4.5 Review

Thalamic pathology in frontotemporal dementia: Predilection for specific nuclei, phenotype-specific signatures, clinical correlates, and practical relevance

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Resting-state EEG reveals four subphenotypes of amyotrophic lateral sclerosis

Stefan Dukic et al.

Summary: Amyotrophic lateral sclerosis (ALS) is a devastating disease that affects the motor system and can lead to cognitive and behavioral changes. Current subtyping methods of ALS do not fully predict disease progression or prognosis. Recent research using resting-state EEG has shown that different patterns of network disruption in ALS patients can be used for clustering analysis, resulting in the identification of four distinct phenotypes. These phenotypes are associated with different neurophysiological profiles and have correlations with clinical profiles and disease trajectories.
Article Clinical Neurology

Cortical and subcortical pathological burden and neuronal loss in an autopsy series of FTLD-TDP-type C

Allegra Kawles et al.

Summary: This study provides a detailed characterization of the pathological distribution of TDP-43 and gliosis in FTLD-TDP-type C, and investigates the relationship between inclusions and neurodegeneration. The findings suggest an inverse relationship between the extent of TDP-positive inclusions and neuronal loss.
Article Neuroimaging

Mapping cortical disease-burden at individual-level in frontotemporal dementia: implications for clinical care and pharmacological trials

Mary Clare McKenna et al.

Summary: Imaging studies of Frontotemporal Dementia (FTD) often focus on group-level statistics of genetically, molecularly, or clinically stratified patients to assess radiological traits and genotype-related signatures. However, in a clinical context, the emphasis is on interpreting imaging data from individual patients for diagnostic classification and monitoring disease progression. A prospective computational neuroimaging study in a cohort of FTD patients revealed distinct cortical changes across different phenotypes, highlighting the potential for individualized diagnosis and monitoring of disease progression.

BRAIN IMAGING AND BEHAVIOR (2022)

Article Neurosciences

Influence of periaqueductal gray on other salience network nodes predicts social sensitivity

Myrthe G. Rijpma et al.

Summary: This study investigated the effective connectivity patterns in the salience network using spectral dynamic causal modeling. The results showed that the output from the periaqueductal gray to cortical and thalamic nodes plays a key role in socioemotional sensitivity for healthy individuals, but this effect is weakened in patients with behavioral variant frontotemporal dementia (bvFTD), leading to deficits in social behavior.

HUMAN BRAIN MAPPING (2022)

Article Behavioral Sciences

White matter microstructure alterations in frontotemporal dementia: Phenotype-associated signatures and single-subject interpretation

Mary Clare McKenna et al.

Summary: This study aims to demonstrate the feasibility of single-subject magnetic resonance imaging (MRI) interpretation. The results suggest that it is possible to meaningfully evaluate the diffusion profile of individual FTD patients using normative data. Computational imaging offers objective, quantitative insights into white matter integrity changes even at the single-subject level.

BRAIN AND BEHAVIOR (2022)

Review Clinical Neurology

The changing landscape of neuroimaging in frontotemporal lobar degeneration: from group-level observations to single-subject data interpretation

Mary Clare McKenna et al.

Summary: This article reviews the challenges in interpreting single MRI scans in frontotemporal lobar degeneration (FTLD) patients and the need for reliable individual subject data interpretation in the clinical setting. It also discusses the feasibility of categorizing FTLD patients into diagnostic groups based on multiparametric imaging data and the limitations of current single-subject data interpretation models. Further improvements are needed before these models can be developed into viable clinical applications.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2022)

Review Neurosciences

Neurometabolic Alterations in Motor Neuron Disease: Insights from Magnetic Resonance Spectroscopy

Foteini Christidi et al.

Summary: Magnetic resonance spectroscopy has significant potential in advancing both academic understanding and practical applications in motor neuron diseases.

JOURNAL OF INTEGRATIVE NEUROSCIENCE (2022)

Article Neurosciences

Alterations in somatosensory, visual and auditory pathways in amyotrophic lateral sclerosis: an under-recognised facet of ALS

Rangariroyashe H. Chipika et al.

