4.5 Article

Widening the Spectrum of Risk Factors, Comorbidities, and Prodromal Features of Parkinson Disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Public, Environmental & Occupational Health

Identification of Prodromal Presentations of Parkinson's Disease among Primary Care Outpatients in Germany

Jens Bohlken et al.

Summary: This study identified clinical features that appear before the diagnosis of Parkinson's disease, including increased motor, neuropsychiatric, and autonomic symptoms. In the period before diagnosis, depression, dizziness, insomnia, and constipation were the most common clinical presentations.

NEUROEPIDEMIOLOGY (2022)

Review Neurosciences

Self-Reported Visual Complaints in People with Parkinson's Disease: A Systematic Review

Iris van der Lijn et al.

Summary: This review provides an overview of the nature and prevalence of self-reported visual complaints in people with Parkinson's disease (PD). Visual complaints range from function-related to activity-related and are more prevalent in people with PD compared to healthy controls. These complaints negatively affect the quality of life of PD patients.

JOURNAL OF PARKINSONS DISEASE (2022)

Article Gastroenterology & Hepatology

Risk of Neurodegenerative Diseases in Patients with Inflammatory Bowel Disease: A Nationwide Population-based Cohort Study

Ga Hee Kim et al.

Summary: The study found that patients with inflammatory bowel disease (IBD) have a higher risk of neurodegenerative diseases compared to the non-IBD population. IBD patients aged 40-65 had a higher risk of Parkinson's disease, while patients aged 65 and above had an increased risk of Alzheimer's disease.

JOURNAL OF CROHNS & COLITIS (2022)

Article Clinical Neurology

Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population

Cristina Simonet et al.

Summary: This study investigates the association between risk factors and prediagnostic presentations of Parkinson disease (PD) in an ethnically diverse population with high socioeconomic deprivation but universal access to health care. The findings suggest that several comorbidities and symptoms are encountered in primary care settings before PD diagnosis, including tremor, memory symptoms, hypertension, type 2 diabetes, hypotension, constipation, depression, epilepsy, and hearing loss. These associations provide valuable insights into the early features and diagnosis of PD.

JAMA NEUROLOGY (2022)

Article Neurosciences

Genome-wide Association Analysis of Parkinson's Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci

Olav B. Smeland et al.

Summary: The study reveals genetic overlap between PD and SCZ, identifying novel risk loci and shared genomic loci. These findings suggest common molecular mechanisms contributing to overlap in pathophysiological and clinical features between the disorders.

BIOLOGICAL PSYCHIATRY (2021)

Editorial Material Clinical Neurology

Does Restless Legs Syndrome Have a Different Pathomechanism in Premotor and Motor Parkinson's Disease?

Stefano Calzetti et al.

JOURNAL OF MOVEMENT DISORDERS (2021)

Article Clinical Neurology

Parkinson's disease outside the brain: targeting the autonomic nervous system

Yehonatan Sharabi et al.

Summary: Patients with Parkinson's disease may exhibit signs of dysregulation of the peripheral autonomic nervous system, which could serve as early biomarkers for the disease. Dysfunction of the autonomic nervous system may play a role in the spread of Parkinson's disease pathology, emphasizing the importance of developing early diagnostic tests and strategies to prevent neurodegeneration.

LANCET NEUROLOGY (2021)

Article Clinical Neurology

Long-term Risk of Parkinson Disease Following Influenza and Other Infections

Noelle M. Cocoros et al.

Summary: This study found that influenza was associated with Parkinson disease diagnoses more than 10 years after infection, while other infections had weaker associations with Parkinson disease more than 10 years after infection. These results suggest a link between influenza and Parkinson disease, but do not prove causality. The shorter-term associations of other infections with Parkinson disease may not be causal.

JAMA NEUROLOGY (2021)

Article Neurosciences

Diagnostic value of skin RT-QuIC in Parkinson's disease: a two-laboratory study

Anastasia Kuzkina et al.

