Engineering zinc oxide hybrid selenium nanoparticles for synergetic anti-tuberculosis treatment by combining Mycobacterium tuberculosis killings and host cell immunological inhibition

Article Biotechnology & Applied Microbiology

Nanocages engineered from Bacillus Calmette-Guerin facilitate protective Vγ2Vδ2 T cell immunity against Mycobacterium tuberculosis infection

Jiang Pi et al.

Summary: Engineering Mycobacterium tuberculosis into nanoscale particles improves the safety and efficacy of the TB vaccine, providing better protection against TB infection.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Biochemistry & Molecular Biology

An Overview of Zinc Oxide Nanoparticles Produced by Plant Extracts for Anti-tuberculosis Treatments

Farahnaz Behzad et al.

Summary: Tuberculosis (TB) is a fatal infectious disease and drug-resistant TB poses a major challenge to TB control. The development of nanotechnology has opened up new possibilities for TB treatment, and zinc oxide nanoparticles (ZnO NPs) have shown potential as a novel strategy for anti-TB and drug-resistant TB treatment. Plant extracts have also been found to have antibacterial activity and may be effective for the treatment of infectious diseases.

CURRENT MEDICINAL CHEMISTRY (2022)

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Review Immunology

Immunomodulatory roles of selenium nanoparticles: Novel arts for potential immunotherapy strategy development

Gengshi Chen et al.

Summary: Current chemotherapy strategies have limitations due to low targeting effects and strong side effects. Selenium nanoparticles, utilizing nanotechnology, have shown great potential in immunotherapy as they can regulate innate and adaptive immunity, enhancing disease control and treatment efficiency. They can also be used as adjunctive therapy strategies for current chemotherapy.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Engineering, Biomedical

Cobalt oxide nanoparticle-synergized protein degradation and phototherapy for enhanced anticancer therapeutics

Xueqin Huang et al.

Summary: Manipulating protein degradation pathways such as ALP and UPS with Co3O4 NPs can enhance anticancer treatments by inducing autolysosome accumulation and inhibiting lysosomal proteolytic activity. Combining Co3O4 NPs with proteasome inhibitors also promotes the accumulation of autophagic substrates and protein ubiquitination to inhibit cancer progression. Additionally, leveraging the photothermal conversion efficiency of Co3O4 NPs enhances the anticancer efficacy of existing treatments in vitro and in vivo.

ACTA BIOMATERIALIA (2021)

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Article Immunology

A CD4+CD161+T-Cell Subset Present in Unexposed Humans, Not Tb Patients, Are Fast Acting Cells That Inhibit the Growth of Intracellular Mycobacteria Involving CD161 Pathway, Perforin, and IFN-γ/Autophagy

Rui Yang et al.

Summary: The primary CD4+CD161+ T-cell subset in unexposed individuals can quickly inhibit the growth of intracellular Mtb and BCG, but these cells lose this ability in TB patients.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Engineering, Biomedical

Tumor targeting and penetrating biomimetic mesoporous polydopamine nanoparticles facilitate photothermal killing and autophagy blocking for synergistic tumor ablation

Xueqin Huang et al.

Summary: Creating a biomimetic nanoplatform by coating homologous cancer cell membranes onto mesoporous polydopamine nanoparticles encapsulating the autophagy inhibitor chloroquine allows for synergistic manipulation of photothermal therapy and autophagy to achieve enhanced anticancer efficiency with high tumor targeting and penetration abilities against prostate cancer.

ACTA BIOMATERIALIA (2021)

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Review Engineering, Biomedical

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

Claudio Ferro et al.

Summary: Selenium is an essential element for human health, incorporated into selenocysteine in the body and used to synthesize selenoproteins. While it has beneficial properties, excessive intake can lead to toxicity. Selenium nanoparticles are a less toxic alternative for delivering drug payloads to specific cells, with potential applications in cancer therapy.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Infectious Diseases

The Role of Interferon-Gamma and Interferon-Gamma Receptor in Tuberculosis and Nontuberculous Mycobacterial Infections

Jalaledin Ghanavi et al.

Summary: Mycobacterium tuberculosis (Mtb) and nontuberculous mycobacteria (NTM) are leading causes of lung disease worldwide. Interferon-gamma (IFN-gamma) plays a crucial role in immunity against these pathogens, activating macrophages and promoting antibacterial methods. New therapeutic approaches involving IFN-gamma and IFN-gamma R modulation are introduced for treating M. tuberculosis complex (MTC) and NTM disease.

INTERNATIONAL JOURNAL OF MYCOBACTERIOLOGY (2021)

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Review Gastroenterology & Hepatology

Modulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response

Amir Hossein Mohseni et al.

Summary: The PI3K/Akt/mTOR signaling pathways are aberrantly activated in various diseases, and exposure to probiotics can regulate immune responses. Probiotics and PI3K/Akt/mTOR pathways play important roles in gastrointestinal disorders, skin diseases, allergies, salmonella infection, and aging.

GUT MICROBES (2021)

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Article Immunology

Circular RNA TRAPPC6B inhibits intracellular Mycobacterium tuberculosis growth while inducing autophagy in macrophages by targeting microRNA-874-3p

Hou-Long Luo et al.

