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Autophagy: An important target for natural products in the treatment of bone metabolic diseases

FRONTIERS IN PHARMACOLOGY (2022)

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Summary: This review provides a comprehensive collation of important information on the biosynthesis, mechanism of action, bioactivities, bioavailability, and toxicological potential of kaempferol. It highlights the antioxidant, antimicrobial, anticancer, neuroprotective, and hepatoprotective activity of kaempferol, while also mentioning the limitations of its poor water solubility and low bioavailability. The review suggests the utilization of advanced delivery systems to improve the stability and efficacy of kaempferol.

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Summary: This study shows that nicotinamide mononucleotide (NMN) could partially reverse the negative effects of tumor necrosis factor-alpha (TNF-α) on osteoblasts, including inducing senescence, reducing differentiation ability, and affecting mitochondrial function. In addition, NMN can protect cells from aging damage by increasing mitophagy activity.

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Corresponding Changes of Autophagy-Related Genes and Proteins in Different Stages of Knee Osteoarthritis: An Animal Model Study

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Current Evidence and Future Directions of Berberine Intervention in Depression

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Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK/PINK1/Parkin-mediated mitophagy

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LIFE SCIENCES (2021)

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Estrogen protects against acidosis-mediated articular chondrocyte injury by promoting ASIC1a protein degradation

Jing-Wen Su et al.

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EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Aucubin prevents steroid-induced osteoblast apoptosis by enhancing autophagy via AMPK activation

Chen Yue et al.

Summary: The research found that aucubin could prevent dexamethasone-induced osteoblast apoptosis by enhancing autophagy levels, and its regulatory effect on autophagy and apoptosis was achieved through activating the AMPK signaling pathway.

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Hsuan-Ti Huang et al.

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Synergistic stimulation of osteoblast differentiation of rat mesenchymal stem cells by leptin and 25(OH)D3 is mediated by inhibition of chaperone-mediated autophagy

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Phytochemicals Mediate Autophagy Against Osteoarthritis by Maintaining Cartilage Homeostasis

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FRONTIERS IN PHARMACOLOGY (2021)

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Paeoniflorin Attenuates Dexamethasone-Induced Apoptosis of Osteoblast Cells and Promotes Bone Formation via Regulating AKT/mTOR/Autophagy Signaling Pathway

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Autophagy Prevents Osteocyte Cell Death under Hypoxic Conditions

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Icariin promotes osteogenic differentiation of bone marrow stromal cells and prevents bone loss in OVX mice via activating autophagy

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Icariin Activates Autophagy via Down-Regulation of the NF-κB Signaling-Mediated Apoptosis in Chondrocytes

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Human mesenchymal stem cells/multipotent stromal cells consume accumulated autophagosomes early in differentiation

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Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation

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Suppression of Autophagy by FIP200 Deletion Leads to Osteopenia in Mice Through the Inhibition of Osteoblast Terminal Differentiation

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Autophagy modulates osteoarthritis-related gene expression in human chondrocytes

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Association of Oxidative Stress with Postmenopausal Osteoporosis and the Effects of Hydrogen Peroxide on Osteoclast Formation in Human Bone Marrow Cell Cultures

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IL-21 regulates Th17 cells in rheumatoid arthritis

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Autophagy induction and CHOP under-expression promotes survival of fibroblasts from rheumatoid arthritis patients under endoplasmic reticulum stress

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Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

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Actin cytoskeletal organisation in osteoclasts: A model to decipher transmigration and matrix degradation

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