Ferroptosis as a therapeutic target for inflammation-related intestinal diseases

Ferroptosis is an iron-dependent programmed cell death characterized by reactive oxygen species-induced lipid peroxidation and resultant membrane damage. Recent research has elucidated the mechanism of ferroptosis and investigated the relationship between ferroptosis and various diseases, including degenerative diseases, cancer, and inflammation. Ferroptosis is associated with inflammation-related intestinal diseases such as colitis and colitis-associated cancer. New insights into the role of ferroptosis in the pathogenesis of inflammation-related gut diseases have suggested novel therapeutic targets. In this review, we summarize current information on the molecular mechanisms of ferroptosis and describe its emerging role and therapeutic potential in inflammation-related intestinal diseases.

Automated summary

Ferroptosis is a type of programmed cell death that depends on iron and is characterized by lipid peroxidation induced by reactive oxygen species and resulting membrane damage. Recent research has revealed its mechanism and explored its connection to various diseases, including degenerative diseases, cancer, and inflammation. Inflammation-related intestinal diseases such as colitis and colitis-associated cancer are associated with ferroptosis. Understanding the role of ferroptosis in the pathogenesis of these diseases has led to the identification of potential therapeutic targets. This review summarizes the current knowledge on the molecular mechanisms of ferroptosis and discusses its emerging role and therapeutic potential in inflammation-related intestinal diseases.