Venlafaxine, an anti-depressant drug, induces apoptosis in MV3 human melanoma cells through JNK1/2-Nur77 signaling pathway

Article Pharmacology & Pharmacy

Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway

Xiaohua Xie et al.

Summary: Fluvoxamine exhibits therapeutic activities in IPF by inhibiting fibroblast activation and migration, reducing inflammation and excessive extracellular matrix production, and improving pulmonary function.

PHARMACOLOGICAL RESEARCH (2023)

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Letter Pharmacology & Pharmacy

Postmenopausal exogenous hormone therapy and Melanoma risk in women: A systematic review and time-response meta-analysis

Manuela Chiavarini et al.

PHARMACOLOGICAL RESEARCH (2022)

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Article Pharmacology & Pharmacy

Inhibition of Src/STAT3 signaling-mediated angiogenesis is involved in the anti-melanoma effects of dioscin

Yu-Xi Liu et al.

Summary: This study demonstrates that Dioscin exerts anti-melanoma effects by inhibiting Src/STAT3 signaling-mediated angiogenesis. Mechanistic studies revealed that Dioscin inhibits activation of Src and STAT3, and decreases secretion of pro-angiogenic cytokines from melanoma cells. This research provides a pharmacological basis for developing Dioscin as an anti-melanoma agent.

PHARMACOLOGICAL RESEARCH (2022)

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Article Pharmacology & Pharmacy

Genetic Blockade of NAAA Cell-specifically Regulates Fatty Acid Ethanolamides (FAEs) Metabolism and Inflammatory Responses

Xiaohua Xie et al.

Summary: NAAA is a lysosomal enzyme responsible for the hydrolysis of FAEs. This study generated NAAA-deficient mice and found that the deletion of NAAA increased the levels of PEA and AEA in bone marrow and macrophages, and elevated AEA levels in lungs. Unexpectedly, genetic blockade of NAAA showed moderately effective anti-inflammatory effects in acute lung injury, but poor analgesic effects in hyperalgesia and mechanical allodynia models. These phenotypes were associated with the absence of NAAA in non-BM cells. Overall, the study suggests that genetic blockade of NAAA regulates FAEs metabolism and inflammatory responses in a cell-specific manner.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Drug Repurposing: Escitalopram attenuates acute lung injury by inhibiting the SIK2/ HDAC4/ NF-κB signaling cascade

Tiantian Wang et al.

Summary: Escitalopram has been identified as a potential new treatment for acute lung injury (ALI) by inhibiting SIK2 activity and inducing HDAC4 dephosphorylation, leading to the inhibition of LPS-induced inflammation and improvement of lung injury.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Article Pharmacology & Pharmacy

Oleoylethanolamide as a New Therapeutic Strategy to Alleviate Doxorubicin-Induced Cardiotoxicity

Yeyu Qin et al.

Summary: This study suggests that Oleoylethanolamide (OEA) treatment can protect the heart from the toxic effects of Doxorubicin (DOX). This protective effect is mediated by the activation of TRPV1 channel and upregulation of the PI3K/Akt signaling pathway.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Clinical Neurology

Electrical stimulus combined with venlafaxine and mirtazapine improves brain Ca2+activity, pre-pulse inhibition, and immobility time in a model of major depressive disorder in schizophrenia

Chuanjun Zhuo et al.

Summary: This study investigated the treatment effects of different medications for patients with schizophrenia and major depressive disorder using a mouse model. The results showed that ECS + venlafaxine + mirtazapine had significant effects in alleviating major depressive disorder, as reflected by brain Ca2+ activity and behavioral assay performance. Clozapine + venlafaxine + mirtazapine did not have an ideal treatment effect.

JOURNAL OF AFFECTIVE DISORDERS (2022)

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Article Pharmacology & Pharmacy

BRAFV600E;K601Q metastatic melanoma patient-derived organoids and docking analysis to predict the response to targeted therapy

Letizia Porcelli et al.

