Motilin and its receptor are expressed in the dorsal horn in a rat model of acute incisional pain: Intrathecal motilin injection alleviates pain behaviors

Article Biochemistry & Molecular Biology

The neuroinflammatory component of negative affect in patients with chronic pain

D. S. Albrecht et al.

Summary: This study found that negative affect in chronic pain patients is associated with elevated levels of the glial marker TSPO in the brain and changes in functional connectivity.

MOLECULAR PSYCHIATRY (2021)

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Review Gastroenterology & Hepatology

Effects of the herbal medicine Rikkunshito, for functional dyspepsia: A systematic review and meta-analysis

Seok-Jae Ko et al.

Summary: Rikkunshito (RKT) shows significant improvement in the treatment of functional dyspepsia (FD), with better symptom improvement and higher total clinical efficacy rate (TCE) compared to western medicine alone; Combination therapy brings better efficacy and significant symptom improvement compared to western medicine alone; Further rigorously designed and high-quality randomized controlled trials are needed to confirm these findings.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Review Biology

Gut Hormones as Potential Therapeutic Targets or Biomarkers of Response in Depression: The Case of Motilin

Ravi Philip Rajkumar

Summary: This research examines the potential role of gut hormone motilin in the pathophysiology and treatment of depression, with evidence suggesting interactions with diet, monoamine, and neuroendocrine pathways. The study also found a significant correlation between rs2281820 allele frequencies and the prevalence of depression, indicating the need for further evaluation of gut peptides as markers of antidepressant response and potential mechanisms for drug development in the future.

LIFE-BASEL (2021)

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Article Physiology

Roles of Endothelial Motilin Receptor and Its Signal Transduction Pathway in Motilin-Induced Left Gastric Artery Relaxation in Dogs

HongYu Li et al.

Summary: The study demonstrates that motilin-induced relaxation of the left gastric artery (LGA) in dogs is dependent on the endothelial motilin receptor (MLNR) through the G protein-PLC-IP3 pathway and Ca2+ influx. The NOS-NO-sGC-cGMP pathway, prostacyclin, myoendothelial gap junction (MEGJ), and K+ channels (especially K-Ca) are also involved in endothelial-dependent relaxation of vascular smooth muscle (VSM) cells.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Endocrinology & Metabolism

Stimulation of motilin secretion by bile, free fatty acids, and acidification in human duodenal organoids

Emily L. Miedzybrodzka et al.

Summary: This study provides a comprehensive understanding of the regulation of motilin secretion in human duodenal M-cells, identifying key receptors involved in this process.

MOLECULAR METABOLISM (2021)

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Review Gastroenterology & Hepatology

The gastrointestinal tract in hunger and satiety signalling

Jan Tack et al.

Summary: Various gastrointestinal mechanisms, including mechano-chemoreceptors, peptide hormones, and neural pathways, play a role in regulating hunger and satiety signaling in humans. Mechanisms such as gastric accommodation reflex and motilin release are key determinants of satiety and hunger, influencing meal volume and energy intake.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2021)

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Review Endocrinology & Metabolism

Motilin Comparative Study: Structure, Distribution, Receptors, and Gastrointestinal Motility

Takio Kitazawa et al.

Summary: Motilin, produced in the upper intestine, acts as an important regulator of gastrointestinal motility and mediates the phase III of interdigestive migrating motor complex in the stomach of humans, dogs, and musk shrews. It helps maintain normal GI functions and transmits hunger signals from the stomach to the brain. The structure, distribution, receptor, and regulatory function of motilin vary among vertebrates from fish to mammals.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Oncology

Analysis of Changes of Intestinal Flora in Elderly Patients with Alzheimer's Disease and Liver Cancer and Its Correlation with Abnormal Gastrointestinal Motility

Weiwei Zhang et al.

Summary: Elderly patients with Alzheimer's disease and liver cancer often experience changes in intestinal flora, which are correlated with abnormal gastrointestinal motility. The study found that the levels of Bifidobacteria and Lactobacilli were lower in the observation group compared to the control group, while the levels of Escherichia coli, Helicobacter pylori, and Streptococcus were higher. Additionally, the diversity indices of intestinal flora were higher in the observation group.

JOURNAL OF ONCOLOGY (2021)

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Review Biochemistry & Molecular Biology

Purinergic signalling in spinal pain processing

Theresa H. Tam et al.

Summary: Purinergic signaling plays important roles in somatosensory and nociceptive transmission in the dorsal horn of the spinal cord, mediating both physiological and pathological pain processing. Additionally, there is evidence of sexual dimorphism in the involvement of purinergic signaling in pain, with P2X4 receptors being implicated in pain hypersensitivity primarily in males.

PURINERGIC SIGNALLING (2021)

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Review Psychology, Clinical

The gut microbiota in anxiety and depression - A systematic review

Carra A. Simpson et al.

Summary: The gut microbiota is associated with anxiety and depressive disorders, with inconsistent findings in diversity but potential links to peripheral inflammation influencing the brain's pathophysiology. Future research should consider confounders like diet and medications, and investigate microorganism function.

CLINICAL PSYCHOLOGY REVIEW (2021)

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Article Plant Sciences

Effects of Zuojin pill on depressive behavior and gastrointestinal function in rats with chronic unpredictable mild stress: Role of the brain-gut axis

Tao Wang et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Review Psychiatry

The Role of GI Peptides in Functional Dyspepsia and Gastroparesis: A Systematic Review

Karen Van den Houte et al.

