相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading
Yin Xu et al.
MOLECULAR PSYCHIATRY (2021)
TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy
Carolina Alquezar et al.
SCIENCE ADVANCES (2021)
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
Benjamin Caballero et al.
NATURE COMMUNICATIONS (2021)
ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids
Kathryn R. Bowles et al.
CELL (2021)
Genetically engineered MAPT 10+16 mutation causes pathophysiological excitability of human iPSC-derived neurons related to 4R tau-induced dementia
Olga Kopach et al.
CELL DEATH & DISEASE (2021)
Impairment of Lysosome Function and Autophagy in Rare Neurodegenerative Diseases
Frederic Darios et al.
JOURNAL OF MOLECULAR BIOLOGY (2020)
A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease
Nicolas R. Barthelemy et al.
NATURE MEDICINE (2020)
Modeling of Frontotemporal Dementia Using iPSC Technology
Minchul Kim et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy
Israel Hernandez et al.
SCIENCE TRANSLATIONAL MEDICINE (2019)
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models
M. Catarina Silva et al.
ELIFE (2019)
Modeling neuronopathic storage diseases with patient-derived culture systems
Friederike Zunke et al.
NEUROBIOLOGY OF DISEASE (2019)
Progranulin deficiency leads to reduced glucocerebrosidase activity
Xiaolai Zhou et al.
PLOS ONE (2019)
Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis
Peter Dongmin Sohn et al.
NEURON (2019)
A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies
Celeste M. Karch et al.
STEM CELL REPORTS (2019)
Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs
Mari Nakamura et al.
STEM CELL REPORTS (2019)
Reliability of human cortical organoid generation
Se-Jin Yoon et al.
NATURE METHODS (2019)
Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease
Angelique di Domenico et al.
STEM CELL REPORTS (2019)
Degradation of dendritic cargos requires Rab7-dependent transport to somatic lysosomes
Chan Choo Yap et al.
JOURNAL OF CELL BIOLOGY (2018)
Tau Kinetics in Neurons and the Human Central Nervous System
Chihiro Sato et al.
NEURON (2018)
Neuronal endosomes to lysosomes: A journey to the soma
Vineet Vinay Kulkarni et al.
JOURNAL OF CELL BIOLOGY (2018)
TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading
Heidi Martini-Stoica et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2018)
Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP
Shan Jiang et al.
TRANSLATIONAL PSYCHIATRY (2018)
Interplay of pathogenic forms of human tau with different autophagic pathways
Benjamin Caballero et al.
AGING CELL (2018)
Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients
Clarissa Valdez et al.
HUMAN MOLECULAR GENETICS (2017)
Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia
Jinsoo Seo et al.
JOURNAL OF NEUROSCIENCE (2017)
Primary fibroblasts from CSPα mutation carriers recapitulate hallmarks of the adult onset neuronal ceroid lipofuscinosis
Bruno A. Benitez et al.
SCIENTIFIC REPORTS (2017)
Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration
Noemi Esteras et al.
REDOX BIOLOGY (2017)
Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein
Anna-Lena Hallmann et al.
SCIENTIFIC REPORTS (2017)
Mask mitigates MAPT- and FUS-induced degeneration by enhancing autophagy through lysosomal acidification
Mingwei Zhu et al.
AUTOPHAGY (2017)
Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis
Zhenyuan Tang et al.
CELL DEATH AND DIFFERENTIATION (2017)
DQ-Red BSA Trafficking Assay in Cultured Cells to Assess Cargo Delivery to Lysosomes
Rituraj Marwaha et al.
BIO-PROTOCOL (2017)
Tau in physiology and pathology
Yipeng Wang et al.
NATURE REVIEWS NEUROSCIENCE (2016)
Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease
Daniel J. Colacurcio et al.
AGEING RESEARCH REVIEWS (2016)
Lysosomes relax in the cellular suburbs
Swetha Gowrishankar et al.
JOURNAL OF CELL BIOLOGY (2016)
MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations
Md Helal U. Biswas et al.
STEM CELL REPORTS (2016)
Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability
M. Catarina Silva et al.
STEM CELL REPORTS (2016)
Autophagic and lysosomal defects in human tauopathies: analysis of postmortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy
Antonio Piras et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2016)
Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons
Keiko Imamura et al.
SCIENTIFIC REPORTS (2016)
TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits
Hongjie Wang et al.
