Self-assembled FGF21 nanoparticles alleviate drug-induced acute liver injury

Article Cell Biology

FGF21 alleviates acute liver injury by inducing the SIRT1-autophagy signalling pathway

Xiaoning Yang et al.

Summary: This study verified the relationship among FGF21, autophagy, and SIRT1 in CCl4-induced ALI. The results showed that FGF21 alleviated ALI by enhancing SIRT1-mediated autophagy.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

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Article Medicine, Research & Experimental

FTY720 attenuates APAP-induced liver injury via the JAK2/STAT3 signaling pathway

Xiangmin He et al.

Summary: This study found that Fingolimod (FTY720) has a protective effect on acetaminophen (APAP)-induced liver injury (AILI). FTY720 regulates the JAK2/STAT3 signaling pathway to reduce immune cell recruitment and inflammation, inhibit cell apoptosis and oxidative stress, and attenuate liver tissue damage.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2022)

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Article Pharmacology & Pharmacy

Red Blood Cell Membrane-Camouflaged PLGA Nanoparticles Loaded With Basic Fibroblast Growth Factor for Attenuating Sepsis-Induced Cardiac Injury

Xinze Li et al.

Summary: This study demonstrates the therapeutic potential of bFGF in sepsis-induced cardiac injury, using red blood cell membrane-camouflaged nanoparticles for targeted delivery. The results show the protective effects of bFGF against oxidative and inflammatory damage in cardiomyocytes, and its therapeutic benefits in treating myocardial dysfunction.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Chemistry, Multidisciplinary

Ultrasmall Ruthenium Nanoparticles with Boosted Antioxidant Activity Upregulate Regulatory T Cells for Highly Efficient Liver Injury Therapy

Fan Xia et al.

Summary: This study introduces a size regulation strategy to enhance the antioxidant enzyme-like activities of RuNPs, showing promising potential for the treatment of oxidative stress-associated diseases.

SMALL (2022)

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Article Pharmacology & Pharmacy

SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation

Yanying Zhou et al.

Summary: SIRT6 plays a protective role in APAP-induced liver injury by alleviating oxidative stress and promoting hepatocyte proliferation. In addition, SIRT6 also exerts important regulatory functions by interacting with NRF2 and P53.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Nanoscience & Nanotechnology

Applications of Nanobiomaterials in the Therapy and Imaging of Acute Liver Failure

Yuanyuan Jin et al.

Summary: Nanobiomaterials show great promise in the treatment of ALF, enhancing drug bioavailability and increasing therapeutic agent accumulation in the liver for more effective treatment. Additionally, stimuli-responsive, optical, or magnetic nanomaterials offer potential in therapeutical, diagnostic, and imaging applications in ALF.

NANO-MICRO LETTERS (2021)

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Article Medicine, General & Internal

A novel GLP-1 and FGF21 dual agonist has therapeutic potential for diabetes and non-alcoholic steatohepatitis

Qi Pan et al.

Summary: Novel FGF21-Fc-GLP-1 dual-targeted constructs were developed with enhanced activity and prolonged half-life in vivo, showing promising effects in glucose lowering, weight loss, and anti-NASH in various experiments.

EBIOMEDICINE (2021)

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Article Biochemistry & Molecular Biology

Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis

Aimin Wu et al.

Summary: Iron overload-induced ferroptosis in hepatocytes is promoted by excessive HO-1 expression, while FGF21 protein can protect against this process by inhibiting ferroptosis and preventing liver damage. These findings suggest that activating FGF21 could be an effective strategy for potential treatment of iron overload-induced ferroptosis-related diseases like hereditary haemochromatosis.

REDOX BIOLOGY (2021)

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Review Pharmacology & Pharmacy

Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls

Hartmut Jaeschke et al.

Summary: The APAP model is used to study drug-induced liver injury mechanisms and test potential therapeutic interventions. A thorough understanding of the pathophysiology is required to obtain valid results and clinically relevant information. Key factors to consider when studying APAP hepatotoxicity include drug metabolism, mitochondrial dysfunction, necrotic cell death, autophagy, and sterile inflammatory response.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Pharmacology & Pharmacy

Chitosan Nanoparticles at the Biological Interface: Implications for Drug Delivery

Noorjahan Aibani et al.