Summary: The α-synuclein RT-QuIC assay from minimally invasive skin punch biopsy is a reliable and reproducible biomarker for Parkinson's disease, showing high diagnostic accuracy and inter-rater agreement. The seeding activity correlates with disease progression and certain non-motor symptoms.

NPJ PARKINSONS DISEASE (2021)

Article Clinical Neurology

Consistent skin α-synuclein positivity in REM sleep behavior disorder-A two center two-to-four-year follow-up study

K. Doppler et al.

Summary: The presence of dermal p-syn in iRBD patients may serve as an early marker of synucleinopathy and could support indicators for transitioning into a manifest disease state. Follow-up data showed that some skin biopsy-positive patients converted to PD or dementia with Lewy bodies, highlighting the potential predictive value of skin biopsy findings in iRBD patients.

PARKINSONISM & RELATED DISORDERS (2021)

Article Neurosciences

Improving estimation of Parkinson's disease risk-the enhanced PREDICT-PD algorithm

Jonathan P. Bestwick et al.

Summary: The study developed an enhanced algorithm incorporating intermediate markers into the risk model, resulting in a much wider and more accurate range of risk estimates for PD. The enhanced algorithm also showed a closer correlation with subclinical dopamine depletion in the striatum.

NPJ PARKINSONS DISEASE (2021)

Article Neurosciences

Unhealthy Behaviours and Risk of Parkinson's Disease: A Mendelian Randomisation Study

Karl Heilbron et al.

Summary: The study utilized Mendelian randomization and found that smoking may reduce the risk of Parkinson's disease, while alcohol intake and higher BMI may increase the risk.

JOURNAL OF PARKINSONS DISEASE (2021)

Article Behavioral Sciences

Association between diabetes mellitus and risk of Parkinson's disease: A prisma-compliant meta-analysis

Wei Liu et al.

Summary: The meta-analysis suggested that diabetes mellitus is associated with an increased risk of Parkinson's disease, especially in cohort studies. Further large-scale prospective studies are needed to evaluate the relationship between diabetes mellitus and Parkinson's disease.

BRAIN AND BEHAVIOR (2021)

Article Neurosciences

Shared Genetic Background between Parkinson's Disease and Schizophrenia: A Two-Sample Mendelian Randomization Study

Kiwon Kim et al.

Summary: The study found that an increased genetic risk of PD may be associated with an increased risk of schizophrenia, supporting the intrinsic nature of psychotic symptoms in PD. Future research will explore possible comorbidities and shared genetic structure between the two diseases.

BRAIN SCIENCES (2021)

Review Clinical Neurology

Risk of Developing Parkinson Disease in Bipolar Disorder A Systematic Review and Meta-analysis

Patricia R. Faustino et al.

JAMA NEUROLOGY (2020)

Review Clinical Neurology

beta-adrenoreceptors and the risk of Parkinson's disease

Franziska Hopfner et al.

LANCET NEUROLOGY (2020)

Article Clinical Neurology

Prodromal Parkinson disease in patients with idiopathic hyposmia

Paula Marrero-Gonzalez et al.

JOURNAL OF NEUROLOGY (2020)

Article Geriatrics & Gerontology

Single Nucleotide Polymorphisms Associated With Gut Homeostasis Influence Risk and Age-at-Onset of Parkinson's Disease

Anastazja M. Gorecki et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

Article Medicine, General & Internal

Lipid Metabolism is the common pathologic mechanism between Type 2 Diabetes Mellitus and Parkinson's disease

Xi Zhang et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2020)

Article Gastroenterology & Hepatology

Inflammatory Bowel Disease and Parkinson's Disease: A Nationwide Swedish Cohort Study

Petra Weimers et al.

INFLAMMATORY BOWEL DISEASES (2019)

Article Chemistry, Multidisciplinary

Discovery of Volatile Biomarkers of Parkinson's Disease from Sebum

Drupad K. Trivedi et al.

ACS CENTRAL SCIENCE (2019)

Article Clinical Neurology

Evolution of prodromal Parkinson's disease and dementia with Lewy bodies: a prospective study

Seyed-Mohammad Fereshtehnejad et al.

