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Indoleamine 2, 3-dioxygenase 1 inhibitory compounds from natural sources

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Article Chemistry, Analytical

In-depth characterization of phenolic profiling of Moraiolo extra-virgin olive oil extract and initial investigation of the inhibitory effect on Indoleamine-2,3-Dioxygenase (IDO1) enzyme

Federica Ianni et al.

Summary: In this study, the phenolic extract from Moraiolo extra-virgin olive oil was characterized and found to have high levels of phenolic compounds. The extract also showed inhibitory effects on the catalytic activity of IDO1, a promising target for neuroinflammatory-oxidative processes in neurodegenerative diseases.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2022)

Review Biochemistry & Molecular Biology

The role of indoleamine 2,3-dioxygenase in allergic disorders

Seyed-Alireza Esmaeili et al.

Summary: This review discusses the mechanism of immune response regulation through manipulating tryptophan metabolism. Studies suggest that the IDO-kynurenine pathway may play different roles in regulating Th2 cells and Th1 cells immune responses.

MOLECULAR BIOLOGY REPORTS (2022)

Article Neurosciences

Indoleamine 2,3-Dioxygenase-1 Expression is Changed During Bladder Cancer Cell Invasion

Hellen Joyce Sousa Pereira Santos et al.

Summary: The expression of IDO-1 is associated with bladder carcinoma invasion and metastasis. IDO-1 is differentially expressed between invading and non-invading cells, and this difference is lost after long-time subculture. Silencing IDO-1 diminishes the invasiveness of bladder carcinoma cells.

INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH (2022)

Review Cell Biology

Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process

Antero Salminen

Summary: This article explores the function of IDO1-KYN-AhR signaling and analyzes its activation as an enhancer of the aging process. The activation of this signaling pathway can suppress immune cell function, promote immunosenescence, and have adverse effects on cellular autophagy, cellular senescence, and extracellular matrix remodeling, as well as exacerbating the development of osteoporosis and vascular diseases.

AGEING RESEARCH REVIEWS (2022)

Article Chemistry, Medicinal

New phenalenone derivatives from the Hawaiian volcanic soil-associated fungus Penicillium herquei FT729 and their inhibitory effects on indoleamine 2,3-dioxygenase 1 (IDO1)

Jae Sik Yu et al.

Summary: Phenalenone derivatives sourced from fungi have diverse chemical structures and potential bioactivities. In this study, three new phenalenone derivatives were isolated from a Hawaiian soil fungus and their structures were determined. Compound 1 and compounds 5-7 exhibited inhibitory activity against IDO1, indicating their potential as anticancer immunotherapeutic agents.

ARCHIVES OF PHARMACAL RESEARCH (2022)

Review Biochemistry & Molecular Biology

Indoleamine 2,3 Dioxygenase 1-The Potential Link between the Innate Immunity and the Ischemia-Reperfusion-Induced Acute Kidney Injury?

Anna Krupa et al.

Summary: This article presents the potential role of IDO1 activation in regulating the innate immune system in ischemia-reperfusion injury-induced acute kidney injury.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Cell Biology

Metabolic adaptation of ovarian tumors in patients treated with an IDO1 inhibitor constrains antitumor immune responses

Kunle Odunsi et al.

Summary: The study reveals that inhibition of IDO1 in ovarian cancer may result in metabolic adaptation and undermine antitumor T cell responses in the tumor microenvironment.

SCIENCE TRANSLATIONAL MEDICINE (2022)

Review Immunology

Impact of IDO1 and IDO2 on the B Cell Immune Response

Lauren M. F. Merlo et al.

Summary: Indoleamine-2,3-dioxygenase (IDO)1 and IDO2 are closely related enzymes that modulate T cell and B cell function. IDO1 inhibits inflammatory B cell responses while IDO2 drives them. Targeting IDO1 and/or IDO2 shows promise as a therapeutic approach for inflammatory autoimmune diseases.

FRONTIERS IN IMMUNOLOGY (2022)

Review Oncology

The Role of Indoleamine 2, 3-Dioxygenase 1 in Regulating Tumor Microenvironment

Xinting Huang et al.

Summary: In this article, we review the immunosuppression mechanisms mediated by the IDO1 pathway in tumor growth and discuss the challenges and current clinical research progress in using IDO1 as a new tumor immunotherapy target.

CANCERS (2022)

Article Microbiology

Increased Indoleamine 2,3-Dioxygenase 1 (IDO-1) Activity and Inflammatory Responses during Chikungunya Virus Infection

Thiara Manuele Alves de Souza et al.

Summary: This study evaluated the activity of IDO-1 and the patterns of cytokines/chemokines in CHIKV patients. It was found that IDO-1 activity increased during the early acute phase of infection and decreased in the chronic phase. In the acute phase, concentrations of TNF-alpha, IL-6, IFN-gamma, CCL2/MCP-1, and CXCL10/IP-10 were increased. In the chronic phase, concentrations of CCL4/MIP-1 beta were increased, especially in patients with arthritis.

