4.7 Review

Genetically engineered crops for sustainably enhanced food production systems

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CRISPR/Cas9 gene editing and natural variation analysis demonstrate the potential for HvARE1 in improvement of nitrogen use efficiency in barley

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Potentials, prospects and applications of genome editing technologies in livestock production

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The EU's GM crop conundrum Did the EU policy strategy to convert EFSA GMO guidance into legislation deliver on its promises?

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CRISPR-Cas9 based stress tolerance: New hope for abiotic stress tolerance in chickpea (Cicer arietinum)

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The genetic editing of GS3 via CRISPR/Cas9 accelerates the breeding of three-line hybrid rice with superior yield and grain quality

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Applications of CRISPR/Cas9 as New Strategies for Short Breeding to Drought Gene in Rice

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Summary: Recent unpredictable climate change has caused a decline in rice yield, particularly due to drought stress in rainfed agriculture areas like Asia and South America. CRISPR/Cas9 offers an effective solution for gene function study and molecular breeding through targeted genome editing. It is a faster and more efficient method compared to traditional breeding. By editing the drought-induced gene OsSAP in rice, researchers found that OsSAP plays a positive role in drought stress response. The study also showed that CRISPR/Cas9 can be a valuable tool for generating specific and inheritable targeted genome editing in rice, with shorter breeding cycles.

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Genome Editing: A Promising Approach for Achieving Abiotic Stress Tolerance in Plants

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Summary: The susceptibility of crop plants towards abiotic stresses poses a significant threat to global food security. Traditional methods such as plant breeding and genetic engineering have limitations in enhancing stress resilience due to the complex inheritance of adaptive traits. Genome editing has emerged as a promising approach to address this challenge by improving stress tolerance in crops with high precision.

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Myths and Realities about Genetically Modified Food: A Risk-Benefit Analysis

Angelo Vega Rodriguez et al.

Summary: The development and consumption of genetically modified (GM) crops are controversial, but scientific evidence has shown no harm from their use and instead reported multiple benefits. Further research is needed to address concerns about long-term implications of GM crops. Legislation and policies regarding labeling standards for GM products are being discussed.

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Genetic modifications associated with sustainability aspects for sustainable developments

Pooja Sharma et al.

Summary: Genetic engineering technology has significant applications in agriculture, such as increasing yields, reducing costs, and minimizing the ecological footprint. It plays a crucial role in sustainable development. However, issues related to regulation and environmental impact should be addressed.

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Genetically modified foods: bibliometric analysis on consumer perception and preference

R. Sendhil et al.

Summary: This study presents bibliometric trends on consumer perception and preference for genetically modified (GM) foods and suggests policy prescriptions for enabling consumption. The study finds that consumers' response is influenced by government decisions, clear articulation of potential benefits, price discounts, and positive influence from the media. Europe and the USA are leading regions and countries in terms of research outputs.

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Biotechnology in China - regulation, investment, and delayed commercialization

Zhihua Xiao et al.

Summary: China has heavily invested in biotechnology for increasing agricultural productivity, but the commercialization of genetically modified (GM) crops has been slow. The regulatory regime for GMOs in China is not as well understood as those in the US or the EU. This paper provides an overview of China's regulatory regime, R&D investment, and delayed commercialization decisions on biotechnology over the past 40 years, and draws conclusions on the likelihood of future commercialization of major GM crops.

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The state of the 'GMO' debate - toward an increasingly favorable and less polarized media conversation on ag-biotech?

Sarah Evanega et al.

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Development and Application of CRISPR-Cas Based Tools

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Transgene Flow: Challenges to the On-Farm Conservation of Maize Landraces in the Brazilian Semi-Arid Region

Gabriel Bianconi Fernandes et al.

Summary: Brazil is a major producer of genetically modified crops, but faces challenges in managing transgene flow. A monitoring process in the Brazilian Semi-arid Region revealed the presence of genetically modified proteins in a proportion of maize landrace samples. The current biosafety standards in Brazil do not adequately protect local maize genetic resources, highlighting the need for more effective coexistence rules.

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CRISPR/Cas9 Mediated Knockout of the OsbHLH024 Transcription Factor Improves Salt Stress Resistance in Rice (Oryza sativa L.)

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Labeling of Genetically Modified (GM) Foods in Peru: Current Dogma and Insights of the Regulatory and Legal Statutes

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Genetically engineered crops for sustainably enhanced food production systems

Mughair Abdul Aziz et al.