Summary: This prospective neuroimaging study systematically evaluated the differences in processing sensory information between amyotrophic lateral sclerosis (ALS) patients and healthy controls. The results showed widespread alterations in cerebral grey and white matter structures involved in sensory processing, including somatosensory, visual, and auditory regions. These findings suggest that ALS not only affects motor system degeneration and cognitive dysfunction, but also impairs sensory pathways, which is of clinical significance for ALS assessments.

JOURNAL OF INTEGRATIVE NEUROSCIENCE (2022)

Article Clinical Neurology

Focal thalamus pathology in frontotemporal dementia: Phenotype-associated thalamic profiles

Mary Clare McKenna et al.

Summary: Different clinical subtypes of frontotemporal dementia show distinct thalamic pathology and selective degeneration of specific thalamic nuclei, suggesting thalamic degeneration plays a role in the heterogeneity of FTD manifestations. Utilizing a multimodal approach with complementary MRI techniques can provide a comprehensive understanding of thalamic pathology in FTD.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2022)

Review Clinical Neurology

Primary Lateral Sclerosis: Clinical, radiological and molecular features

P. Bede et al.

Summary: Primary Lateral Sclerosis (PLS) is a rare motor neuron disorder with challenging diagnosis and limited therapeutic options. Recent consensus diagnostic criteria and expanding knowledge of extra-motor clinical manifestations have contributed to a better understanding of PLS. Research in PLS, including post-mortem studies and genetic profiling, has gained momentum and has significant clinical implications.

REVUE NEUROLOGIQUE (2022)

Article Medicine, General & Internal

Brain Networks Involved in Depression in Patients with Frontotemporal Dementia and Parkinson's Disease: An Exploratory Resting-State Functional Connectivity MRI Study

Vincenzo Alfano et al.

Summary: This study investigated the brain networks involved in depression in patients with frontotemporal dementia (FTD) and Parkinson's disease (PD), compared to healthy controls. The findings suggest the presence of specific connectivity patterns in depressed patients that may be related to neurocognitive disorders.

DIAGNOSTICS (2022)

Editorial Material Clinical Neurology

Machine-learning in motor neuron diseases: Prospects and pitfalls

Peter Bede et al.

EUROPEAN JOURNAL OF NEUROLOGY (2022)

Article Clinical Neurology

MRI Clustering Reveals Three ALS Subtypes With Unique Neurodegeneration Patterns

Harold H. G. Tan et al.

Summary: This study identifies subtypes of amyotrophic lateral sclerosis (ALS) by comparing patterns of neurodegeneration using brain magnetic resonance imaging (MRI) and explores their phenotypes. Three main patterns of cerebral neurodegeneration are associated with distinct clinical characteristics and cognitive profiles in ALS.

ANNALS OF NEUROLOGY (2022)

Review Pathology

Neuroimaging in hereditary spastic paraplegias: from qualitative cues to precision biomarkers

Grainne Mulkerrin et al.

Summary: This article reviews the progress of imaging techniques in hereditary spastic paraplegias (HSP). The study highlights the use of various imaging modalities, study design, clinical correlations, and methodological approaches in HSP cohorts. Current limitations include genetically admixed cohorts, small sample sizes, lack of postmortem validation, and limited clinical battery. However, collaborative multicenter initiatives and comprehensive clinical profiling have the potential to overcome these limitations and develop viable clinical applications for HSP imaging.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2022)

Article Clinical Neurology

Phenotypic categorisation of individual subjects with motor neuron disease based on radiological disease burden patterns: A machine-learning approach

Peter Bede et al.

Summary: Motor neuron disease is a heterogeneous condition and accurate classification of patients is important for prognosis and management strategies. In this study, machine learning was used to classify patients based on their radiological profile, achieving high accuracy for amyotrophic lateral sclerosis but lower accuracy for other forms of motor neuron disease. The analysis also identified the importance of white matter diffusivity metrics and other variables in discriminating between different phenotypes.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2022)

Review Clinical Neurology

The changing landscape of neuroimaging in frontotemporal lobar degeneration: from group-level observations to single-subject data interpretation

Mary Clare McKenna et al.

Summary: This article reviews single-subject MRI classification strategies in symptomatic and pre-symptomatic FTLD, discusses practical clinical implications, and highlights the limitations of current single-subject data interpretation models.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2022)

Article Clinical Neurology

Distinct network topology in Alzheimer's disease and behavioral variant frontotemporal dementia

Adeline Su Lyn Ng et al.