ENEURO (2016)
Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations
Mariangela Iovino et al.
BRAIN (2015)
Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10+16 splice-site mutation in MAPT
Teresa Sposito et al.
HUMAN MOLECULAR GENETICS (2015)
Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells
Melissa C. Wren et al.
MOLECULAR NEURODEGENERATION (2015)
Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture
Anca M. Pasca et al.
NATURE METHODS (2015)
Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein
Marc Ehrlich et al.
STEM CELL REPORTS (2015)
Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
Vinicia A. Polito et al.
EMBO MOLECULAR MEDICINE (2014)
Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells (vol 127, pg 4089, 2014)
Chieko Kishi-Itakura et al.
JOURNAL OF CELL SCIENCE (2014)
Proteostasis and the Aging Proteome in Health and Disease
Richard I. Morimoto et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)
The role of autophagy in neurodegenerative disease
Ralph A. Nixon
NATURE MEDICINE (2013)
Christianson Syndrome Protein NHE6 Modulates TrkB Endosomal Signaling Required for Neuronal Circuit Development
Qing Ouyang et al.
NEURON (2013)
Tau degradation: The ubiquitin-proteasome system versus the autophagy-lysosome system
Min Jae Lee et al.
PROGRESS IN NEUROBIOLOGY (2013)
Genetic Correction of Tauopathy Phenotypes in Neurons Derived from Human Induced Pluripotent Stem Cells
Helen Fong et al.
STEM CELL REPORTS (2013)
Degradation of tau protein by autophagy and proteasomal pathways
Yipeng Wang et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2012)
Lysosomal storage disorders: The cellular impact of lysosomal dysfunction
Frances M. Platt et al.
JOURNAL OF CELL BIOLOGY (2012)
Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets
Anoop Kumar G. Velikkakath et al.
MOLECULAR BIOLOGY OF THE CELL (2012)
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells
Mason A. Israel et al.
NATURE (2012)
Fiji: an open-source platform for biological-image analysis
Johannes Schindelin et al.
NATURE METHODS (2012)
LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress
Ha Nam Nguyen et al.
CELL STEM CELL (2011)
Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance
Diego L. Medina et al.
DEVELOPMENTAL CELL (2011)
Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways
Michela Palmieri et al.
HUMAN MOLECULAR GENETICS (2011)
TFEB Links Autophagy to Lysosomal Biogenesis
Carmine Settembre et al.
SCIENCE (2011)
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD
Emilie Tresse et al.
AUTOPHAGY (2010)
Human Stem Cell-Derived Neurons: A System to Study Human Tau Function and Dysfunction
Mariangela Iovino et al.
PLOS ONE (2010)
Lysosomal Modulatory Drugs for a Broad Strategy Against Protein Accumulation Disorders
Ben A. Bahr
CURRENT ALZHEIMER RESEARCH (2009)
ToppGene Suite for gene list enrichment analysis and candidate gene prioritization
Jing Chen et al.
NUCLEIC ACIDS RESEARCH (2009)
Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy
Kazuhiro Ohmi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
A Gene Network Regulating Lysosomal Biogenesis and Function
Marco Sardiello et al.
SCIENCE (2009)
Tau as a biomarker of neuro degenerative diseases
Susanna Schraen-Maschke et al.
BIOMARKERS IN MEDICINE (2008)
Alzheimer disease-like clinical phenotype in a family with FTDP-17 caused by a MAPT R406W mutation
S. G. Lindquist et al.
EUROPEAN JOURNAL OF NEUROLOGY (2008)
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
John T. Dimos et al.
SCIENCE (2008)
Hereditary frontotemporal dementia caused by Tau gene mutations
John van Swieten et al.
BRAIN PATHOLOGY (2007)
Identification of the minimal lysosomal enzyme recognition domain in cathepsin D
R Steet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Mutations causing neurodegenerative tauopathies
M Goedert et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2005)
Mutant (R406W) human tau is hyperphosphorylated and does not efficiently bind microtubules in a neuronal cortical cell model
PK Krishnamurthy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Adeno-associated virus 2-mediated gene therapy decreases autofluorescent storage material and increases brain mass in a murine model of infantile neuronal ceroid lipofuscinosis
M Griffey et al.
NEUROBIOLOGY OF DISEASE (2004)
Rab7: A key to lysosome biogenesis
C Bucci et al.
MOLECULAR BIOLOGY OF THE CELL (2000)