Summary: Genetic modification of crops has focused on improving desirable traits, resulting in enhanced yields, quality, and stress tolerance. Despite the potential for sustainable food production, the widespread adoption of genetically modified (GM) crops faces challenges related to the environment, human health, and moral concerns. Scientific investigations are crucial in addressing these concerns. This review discusses the deployment of GM crops and their effects on sustainable food production systems, providing strategies to overcome the barriers. It also highlights the role of genome editing, particularly the CRISPR/Cas9 platform, in achieving sustainable development goals by 2030.

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Agricultural intensification leads to higher nitrate levels in Lake Ontario tributaries

F. S. Liu et al.

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Enabling Genome Editing for Enhanced Agricultural Sustainability

Felicity Keiper et al.

Summary: Agricultural sustainability involves environmental, social, and economic aspects that are influenced by changing environmental pressures and societal expectations. Utilizing innovation and adopting best practices and technologies are necessary for addressing these challenges. Advances in biotechnology and genome editing in plant breeding and research are expected to contribute to agricultural sustainability. However, the adoption of these technologies requires the support of appropriate policies and regulations.

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Genome Editing for Sustainable Agriculture in Africa

Leena Tripathi et al.

Summary: Sustainable intensification of agriculture in Africa is crucial for food and nutritional security and addressing climate change concerns. More efficient approaches to food production, including genome editing, are needed to close the yield gap in staple crops and meet the growing demand for food. CRISPR/Cas-based genome editing is a promising tool for developing improved crop varieties in Africa. Creating a science-based regulatory environment is necessary for the release and adoption of genome-edited products.

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Yuichi Tsuboi et al.

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Contributions of Genome Editing Technologies Towards Improved Nutrition, Environmental Sustainability and Poverty Reduction

Stuart J. Smyth

Summary: This article discusses the potential of genome editing technologies in achieving sustainable development goals such as poverty eradication, improved food security, and increased human health.

FRONTIERS IN GENOME EDITING (2022)

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Crop Quality Improvement Through Genome Editing Strategy

Yihao Yang et al.

Summary: The quality improvement of crops has always been a major concern for breeders and consumers. However, due to the complex nature of crop quality, which is influenced by both genetic systems and environmental factors, traditional breeding strategies have proven to be ineffective. The CRISPR/Cas9 genome editing system has brought about a revolutionary change in crop quality improvement by enabling efficient targeted modifications. This review provides an overview of the various genome editing capabilities of the CRISPR/Cas9 system and highlights the advances in improving crop quality using this system.

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Mil Thi Tran et al.

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From Sequencing to Genome Editing for Cotton Improvement

Renhai Peng et al.

Summary: Traditional breeding techniques are reliable, but genome sequencing offers new data and potential gene targets for improving cotton sustainability. CRISPR/Cas9 technology serves as a powerful tool for precision cotton breeding, yet genome sequencing and editing also come with their own set of challenges.

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Yves Carriere et al.

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Modification of starch composition, structure and properties through editing of TaSBEIIa in both winter and spring wheat varieties by CRISPR/Cas9

Jingying Li et al.

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Farmers' attitudes towards GM crops and their predictors

Muhammad Adzran Che Mustapa et al.

Summary: Farmers in Malaysia show a positive attitude towards GM crops, while recognizing moderate risks and costs, and low government support. The study identifies government support, perceived costs, perceived risks, perceived benefits, and perceived self-efficacy as direct predictors of farmers' attitudes towards GM crops.

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Wheat with greatly reduced accumulation of free asparagine in the grain, produced by CRISPR/Cas9 editing of asparagine synthetase gene TaASN2

Sarah Raffan et al.

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Mutations introduced in susceptibility genes through CRISPR/Cas9 genome editing confer increased late blight resistance in potatoes

Nam Phuong Kieu et al.

Summary: The use of pathogen-resistant cultivars is expected to increase yield and decrease fungicide use in agriculture. However, in potato breeding, increased resistance obtained via resistance genes (R-genes) is hampered because R-gene(s) are often specific for a pathogen race and can be quickly overcome by the evolution of the pathogen.

SCIENTIFIC REPORTS (2021)

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Global Regulation of Genetically Modified Crops Amid the Gene Edited Crop Boom - A Review

Crystal Turnbull et al.

Summary: Products derived from agricultural biotechnology are rapidly becoming one of the largest agricultural trade commodities globally. With the commercialization and legislative development of gene edited crops, the landscape of agricultural biotechnology products is undergoing significant shifts.

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A separation-of-function ZIP4 wheat mutant allows crossover between related chromosomes and is meiotically stable

Azahara C. Martin et al.

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CRISPR-Cas9 mediated mutation in GRAIN WIDTH and WEIGHT2 (GW2) locus improves aleurone layer and grain nutritional quality in rice

V. Mohan Murali Achary et al.

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Amy Wen et al.