Summary: The study revealed distinct alterations in brain network topology between Alzheimer's disease and behavioral variant frontotemporal dementia, which are associated with cognitive decline and severity of neuropsychiatric symptoms.

ALZHEIMERS RESEARCH & THERAPY (2021)

Article Clinical Neurology

Extra-motor manifestations in post-polio syndrome (PPS): fatigue, cognitive symptoms and radiological features

Stacey Li Hi Shing et al.

Summary: Despite common symptoms such as fatigue, cognitive deficits, and self-perceived fatigue in patients with post-polio syndrome (PPS), neuroimaging studies showed only limited cortical, subcortical, and white matter degeneration. Non-structural factors, such as polypharmacy and poor sleep, may contribute to the complex symptomatology of PPS.

NEUROLOGICAL SCIENCES (2021)

Article Neuroimaging

FDG-PET in presymptomatic C9orf72 mutation carriers

Karteek Popuri et al.

Summary: The study aimed to investigate patterns of brain glucose metabolism in presymptomatic carriers of the C9orf72 repeat expansion using FDG-PET. It was found that these carriers exhibit regional hypometabolism in specific brain regions up to 10 years prior to symptom onset, suggesting the potential utility of FDG-PET in monitoring early stages of FTD in individuals with this genetic basis.

NEUROIMAGE-CLINICAL (2021)

Article Clinical Neurology

Evaluation and categorisation of individual patients based on white matter profiles: Single-patient diffusion data interpretation in neurodegeneration

Marlene Tahedl et al.

Summary: This study introduces a computational method to evaluate individual subject diffusion tensor data to highlight white matter integrity alterations. The approach can readily detect white matter degeneration in individual ALS patients and categorize single subjects with a 'blinded diagnosis' as likely 'ALS' or 'control'. The z-score-based strategy enables the interpretation of single DTI datasets and comparison of study groups, making it particularly useful for clinical applications.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2021)

Article Clinical Neurology

Structural MRI Signatures in Genetic Presentations of the Frontotemporal Dementia/Motor Neuron Disease Spectrum

Edoardo Gioele Spinelli et al.

Summary: Cortical, subcortical, and cerebellar gray matter atrophy was assessed in patients with frontotemporal lobar degeneration (FTLD) spectrum disorders using MRI. The study found that genetic FTD patients showed more severe and diffuse GM atrophy, with C9orf72 and GRN mutation carriers exhibiting the most extensive cortical volume loss. Different genetic mutations in FTLD patients showed variations in GM volume loss, which may serve as useful markers for gFTLD, particularly C9orf72-related disorders.

NEUROLOGY (2021)

Review Clinical Neurology

Frontotemporal Pathology in Motor Neuron Disease Phenotypes: Insights From Neuroimaging

Mary Clare McKenna et al.

Summary: Frontotemporal involvement varies among different motor neuron disease phenotypes, with some cases readily detecting frontotemporal degeneration while others show limited cerebral pathology. Neuroimaging plays an important role in studying extra-motor disease burden, but faces challenges such as sample size limitations and longitudinal study biases.

FRONTIERS IN NEUROLOGY (2021)

Article Clinical Neurology

Synaptic density in carriers of C9orf72 mutations: a [11C] UCB-J PET study

Maura Malpetti et al.

Summary: Research shows that pre-symptomatic carriers of C9orf72 mutation exhibit reduced synaptic density in the thalamus compared to controls, and there is extensive synaptic loss in the frontal temporal regions of symptomatic patients with frontotemporal dementia. Therefore, the use of [C-11]UCB-J PET may aid in early assessment, monitoring of disease progression, and evaluation of new preventive treatment strategies.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2021)

Article Clinical Neurology

Neural mechanisms of psychosis vulnerability and perceptual abnormalities in the ALS-FTD spectrum

Emma M. Devenney et al.

