Are brain MRI abnormalities associated with the semiology of functional seizures?

PurposeTo investigate whether radiologically apparent brain magnetic resonance imaging (MRI) abnormalities are associated with the functional seizure (FS) semiology. MethodsAll patients with a diagnosis of FS at the epilepsy centers at Shiraz University of Medical Sciences, Iran; Aichi Medical University Hospital, Japan; University of Michigan, USA; University of California, Los Angeles, USA; Emory University School of Medicine, USA; and Hospital el Cruce, Argentina, were studied. ResultsOne hundred patients were included; 77 (77%) had motor functional seizures. Lobar location of brain abnormality did not have an association with the semiology (p = .83). There was no significant difference between ictal behaviors in patients with frontal or parietal lesions compared to those with temporal or occipital lesions. ConclusionThere were no associations between functional seizure ictal behaviors and locations of the radiologically apparent brain MRI abnormalities. Further studies are needed to evaluate the underpinnings of varying behaviors in FS.

Automated summary

The purpose of this study was to investigate the association between radiologically apparent brain magnetic resonance imaging (MRI) abnormalities and functional seizure (FS) semiology. Patients with FS from various epilepsy centers were included in the study. The results showed no significant association between the location of brain abnormalities and FS semiology, suggesting that further research is needed to understand the underlying causes of varying behaviors in FS.