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Mutation of GmAITR Genes by CRISPR/Cas9 Genome Editing Results in Enhanced Salinity Stress Tolerance in Soybean

Tianya Wang et al.

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Concurrent Disruption of Genetic Interference and Increase of Genetic Recombination Frequency in Hybrid Rice Using CRISPR/Cas9

Chaolei Liu et al.

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Siyu Chen et al.

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Tadesse Fikre Teferra

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Jun Li et al.

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Summary: Food production has made various advancements in developing countries globally, including India. The introduction of the green revolution in India reduced rural poverty, but did not improve health outcomes. While some interventions of the green revolution were successful, they also had negative impacts, highlighting the need for a review of these interventions.

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NATURE BIOTECHNOLOGY (2018)

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PLANT BIOTECHNOLOGY JOURNAL (2018)

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CRISPR/Cas9-mediated genome editing of the fatty acid desaturase 2 gene in Brassica napus

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PLANT PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Mutations in a subfamily of abscisic acid receptor genes promote rice growth and productivity

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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SUSTAINABILITY SCIENCE (2018)

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Lycopene Is Enriched in Tomato Fruit by CRISPR/Cas9-Mediated Multiplex Genome Editing

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FRONTIERS IN PLANT SCIENCE (2018)

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CRISPR for Crop Improvement: An Update Review

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FRONTIERS IN PLANT SCIENCE (2018)

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GM CROPS & FOOD-BIOTECHNOLOGY IN AGRICULTURE AND THE FOOD CHAIN (2018)

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Identifying a large number of high-yield genes in rice by pedigree analysis, whole-genome sequencing, and CRISPR-Cas9 gene knockout

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Plant Sciences

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CRITICAL REVIEWS IN PLANT SCIENCES (2018)

Article Plant Sciences

Generation of self-compatible diploid potato by knockout of S-RNase

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NATURE PLANTS (2018)

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OsMATL mutation induces haploid seed formation in indica rice

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NATURE PLANTS (2018)

Review Biotechnology & Applied Microbiology

Genetically Modified Labeling Policies: Moving Forward or Backward?

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FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2018)

Article Agriculture, Multidisciplinary

Reduced Drought Tolerance by CRISPR/Cas9-Mediated SlMAPK3 Mutagenesis in Tomato Plants

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2017)

Letter Biochemistry & Molecular Biology

High-efficiency breeding of early-maturing rice cultivars via CRISPR/Cas9-mediated genome editing

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JOURNAL OF GENETICS AND GENOMICS (2017)

Letter Biochemistry & Molecular Biology

Generation of thermosensitive male-sterile maize by targeted knockout of the ZmTMS5 gene

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JOURNAL OF GENETICS AND GENOMICS (2017)

Article Biochemistry & Molecular Biology

Suppression or knockout of SaF/SaM overcomes the Sa-mediated hybrid male sterility in rice

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JOURNAL OF INTEGRATIVE PLANT BIOLOGY (2017)

Letter Biochemistry & Molecular Biology

Multiplex Gene Editing in Rice Using the CRISPR-Cpf1 System

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MOLECULAR PLANT (2017)

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Significant enhancement of fatty acid composition in seeds of the allohexaploid, Camelina sativa, using CRISPR/Cas9 gene editing

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PLANT BIOTECHNOLOGY JOURNAL (2017)

Article Biochemistry & Molecular Biology

A Multipurpose Toolkit to Enable Advanced Genome Engineering in Plants

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PLANT CELL (2017)

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Genomic structural variation-mediated allelic suppression causes hybrid male sterility in rice

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NATURE COMMUNICATIONS (2017)

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Matthew Cobb

PLOS BIOLOGY (2017)

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3 BIOTECH (2017)

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GM CROPS & FOOD-BIOTECHNOLOGY IN AGRICULTURE AND THE FOOD CHAIN (2017)

Article Biotechnology & Applied Microbiology

The impact of Genetically Modified (GM) crops in modern agriculture: A review

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GM Crops & Food-Biotechnology in Agriculture and the Food Chain (2017)

Article Multidisciplinary Sciences

Rapid generation of a transgene-free powdery mildew resistant tomato by genome deletion

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SCIENTIFIC REPORTS (2017)

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Efficient increase of γ-aminobutyric acid (GABA) content in tomato fruits by targeted mutagenesis

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SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

Environmental stress is the major cause of transcriptomic and proteomic changes in GM and non-GM plants

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SCIENTIFIC REPORTS (2017)

Review Microbiology

Diversity, classification and evolution of CRISPR-Cas systems

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CURRENT OPINION IN MICROBIOLOGY (2017)