Summary: The V600E mutation in BRAF is associated with increased phosphorylation of Erk1/2 and high sensitivity to BRAFi/MEKi combination in metastatic melanoma. However, a tandem mutation in BRAF, V600 and K601, leads to a different response to the combination treatment. Generating BRAF(V600E;K601Q) patient-derived organoids (PDOs) and conducting docking analysis revealed that the tandem mutation reduced the affinity for Vemurafenib. Tumor analysis also showed increased phosphorylation of Erk1/2 and activation of Notch resistance signaling in BRAF(V600E;K601Q).

PHARMACOLOGICAL RESEARCH (2022)

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Article Pharmacology & Pharmacy

Anti-tumor effects of Skp2 inhibitor AAA-237 on NSCLC by arresting cell cycle at G0/G1 phase and inducing senescence

Jinyi Liu et al.

Summary: Lung cancer is a major cause of cancer deaths worldwide, with non small cell lung cancer (NSCLC) being the most common type. Researchers have discovered a Skp2 inhibitor called AAA-237 that can inhibit the growth of NSCLC cells. This inhibition is achieved by targeting Skp2 protein to regulate the cell cycle and increase the expression of certain genes. AAA-237 treatment can induce apoptosis at high concentrations and cellular senescence at lower concentrations. Similar results were observed in animal models. These findings suggest that AAA-237 could be a potential therapeutic drug for NSCLC patients.

PHARMACOLOGICAL RESEARCH (2022)

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Correction Pharmacology & Pharmacy

N-acylethanolamine acid amidase (NAAA) exacerbates psoriasis inflammation by enhancing dendritic cell (DCs) maturation (vol 185, 106491, 2022)

Yuhang Li et al.

PHARMACOLOGICAL RESEARCH (2022)

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Review Pharmacology & Pharmacy

A renewed concept on the MAPK signaling pathway in cancers: Polyphenols as a choice of therapeutics

Juhaer Anjum et al.

Summary: Abnormalities in the MAPK signaling pathway contribute to carcinogenesis, while polyphenols can modulate this pathway to inhibit cancer cell growth and metastasis.

PHARMACOLOGICAL RESEARCH (2022)

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Article Genetics & Heredity

Drug repositioning for esophageal squamous cell carcinoma

Adam N. Bennett et al.

Summary: Esophageal cancer, particularly esophageal squamous cell carcinoma, is a significant challenge globally, with high incidence and mortality rates. The limited number of effective therapeutic options contributes to the high mortality rate. Repurposing existing drugs approved for other diseases through drug repositioning is a more time and cost-effective strategy. This study identified potential therapeutic drugs for esophageal cancer patients through gene expression analysis and network analysis, including both known drugs like Doxorubicin and potential psychiatric drugs like Venlafaxine.

FRONTIERS IN GENETICS (2022)

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Article Pharmacology & Pharmacy

BRAF(V600E;K601Q) metastatic melanoma patient-derived organoids and docking analysis to predict the response to targeted therapy

Letizia Porcelli et al.

Summary: The study found that patients with the BRAF(V600E;K601Q) mutation, although sensitive to combination therapy with Vemurafenib and Cobimetinib, were not as responsive as those with a single BRAF(V600E) mutation. Furthermore, docking analysis revealed that the tandem mutation may reduce drug affinity, affecting treatment efficacy.

PHARMACOLOGICAL RESEARCH (2022)

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Review Neurosciences

Progress and Promise of Nur77-based Therapeutics for Central Nervous System Disorders

Lu Liu et al.

Summary: Nur77, a member of the nuclear receptor superfamily, can be rapidly increased in expression and activation through various physiological and pathological stimuli. It plays a regulatory role in cell differentiation, apoptosis, metabolism, mitochondrial homeostasis, and other processes. Although research on Nur77 in CNS diseases is limited, evidence suggests its potential therapeutic value in various neurological disorders.

CURRENT NEUROPHARMACOLOGY (2021)

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Review Oncology

The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer

Stephen Safe et al.

Summary: The NR4A genes play a crucial role in maintaining cellular homeostasis and tumor pathophysiology, with NR4A1 and NR4A3 exhibiting tumor suppressor activity in blood-derived cancers, while NR4A1 and NR4A2 showing pro-oncogenic activities in solid tumors. Drugs inducing NR4A expression have potential for leukemia and lymphoma treatment, while NR4A antagonists may be promising for solid tumor therapy.

