HIF-1 signalling pathway was identified as a potential new pathway for Icariin's treatment against Alzheimer's disease based on preclinical evidence and bioinformatics

Article Cell Biology

Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters in 3xTg-AD mice

Fei Yan et al.

Summary: Icariin improves learning and memory impairments in an Alzheimer's disease mouse model by regulating brain insulin signaling and glucose transporters.

NEURAL REGENERATION RESEARCH (2023)

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Article Cell Biology

Exploration of the mechanism by which icariin modulates hippocampal neurogenesis in a rat model of depression

Ning-Xi Zeng et al.

Summary: In this study, the mechanism by which Icariin (ICA) protects against hippocampal injury in depression was investigated through proteomics analysis of cerebrospinal fluid. The results showed that ICA can prevent depression and dysfunctional hippocampal neurogenesis through regulating the expression of certain proteins found in the cerebrospinal fluid.

NEURAL REGENERATION RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Icariin Ameliorates Alzheimer's Disease Pathology by Alleviating Myelin Injury in 3 x Tg-AD Mice

Hongxia Yu et al.

Summary: Alzheimer's disease (AD) is a neurodegenerative disease characterized by the deposition of beta amyloid, hyperphosphorylation of tau protein, and cell death. This study investigates the potential of icariin (ICA), a prenylated flavonol glycoside, in improving cognitive function in AD model mice. The results show that ICA treatment improves learning and memory, reduces A beta deposition and tau protein phosphorylation in the hippocampus, and increases myelin-related gene expression, suggesting its potential therapeutic effects on AD.

NEUROCHEMICAL RESEARCH (2022)

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Article Pharmacology & Pharmacy

Multifunctional icariin and tanshinone IIA co-delivery liposomes with potential application for Alzheimer's disease

Jiao Wang et al.

Summary: In this study, a therapeutic strategy for delivering drugs to the brain was developed using Ang2-ICA/TSIIA liposomes, which not only penetrate the blood-brain barrier but also have potential anti-Alzheimer's disease effects.

DRUG DELIVERY (2022)

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Review Integrative & Complementary Medicine

The Role of PKC and HIF-1 and the Effect of Traditional Chinese Medicinal Compounds on Cerebral Ischemia-Reperfusion Injury

Zheyu Fang et al.

Summary: Neuronal death occurs during cerebral ischemia and is further aggravated during reperfusion, resulting in cerebral ischemia-reperfusion injury (CIRI). Protein kinase C (PKC) and hypoxia-inducible factor-1 (HIF-1) play important roles in CIRI. Traditional Chinese medicine compounds can regulate PKC and HIF-1 signaling pathways to alleviate CIRI and protect brain tissue by improving structural and material changes in brain cells.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Review Physiology

Sirtuins promote brain homeostasis, preventing Alzheimer's disease through targeting neuroinflammation

Mateusz Watroba et al.

Summary: This article discusses the basic pathomechanisms of Alzheimer's disease and the potential preventive role of sirtuins, particularly SIRT1 and SIRT3, in protecting against Alzheimer's disease-related pathology. Sirtuins can inhibit molecular processes associated with the disease, thus preventing its development. The article also explores the mechanisms by which sirtuins may prevent Alzheimer's disease and presents a rationale for boosting sirtuin activity.

FRONTIERS IN PHYSIOLOGY (2022)

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Review Immunology

Pathogenesis, therapeutic strategies and biomarker development based on omics analysis related to microglia in Alzheimer's disease

Chao Gao et al.

Summary: This review summarizes the omics analysis of microglia in Alzheimer's disease (AD) and highlights the important role of microglia in the pathogenesis of AD. Omics approaches provide valuable insights into the mechanisms of microglia in AD and offer potential for the discovery of diagnostic biomarkers and monitoring disease progression.

JOURNAL OF NEUROINFLAMMATION (2022)

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Review Biochemistry & Molecular Biology

Review on Alzheimer's disease: Inhibition of amyloid beta and tau tangle formation

Hossein Ashrafian et al.