Summary: This study aimed to explore psychotic experiences and abnormal perceptions in the ALS-FTD spectrum, identifying high rates of these experiences and abnormalities across the continuum, especially in those with C9orf72 expansions. Social anxiety and ACE-III scores were found to be the best predictors of psychosis proneness, with findings suggesting complex interactions between cognitive, social, and neurobiological factors in determining vulnerability to psychosis in ALS-FTD.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2021)

Article Clinical Neurology

Tackling clinical heterogeneity across the amyotrophic lateral sclerosis-frontotemporal dementia spectrum using a transdiagnostic approach

Rebekah M. Ahmed et al.

Summary: Distinct patterns of brain atrophy were observed across the spectrum of ALS and FTD, with specific regions affected in different clinical subtypes. Significant differences were found between patient groups, highlighting the need for further research into these diseases.

BRAIN COMMUNICATIONS (2021)

Article Neuroimaging

Differential early subcortical involvement in genetic FTD within the GENFI cohort

Martina Bocchetta et al.

Summary: Studies have shown evidence of early subcortical involvement in genetic FTD, with C9orf72 expansion carriers exhibiting the earliest and most widespread changes. Investigating individual subregions, early changes can also be seen in MAPT mutation carriers within the limbic system.

NEUROIMAGE-CLINICAL (2021)

Article Clinical Neurology

In vivo staging of frontotemporal lobar degeneration TDP-43 type C pathology

Martina Bocchetta et al.

ALZHEIMERS RESEARCH & THERAPY (2020)

Article Clinical Neurology

Serum neurofilament light chain in FTLD: association with C9orf72, clinical phenotype, and prognosis

Antti Cajanus et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2020)

Article Clinical Neurology

Multimodal longitudinal study of structural brain involvement in amyotrophic lateral sclerosis

Hannelore K. van der Burgh et al.

NEUROLOGY (2020)

Article Clinical Neurology

Abnormal pain perception is associated with thalamo-cortico-striatal atrophy in C9orf72 expansion carriers in the GENFI cohort

Rhian S. Convery et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2020)

Article Clinical Neurology

Amygdala pathology in amyotrophic lateral sclerosis and primary lateral sclerosis

Rangariroyashe H. Chipika et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2020)

Article Neuroimaging

Longitudinal changes in resting state networks in early presymptomatic carriers of C9orf72 expansions

Rachel Smallwood Shoukry et al.

NEUROIMAGE-CLINICAL (2020)

Review Neurosciences

Machine Learning in Amyotrophic Lateral Sclerosis: Achievements, Pitfalls, and Future Directions

Vincent Grollemund et al.

FRONTIERS IN NEUROSCIENCE (2019)

Review Clinical Neurology

Tracking a Fast-Moving Disease: Longitudinal Markers, Monitoring, and Clinical Trial Endpoints in ALS

Rangariroyashe Hannah Chipika et al.

FRONTIERS IN NEUROLOGY (2019)

Review Clinical Neurology

Pathological Crying and Laughing in Motor Neuron Disease: Pathobiology, Screening, Intervention

Eoin Finegan et al.

FRONTIERS IN NEUROLOGY (2019)

Review Clinical Neurology

Spinal Cord Imaging in Amyotrophic Lateral Sclerosis: Historical Concepts-Novel Techniques

Mohamed Mounir El Mendili et al.

FRONTIERS IN NEUROLOGY (2019)

Review Clinical Neurology

Post-polio Syndrome: More Than Just a Lower Motor Neuron Disease

Stacey Li Hi Shing et al.

FRONTIERS IN NEUROLOGY (2019)

Article Clinical Neurology

Neural networks associated with body composition in frontotemporal dementia

Rebekah M. Ahmed et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2019)

Article Geriatrics & Gerontology

Gray and white matter changes in presymptomatic genetic frontotemporal dementia: a longitudinal MRI study

Jessica L. Panman et al.

NEUROBIOLOGY OF AGING (2019)

Review Clinical Neurology

Imaging Cerebral Activity in Amyotrophic Lateral Sclerosis

Malcolm Proudfoot et al.

FRONTIERS IN NEUROLOGY (2019)

Editorial Material Clinical Neurology

Revisiting the pathoanatomy of pseudobulbar affect: mechanisms beyond corticobulbar dysfunction

Peter Bede et al.

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2018)

Article Clinical Neurology

Fatigue Is Associated With Global and Regional Thalamic Morphometry in Veterans With a History of Mild Traumatic Brain Injury

Alexandra L. Clark et al.

