期刊
TRANSLATIONAL PSYCHIATRY
卷 12, 期 1, 页码 -出版社
SPRINGERNATURE
DOI: 10.1038/s41398-022-02248-7
关键词
-
类别
资金
- Swedish Research Council [2018-05973, 2017-00641]
- Medical Research (ZonMW): Netherlands Twin Registry Repository [NWO 480-15-001/674]
- Biobank-based integrative omics study (BIOS) - BBMRI-NL (NWO) [184.021.007, 184.033.111]
- European Science Council (ERC) Genetics of Mental Illness (ERC Advanced) [230374]
- Royal Netherlands Academy of Science Professor Award [PAH/6635]
- Rutgers University Cell and DNA Repository [NIMH U24 MH068457-06]
- Avera Institute, Sioux Falls, South Dakota (USA)
- National Institutes of Health (NIH ) [R01 HD042157-01A1]
- Genetic Association Information Network (GAIN) of the Foundation for the National Institutes of Health and Grand Opportunity grants [1RC2 MH089951]
- Wellcome Trust
- Medical Research Council
- Versus Arthritis
- European Union Horizon 2020
- Chronic Disease Research Foundation (CDRF)
- Zoe Ltd.
- National Institute for Health and Care Research (NIHR) Clinical Research Network (CRN)
- Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust in partnership with King's College London
- Canadian Institutes of Health Research [MOP-93696, MOP-106573]
- Alberta Innovates Translational Health Chair in Child and Youth Mental Health
- Open Access Publication Fund of Humboldt-Universitat zu Berlin
- Netherlands Organisations for Scientific Research (NWO)
This study reveals the heritability of hoarding symptoms and identifies genetic associations with schizophrenia, autism spectrum disorder, and educational attainment. However, no significant loci were detected in the genome-wide analysis.
Hoarding Disorder (HD) is a mental disorder characterized by persistent difficulties discarding or parting with possessions, often resulting in cluttered living spaces, distress, and impairment. Its etiology is largely unknown, but twin studies suggest that it is moderately heritable. In this study, we pooled phenotypic and genomic data from seven international cohorts (N = 27,537 individuals) and conducted a genome wide association study (GWAS) meta-analysis of parent- or self-reported hoarding symptoms (HS). We followed up the results with gene-based and gene-set analyses, as well as leave-one-out HS polygenic risk score (PRS) analyses. To examine a possible genetic association between hoarding symptoms and other phenotypes we conducted cross-trait PRS analyses. Though we did not report any genome-wide significant SNPs, we report heritability estimates for the twin-cohorts between 26-48%, and a SNP-heritability of 11% for an unrelated sub-cohort. Cross-trait PRS analyses showed that the genetic risk for schizophrenia and autism spectrum disorder were significantly associated with hoarding symptoms. We also found suggestive evidence for an association with educational attainment. There were no significant associations with other phenotypes previously linked to HD, such as obsessive-compulsive disorder, depression, anxiety, or attention-deficit hyperactivity disorder. To conclude, we found that HS are heritable, confirming and extending previous twin studies but we had limited power to detect any genome-wide significant loci. Much larger samples will be needed to further extend these findings and reach a gene discovery zone. To move the field forward, future research should not only include genetic analyses of quantitative hoarding traits in larger samples, but also in samples of individuals meeting strict diagnostic criteria for HD, and more ethnically diverse samples.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据