Summary: Approximately 40 million people globally suffer from dementia, with Alzheimer's disease being the most common cause. Aggregation of Aβ outside of neuron cells and tau protein tangle formation inside cells are believed to play crucial roles. This paper reviews studies targeting the inhibition of these protein aggregations to suppress or postpone AD.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Clinical Neurology

Anti-Neurodegenerative Benefits of Acetylcholinesterase Inhibitors in Alzheimer's Disease: Nexus of Cholinergic and Nerve Growth Factor Dys-function

Donald E. Moss et al.

Summary: Alzheimer's disease is a progressive neurodegenerative disorder with no effective treatments currently available. The use of AChE inhibitors can alleviate symptoms and slow disease progression, but the current inhibitors have relatively low levels of inhibition in the central nervous system. Irreversible inhibitors may be a way to enhance therapeutic benefits.

CURRENT ALZHEIMER RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Icariin ameliorate Alzheimer's disease by influencing SIRT1 and inhibiting Aβ cascade pathogenesis

Yaochen Chuang et al.

Summary: Alzheimer's disease, with the highest proportion of cases among all types of dementia, is closely associated with the aggregation of amyloid-beta protein. Icariin, the main ingredient extracted from Epimedium, may ameliorate Alzheimer's disease by regulating Sirtuin1 to inhibit amyloid-beta protein and improve other amyloid-beta cascade pathogenesis, providing a reference for future treatment strategies.

JOURNAL OF CHEMICAL NEUROANATOMY (2021)

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Article Chemistry, Physical

gmx_MMPBSA: A New Tool to Perform End-State Free Energy Calculations with GROMACS

Mario S. Valdes-Tresanco et al.

Summary: gmx_MMPBSA is a new tool for performing end-state free energy calculations from GROMACS molecular dynamics trajectories, offering various options including binding free energy calculations with different solvation models, stability calculations, computational alanine scanning, entropy corrections, and binding free energy decomposition. Additionally, promising methodologies for calculating relative binding free energies have been implemented.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2021)

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Review Behavioral Sciences

The effects of treadmill exercise in animal models of Parkinson's disease: A systematic review

Ana Flavia F. Ferreira et al.

Summary: Exercise has been shown to alleviate symptoms of Parkinson's disease and improve patient quality of life. However, systematic review of literature on treadmill exercise in PD animal models reveals high risk of bias and lack of study design information, which needs attention for data reproducibility.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

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Review Neurosciences

Role of Hypoxia Inducible Factor-1α in Alzheimer's Disease

Yang-Yang Wang et al.

Summary: HIF-1 alpha plays a dual role in Alzheimer's disease, both promoting pathological development and resisting pathogenic effects, making it a complex factor with potential therapeutic implications.

JOURNAL OF ALZHEIMERS DISEASE (2021)

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Article Cell Biology

The Combination of β-Asarone and Icariin Inhibits Amyloid-β and Reverses Cognitive Deficits by Promoting Mitophagy in Models of Alzheimer's Disease

Nanbu Wang et al.

Summary: This study primarily explores the effects of the combination of beta-asarone and ICA on clearing noxious proteins and reversing cognitive deficits, as well as the role of mitophagy in the pathogenesis of AD. Combined treatment with mitophagy inducers may represent a potential strategy for therapeutic intervention in AD.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Oncology

CART mitigates oxidative stress and DNA damage in memory deficits of APP/PS1 mice via upregulating β-amyloid metabolism-associated enzymes

Hui Jiang et al.

Summary: The study found that CART can improve memory deficits in APP/PS1 mice by reducing oxidative stress, inhibiting DNA damage, and protecting mitochondrial function in the cerebral cortex and hippocampus. Additionally, CART promotes Aβ degradation by modulating enzymes associated with Aβ metabolism.

MOLECULAR MEDICINE REPORTS (2021)

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Article Biochemistry & Molecular Biology

Bioactive Flavonoids Icaritin and Icariin Protect against Cerebral Ischemia-Reperfusion-Associated Apoptosis and Extracellular Matrix Accumulation in an Ischemic Stroke Mouse Model

Cheng-Tien Wu et al.

Summary: This study found that both ICA and ICT have neuroprotective effects in acute cerebral ischemic stroke mice, with ICT showing slightly better results than ICA. Pretreatment with both ICA and ICT improves neuronal cell apoptosis, responses to oxidative/nitrosative stress, and counteracts ECM accumulation in the brains of acute cerebral ischemic stroke mice.

