Vaginal Lactobacillus iners abundance is associated with outcome in antibiotic treatment of bacterial vaginosis and capable of inhibiting Gardnerella

Article Immunology

Sialidase Activity in the Cervicovaginal Fluid Is Associated With Changes in Bacterial Components of Lactobacillus-Deprived Microbiota

Carolina Sanita Tafner Ferreira et al.

Summary: Sialidase activity in cervicovaginal fluid is associated with changes in bacterial composition, potentially leading to diminished local defenses against pathogens.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Review Immunology

Bacterial Vaginosis: What Do We Currently Know?

Linda Abou Chacra et al.

Summary: The vaginal microbiome is an important part of the human microbiome, characterized by unique conditions. Increased diversity in the microbiota can lead to dysbiosis such as bacterial vaginosis, with significant health consequences. Diagnosis and treatment methods are evolving, and research on this topic is becoming increasingly important.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Article Infectious Diseases

In vitro interactions within a biofilm containing three species found in bacterial vaginosis (BV) support the higher antimicrobial tolerance associated with BV recurrence

Aliona S. Rosca et al.

Summary: This study investigated the role of interactions between bacterial species in multi-species biofilms in bacterial vaginosis (BV) in relation to antimicrobial tolerance. The results showed that when these species were co-cultured, they could synergistically increase resistance to antibiotics.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2022)

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Article Infectious Diseases

Characteristics associated with Lactobacillus iners-dominated vaginal microbiota

Juliano Novak et al.

Summary: The study in Brazilian women of reproductive age found associations between L. iners-dominated microbiota with having multiple sexual partners, detection of Candida sp. in vaginal smears, lack of condom use, lower educational levels, and diet with milk/dairy intake. These findings suggest that unprotected sex practices and certain sociodemographic factors may help identify women with suboptimal protective properties of L. iners-dominated microbiota, warranting further investigation.

SEXUALLY TRANSMITTED INFECTIONS (2022)

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Article Immunology

Clustering Analysis of the Multi-Microbial Consortium by Lactobacillus Species Against Vaginal Dysbiosis Among Ecuadorian Women

David Pacha-Herrera et al.

Summary: The vaginal microbiota plays a crucial role in protecting women, with the probiotic activity provided by individual lactobacillus species and their multi-microbial interactions. This study analyzed the prevalence of five vaginal lactobacilli among healthy women and those with bacterial vaginosis (BV) or aerobic vaginitis (AV). The findings showed that Lactobacillus acidophilus, Lactobacillus jensenii, and Lactobacillus crispatus had the highest normalized importance values in protecting against vaginal dysbiosis, with L. acidophilus and L. jensenii exhibiting statistical significance. Additionally, a strong multi-microbial consortium of L. iners, L. jensenii, L. gasseri, and L. acidophilus was found to protect against AV and BV.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Review Immunology

Research Progress on the Correlation Between Gardnerella Typing and Bacterial Vaginosis

Hanyu Qin et al.

Summary: Bacterial vaginosis (BV) is a common infectious disease in women of reproductive age, characterized by an imbalance in the vaginal microbiome. Gardnerella spp. are considered a major cause of BV, but they can also be detected in the vaginal microbiome of healthy women. Recent studies have identified three new species of Gardnerella. This review discusses the types, genetic diversity, and correlation between different Gardnerella spp. and BV.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Article Microbiology

Cysteine dependence of Lactobacillus iners is a potential therapeutic target for vaginal microbiota modulation

Seth M. Bloom et al.

Summary: The composition of vaginal microbiota has a significant impact on reproductive health. Lactobacillus iners-dominated communities are associated with poorer outcomes. This study reveals that the growth of L. iners is dependent on L-cysteine, and the concentration of cysteine correlates with Lactobacillus abundance in vivo. Combining a cystine uptake inhibitor with metronidazole can suppress L. iners growth in favor of L. crispatus.

NATURE MICROBIOLOGY (2022)

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Review Microbiology

Towards a deeper understanding of the vaginal microbiota

Michael France et al.

Summary: The vaginal microbiota plays a crucial role in vaginal health, with lactobacilli being dominant but other microbes also present. Lack of lactobacilli is associated with adverse health outcomes. The mechanisms behind these associations are not well understood, and more research on causative relationships is needed.