PATHOGENS (2022)

Article Cardiac & Cardiovascular Systems

Indoleamine 2,3-Dioxygenase 1 Deletion-Mediated Kynurenine Insufficiency in Vascular Smooth Muscle Cells Exacerbates Arterial Calcification

Liu Ouyang et al.

Summary: Aberrant IDO1-regulated tryptophan metabolism may result in osteogenic reprogramming and calcification of VSMCs, while L-tryptophan can inhibit this process via an aryl hydrocarbon receptor-dependent pathway.

CIRCULATION (2022)

Review Chemistry, Medicinal

Dual-target inhibitors of indoleamine 2, 3 dioxygenase 1 (Ido1): A promising direction in cancer immunotherapy

Ya Zhang et al.

Summary: This review summarizes the recent development of IDO1 dual-target inhibitors and focuses on the structure optimization process, structure-activity relationship, and the efficacy of in vitro and in vivo experiments. Dual-target inhibitors show great potential and advantages in addressing the challenges faced by IDO1 inhibitors in clinical trials.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

Article Immunology

Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication

Marco Gargaro et al.

Summary: This study identifies a previously unrecognized metabolic communication pathway, in which cDC1 cells extend their immunoregulatory capacity to cDC2 through the production of L-kynurenine. This finding has potential therapeutic implications in treating autoimmune demyelinating diseases.

IMMUNITY (2022)

Article Biochemistry & Molecular Biology

Eleven undescribed alkaloids from the rhizomes of Sinomenium acutum and their IDO1 and TDO inhibitory activities

Ran Bi et al.

Summary: Eleven previously undescribed alkaloids, named sinometumines A-K, were isolated from Sinomenium acutum. The chemical structures and absolute configurations of these compounds were determined. Two of these alkaloids exhibited dual inhibitory activities against IDO1 and TDO.

PHYTOCHEMISTRY (2022)

Review Oncology

The Kynurenine Pathway and Cancer: Why Keep It Simple When You Can Make It Complicated

Roumaissa Gouasmi et al.

Summary: The kynurenine pathway plays important roles in tumor development by protecting organs from immune reactions and providing essential metabolites to cells. Abnormal activation of this pathway promotes tumor growth, metastasis, and chemoresistance. The complex regulation of this pathway poses challenges for clinical interventions.

CANCERS (2022)

Review Immunology

Indoleamine 2, 3-Dioxygenase: A Professional Immunomodulator and Its Potential Functions in Immune Related Diseases

Fahimeh Heidari et al.

Summary: This article describes the immunomodulatory function of IDO and IDO-based therapeutic strategies for immune related diseases, highlighting the role of IDO in the tumor microenvironment. According to the research, IDO can be targeted as an immunostimulatory approach for cancer immunotherapy, but it also has different influences on immunity, so further evaluation of its function is needed.

INTERNATIONAL REVIEWS OF IMMUNOLOGY (2022)

Review Chemistry, Medicinal

Recent advances of quinones as a privileged structure in drug discovery

Li Zhang et al.

Summary: Privileged structures like quinones are valuable in discovering new bioactive substances due to their ability to bind to multiple targets with high affinity. This article highlights the recent developments of quinones in various fields such as antitumor, antibacterial, antiviral, anti-Alzheimer's disease, and antimalarial, focusing on their biological activities, structural modifications, and mechanisms of action.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Chemistry, Medicinal

Design, synthesis and biological evaluation of exiguamine A analogues as IDO1 inhibitors

Junmin Dong et al.

Summary: Newly synthesized exiguamine A analogues demonstrated potent inhibitory activities against IDO1, with compound 21f showing high selectivity for IDO1 and no cytotoxicity. Further optimization and evaluation of compound 21f is warranted.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Biochemistry & Molecular Biology

The ups, downs and new trends of IDO1 inhibitors

Shulun Chen et al.

Summary: Cancer immunotherapy, although showing significant clinical benefits, still falls short of the expected response rates. While some new IDO1 inhibitors have shown promise in preclinical studies, the failure of clinical trials has raised concerns. However, new trends in targeting IDO1 continue to emerge, aiming to bridge the gap between lab research and clinical applications.

BIOORGANIC CHEMISTRY (2021)

Review Pharmacology & Pharmacy

Indoleamine and tryptophan 2,3-dioxygenases as important future therapeutic targets

Ana Dolsak et al.

Summary: This review discusses the key step of tryptophan metabolism and the importance of relevant enzymes in pathological conditions. In recent years, many inhibitors targeting these enzymes have been developed, and these inhibitors have entered clinical trials.

PHARMACOLOGY & THERAPEUTICS (2021)

Review Immunology

Tryptophan metabolism in brain tumors-IDO and beyond

Michael Platten et al.

Summary: Tryptophan metabolism plays a crucial role in cancer immunotherapy, particularly in promoting malignant phenotypes and immunosuppressive tumor microenvironments in brain tumors. Recent research has advanced our understanding of the role of tryptophan metabolism and its metabolites in regulating brain function and neuronal integrity, as well as potential therapeutic targets for glioma treatment.