BIOMEDICINES (2021)

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Article Endocrinology & Metabolism

Icariin enhance mild hypothermia-induced neuroprotection via inhibiting the activation of NF-κB in experimental ischemic stroke

Mingming Dai et al.

Summary: This research investigated the neuroprotective effects of therapeutic hypothermia and icariin on ischemic stroke. The results showed that mild hypothermia, icariin, and NF-kappa B inhibitor could reduce cerebral infarct volume, neurological deficits, and cerebral cell death through the regulation of multiple pathways. Icariin was found to enhance the effects of mild hypothermia and promote neuroprotection through inhibition of NF-kappa B activation.

METABOLIC BRAIN DISEASE (2021)

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Article Cell & Tissue Engineering

Icariin Promotes Survival, Proliferation, and Differentiation of Neural Stem Cells In Vitro and in a Rat Model of Alzheimer's Disease

Denglei Ma et al.

Summary: The study suggests that icariin can promote the survival, proliferation, and differentiation of neural stem cells in the basal forebrain, increasing the number of cholinergic neurons. This combination therapy may offer a new potential and effective approach for Alzheimer's disease treatment.

STEM CELLS INTERNATIONAL (2021)

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Article Pharmacology & Pharmacy

Guhong Injection Alleviates Cerebral Ischemia-Reperfusion Injury via the PKC/HIF-1α Pathway in Rats

Li Yu et al.

Summary: This study investigated the therapeutic effect of Guhong injection (GHI) on cerebral ischemia-reperfusion injury in rats through the PKC/HIF-1 alpha pathway. The results demonstrated that GHI can ameliorate neurological damage in MCAO rats by reducing levels of HIF-1 alpha, PKC, and other related markers in the brain.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Cell Biology

Hypoxia-Inducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease

Elena V. Mitroshina et al.

Summary: Hypoxia is a common pathological condition induced by various events, with the body's adaptation to it being crucial for health and disease. HIFs, a family of transcription factors, play a key role in cellular responses to hypoxia and are increasingly viewed as potential targets for treating a range of hypoxia-associated diseases. The role of HIFs in adaptation to hypoxia is universal across tissue types, including the CNS, where they are involved in regulating neurogenesis, nerve cell differentiation, and neuronal apoptosis, potentially offering new therapeutic opportunities.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Plant Sciences

Icariin improves brain function decline in aging rats by enhancing neuronal autophagy through the AMPK/mTOR/ULK1 pathway

Jie Zheng et al.

Summary: Icariin improves neuronal degeneration associated with aging and increases the staining of Nissl bodies by upregulating autophagy-related proteins and p-AMPK, and downregulating p-MTOR in aging rats.

PHARMACEUTICAL BIOLOGY (2021)

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Article Orthopedics

Icariin increases chondrocyte vitality by promoting hypoxia-inducible factor-1 alpha expression and anaerobic glycolysis

Pengzhen Wang et al.

KNEE (2020)

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Article Pharmacology & Pharmacy

Intranasal delivery of icariin via a nanogel-thermoresponsive hydrogel compound system to improve its antidepressant-like activity

Dong Xu et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Pharmacology & Pharmacy

Icariin ameliorates the progression of experimental autoimmune encephalomyelitis by down-regulating the major inflammatory signal pathways in a mouse relapse-remission model of multiple sclerosis

Hengri Cong et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

Comprehensive Review on Alzheimer's Disease: Causes and Treatment

Zeinab Breijyeh et al.

MOLECULES (2020)

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Correction Neurosciences

Combination Treatment of Icariin and L-DOPA Against 6-OHDA-Lesioned Dopamine Neurotoxicity (vol 11, 155, 2018)

Di-Sheng Lu et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)

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Review Integrative & Complementary Medicine

Traditional Chinese Medicine for Alzheimer's Disease and Other Cognitive Impairment: A Review

Hui Pei et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2020)

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Article Immunology

Glial activation and inflammation along the Alzheimer's disease continuum

Kaja Nordengen et al.

JOURNAL OF NEUROINFLAMMATION (2019)

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Article Pharmacology & Pharmacy

Icariin Delays Brain Aging in Senescence-Accelerated Mouse Prone 8 (SAMP8) Model via Inhibiting Autophagy

Fa-Ju Chen et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2019)

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Review Medicine, Research & Experimental

MAPT mutations, tauopathy, and mechanisms of neurodegeneration

Kevin H. Strang et al.