NATURE MICROBIOLOGY (2022)

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Article Immunology

Vaginosis: Advances in new therapeutic development and microbiome restoration

Balasubramaniam Mohankumar et al.

Summary: Vaginosis is a condition caused by an imbalance in the vaginal microbiome, and can be treated through various methods. However, drug resistance and recurrence remain significant challenges. Vaginal microbiome transplant is an emerging treatment approach.

MICROBIAL PATHOGENESIS (2022)

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Article Medicine, Research & Experimental

Metronidazole treatment rapidly reduces genital inflammation through effects on bacterial vaginosis-associated bacteria rather than lactobacilli

Eric Armstrong et al.

Summary: The study found that after BV treatment, the vaginal microbiota shifted to dominance by Lactobacillus species, but this change was primarily driven by a decrease in BV-associated bacteria. Although there were minor increases in Lactobacillus species after treatment, they were not independently associated with reduced inflammation.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Biotechnology & Applied Microbiology

Insight into the ecology of vaginal bacteria through integrative analyses of metagenomic and metatranscriptomic data

Michael T. France et al.

Summary: This study characterized the genetic composition and transcriptional activities of vaginal microbiota in healthy women to determine the factors that drive vaginal community composition. The results show that species abundance does not always indicate its transcriptional activity and impending changes in community composition can be predicted from metatranscriptomic data. Additionally, the degradation of mucin by communities not dominated by Lactobacillus may play a role in their association with adverse health outcomes. The transcriptional activities of L. crispatus, L. iners, and Gardnerella vaginalis vary with the taxonomic composition of the communities in which they reside.

GENOME BIOLOGY (2022)

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Review Obstetrics & Gynecology

Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease

Jacques Ravel et al.

Summary: Bacterial vaginosis, pelvic inflammatory disease, and endometritis can lead to infertility due to factors such as inflammation, immune response, bacterial toxins, and increased risk of sexually transmitted infections. Diagnosing and treating these conditions before attempting conception may improve outcomes of natural and assisted reproduction for symptomatic women.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2021)

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Article Ecology

A Generalist Lifestyle Allows Rare Gardnerella spp. to Persist at Low Levels in the Vaginal Microbiome

Salahuddin Khan et al.

Summary: Gardnerella spp. is a hallmark of bacterial vaginosis, with four subgroups identified. Subgroup D is favored by negative frequency-dependent selection in the vaginal microbiome, maintaining its presence through a generalist lifestyle and minimal niche overlap with other Gardnerella spp.

MICROBIAL ECOLOGY (2021)

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Review Immunology

Contribution of Lactobacillus iners to Vaginal Health and Diseases: A Systematic Review

Nengneng Zheng et al.

Summary: Lactobacillus iners, first described in 1999, is a prevalent bacterial species of the vaginal microbiome. While it has probiotic characteristics, it can also contribute to vaginal dysbiosis under certain conditions, leading to diseases. Further studies are needed to fully understand its role in vaginal health and diseases.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Ecology

Analysis of similarities (ANOSIM) for 2-way layouts using a generalised ANOSIM statistic, with comparative notes on Permutational Multivariate Analysis of Variance (PERMANOVA)

Paul J. Somerfield et al.

Summary: ANOSIM is a robust non-parametric framework for comparing differences in resemblances among groups of samples. The generalised statistic R-O replaces the null hypothesis and describes resemblances among samples under an alternative model. The article discusses the use of the generalised statistic in various designs and provides examples of tests with ordered factors in marine ecological studies.

AUSTRAL ECOLOGY (2021)

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Article Multidisciplinary Sciences

Prognosis of recurrent bacterial vaginosis based on longitudinal changes in abundance of Lactobacillus and specific species of Gardnerella

Essence Turner et al.

Summary: The study found that persistently high levels of Gardnerella Gsp07 were associated with poor clinical outcomes in refractory bacterial vaginosis patients, while persistently low levels of Gardnerella Gsp07 and G. swidsinskii / G. leopoldii were associated with remission. In most recurrent and remission patients, Lactobacillus species abundance increased 4-14 days after treatment initiation, with more sustained increases in remission patients. The findings suggest that targeting specific strains of Gardnerella may improve patient outcomes.