CURRENT OPINION IN IMMUNOLOGY (2021)

Article Chemistry, Medicinal

Discovery of 5-(pyridin-3-yl)-1H-indole-4,7-diones as indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

Kai-min Kong et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2020)

Review Geriatrics & Gerontology

IDO activation, inflammation and musculoskeletal disease

Joy Ogbechi et al.

EXPERIMENTAL GERONTOLOGY (2020)

Review Medicine, General & Internal

Tumor Microenvironment

Borros Arneth

MEDICINA-LITHUANIA (2020)

Review Immunology

IDO and Kynurenine Metabolites in Peripheral and CNS Disorders

Yi-Shu Huang et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

Rational design, synthesis and biological evaluation of ubiquinone derivatives as IDO1 inhibitors

Yuyang Ding et al.

BIOORGANIC CHEMISTRY (2019)

Review Biotechnology & Applied Microbiology

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

Michael Platten et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Article Biochemistry & Molecular Biology

The interplay between cytokines and the Kynurenine pathway in inflammation and atherosclerosis

Roland Baumgartner et al.

CYTOKINE (2019)

Article Chemistry, Multidisciplinary

Structural Basis of Inhibitor Selectivity in Human Indoleamine 2,3-Dioxygenase 1 and Tryptophan Dioxygenase

Khoa N. Pham et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Review Immunology

Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target

Freek J. H. Sorgdrager et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Inhibitory effects of flavonoids isolated from Sophora flavescens on indoleamine 2,3-dioxygenase 1 activity

Mincheol Kwon et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2019)

Article Chemistry, Medicinal

Synthesis and biological evaluation of new berberine derivatives as cancer immunotherapy agents through targeting IDO1

Yan-Xiang Wang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Chemistry, Medicinal

Design, synthesis and biological evaluation of novel naphthoquinone derivatives as IDO1 inhibitors

Liangkun Pan et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Cell Biology

Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1

Elisa Albini et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2017)

Review Multidisciplinary Sciences

Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health

Igor Cervenka et al.

SCIENCE (2017)

Article Multidisciplinary Sciences

Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1

Ariel Lewis-Ballester et al.

NATURE COMMUNICATIONS (2017)

Review Oncology

Tumor microenvironment and therapeutic response

Ting Wu et al.

CANCER LETTERS (2017)

Review Immunology

IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance

David H. Munn et al.

TRENDS IN IMMUNOLOGY (2016)

Article Biochemistry & Molecular Biology

Tryptophan-kynurenine pathway is dysregulated in inflammation, and immune activation

Qiongxin Wang et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2015)

Article Chemistry, Medicinal

Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway

Amy B. Dounay et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

Review Cell Biology

The kynurenine pathway and neurodegenerative disease

Daniel C. Maddison et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Antitumour agents as inhibitors of tryptophan 2,3-dioxygenase

Georgios Pantouris et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Chemistry, Organic

Benzofuranquinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis and biological evaluation

Catarina Carvalho et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2014)

Article Chemistry, Medicinal

Indoleamine 2,3-dioxygenase inhibitory activity of derivatives of marine alkaloid tsitsikammamine A

Eduard Dolusic et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

Review Biotechnology & Applied Microbiology

Kynurenines in the CNS: recent advances and new questions

Laszlo Vecsei et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Article Chemistry, Medicinal

Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2

Supun M. Bakmiwewa et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

Review Chemistry, Medicinal

Marine Natural Products and Other Derivatives as Potent Indoleamine 2,3-Dioxygenase Inhibitors

Evelyne Delfourne

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2012)

Article Chemistry, Medicinal

Tryptophan 2,3-Dioxygenase (TDO) Inhibitors. 3-(2-(Pyridyl)ethenyl)indoles as Potential Anticancer Immunomodulators

Eduard Dolusic et al.

JOURNAL OF MEDICINAL CHEMISTRY (2011)

Article Chemistry, Medicinal

Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors

Sanjeev Kumar et al.

JOURNAL OF MEDICINAL CHEMISTRY (2008)

Article Chemistry, Medicinal

Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A

Gavin Carr et al.

JOURNAL OF MEDICINAL CHEMISTRY (2008)

Review Multidisciplinary Sciences

Origin and physiological roles of inflammation

Ruslan Medzhitov

NATURE (2008)

Article Plant Sciences

Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific marine hydroid Garveia annulata

Alban Pereira et al.

JOURNAL OF NATURAL PRODUCTS (2006)

Article Multidisciplinary Sciences

Crystal structure of human indoleamine 2,3-dioxygenase:: Catalytic mechanism of O2 incorporation by a heme-containing dioxygenase

H Sugimoto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Medical Laboratory Technology

Monitoring tryptophan metabolism in chronic immune activation

K Schröcksnadel et al.

CLINICA CHIMICA ACTA (2006)

Article Chemistry, Medicinal

Structure-activity study of Brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors

P Gaspari et al.

JOURNAL OF MEDICINAL CHEMISTRY (2006)

Review Biochemistry & Molecular Biology

Biochemical and medical aspects of the indoleamine 2,3-dioxygenase-initiated L-tryptophan metabolism

O Takikawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Review Biochemistry & Molecular Biology

Metabolism and function of coenzyme Q

M Turunen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2004)