Ganoderma lucidum: Current advancements of characteristic components and experimental progress in anti-liver fibrosis

Ganoderma lucidum (G. lucidum, Lingzhi) is a well-known herbal medicine with a variety of pharmacological effects. Studies have found that G. lucidum has pharmacological effects such as antioxidant, antitumor, anti-aging, anti-liver fibrosis, and immunomodulation. The main active components of G. lucidum include triterpenoids, polysaccharides, sterols, peptides and other bioactive components. Among them, the triterpenoids and polysaccharide components of G. lucidum have a wide range of anti-liver fibrotic effects. Currently, there have been more reviews and studies on the antioxidant, antitumor, and anti-aging properties of G. lucidum. Based on the current trend of increasing number of liver fibrosis patients in the world, we summarized the role of G.lucidum extract in anti-liver fibrosis and the effect of G. lucidum extract on liver fibrosis induced by different pathogenesis, which were discussed and analyzed. Research and development ideas and references are provided for the subsequent application of G. lucidum extracts in anti-liver fibrosis treatment.

Automated summary

Ganoderma lucidum, also known as Lingzhi, is a widely-used herbal medicine with various pharmacological effects including antioxidant, antitumor, anti-aging, anti-liver fibrosis, and immunomodulation. Its main active components include triterpenoids, polysaccharides, sterols, peptides, and other bioactive ingredients. The triterpenoids and polysaccharides in G. lucidum have shown significant anti-liver fibrotic effects. Given the global increase in liver fibrosis cases, this review summarizes the role of G. lucidum extract in anti-liver fibrosis and its effects on fibrosis induced by different causes, providing insights for the development of G. lucidum extracts in anti-liver fibrosis treatment.