Summary: Chitosan, with its unique properties, is a valuable choice for nanoparticulate drug delivery applications, but its interactions at cellular and systemic levels require further study. The positive charge of chitosan allows for efficient attachment to cells, enhancing cellular uptake.

PHARMACEUTICS (2021)

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Article Immunology

Peroxiredoxin 3 Inhibits Acetaminophen-Induced Liver Pyroptosis Through the Regulation of Mitochondrial ROS

Yue Wang et al.

Summary: This study demonstrated that pyroptosis, oxidative stress, and inflammation occur simultaneously in APAP-induced liver injury, and PRX3 plays an important role in inhibiting NLRP3-dependent pyroptosis by regulating mtROS. Therefore, PRX3 has a significant protective effect in APAP-induced liver injury.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Nanoscience & Nanotechnology

Prussian Blue Nanozymes Prevent Anthracycline-Induced Liver Injury by Attenuating Oxidative Stress and Regulating Inflammation

Huiyuan Bai et al.

Summary: Artificial Prussian blue nanozymes (PBZs) can prevent anthracycline-induced liver injury by attenuating reactive oxygen species (ROS) production and regulating inflammation. PBZs exhibit multienzyme activity, scavenging ROS and free radicals, and reducing levels of inflammatory cytokines.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

Ultrasound-assisted C3F8-filled PLGA nanobubbles for enhanced FGF21 delivery and improved prophylactic treatment of diabetic cardiomyopathy

Jiameng Gao et al.

Summary: This study developed polyethylenimine (PEI)-doped poly (lactic-co-glycolic acid) (PLGA) nanobubbles loaded with fibroblast growth factor 21 (FGF21) for the prophylactic treatment of diabetic cardiomyopathy (DCM). The nanobubbles effectively delivered FGF21 to myocardial tissue through low-frequency ultrasound (LFUS)-induced cavitation, resulting in significant downregulation of genes related to myocardial hypertrophy, apoptosis, and interstitial fibrosis in DCM mice. This novel delivery system shows promise for the diagnosis and prophylactic treatment of DCM.

ACTA BIOMATERIALIA (2021)

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Review Biochemistry & Molecular Biology

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Veronika Mikusova et al.

Summary: Polymeric nanoparticles based on chitosan have significant potential as drug carriers due to their beneficial properties, and factors such as cross-linking, morphology, size, density, and drug properties play a crucial role in drug transport and release. Recent research focuses on enhancing chitosan properties and optimizing drug delivery in novel ways.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

TRPM2 Non-Selective Cation Channels in Liver Injury Mediated by Reactive Oxygen Species

Eunus S. Ali et al.

Summary: TRPM2 channels allow for the movement of Ca2+ and Na+ across the plasma membrane and release of Ca2+ and Zn2+ from lysosomes. Activation of TRPM2 by ROS plays a key role in cell injury and death, particularly in chronic liver diseases and acute liver injury. Inhibiting TRPM2 using compounds like curcumin shows promise in reducing ROS-induced liver cell damage.

ANTIOXIDANTS (2021)

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Article Medicine, Research & Experimental

Microenvironment Activatable Nanoprodrug Based on Gripper-like Cyclic Phenylboronic Acid to Precisely and Effectively Alleviate Drug-induced Hepatitis

Qixiong Zhang et al.

Summary: Development of a nanoprodrug for precise drug release at the disease site has shown promising therapeutic effects in alleviating drug-induced hepatitis through H2O2 and acid-sensitive properties, reducing oxidative stress and inflammation.

THERANOSTICS (2021)

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Review Pharmacology & Pharmacy

Lipid-based nanoparticle technologies for liver targeting

Roland Boettger et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Food Science & Technology

A mitochondrial journey through acetaminophen hepatotoxicity

Anup Ramachandran et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

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Review Endocrinology & Metabolism

The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic

Leiluo Geng et al.