PLOS ONE (2021)

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Article Infectious Diseases

Comparative Effectiveness of Treatments for Bacterial Vaginosis: A Network Meta-Analysis

Alison Munoz-Barreno et al.

Summary: This study conducted a meta-analysis on the clinical cure rates of bacterial vaginosis treatments and found that combined therapies showed the best outcomes. However, due to the heterogeneity of trial results, further research on RCTs is needed to determine the best BV treatment.

ANTIBIOTICS-BASEL (2021)

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Article Obstetrics & Gynecology

Impact of oral metronidazole treatment on the vaginal microbiota and correlates of treatment failure

Marijn C. Verwijs et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2020)

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Review Immunology

Cholesterol-Dependent Cytolysins Produced by Vaginal Bacteria: Certainties and Controversies

Milda Pleckaityte

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Review Immunology

Gardnerella vaginalis as a Cause of Bacterial Vaginosis: Appraisal of the Evidence From in vivo Models

Sydney Morrill et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Article Microbiology

Recovery of Vaginal Microbiota after Standard Treatment for Bacterial Vaginosis Infection: An Observational Study

Liisa Lehtoranta et al.

MICROORGANISMS (2020)

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Article Multidisciplinary Sciences

Quantitative modeling predicts mechanistic links between pre-treatment microbiome composition and metronidazole efficacy in bacterial vaginosis

Christina Y. Lee et al.

NATURE COMMUNICATIONS (2020)

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Article Microbiology

Complete Genome Sequences of Six Lactobacillus iners Strains Isolated from the Human Vagina

Michael T. France et al.

MICROBIOLOGY RESOURCE ANNOUNCEMENTS (2020)

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Review Infectious Diseases

Bacterial Biofilm and its Role in the Pathogenesis of Disease

Lene K. Vestby et al.

ANTIBIOTICS-BASEL (2020)

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Article Genetics & Heredity

Quantitation of all Four Gardnerella vaginalis Clades Detects Abnormal Vaginal Microbiota Characteristic of Bacterial Vaginosis More Accurately than Putative G. vaginalis Sialidase A Gene Count

Elena Shipitsyna et al.

MOLECULAR DIAGNOSIS & THERAPY (2019)

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Review Immunology

An Updated Conceptual Model on the Pathogenesis of Bacterial Vaginosis

Christina A. Muzny et al.

JOURNAL OF INFECTIOUS DISEASES (2019)

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Article Multidisciplinary Sciences

Inerolysin and vaginolysin, the cytolysins implicated in vaginal dysbiosis, differently impair molecular integrity of phospholipid membranes

Tadas Ragaliauskas et al.

SCIENTIFIC REPORTS (2019)

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Article Immunology

Resolution and Cooccurrence Patterns of Gardnerella leopoldii, G. swidsinskii, G. piotii, and G. vaginalis within the Vaginal Microbiome

Janet E. Hill et al.

INFECTION AND IMMUNITY (2019)

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Article Public, Environmental & Occupational Health

Characterization and Treatment of Recurrent Bacterial Vaginosis

Brooke M. Faught et al.

JOURNAL OF WOMENS HEALTH (2019)

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Article Microbiology

Emended description of Gardnerella vaginalis and description of Gardnerella leopoldii sp. nov., Gardnerella piotii sp. nov. and Gardnerella swidsinskii sp. nov., with delineation of 13 genomic species within the genus Gardnerella

Mario Vaneechoutte et al.

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (2019)

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Article Immunology

Identification of Key Bacteria Involved in the Induction of Incident Bacterial Vaginosis: A Prospective Study

Christina A. Muzny et al.

JOURNAL OF INFECTIOUS DISEASES (2018)

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Article Multidisciplinary Sciences

Phenotypic characterization of Gardnerella vaginalis subgroups suggests differences in their virulence potential

Migle Janulaitiene et al.

PLOS ONE (2018)

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Article Microbiology

Metatranscriptome Analysis of the Vaginal Microbiota Reveals Potential Mechanisms for Protection against Metronidazole in Bacterial Vaginosis

Zhi-Luo Deng et al.

