Natural products against inflammation and atherosclerosis: Targeting on gut microbiota

The gut microbiota (GM) has become recognized as a crucial element in preserving human fitness and influencing disease consequences. Commensal and pathogenic gut microorganisms are correlated with pathological progress in atherosclerosis (AS). GM may thus be a promising therapeutic target for AS. Natural products with cardioprotective qualities might improve the inflammation of AS by modulating the GM ecosystem, opening new avenues for researches and therapies. However, it is unclear what components of natural products are useful and what the actual mechanisms are. In this review, we have summarized the natural products relieving inflammation of AS by regulating the GM balance and active metabolites produced by GM.

Automated summary

The gut microbiota plays a crucial role in human health and disease, especially in atherosclerosis (AS). Targeting the gut microbiota may be a promising therapeutic strategy for AS, and natural products with cardioprotective qualities could offer new avenues for research and treatment by modulating the gut microbiota and its metabolites. However, the specific components and mechanisms of natural products are still unclear.