Article Clinical Neurology

Bipolar disorder and risk of Parkinson disease A nationwide longitudinal study

Mao-Hsuan Huang et al.

NEUROLOGY (2019)

Article Clinical Neurology

Association between diabetes and subsequent Parkinson disease A record-linkage cohort study

Eduardo De Pablo-Fernandez et al.

NEUROLOGY (2018)

Article Clinical Neurology

The association between restless legs syndrome and premotor symptoms of Parkinson's disease

Hirotaka Iwaki et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2018)

Review Clinical Neurology

Cognitive Changes in Prodromal Parkinson's Disease: A Review

Sophie Fengler et al.

MOVEMENT DISORDERS (2017)

Review Clinical Neurology

Sleep-wake disturbances in the premotor and early stage of Parkinson's disease

Panagiotis Bargiotas et al.

CURRENT OPINION IN NEUROLOGY (2016)

Article Clinical Neurology

Untitled

HEADACHE (2016)

Article Neurosciences

Untitled

JOURNAL OF NEUROSCIENCE RESEARCH (2016)

Review Dermatology

Bullous pemphigoid and its association with neurological diseases: a systematic review and meta-analysis

Y. C. Lai et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2016)

Article Clinical Neurology

Untitled

ANNALS OF NEUROLOGY (2016)

Article Clinical Neurology

Untitled

MOVEMENT DISORDERS (2016)

Article Clinical Neurology

Untitled

MOVEMENT DISORDERS (2016)

Article Public, Environmental & Occupational Health

Hearing Loss is Associated With Risk of Alzheimer's Disease: A Case-Control Study in Older People

Shih-Chang Hung et al.

JOURNAL OF EPIDEMIOLOGY (2015)

Article Clinical Neurology

Prediagnostic presentations of Parkinson's disease in primary care: a case-control study

Anette Schrag et al.

LANCET NEUROLOGY (2015)

Review Clinical Neurology

MDS research criteria for prodromal Parkinson's disease

Daniela Berg et al.

MOVEMENT DISORDERS (2015)

Article Clinical Neurology

The association between infectious burden and Parkinson's disease: A case-control study

Xian-Le Bu et al.

PARKINSONISM & RELATED DISORDERS (2015)

Article Nutrition & Dietetics

Cardiovascular risk factors and the risk of Parkinson's disease

M. Vikdahl et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2015)

Article Clinical Neurology

Hearing loss may be a non-motor feature of Parkinson's disease in older people in Taiwan

S. -W. Lai et al.

EUROPEAN JOURNAL OF NEUROLOGY (2014)

Article Clinical Neurology

Imaging prodromal Parkinson disease The Parkinson Associated Risk Syndrome Study

Danna Jennings et al.

NEUROLOGY (2014)

Article Clinical Neurology

Dietary fat intake, pesticide use, and Parkinson's disease

Freya Kamel et al.

PARKINSONISM & RELATED DISORDERS (2014)

Article Clinical Neurology

Hypothesis: A role for EBV-induced molecular mimicry in Parkinson's disease

John M. Woulfe et al.

PARKINSONISM & RELATED DISORDERS (2014)

Article Clinical Neurology

Time trends in incidence of Parkinson's disease diagnosis in UK primary care

Laura Horsfall et al.

JOURNAL OF NEUROLOGY (2013)

Article Clinical Neurology

Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome study

Andrew Siderowf et al.

MOVEMENT DISORDERS (2012)

Article Clinical Neurology

Olfactory testing combined with dopamine transporter imaging as a method to detect prodromal Parkinson's disease

Mirthe M. Ponsen et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2010)

Article Clinical Neurology

Case-control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan

Yoshihiro Miyake et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2010)

Article Clinical Neurology

Dietary fats, cholesterol and iron as risk factors for Parkinson's disease

Karen M. Powers et al.

PARKINSONISM & RELATED DISORDERS (2009)

Article Clinical Neurology

Olfaction in neurodegenerative disorder

C Hawkes

MOVEMENT DISORDERS (2003)