期刊
FRONTIERS IN PLANT SCIENCE
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fpls.2022.1049015
关键词
endophytic fungus; Phomopsis; secondary metabolites; antibacterial activity; cytotoxic activity
资金
- National Natural Science Foundation of China [82173711]
- Youth Innovation Promotion Association of CAS [2020342]
- Natural Science Foundation of Guangdong Province [2019A1515011694]
- Natural Science Foundation of Hunan Province [2021JJ30917]
- High-tech Industry Science and Technology Innovation Project of Hunan Province [2020GK4083]
- Postgraduate Research and Innovation Project of Hunan Province [CX20210341]
- Postgraduates Innovation Program of Central South University [2021zzts0978, 2021zzts0994, 2022zzts0899]
- Open Sharing Fund for the Large-Scale Instruments and Equipment of Central South University
Two previously undescribed lactones and three new sesquiterpenoids were isolated from the fungus Phomopsis sp. SZSJ-7B. Their chemical structures were determined by various analytical techniques, and one of the lactones showed significant antibacterial activity against methicillin-resistant Staphylococcus aureus.
Two previously undescribed lactones, phomolides A and B (1 and 2), and three new sesquiterpenoids, phomenes A-C (3-5), together with one known compound, colletotricholide A (6), were isolated from the endophytic fungus Phomopsis sp. SZSJ-7B. Their chemical structures, including the absolute configurations, were comprehensively established by extensive analyses of NMR, high-resolution electrospray ionization mass spectrometry, electronic circular dichroism powered by theoretical calculations, and X-ray diffractions. Moreover, the cytotoxic and antibacterial activities of compounds 1-6 were also evaluated, and the results demonstrated that compound 2 showed significant antibacterial effects towards methicillin-resistant Staphylococcus aureus and S. aureus strains with minimum inhibitory concentration as low as 6.25 mu g/ml, which was comparable to that of the clinical drug vancomycin. Moreover, all compounds showed no cytotoxic activity.
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