Place of magistral preparations to continue the treatment if the drug is commercially stopped worldwide? A case report of a 10-year-old child with subacute sclerosing panencephalitis (SSPE) requiring inosiplex

Subacute sclerosing panencephalitis (SSPE) is a late-onset and fatal viral disease caused by persistent infection of the central nervous system by measles virus (MeV). We present the case of a 10-year-old child from South Asia affected by SSPE, stabilized with a combination of intrathecal interferon-alpha 2b (INF-alpha 2b) injections and oral inosiplex and how we continued the treatment when inosiplex was commercially stopped worldwide.

Automated summary

Subacute sclerosing panencephalitis (SSPE) is a late-onset and fatal viral disease caused by persistent infection of the central nervous system by measles virus (MeV). In this study, we present a case of a 10-year-old child from South Asia affected by SSPE, who was stabilized with a combination of intrathecal interferon-alpha 2b (INF-alpha 2b) injections and oral inosiplex. We also describe how we continued the treatment when inosiplex was commercially stopped worldwide.