JOURNAL OF HEAD TRAUMA REHABILITATION (2018)

Article Geriatrics & Gerontology

Patterns of gray matter atrophy in genetic frontotemporal dementia: results from the GENFI study

David M. Cash et al.

NEUROBIOLOGY OF AGING (2018)

Article Clinical Neurology

Brain signature of mild stages of cognitive and behavioral impairment in amyotrophic lateral sclerosis

Lucas M. T. Branco et al.

PSYCHIATRY RESEARCH-NEUROIMAGING (2018)

Article Geriatrics & Gerontology

Atrophy in the Thalamus But Not Cerebellum Is Specific for C9orf72 FTD and ALS Patients - An Atlas-Based Volumetric MRI Study

Sonja Schoenecker et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

Article Neuroimaging

Thalamic atrophy in frontotemporal dementia-Not just a C9orf72 problem

Martina Bocchetta et al.

NEUROIMAGE-CLINICAL (2018)

Article Neuroimaging

Gray matter changes in asymptomatic C9orf72 and GRN mutation carriers

Karteek Popuri et al.

NEUROIMAGE-CLINICAL (2018)

Review Clinical Neurology

Biomarkers of Spinal and Bulbar Muscle Atrophy (SBMA): A Comprehensive Review

Giorgia Querin et al.

FRONTIERS IN NEUROLOGY (2018)

Review Clinical Neurology

Clinical and Radiological Markers of Extra-Motor Deficits in Amyotrophic Lateral Sclerosis

Foteini Christidi et al.

FRONTIERS IN NEUROLOGY (2018)

Article Neurosciences

Differential Impairment of Thalamocortical Structural Connectivity in Amyotrophic Lateral Sclerosis

Jiu-Quan Zhang et al.

CNS NEUROSCIENCE & THERAPEUTICS (2017)

Article Clinical Neurology

Thalamocortical connectivity in major depressive disorder

Elliot C. Brown et al.

JOURNAL OF AFFECTIVE DISORDERS (2017)

Article Geriatrics & Gerontology

Structural and functional brain signatures of C9orf72 in motor neuron disease

Federica Agosta et al.

NEUROBIOLOGY OF AGING (2017)

Article Neurosciences

Functional anatomy of the human thalamus at rest

Vinod Jangir Kumar et al.

NEUROIMAGE (2017)

Article Behavioral Sciences

Prosocial deficits in behavioral variant frontotemporal dementia relate to reward network atrophy

Virginia E. Sturm et al.

BRAIN AND BEHAVIOR (2017)

Article Neuroimaging

Network degeneration and dysfunction in presymptomatic C9ORF72 expansion carriers

Suzee E. Lee et al.

NEUROIMAGE-CLINICAL (2017)

Article Clinical Neurology

Deep clinical and neuropathological phenotyping of Pick disease

David J. Irwin et al.

ANNALS OF NEUROLOGY (2016)

Article Clinical Neurology

Hippocampal Sclerosis but Not Normal Aging or Alzheimer Disease Is Associated With TDP-43 Pathology in the Basal Forebrain of Aged Persons

Matthew D. Cykowski et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2016)

Article Neurosciences

In vitro prion-like behaviour of TDP-43 in ALS

Phillip Smethurst et al.

NEUROBIOLOGY OF DISEASE (2016)

Article Clinical Neurology

Discordant performance on the 'Reading the Mind in the Eyes' Test, based on disease onset in amyotrophic lateral sclerosis

Tom Burke et al.

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2016)

Article Clinical Neurology

Involvement of the caudate nucleus head and its networks in sporadic amyotrophic lateral sclerosis-frontotemporal dementia continuum

Michihito Masuda et al.

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2016)

Article Neuroimaging

Longitudinal imaging in C9orf72 mutation carriers: Relationship to phenotype

Mary Kay Floeter et al.

NEUROIMAGE-CLINICAL (2016)

Article Clinical Neurology

Topography of primitive reflexes in dementia: an F-18 fluorodeoxyglucose positron emission tomography study

J. A. Matias-Guiu et al.

EUROPEAN JOURNAL OF NEUROLOGY (2015)

Article Cell Biology

TDP-43 is intercellularly transmitted across axon terminals

Marisa S. Feiler et al.

