Ultra-Flexible Giant Magnetoresistance Biosensors for Lab-on-a-Needle Biosensing

Flexible biosensors exhibit great potential for the detection of various biomarkers with the ability to adapt to different surface textures. Here, a lab-on-a-needle biosensing platform based on ultra-flexible giant magnetoresistance (GMR) biosensors is developed. The fabricated flexible GMR sensors exhibit a MR ratio of 5.2% and a sensitivity of 0.13%/Oe in the linear region, which are comparable to their rigid counterparts. It is found that the magnetic properties of the flexible GMR sensors remain unchanged after 500 cycles of compressive and tensile stress, indicating strong robustness even when applied to a surface that is constantly in motion. The developed platform is then employed for the detection of different concentrations of canine osteosarcoma (OSCA-8) cells with a limit of detection (LOD) of 200 cells in 20 mu L sample (10(4) cells per mL), which demonstrate the ability to perform real-time, sensitive, and quantitative cell detection.

Automated summary

Flexible biosensors based on ultra-flexible giant magnetoresistance (GMR) biosensors have been developed for the detection of various biomarkers. These sensors exhibit similar performance to their rigid counterparts and have strong robustness even under constant motion. The developed platform has demonstrated the ability to perform real-time, sensitive, and quantitative detection of canine osteosarcoma (OSCA-8) cells with a low limit of detection.