MOLECULAR CANCER RESEARCH (2021)

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Article Pharmacology & Pharmacy

NAAA inhibitor F96 attenuates BBB disruption and secondary injury after traumatic brain injury (TBI)

Yitian Li et al.

Summary: TBI induced an increase in PEA levels, preventing BBB disruption, but NAAA facilitated PEA degradation through neutrophils, weakening the BBB protective effects and exacerbating tissue injury.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Review Cell Biology

Targeting NR4A Nuclear Receptors to Control Stromal Cell Inflammation, Metabolism, Angiogenesis, and Tumorigenesis

Daniel Crean et al.

Summary: The NR4A1-NR4A3 subfamily of nuclear receptors, induced by various stimuli, serves as potent sensors of cellular microenvironment changes to control physiological and pathological processes through genomic and non-genomic actions, impacting metabolism, cardiovascular and neurological functions, immune cell homeostasis, chronic inflammation, altered immune responses, and cancer development.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Pharmacology & Pharmacy

Malayoside, a cardenolide glycoside extracted from Antiaris toxicaria Lesch, induces apoptosis in human non-small lung cancer cells via MAPK-Nur77 signaling pathway

Qiong-Ying Hu et al.

Summary: Studies have shown that malayoside has anti-NSCLC activity both in vitro and in vivo, mainly through activation of the MAPK-Nur77 signaling pathway, indicating that malayoside is a promising chemotherapeutic candidate for NSCLC.

BIOCHEMICAL PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

TOP1 modulation during melanoma progression and in adaptative resistance to BRAF and MEK inhibitors

Erica Aparecida de Oliveira et al.

Summary: TOP1 expression is correlated with invasive gene signature in metastatic melanoma, with highest expression in metastatic cells and lowest expression in BRAFi- and BRAFi/MEKi-resistant cells. These results suggest a potential role of TOP1 in melanoma progression and resistance.

PHARMACOLOGICAL RESEARCH (2021)

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Article Multidisciplinary Sciences

The retinoid X receptor α modulator K-80003 suppresses inflammatory and catabolic responses in a rat model of osteoarthritis

Hua Li et al.

Summary: The study revealed that the RXR alpha modulator K-80003 could effectively treat osteoarthritis by reducing articular cartilage degeneration, alleviating synovial inflammation, and relieving pain. Furthermore, the K-80003 suppressed inflammatory and catabolic responses in osteoarthritis by inhibiting specific molecular pathways.

SCIENTIFIC REPORTS (2021)

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Review Biochemistry & Molecular Biology

Signal pathways of melanoma and targeted therapy

Weinan Guo et al.

Summary: Melanoma, a lethal skin cancer, has limited therapeutic options. Innovations in targeting mutated driver genes and immune checkpoints have improved patient prognosis, but resistance and low response rates remain challenges in melanoma treatment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Pharmacology & Pharmacy

Topical treatments for skin cancer

Jason K. Cullen et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Oncology

Colorectal cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

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Article Cell Biology

ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis

Jianxin Huo et al.

CELLS (2020)

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Article Chemistry, Medicinal

12-Deacetyl-12-epi-Scalaradial, a Scalarane Sesterterpenoid from a Marine Sponge Hippospongia sp., Induces HeLa Cells Apoptosis via MAPK/ERK Pathway and Modulates Nuclear Receptor Nur77

Mi Zhou et al.

MARINE DRUGS (2020)

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Article Oncology

BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway

Xiaohui Chen et al.

MOLECULAR CANCER THERAPEUTICS (2019)

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Review Obstetrics & Gynecology

Managing vasomotor symptoms in women after cancer

J. V. Pinkerton et al.

CLIMACTERIC (2019)

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Article Pharmacology & Pharmacy

Venlafaxine Improves the Cognitive Impairment and Depression-Like Behaviors in a Cuprizone Mouse Model by Alleviating Demyelination and Neuroinflammation in the Brain

Yanbo Zhang et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Biochemistry & Molecular Biology

miR-139-5p inhibits isoproterenol-induced cardiac hypertrophy by targetting c-Jun

Su Ming et al.