JOURNAL OF CELL BIOLOGY (2015)

Article Clinical Neurology

Basal ganglia pathology in ALS is associated with neuropsychological deficits

Judith Machts et al.

NEUROLOGY (2015)

Article Behavioral Sciences

Do I know you? Examining face and object memory in frontotemporal dementia

Fiona Kumfor et al.

NEUROPSYCHOLOGIA (2015)

Review Behavioral Sciences

Limbic circuitry of the midline thalamus

Robert P. Vertes et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2015)

Letter Clinical Neurology

Mind the gap: The mismatch between clinical and imaging metrics in ALS

Esther Verstraete et al.

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2015)

Review Clinical Neurology

Beyond and below the cortex: the contribution of striatal dysfunction to cognition and behaviour in neurodegeneration

Claire O'Callaghan et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2014)

Article Geriatrics & Gerontology

Neural Correlates of Activities of Daily Living in Frontotemporal Dementia

E. Mioshi et al.

JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY (2013)

Article Clinical Neurology

Multiparametric MRI study of ALS stratified for the C9orf72 genotype

Peter Bede et al.

NEUROLOGY (2013)

Article Clinical Neurology

Basal ganglia involvement in amyotrophic lateral sclerosis

Peter Bede et al.

NEUROLOGY (2013)

Article Cell Biology

Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains

Takashi Nonaka et al.

CELL REPORTS (2013)

Review Clinical Neurology

Spinal cord markers in ALS: Diagnostic and biomarker considerations

Peter Bede et al.

AMYOTROPHIC LATERAL SCLEROSIS (2012)

Article Clinical Neurology

The Frontal-Anatomic Specificity of Design Fluency Repetitions and Their Diagnostic Relevance for Behavioral Variant Frontotemporal Dementia

Katherine L. Possin et al.

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY (2012)

Article Clinical Neurology

Longitudinal neuroimaging and neuropsychological profiles of frontotemporal dementia with C9ORF72 expansions

Colin J. Mahoney et al.

ALZHEIMERS RESEARCH & THERAPY (2012)

Article Clinical Neurology

Structural neuroanatomy of tinnitus and hyperacusis in semantic dementia

Colin J. Mahoney et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2011)

Article Geriatrics & Gerontology

Subcortical and deep cortical atrophy in Frontotemporal Lobar Degeneration

Valentina Garibotto et al.

NEUROBIOLOGY OF AGING (2011)

Article Neurosciences

A Bayesian model of shape and appearance for subcortical brain segmentation

Brian Patenaude et al.

NEUROIMAGE (2011)

Article Biophysics

1H MRS of basal ganglia and thalamus in amyotrophic lateral sclerosis

Khema R. Sharma et al.

NMR IN BIOMEDICINE (2011)

Article Geriatrics & Gerontology

Apathy Is Not Associated with Basal Ganglia Atrophy in Frontotemporal Dementia

Kira A. Links et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2009)

Article Geriatrics & Gerontology

Magnetic resonance imaging in frontotemporal dementia shows subcortical atrophy

Tiffany W. Chow et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2008)

Article Neurosciences

Intrinsic functional relations between human cerebral cortex and thalamus

Dongyang Zhang et al.

JOURNAL OF NEUROPHYSIOLOGY (2008)

Article Clinical Neurology

Impaired action knowledge in amyotrophic lateral sclerosis

M. Grossman et al.

NEUROLOGY (2008)

Article Clinical Neurology

Deformation-based morphometry reveals brain atrophy in frontotemporal dementia

Valerie A. Cardenas et al.

ARCHIVES OF NEUROLOGY (2007)

Article Geriatrics & Gerontology

Decline of cerebral glucose metabolism in frontotemporal dementia: a longitudinal 18F-FDG-PET-study

J. Diehl-Schmid et al.

NEUROBIOLOGY OF AGING (2007)

Article Geriatrics & Gerontology

Region-specific decline of cerebral glucose metabolism in patients with frontotemporal dementia: A prospective F-18-FDG-PET study

T Grimmer et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2004)

Review Clinical Neurology

Vascular syndromes of the thalamus

JD Schmahmann

STROKE (2003)