Review Biochemistry & Molecular Biology

Precision genome editing in the CRISPR era

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BIOCHEMISTRY AND CELL BIOLOGY (2017)

Review Biotechnology & Applied Microbiology

Genetically modified crops and small-scale farmers: main opportunities and challenges

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CRITICAL REVIEWS IN BIOTECHNOLOGY (2016)

Article Cell Biology

Turning rice meiosis into mitosis

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CELL RESEARCH (2016)

Letter Biochemistry & Molecular Biology

Development of japonica Photo-Sensitive Genic Male Sterile Rice Lines by Editing Carbon Starved Anther Using CRISPR/Cas9

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JOURNAL OF GENETICS AND GENOMICS (2016)

Letter Biochemistry & Molecular Biology

Rapid improvement of grain weight via highly efficient CRISPR/Cas9-mediated multiplex genome editing in rice

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JOURNAL OF GENETICS AND GENOMICS (2016)

Article Plant Sciences

Development of broad virus resistance in non-transgenic cucumber using CRISPR/Cas9 technology

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MOLECULAR PLANT PATHOLOGY (2016)

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Gene-edited CRISPR mushroom escapes US regulation

Emily Waltz

NATURE (2016)

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CRISPR-edited crops free to enter market, skip regulation

Emily Waltz

NATURE BIOTECHNOLOGY (2016)

Article Biotechnology & Applied Microbiology

The OsmiR396c-OsGRF4-OsGIF1 regulatory module determines grain size and yield in rice

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PLANT BIOTECHNOLOGY JOURNAL (2016)

Article Plant Sciences

CRISPR/Cas9: A Tool to Circumscribe Cotton Leaf Curl Disease

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FRONTIERS IN PLANT SCIENCE (2016)

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GM CROPS & FOOD-BIOTECHNOLOGY IN AGRICULTURE AND THE FOOD CHAIN (2016)

Article Biotechnology & Applied Microbiology

Creation of fragrant rice by targeted knockout of the OsBADH2 gene using TALEN technology

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PLANT BIOTECHNOLOGY JOURNAL (2015)

Article Multidisciplinary Sciences

Boosting CRISPR/Cas9 multiplex editing capability with the endogenous tRNA-processing system

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Virology

Public Acceptance of Plant Biotechnology and GM Crops

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VIRUSES-BASEL (2015)

Review Nutrition & Dietetics

Consumer Perception of Genetically Modified Organisms and Sources of Information

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ADVANCES IN NUTRITION (2015)

Article Agronomy

Environmental impacts of genetically modified (GM) crop use 1996-2013: Impacts on pesticide use and carbon emissions

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GM CROPS & FOOD-BIOTECHNOLOGY IN AGRICULTURE AND THE FOOD CHAIN (2015)

Article Multidisciplinary Sciences

CRISPR/Cas9-Mediated Genome Editing in Soybean Hairy Roots

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PLOS ONE (2015)

Article Biotechnology & Applied Microbiology

Who Owns the Intellectual Property Rights to Chinese Genetically Modified Rice? Evidence from Patent Portfolio Analysis

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BIOTECHNOLOGY LAW REPORT (2014)

Article Biochemistry & Molecular Biology

Self- processing of ribozyme- flanked RNAs into guide RNAs in vitro and in vivo for CRISPR- mediated genome editing

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JOURNAL OF INTEGRATIVE PLANT BIOLOGY (2014)

Article Biotechnology & Applied Microbiology

Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew

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NATURE BIOTECHNOLOGY (2014)

Article Multidisciplinary Sciences

A Meta-Analysis of the Impacts of Genetically Modified Crops

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PLOS ONE (2014)

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Genetically modified foods, cancer, and diet: myths and reality

L. Z. G. Touyz

CURRENT ONCOLOGY (2013)

Review Food Science & Technology

Genetically modified foods: safety, risks and public concerns-a review

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JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE (2013)

Letter Biotechnology & Applied Microbiology

Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNA-guided endonuclease

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NATURE BIOTECHNOLOGY (2013)

Review Biotechnology & Applied Microbiology

Intragenesis and cisgenesis as alternatives to transgenic crop development

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PLANT BIOTECHNOLOGY JOURNAL (2013)

Review Biotechnology & Applied Microbiology

Site-directed nucleases: a paradigm shift in predictable, knowledge-based plant breeding

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Article Biotechnology & Applied Microbiology

Deployment of new biotechnologies in plant breeding

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NATURE BIOTECHNOLOGY (2012)

Article Multidisciplinary Sciences

Intellectual property rights related to the genetically modified glyphosate tolerant soybeans in Brazil

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ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS (2011)

Article Agricultural Economics & Policy

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Development Studies

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