MSPHERE (2018)

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Article Infectious Diseases

Gardnerella vaginalis population dynamics in bacterial vaginosis

D. W. Hilbert et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2017)

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Article Microbiology

Gardnerella vaginalis diversity and ecology in relation to vaginal symptoms

John J. Schellenberg et al.

RESEARCH IN MICROBIOLOGY (2017)

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Article Microbiology

Lactobacillus iners, the unusual suspect

Mario Vaneechoutte

RESEARCH IN MICROBIOLOGY (2017)

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Article Multidisciplinary Sciences

The presence of the putative Gardnerella vaginalis sialidase A gene in vaginal specimens is associated with bacterial vaginosis biofilm

Liselotte Hardy et al.

PLOS ONE (2017)

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Article Multidisciplinary Sciences

The influence of sexual activity on the vaginal microbiota and Gardnerella vaginalis clade diversity in young women

Lenka A. Vodstrcil et al.

PLOS ONE (2017)

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Review Microbiology

Etiology of bacterial vaginosis and polymicrobial biofilm formation

Hyun-Sul Jung et al.

CRITICAL REVIEWS IN MICROBIOLOGY (2017)

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Article Biotechnology & Applied Microbiology

Genomic Comparisons of Lactobacillus crispatus and Lactobacillus iners Reveal Potential Ecological Drivers of Community Composition in the Vagina

Michael T. France et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2016)

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Review Microbiology

The Human Microbiome during Bacterial Vaginosis

Andrew B. Onderdonk et al.

CLINICAL MICROBIOLOGY REVIEWS (2016)

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Article Microbiology

Antimicrobial resistance genes and modelling of treatment failure in bacterial vaginosis: clinical study of 289 symptomatic women

David G. Bostwick et al.

JOURNAL OF MEDICAL MICROBIOLOGY (2016)

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Article Multidisciplinary Sciences

Gardnerella vaginalis Subgroups Defined by cpn60 Sequencing and Sialidase Activity in Isolates from Canada, Belgium and Kenya

John J. Schellenberg et al.

PLOS ONE (2016)

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Article Multidisciplinary Sciences

Population-level analysis of gut microbiome variation

Gwen Falony et al.

SCIENCE (2016)

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Review Immunology

Role of Gardnerella vaginalis in the Pathogenesis of Bacterial Vaginosis: A Conceptual Model

Jane R. Schwebke et al.

JOURNAL OF INFECTIOUS DISEASES (2014)

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Review Obstetrics & Gynecology

The global epidemiology of bacterial vaginosis: a systematic review

Chris Kenyon et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2013)

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Article Multidisciplinary Sciences

Bacterial Communities in Women with Bacterial Vaginosis: High Resolution Phylogenetic Analyses Reveal Relationships of Microbiota to Clinical Criteria

Sujatha Srinivasan et al.

PLOS ONE (2012)

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Article Obstetrics & Gynecology

Gardnerella vaginalis comprises three distinct genotypes of which only two produce sialidase

Guido Lopes dos Santos Santiago et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2011)

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Article Biochemical Research Methods

UCHIME improves sensitivity and speed of chimera detection

Robert C. Edgar et al.

BIOINFORMATICS (2011)

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Article Biochemical Research Methods

FLASH: fast length adjustment of short reads to improve genome assemblies

Tanja Magoc et al.

BIOINFORMATICS (2011)

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Article Multidisciplinary Sciences

Vaginal microbiome of reproductive-age women

Jacques Ravel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Article Biotechnology & Applied Microbiology

Drawing the line between commensal and pathogenic Gardnerella vaginalis through genome analysis and virulence studies

Michael D. Harwich et al.

BMC GENOMICS (2010)

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Article Immunology

The vaginal bacterial communities of Japanese women resemble those of women in other racial groups

Xia Zhou et al.

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY (2010)

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Article Medicine, Research & Experimental

Importance of isolation and biotypization of Gardnerella vaginalis in diagnosis of bacterial vaginosis

Fatima Numanovic et al.

BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES (2008)

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Article Biotechnology & Applied Microbiology

Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy

Qiong Wang et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2007)

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Vaginal Lactobacillus iners abundance is associated with outcome in antibiotic treatment of bacterial vaginosis and capable of inhibiting Gardnerella

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