4.6 Article

LncRNA DICER1-AS1 promotes colorectal cancer progression by activating the MAPK/ERK signaling pathway through sponging miR-650

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Article Oncology

LncRNA MIR155HG induces M2 macrophage polarization and drug resistance of colorectal cancer cells by regulating ANXA2

Lin Zhou et al.

Summary: In this study, MIR155HG and ANXA2 were found to be highly expressed in CRC tissues/cells and have prognostic value for CRC patients. MIR155HG promotes CRC progression and enhances oxaliplatin resistance in CRC cells through M2 macrophage polarization by regulating the miR-650/ANXA2 axis.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2022)

Article Oncology

Long noncoding RNA TINCR facilitates hepatocellular carcinoma progression and dampens chemosensitivity to oxaliplatin by regulating the miR-195-3p/ST6GAL1/NF-kappa B pathway

Jie Mei et al.

Summary: This study reveals that TINCR is upregulated in HCC and associated with poor patient prognosis. Functional experiments show that silencing TINCR inhibits HCC proliferation, migration, invasion, and oxaliplatin resistance, while overexpressing TINCR has the opposite effects. Mechanistically, TINCR acts as a competing endogenous RNA to sponge miR-195-3p, relieving its repression on ST6GAL1 and activating nuclear factor kappa B signaling.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Article Oncology

A reciprocal feedback between N6-methyladenosine reader YTHDF3 and lncRNA DICER1-AS1 promotes glycolysis of pancreatic cancer through inhibiting maturation of miR-5586-5p

Yuhang Hu et al.

Summary: This study reveals a negative feedback regulation between the m6A reader YTHDF3 and the glycolytic lncRNA DICER1-AS1, which is involved in glycolysis and tumorigenesis of pancreatic cancer.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Review Oncology

Functions and underlying mechanisms of miR-650 in human cancers

Yuanshuai Su et al.

Summary: MicroRNAs (miRNAs) are noncoding RNAs that regulate gene expression by interfering with mRNA translation and causing posttranscriptional gene silencing. miR-650 is a newly identified miRNA that plays critical roles in cancer progression. However, the associations between the expression patterns and molecular mechanisms of miR-650 in cancer have not been comprehensively described.

CANCER CELL INTERNATIONAL (2022)

Article Oncology

PICALM exerts a role in promoting CRC progression through ERK/MAPK signaling pathway

Xitao Zhang et al.

Summary: This study revealed that PICALM promotes CRC progression through the ERK/MAPK signaling pathway, highlighting its potential as a therapeutic target in clinical applications.

CANCER CELL INTERNATIONAL (2022)

Article Biochemistry & Molecular Biology

Long non-coding RNA LINC00680 functions as a ceRNA to promote esophageal squamous cell carcinoma progression through the miR-423-5p/PAK6 axis

Song-Tao Xue et al.

Summary: ESCC was found to have dysregulated expression of lncRNAs, with LINC00680 being highly expressed and associated with poor prognosis. LINC00680 acts as a ceRNA by sponging miR-423-5p to regulate PAK6 expression in ESCC cells, suggesting its potential as a diagnostic, prognostic, and therapeutic target for ESCC.

MOLECULAR CANCER (2022)

Article Oncology

Oncopeptide MBOP Encoded by LINC01234 Promotes Colorectal Cancer through MAPK Signaling Pathway

Chunyuan Tang et al.

Summary: This study reports the identification and characterization of a peptide called MEK1-binding oncopeptide (MBOP) encoded by LINC01234, which is highly expressed in colorectal cancer (CRC) and plays an oncogenic role in tumorigenesis. MBOP interacts with MEK1 and activates the MEK1/pERK/MMP2/MMP9 signaling pathway. The degradation of MBOP is mediated by the E3 ubiquitin-protein transferases MAEA and RMND5A. These findings suggest that MBOP could serve as a potential target and prognostic indicator for clinical therapy of CRC.

CANCERS (2022)

Article Oncology

Role of lncSLCO1C1 in gastric cancer progression and resistance to oxaliplatin therapy

Yu-Feng Xiao et al.

Summary: This study found that lncSLCO1C1 is highly expressed in gastric carcinoma (GC) tissue samples and is associated with poor overall survival in patients. lncSLCO1C1 promotes cell proliferation and migration in GC, as well as conferring resistance to oxaliplatin chemotherapy. It acts as a scaffold for the SSRP1/H2A/H2B complex and absorbs miR-211-5p and miR-204-5p, leading to increased expression of SSRP1. The findings highlight the role of lncSLCO1C1 in GC progression.

CLINICAL AND TRANSLATIONAL MEDICINE (2022)

Article Cell Biology

miR-5000-3p confers oxaliplatin resistance by targeting ubiquitin-specific peptidase 49 in colorectal cancer

Yan-yan Zhuang et al.

Summary: The study reveals that miR-5000-3p may play a role in drug resistance progression of CRC by regulating the USP49 gene, resulting in cancer cells sensitized to oxaliplatin.

CELL DEATH DISCOVERY (2021)

Article Cell Biology

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

Bas Ponsioen et al.

Summary: The study illustrates how EGFR activity enhances signal transduction efficiency in KRAS or BRAF mutant MAPK pathways, revealing a potential mechanism for using EGFR inhibitors in colorectal cancer with KRAS and BRAF mutations.

NATURE CELL BIOLOGY (2021)

Article Gastroenterology & Hepatology

Peptide SMIM30 promotes HCC development by inducing SRC/YES1 membrane anchoring and MAPK pathway activation

Yanan Pang et al.

JOURNAL OF HEPATOLOGY (2020)

Article Multidisciplinary Sciences

LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc

Jiayin Tang et al.

NATURE COMMUNICATIONS (2019)

Article Oncology

The NF-κB signalling pathway in colorectal cancer: associations between dysregulated gene and miRNA expression

Martha L. Slattery et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2018)

Article Medicine, Research & Experimental

LncRNA DICER1-AS1 promotes the proliferation, invasion and autophagy of osteosarcoma cells via miR-30b/ATG5

Zenghui Gu et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Medicine, Research & Experimental

Granulin epithelin precursor promotes colorectal carcinogenesis by activating MARK/ERK pathway

Yi Pan et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2018)

Article Biochemistry & Molecular Biology

A miR-20a/MAPK1/c-Myc regulatory feedback loop regulates breast carcinogenesis and chemoresistance

Wengong Si et al.

CELL DEATH AND DIFFERENTIATION (2018)

Article Gastroenterology & Hepatology

Global patterns and trends in colorectal cancer incidence and mortality

Melina Arnold et al.

Review Oncology

Potential of long non-coding RNAs in cancer patients: From biomarkers to therapeutic targets

Subash Chandra Gupta et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

Article Oncology

miR-422a inhibits cell proliferation in colorectal cancer by targeting AKT1 and MAPK1

Wen-Ting Wei et al.

CANCER CELL INTERNATIONAL (2017)

Review Cell Biology

ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy?

Roser Busca et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)

Review Biochemistry & Molecular Biology

Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

Yu Sun et al.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2015)

Review Pharmacology & Pharmacy

ERK1/2 MAP kinases: Structure, function, and regulation

Robert Roskoski

PHARMACOLOGICAL RESEARCH (2012)

Article Biochemistry & Molecular Biology

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

Leonardo Salmena et al.

Review Genetics & Heredity

Non-coding RNAs in human disease

Manel Esteller

NATURE REVIEWS GENETICS (2011)

Review Genetics & Heredity

Long non-coding RNAs: insights into functions

Tim R. Mercer et al.

NATURE REVIEWS GENETICS (2009)