LABORATORY INVESTIGATION (2019)

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Review Pharmacology & Pharmacy

Network Pharmacology Databases for Traditional Chinese Medicine: Review and Assessment

Runzhi Zhang et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Geriatrics & Gerontology

Long-term icariin treatment ameliorates cognitive deficits via CD4+ T cell-mediated immuno-inflammatory responses in APP/PS1 mice

Tianrui Zhu et al.

CLINICAL INTERVENTIONS IN AGING (2019)

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Review Biochemistry & Molecular Biology

Molecular Docking: Shifting Paradigms in Drug Discovery

Luca Pinzi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Medicine, Research & Experimental

Icariin improves the cognitive function of APP/PS1 mice via suppressing endoplasmic reticulum stress

Fei Li et al.

LIFE SCIENCES (2019)

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Article Biochemistry & Molecular Biology

PI3K-AKT Signaling Activation and Icariin: The Potential Effects on the Perimenopausal Depression-Like Rat Model

Li-Hua Cao et al.

MOLECULES (2019)

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Article Biochemistry & Molecular Biology

Icariin Ameliorates Amyloid Pathologies by Maintaining Homeostasis of Autophagic Systems in Aβ1-42-Injected Rats

Xia Jiang et al.

NEUROCHEMICAL RESEARCH (2019)

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Review Biochemistry & Molecular Biology

Pathological Impacts of Chronic Hypoxia on Alzheimer's Disease

Feng Zhang et al.

ACS CHEMICAL NEUROSCIENCE (2019)

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Review Pharmacology & Pharmacy

An outline for the pharmacological effect of icariin in the nervous system

Jie Jin et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

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Review Neurosciences

Treatment Combinations for Alzheimer's Disease: Current and Future Pharmacotherapy Options

Jeffrey L. Cummings et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

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Review Medicine, General & Internal

Cognitive symptoms of Alzheimer's disease: clinical management and prevention

Elizabeth Joe et al.

BMJ-BRITISH MEDICAL JOURNAL (2019)

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Article Biochemistry & Molecular Biology

Copper affects the binding of HIF-1α to the critical motifs of its target genes

Zhijuan Wu et al.

METALLOMICS (2019)

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Article Toxicology

Icariin-mediated activation of autophagy confers protective effect on rotenone induced neurotoxicity in vivo and in vitro

Ru Zeng et al.

TOXICOLOGY REPORTS (2019)

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Article Chemistry, Medicinal

Evaluation of AutoDock and AutoDock Vina on the CASF-2013 Benchmark

Thomas Gaillard

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2018)

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Article Medicine, Research & Experimental

Icariin and mesenchymal stem cells synergistically promote angiogenesis and neurogenesis after cerebral ischemia via PI3K and ERK1/2 pathways

Dandan Liu et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Review Neurosciences

Understanding the Role of Hypoxia Inducible Factor During Neuro-degeneration for New Therapeutics Opportunities

Amalia Merelli et al.

CURRENT NEUROPHARMACOLOGY (2018)

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Article Chemistry, Medicinal

Icariin promotes the migration of bone marrow stromal cells via the SDF-1 alpha/HIF-1 alpha/CXCR4 pathway

Haiyan Zhu et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2018)

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Review Cell Biology

The Role of Hypoxia-Inducible Factor 1 in Mild Cognitive Impairment

Osigbemhe Iyalomhe et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2017)

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Article Clinical Neurology

Utilization of Western medicine and traditional Chinese medicine among patients with Alzheimer's disease in Taiwan: a nationwide population-based study

C. -Y. Lai et al.

EUROPEAN JOURNAL OF NEUROLOGY (2017)

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Review Neurosciences

The blood-brain barrier in Alzheimer's disease

Elena Zenaro et al.

NEUROBIOLOGY OF DISEASE (2017)

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Article Neurosciences

Intranasal Lactoferrin Enhances α-Secretase-Dependent Amyloid Precursor Protein Processing via the ERK1/2-CREB and HIF-1α Pathways in an Alzheimer's Disease Mouse Model

Chuang Guo et al.

