNATIONAL JOURNAL OF CANCER (2016)

添加到收藏夹

Article Oncology

Interleukin-6 stimulates aerobic glycolysis by regulating PFKFB3 at early stage of colorectal cancer

Jun Han et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

IL-33 signaling fuels outgrowth and metastasis of human lung cancer

Chunhong Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

添加到收藏夹

Review Cell Biology

The Emerging Hallmarks of Cancer Metabolism

Natalya N. Pavlova et al.

CELL METABOLISM (2016)

添加到收藏夹

Article Cell Biology

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

Almut Brand et al.

Cell Metabolism (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

Ninel Azoitei et al.

MOLECULAR CANCER (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

Chih-Hao Chang et al.

CELL (2015)

添加到收藏夹

Review Oncology

Using tumour phylogenetics to identify the roots of metastasis in humans

Kamila Naxerova et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Novel Markers to Delineate Murine M1 and M2 Macrophages

Kyle A. Jablonski et al.

PLOS ONE (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Hypermutable DNA chronicles the evolution of human colon cancer

Kamila Naxerova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Article Oncology

Tumor necrosis factor alpha induces Warburg-like metabolism and is reversed by anti-inflammatory curcumin in breast epithelial cells

Roger A. Vaughan et al.

INTERNATIONAL JOURNAL OF CANCER (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

TNFα and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells

Daniel S. Straus

MOLECULAR CANCER (2013)

添加到收藏夹

Article Oncology

Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets

Vera Miranda-Goncalves et al.

NEURO-ONCOLOGY (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

Qian Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

添加到收藏夹

Article Oncology

Lactate promotes glioma migration by TGF-β2-dependent regulation of matrix metalloproteinase-2

Fusun Baumann et al.

NEURO-ONCOLOGY (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cancer cell metabolism: Warburg and beyond

Peggy P. Hsu et al.

CELL (2008)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.