NATURE REVIEWS ENDOCRINOLOGY (2020)

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Review Pharmacology & Pharmacy

Current etiological comprehension and therapeutic targets of acetaminophen-induced hepatotoxicity

Apu Chowdhury et al.

PHARMACOLOGICAL RESEARCH (2020)

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Review Gastroenterology & Hepatology

Acetaminophen Hepatotoxicity

Anup Ramachandran et al.

SEMINARS IN LIVER DISEASE (2019)

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Article Pharmacology & Pharmacy

pH-Sensitive Chitosan-Heparin Nanoparticles for Effective Delivery of Genetic Drugs into Epithelial Cells

Iuliia Pilipenko et al.

PHARMACEUTICS (2019)

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Review Endocrinology & Metabolism

Fibroblast growth factor 21 in non-alcoholic fatty liver disease

Bradley Tucker et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2019)

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Review Gastroenterology & Hepatology

Role and mechanisms of autophagy in acetaminophen-induced liver injury

Xiaojuan Chao et al.

LIVER INTERNATIONAL (2018)

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Review Biochemistry & Molecular Biology

Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions

Mingzhu Yan et al.

REDOX BIOLOGY (2018)

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Article Chemistry, Multidisciplinary

Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles, and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics

Zehua Liu et al.

ADVANCED MATERIALS (2018)

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Review Nanoscience & Nanotechnology

Nanoparticles for the treatment of liver fibrosis

Suchithra Poilil Surendran et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Review Pharmacology & Pharmacy

Chitosan and its derivatives as vehicles for drug delivery

Gangliang Huang et al.

DRUG DELIVERY (2017)

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Article Chemistry, Applied

Nerve growth factor loaded heparin/chitosan scaffolds for accelerating peripheral nerve regeneration

Guicai Li et al.

CARBOHYDRATE POLYMERS (2017)

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Review Physiology

Understanding the Physiology of FGF21

Ffolliott Martin Fisher et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 78 (2016)

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Article Pharmacology & Pharmacy

Genetic fusion of human FGF21 to a synthetic polypeptide improves pharmacokinetics and pharmacodynamics in a mouse model of obesity

Jun Yin et al.

BRITISH JOURNAL OF PHARMACOLOGY (2016)

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Article Nanoscience & Nanotechnology

Analysis of nanoparticle delivery to tumours

Stefan Wilhelm et al.

NATURE REVIEWS MATERIALS (2016)

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Article Biochemistry & Molecular Biology

Enhancement of the Pharmacological Efficacy of FGF-21 by Genetic Modification and PEGylation

Xianlong Ye et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2014)

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Article Gastroenterology & Hepatology

Fibroblast Growth Factor 21 Protects Against Acetaminophen-Induced Hepatotoxicity by Potentiating Peroxisome Proliferator-Activated Receptor Coactivator Protein-1α-Mediated Antioxidant Capacity in Mice

Dewei Ye et al.

HEPATOLOGY (2014)

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Review Radiology, Nuclear Medicine & Medical Imaging

Nanoparticles for Imaging: Top or Flop?

Fabian Kiessling et al.

RADIOLOGY (2014)

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Review Immunology

Immune surveillance by the liver

Craig N. Jenne et al.

NATURE IMMUNOLOGY (2013)

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Article Gastroenterology & Hepatology

Nanotechnology for therapy and imaging of liver diseases

L. Harivardhan Reddy et al.

JOURNAL OF HEPATOLOGY (2011)

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Review Environmental Sciences

TOXICOLOGY OF NANOMATERIALS USED IN NANOMEDICINE

Jinshun Zhao et al.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2011)

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Article Toxicology

Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose

Nasrin Pakravan et al.

CLINICAL TOXICOLOGY (2008)

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Article Engineering, Biomedical

Heparin/chitosan nanoparticle carriers prepared by polyelectrolyte complexation

Zonghua Liu et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2007)

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Self-assembled FGF21 nanoparticles alleviate drug-induced acute liver injury

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