NEUROPSYCHOPHARMACOLOGY (2017)

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Article Biotechnology & Applied Microbiology

Icariin Attenuates Synaptic and Cognitive Deficits in an A ss(1-42)-Induced Rat Model of Alzheimer's Disease

Chenxia Sheng et al.

BIOMED RESEARCH INTERNATIONAL (2017)

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Article Multidisciplinary Sciences

Palmitic Acid-BSA enhances Amyloid-β production through GPR40-mediated dual pathways in neuronal cells: Involvement of the Akt/mTOR/HIF-1α and Akt/NF-κB pathways

Jeong Yeon Kim et al.

SCIENTIFIC REPORTS (2017)

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Article Environmental Sciences

Motor assessment in Parkinson's disease

Jozef A. Opara et al.

ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE (2017)

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Article Pharmacology & Pharmacy

Chinese herbal medicine for Alzheimer's disease: Clinical evidence and possible mechanism of neurogenesis

Wen-ting Yang et al.

BIOCHEMICAL PHARMACOLOGY (2017)

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Article Neurosciences

Neuroprotective Effects of Icariin on Brain Metabolism, Mitochondrial Functions, and Cognition in Triple-Transgenic Alzheimer's Disease Mice

Yi-Jing Chen et al.

CNS NEUROSCIENCE & THERAPEUTICS (2016)

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Article Neurosciences

Microglia Contributes to Plaque Growth by Cell Death Due to Uptake of Amyloid β in the Brain of Alzheimer's Disease Mouse Model

Sung Hoon Baik et al.

GLIA (2016)

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Article Biochemistry & Molecular Biology

The Protective Effect of Icariin on Mitochondrial Transport and Distribution in Primary Hippocampal Neurons from 3 x Tg-AD Mice

Yijing Chen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Immunology

A natural flavonoid glucoside icariin inhibits Th1 and Th17 cell differentiation and ameliorates experimental autoimmune encephalomyelitis

Ruile Shen et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2015)

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Article Neurosciences

ICARIIN DECREASES BOTH APP AND Aβ LEVELS AND INCREASES NEUROGENESIS IN THE BRAIN OF Tg2576 MICE

F. Li et al.

NEUROSCIENCE (2015)

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Article Multidisciplinary Sciences

CART treatment improves memory and synaptic structure in APP/PS1 mice

Jia-li Jin et al.

SCIENTIFIC REPORTS (2015)

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Article Biochemistry & Molecular Biology

Icariin Decreases the Expression of APP and BACE-1 and Reduces the β-amyloid Burden in an APP Transgenic Mouse Model of Alzheimer's Disease

Lan Zhang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2014)

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Article Cell Biology

A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis

Xiqing Chai et al.

NEURAL REGENERATION RESEARCH (2014)

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Article Multidisciplinary Sciences

Icariin Ameliorates Neuropathological Changes, TGF-β1 Accumulation and Behavioral Deficits in a Mouse Model of Cerebral Amyloidosis

Zhi-Yuan Zhang et al.

PLOS ONE (2014)

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Review Environmental Sciences

Instruments for Assessing Risk of Bias and Other Methodological Criteria of Published Animal Studies: A Systematic Review

David Krauth et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2013)

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Article Pharmacology & Pharmacy

Icariin inhibits beta-amyloid peptide segment 25-35 induced expression of β-secretase in rat hippocampus

Jing Nie et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2010)

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Article Chemistry, Medicinal

Icariin Improves Memory Impairment in Alzheimer's Disease Model Mice (5xFAD) and Attenuates Amyloid β-induced Neurite Atrophy

Takuya Urano et al.

PHYTOTHERAPY RESEARCH (2010)

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Article Biochemistry & Molecular Biology

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

Ying Liu et al.

FEBS LETTERS (2008)

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Article Neurosciences

Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance

Tristan Bolmont et al.

JOURNAL OF NEUROSCIENCE (2008)

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Article Chemistry, Physical

Langevin stabilization of molecular-dynamics simulations of polymers by means of quasisymplectic algorithms

L. Larini et al.

JOURNAL OF CHEMICAL PHYSICS (2007)

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Article Chemistry, Multidisciplinary

Development and testing of a general amber force field

JM Wang et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

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HIF-1 signalling pathway was identified as a potential new pathway for Icariin's treatment against Alzheimer's disease based on preclinical evidence and bioinformatics

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