4.7 Article

Xanthohumol alleviates oxidative stress and impaired autophagy in experimental severe acute pancreatitis through inhibition of AKT/mTOR

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Activation of TLR4 induces severe acute pancreatitis-associated spleen injury via ROS-disrupted mitophagy pathway

E. Wen et al.

Summary: This study investigated the mechanism of spleen injury caused by severe acute pancreatitis (SAP) and explored the potential use of tuftsin in treating spleen damage. The researchers found that the up-regulation of Toll-like receptor 4 (TLR4) in the spleen leads to the accumulation of reactive oxygen species (ROS) and mitochondrial dysfunction under SAP conditions. They also discovered that N-acetylcysteine (NAC) treatment or knocking out TLR4 can improve splenic ROS and mitochondrial dysfunction in SAP mice. Furthermore, they verified that spleen injury is caused by splenic ROS affecting the PI3K/p-AKT/mTOR pathway-mediated autophagy. The study also showed that tuftsin supplementation can ameliorate the pathological damage, ROS accumulation, impaired autophagy, inflammation expression, and apoptosis in damaged spleen.

MOLECULAR IMMUNOLOGY (2022)

Article Medicine, Research & Experimental

Pirfenidone increases IL-10 and improves acute pancreatitis in multiple clinically relevant murine models

Ejas Palathingal Bava et al.

Summary: This study evaluated the efficacy of pirfenidone in treating acute pancreatitis. The results showed that pirfenidone can reduce local and systemic injury and inflammation caused by pancreatitis, suggesting its potential therapeutic effects. Pirfenidone acts by decreasing cytokine release and disrupting cellular interactions.

JCI INSIGHT (2022)

Article Pharmacology & Pharmacy

Rhein Protects Against Severe Acute Pancreatitis In vitro and In vivo by Regulating the JAK2/STAT3 Pathway

Xiaofang Yang et al.

Summary: The study investigated the protective effects of rhein against severe acute pancreatitis using in vitro and in vivo models, potentially through regulating the JAK2/STAT3 signaling pathway.

FRONTIERS IN PHARMACOLOGY (2022)

Review Cell Biology

Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles

Ren-Qi Yao et al.

Summary: The structural integrity and functional stability of organelles are crucial for cell viability and responsiveness. Dysfunction of multiple organelles is involved in the pathogenesis and progression of various diseases. Organelle-specific autophagy plays a beneficial role in inflammatory disorders by eliminating damaged organelles and maintaining homeostasis.

AUTOPHAGY (2021)

Article Pharmacology & Pharmacy

Xanthohumol attenuates isoprenaline-induced cardiac hypertrophy and fibrosis through regulating PTEN/AKT/mTOR pathway

Tao-Li Sun et al.

Summary: Xanthohumol (Xn), a prenylated flavonoid isolated from hops, shows cardiovascular protective effects by attenuating isoprenaline (ISO)-induced cardiac hypertrophy and fibrosis through regulating the PTEN/AKT/mTOR pathway.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Review Medicine, General & Internal

Acute Pancreatitis: A Review

Michael A. Mederos et al.

Summary: Acute pancreatitis is a significant cause of hospital admissions from gastrointestinal diseases in the United States, with proper management involving risk stratification, fluid and nutritional management. Early aggressive fluid resuscitation and enteral nutrition are associated with better outcomes, but the optimal fluid type and rate are still uncertain.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Medicine, Research & Experimental

Xanthohumol suppresses inflammation in chondrocytes and ameliorates osteoarthritis in mice

Ximiao Chen et al.

Summary: The research found that Xanthohumol (XN) can inhibit the expression of nitric oxide synthase (INOS), IL-1 beta-promoted inducible nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and cyclooxygenase-2 (COX-2) in vitro. Additionally, it down-regulates matrix metalloproteinase-13 and prothrombin, while up-regulating type II collagen and Aggrecan expression. XN also activates nuclear factor (Nrf2) and inhibits nuclear factor B (NF-kappaB) signal transduction to slow down the progression of osteoarthritis.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Pharmacology & Pharmacy

Xanthohumol ameliorates memory impairment and reduces the deposition of β-amyloid in APP/PS1 mice via regulating the mTOR/LC3II and Bax/Bcl-2 signalling pathways

Xiao-Lei Sun et al.

Summary: Xanthohumol effectively ameliorates memory impairment of APP/PS1 mice by activating mTOR/LC3 and Bax/Bcl-2 signalling pathways, providing new insight into the neuroprotective effects of Xanthohumol.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2021)

Review Pharmacology & Pharmacy

Targeting autophagy using saponins as a therapeutic and preventive strategy against human diseases

Bing Han et al.