BIOSCIENCE REPORTS (2018)

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Review Medicine, Research & Experimental

Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway

Iman W. Achkar et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2018)

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Article Biochemistry & Molecular Biology

Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation

Xiao-xue Li et al.

MOLECULAR CELL (2018)

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Review Dermatology

Minoxidil in the treatment of androgenetic alopecia

Andy Goren et al.

DERMATOLOGIC THERAPY (2018)

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Review Oncology

Characteristics of Nur77 and its ligands as potential anticancer compounds

Lingjuan Wu et al.

MOLECULAR MEDICINE REPORTS (2018)

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Article Cell Biology

Triclosan Suppresses Testicular Steroidogenesis via the miR-6321/JNK/ Nur77 Cascade

Mei Ha et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Review Anesthesiology

Pharmacological Treatment of Pain in Cancer Patients: The Role of Adjuvant Analgesics, a Systematic Review

Marieke H. J. van den Beuken-van Everdingen et al.

PAIN PRACTICE (2017)

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Article Biochemistry & Molecular Biology

Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy

Mengjie Hu et al.

MOLECULAR CELL (2017)

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Article Oncology

Modulation of the Nur77-Bcl-2 apoptotic pathway by p38α MAPK

Jie Liu et al.

ONCOTARGET (2017)

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Article Oncology

Endocannabinoid and ceramide levels are altered in patients with colorectal cancer

Ling Chen et al.

ONCOLOGY REPORTS (2015)

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Article Oncology

Induction of Nur77-dependent apoptotic pathway by a coumarin derivative through activation of JNK and p38 MAPK

Yuqi Zhou et al.

CARCINOGENESIS (2014)

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Article Pharmacology & Pharmacy

Comparison of Sertraline, Venlafaxine and Desipramine Effects on Depression, Cognition and the Daily Living Activities in Alzheimer Patients

N. Mokhber et al.

PHARMACOPSYCHIATRY (2014)

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Article Pharmacology & Pharmacy

Inhibitory effect of antidepressants on B16F10 melanoma tumor growth

Beata Grygier et al.

PHARMACOLOGICAL REPORTS (2013)

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Article Endocrinology & Metabolism

ERK Signaling, But Not c-Raf, Is Required for Gonadotropin-Releasing Hormone (GnRH)-Induced Regulation of Nur77 in Pituitary Gonadotropes

Stuart P. Bliss et al.

ENDOCRINOLOGY (2012)

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Review Pharmacology & Pharmacy

Nur77: a potential therapeutic target in cancer

Sally K. Y. To et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2012)

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Article Pharmacology & Pharmacy

Age-dependent stimulatory effect of desipramine, and fluoxetine pretreatment on metastasis formation by B16F10 melanoma in male C57BL/6 mice

Marta Kubera et al.

PHARMACOLOGICAL REPORTS (2009)

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Article Oncology

A short Nur77-derived peptide converts Bcl-2 from a protector to a killer

Siva Kumar Kolluri et al.

CANCER CELL (2008)

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Article Biochemistry & Molecular Biology

Extracellular signal-regulated kinases (ERK) and protein kinase C (PKC) activities are involved in the modulation of Nur77 and Nor-1 expression by dopaminergic drugs

Emmanuelle Bourhis et al.

JOURNAL OF NEUROCHEMISTRY (2008)

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Review Pharmacology & Pharmacy

Targeting Nur77 translocation

Xiao-kun Zhang

EXPERT OPINION ON THERAPEUTIC TARGETS (2007)

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Article Biochemistry & Molecular Biology

Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt

Y-H Han et al.

ONCOGENE (2006)

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Article Pharmacology & Pharmacy

Venlafaxine for the treatment of depressive episode during the course of schizophrenia

D Mazeh et al.

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2004)

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Article Cell Biology

p38 mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest

K Deacon et al.

MOLECULAR BIOLOGY OF THE CELL (2003)

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Venlafaxine, an anti-depressant drug, induces apoptosis in MV3 human melanoma cells through JNK1/2-Nur77 signaling pathway

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