Summary: Genetic and epigenetic mechanisms regulate antimicrobial immunity against Mycobacterium tuberculosis (Mtb) infection. The circular RNA TRAPPC6B (circTRAPPC6B) enhances autophagy and sequestration to restrict Mtb growth by targeting miR-874-3p and inhibiting its ability to suppress ATG16L1 in Mtb-infected macrophages. Both circTRAPPC6B and miR-874-3p mechanisms have the potential to be explored as therapeutics against Mtb infection.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Macrophage-Targeted Isoniazid-Selenium Nanoparticles Promote Antimicrobial Immunity and Synergize Bactericidal Destruction of Tuberculosis Bacilli

Jiang Pi et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Microbiology

Antimycobacterial Effect of Selenium Nanoparticles on Mycobacterium tuberculosis

Hector Estevez et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Synthesis, Properties, and Biological Applications of Metallic Alloy Nanoparticles

Kim-Hung Huynh et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Materials Science, Biomaterials

The regulation of nanomaterials and nanomedicines for clinical application: current and future perspectives

Rachel Foulkes et al.

BIOMATERIALS SCIENCE (2020)

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Review Immunology

The Metabolic Signature of Macrophage Responses

Antonella Viola et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Infectious Diseases

The Anti-Mycobacterial Activity Of Ag, ZnO, And Ag- ZnO Nanoparticles Against MDR- And XDR-Mycobacterium tuberculosis

Mohsen Heidary et al.

INFECTION AND DRUG RESISTANCE (2019)

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Review Chemistry, Multidisciplinary

Combatting antibiotic-resistant bacteria using nanomaterials

Akash Gupta et al.

CHEMICAL SOCIETY REVIEWS (2019)

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Review Biochemistry & Molecular Biology

The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications

Jinhuan Jiang et al.

BIOINORGANIC CHEMISTRY AND APPLICATIONS (2018)

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Review Cell Biology

Role of Oxidative Stress in the Pathology and Management of Human Tuberculosis

Madhur D. Shastri et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Article Chemistry, Medicinal

Role of Reactive Oxygen Species (ROS) in Therapeutics and Drug Resistance in Cancer and Bacteria

Allimuthu T. Dharmaraja

JOURNAL OF MEDICINAL CHEMISTRY (2017)

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Review Biochemistry & Molecular Biology

The Role of Reactive Oxygen Species in Antibiotic-Mediated Killing of Bacteria

Heleen Van Acker et al.

TRENDS IN MICROBIOLOGY (2017)

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Review Microbiology

Nitric Oxide in the Pathogenesis and Treatment of Tuberculosis

Hamidreza Jamaati et al.

FRONTIERS IN MICROBIOLOGY (2017)

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Correction Microbiology

The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense (vol 21, pg 59, 2017)

Luis H. Franco et al.

CELL HOST & MICROBE (2017)

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Review Physiology

Role of apoptosis and autophagy in tuberculosis

Adam Lam et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2017)

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Article Biotechnology & Applied Microbiology

Genome-wide association and replication study of anti-tuberculosis drugs-induced liver toxicity

Zelalem Petros et al.

BMC GENOMICS (2016)

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Review Chemistry, Multidisciplinary

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

Daniel Bobo et al.

PHARMACEUTICAL RESEARCH (2016)

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Review Biochemistry & Molecular Biology

Macrophage polarization in pathology

Antonio Sica et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2015)

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Review Chemistry, Multidisciplinary

Clinical Translation of Nanomedicine

Yuanzeng Min et al.

CHEMICAL REVIEWS (2015)

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Review Medicine, General & Internal

Totally drug-resistant tuberculosis and adjunct therapies

S. K. Parida et al.

JOURNAL OF INTERNAL MEDICINE (2015)

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Article Integrative & Complementary Medicine

Evaluation of cell membrane integrity as a potential antimicrobial target for plant products

Tariro A. Chitemerere et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2014)

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Review Cell Biology

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

David Heras-Sandoval et al.

CELLULAR SIGNALLING (2014)

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Review Cell Biology

Insights into battles between Mycobacterium tuberculosis and macrophages

Guanghua Xu et al.

PROTEIN & CELL (2014)

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Review Oncology

Targeting PI3K/Akt/mTOR signaling in cancer

Camillo Porta et al.

FRONTIERS IN ONCOLOGY (2014)

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Article Biotechnology & Applied Microbiology

Glucose Triggers ATP Secretion from Bacteria in a Growth-Phase-Dependent Manner

Ippei Hironaka et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2013)

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Review Pharmacology & Pharmacy

Bedaquiline - The first ATP synthase inhibitor against multi drug resistant tuberculosis

Mageshwaran Lakshmanan et al.

JOURNAL OF YOUNG PHARMACISTS (2013)

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Article Biochemistry & Molecular Biology

Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells

Sokbom Kang et al.

APOPTOSIS (2012)

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Article Immunology

M1 and M2 Macrophages: Oracles of Health and Disease

Charles D. Mills

CRITICAL REVIEWS IN IMMUNOLOGY (2012)

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Article Immunology

Stem Bromelain-Induced Macrophage Apoptosis and Activation Curtail Mycobacterium tuberculosis Persistence

Sahil Mahajan et al.

JOURNAL OF INFECTIOUS DISEASES (2012)

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Review Chemistry, Multidisciplinary

Chemiresistive Sensing with Chemically Modified Metal and Alloy Nanoparticles

Francisco J. Ibanez et al.

SMALL (2012)

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Review Immunology

Macrophage polarization in bacterial infections

Marie Benoit et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Biochemistry & Molecular Biology

Mitochondria, oxidative stress and cell death

Martin Ott et al.

APOPTOSIS (2007)

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Engineering zinc oxide hybrid selenium nanoparticles for synergetic anti-tuberculosis treatment by combining Mycobacterium tuberculosis killings and host cell immunological inhibition

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