Summary: Autophagy is a common mechanism for maintaining cellular homeostasis by degrading proteins, protein aggregates, and organelles, and dysfunction of autophagy is observed in many diseases. Saponins, natural compounds with autophagy-modulating effects, may have therapeutic and preventive effects on autophagy-related diseases.

PHARMACOLOGICAL RESEARCH (2021)

Review Immunology

Role of Interleukin-17 in Acute Pancreatitis

Guanqun Li et al.

Summary: Acute pancreatitis is a severe disease often leading to death, with systemic manifestations. IL-17 plays a crucial role in AP by affecting immune response and interactions between different cells. Inhibiting the IL-17 cytokine family could potentially alleviate the pathogenic process of AP.

FRONTIERS IN IMMUNOLOGY (2021)

Review Biochemistry & Molecular Biology

Multifactorial Scores and Biomarkers of Prognosis of Acute Pancreatitis: Applications to Research and Practice

Pedro Silva-Vaz et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Gastroenterology & Hepatology

Early Intra-Acinar Events in Pathogenesis of Pancreatitis

Ashok Saluja et al.

GASTROENTEROLOGY (2019)

Review Plant Sciences

Linking Autophagy to Abiotic and Biotic Stress Responses

Santiago Signorelli et al.

TRENDS IN PLANT SCIENCE (2019)

Article Gastroenterology & Hepatology

Acute Pancreatitis: A Multifaceted Set of Organelle and Cellular Interactions

Aida Habtezion et al.

GASTROENTEROLOGY (2019)

Review Medicine, General & Internal

Management of severe acute pancreatitis

O. Joe Hines et al.

BMJ-BRITISH MEDICAL JOURNAL (2019)

Article Biochemistry & Molecular Biology

PI3K/AKT/mTOR activation and autophagy inhibition plays a key role in increased cholesterol during IL-17A mediated inflammatory response in psoriasis

Pallavi Varshney et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

Article Gastroenterology & Hepatology

Emodin Attenuates Autophagy Response to Protect the Pancreas From Acute Pancreatitis Failure

Xiaozheng Yu et al.

PANCREAS (2018)

Review Gastroenterology & Hepatology

Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis

Anna S. Gukovskaya et al.

GASTROENTEROLOGY (2017)

Review Biochemistry & Molecular Biology

mTOR Signaling in Growth, Metabolism, and Disease

Robert A. Saxton et al.

Review Biochemistry & Molecular Biology

Necroptosis: a potential, promising target and switch in acute pancreatitis

Gang Wang et al.

APOPTOSIS (2016)

Article Medicine, Research & Experimental

IL-17A and IL-17F induce autophagy in RAW 264.7 macrophages

Laszlo Orosz et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

Review Cell Biology

ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms

Lulu Li et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2015)

Article Gastroenterology & Hepatology

Impaired Autophagy Induces Chronic Atrophic Pancreatitis in Mice via Sex- and Nutrition-Dependent Processes

Kalliope N. Diakopoulos et al.

GASTROENTEROLOGY (2015)

Article Engineering, Biomedical

Serum interleukin 17 as an early prognostic biomarker of severe acute pancreatitis receiving continuous blood purification

Shu R. Dai et al.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2015)

Review Medicine, Research & Experimental

mTOR: a pharmacologic target for autophagy regulation

Young Chul Kim et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Review Cell Biology

Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family

Erna Sziksz et al.

MEDIATORS OF INFLAMMATION (2015)

Article Multidisciplinary Sciences

Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress

Laura Antonucci et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Gastroenterology & Hepatology

Ulinastatin activates the renin-angiotensin system to ameliorate the pathophysiology of severe acute pancreatitis

Ruixia Liu et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014)

Article Gastroenterology & Hepatology

Oxidative stress and inflammatory signaling in cerulein pancreatitis

Ji Hoon Yu et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

Review Gastroenterology & Hepatology

Models of Acute and Chronic Pancreatitis

Markus M. Lerch et al.

GASTROENTEROLOGY (2013)

Article Medicine, Research & Experimental

IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality

Hong Zhang et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Multidisciplinary Sciences

Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy

Julia V. Gerasimenko et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Review Biochemistry & Molecular Biology

Autophagy: Renovation of Cells and Tissues

Noboru Mizushima et al.

Article Biochemistry & Molecular Biology

Chaiqin Chengqi Decoction decreases IL-6 levels in patients with acute pancreatitis

Ling Wang et al.

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B (2011)