4.7 Article

Antibiotic use in elderly patients in ambulatory care: A comparison between Hungary and Sweden

期刊

FRONTIERS IN PHARMACOLOGY
卷 13, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.1042418

关键词

drug utilization study; ambulatory care; antibacterials; elderly; cross national comparison; prescrptions/1000 inhabitants/year; public health; antibiotic stewardship

资金

  1. Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund
  2. ITM NKFIA [TKP2021-EGA-32]
  3. Janos Bolyai Research Scholarship of the Hungarian Academy of Science

向作者/读者索取更多资源

The study compared antibiotic use in the elderly in ambulatory care sector between Hungary and Sweden, finding that Hungary had higher antibiotic exposure in the elderly population compared to Sweden. There were significant differences in antibiotics used in the elderly between the two countries, with Hungary more frequently prescribing penicillin, beta-lactamase combinations, and quinolones, while Sweden primarily prescribed narrow spectrum penicillins.
Background: The elderly use antibiotics frequently due to their increasing infection susceptibility. Given the high and increasing proportion of elderly in the population, their antibiotic use is substantial. Objective: This study aimed to compare antibiotic use in the elderly in the ambulatory care sector between Hungary and Sweden. Methods: This retrospective, descriptive, cross-national, comparative study included antibacterial use data from the Hungarian National Health Insurance Fund and the Swedish eHealth Agency. Antibiotic use (anatomical therapeutical chemical: J01) was expressed as the number of prescriptions/1000 inhabitants/year or month and was further stratified by age and sex. Results: Antibiotic exposure was higher in the Hungarian elderly population (649.8 prescriptions/1000 inhabitants/year) compared to its Swedish counterparts (545.0 prescriptions/1000 inhabitants/year). Hungary had a similar scale of antibacterial exposure across all elderly age subgroups, with different trends in males and females, while Sweden had a stepwise increase in antibiotic exposure by age in both sexes. The seasonal fluctuation was high in Hungary and reached a peak of 80.7 prescriptions/1000 inhabitants/month in January 2017, while even antibiotic use was detected throughout the year in Sweden. The pattern of antibiotic use in the elderly considerably differed between the two countries. Penicillin and beta-lactamase combinations, such as co-amoxiclav, were more frequently used in Hungary than in Sweden (19.08% vs 1.83% of corresponding total ambulatory antibiotic use). Likewise, quinolones were more commonly used in Hungary than in Sweden (34.53% vs. 9.98). The elderly in Sweden were mostly prescribed narrow spectra penicillins (26.71% vs. 0.29% in Hungary). Conclusion: This cross-national comparison revealed important differences in all aspects of antibiotic use in the elderly between the two countries. The identical scale and pattern of antibiotic use cannot be anticipated due to the poorer health status of the Hungarian elderly population. However, the substantial differences indicate some room for improvement in the antibiotic prescription for the Hungarian elderly.

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