FRONTIERS IN PSYCHIATRY (2020)

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Review Multidisciplinary Sciences

Central circuit mechanisms of itch

Xiao-Jun Chen et al.

NATURE COMMUNICATIONS (2020)

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Article Integrative & Complementary Medicine

Effect of Artemisia rupestris L. Extract on Gastrointestinal Hormones and Brain-Gut Peptides in Functional Dyspepsia Rats

Chun Wang et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

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Article Immunology

Systemic administration of orexin A ameliorates established experimental autoimmune encephalomyelitis by diminishing neuroinflammation

Laurine Becquet et al.

JOURNAL OF NEUROINFLAMMATION (2019)

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Article Anesthesiology

Revision of expert panel's guidelines on postoperative pain management

Frederic Aubrun et al.

ANAESTHESIA CRITICAL CARE & PAIN MEDICINE (2019)

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Review Medicine, General & Internal

Nonnarcotic Methods of Pain Management

Nanna B. Finnerup

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Review Clinical Neurology

Pharmacological treatments of neuropathic pain: The latest recommendations

N. Attal

REVUE NEUROLOGIQUE (2019)

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Article Multidisciplinary Sciences

The motilin agonist erythromycin increases hunger by modulating homeostatic and hedonic brain circuits in healthy women: a randomized, placebo-controlled study

Dongxing Zhao et al.

SCIENTIFIC REPORTS (2018)

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Article Neurosciences

Presynaptic Inhibition of Primary Nociceptive Signals to Dorsal Horn Lamina I Neurons by Dopamine

Yong Lu et al.

JOURNAL OF NEUROSCIENCE (2018)

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Article Clinical Neurology

Pain as a disease: an overview

William Raffaeli et al.

JOURNAL OF PAIN RESEARCH (2017)

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Article Public, Environmental & Occupational Health

Vital Signs: Changes in Opioid Prescribing in the United States, 2006-2015

Gery P. Guy et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2017)

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Article Multidisciplinary Sciences

The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity

Stephan W. Hohmann et al.

SCIENTIFIC REPORTS (2017)

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Review Biochemistry & Molecular Biology

Chemokines in neuron-glial cell interaction and pathogenesis of neuropathic pain

Zhi-Jun Zhang et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2017)

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Article Endocrinology & Metabolism

Molecular cloning of motilin and mechanism of motilin-induced gastrointestinal motility in Japanese quail

Auvijit Saha Apu et al.

GENERAL AND COMPARATIVE ENDOCRINOLOGY (2016)

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Article Neurosciences

Cingulate GABA levels inversely correlate with the intensity of ongoing chronic knee osteoarthritis pain

Diane Reckziegel et al.

MOLECULAR PAIN (2016)

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Review Gastroenterology & Hepatology

Vagal tone: effects on sensitivity, motility, and inflammation

B. Bonaz et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2016)

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Article Clinical Neurology

A modified procedure for lumbar intrathecal catheterization in rats

Yongheng Hou et al.

NEUROLOGICAL RESEARCH (2016)

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Article Gastroenterology & Hepatology

Beneficial effects of antidepressant mirtazapine in functional dyspepsia patients with weight loss

Shu-Man Jiang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

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Article Clinical Neurology

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

Nanna B. Finnerup et al.

LANCET NEUROLOGY (2015)

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Article Clinical Neurology

Spinal sample showing p-JNK and P38 associated with the pain signaling transduction of glial cell in neuropathic pain

J. Cao et al.

SPINAL CORD (2015)

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Article Medicine, Research & Experimental

Effects of intrathecal opioids combined with low-dose naloxone on motilin and its receptor in a rat model of postoperative pain

Jun Zhao et al.

LIFE SCIENCES (2014)

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Article Gastroenterology & Hepatology

Xiaoyao pill for treatment of functional dyspepsia in perimenopausal women with depression

Han-Guang Du et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

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Article Pharmacology & Pharmacy

Anti-emetic and emetic effects of erythromycin in Suncus murinus: Role of vagal nerve activation, gastric motility stimulation and motilin receptors

Farideh A. Javid et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2013)

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Review Neurosciences

Anxiolytic Actions of Motilin in the Basolateral Amygdala

Bin Feng et al.

MOLECULAR NEUROBIOLOGY (2013)

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Article Endocrinology & Metabolism

The Paraventricular Nucleus Modulates Thyroidal Motilin Release and Rat Gastric Motility

F. Guo et al.

JOURNAL OF NEUROENDOCRINOLOGY (2011)

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Article Gastroenterology & Hepatology

Erythromycin inhibited glycinergic inputs to gastric vagal motoneurons in brainstem slices of newborn rats

H. Liu et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2010)

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Review Neurosciences

Descending control of nociception: Specificity, recruitment and plasticity

M. M. Heinricher et al.

BRAIN RESEARCH REVIEWS (2009)

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Review Biochemistry & Molecular Biology

Cellular and Molecular Mechanisms of Pain

Allan I. Basbaum et al.

CELL (2009)

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Article Biochemistry & Molecular Biology

Effect of motilin on the discharge of rat hippocampal neurons responding to gastric distension and its potential mechanism

Luo Xu et al.

PEPTIDES (2008)

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Motilin and its receptor are expressed in the dorsal horn in a rat model of acute incisional pain: Intrathecal motilin injection alleviates pain behaviors

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