相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。The Role of Fatty Acid Metabolism in Drug Tolerance of Mycobacterium tuberculosis
Camila G. Quinonez et al.
MBIO (2022)
Combination of Mycobacterium tuberculosis RS Ratio and CFU Improves the Ability of Murine Efficacy Experiments to Distinguish between Drug Treatments
Christian Dide-Agossou et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2022)
Spatial relationships of intra-lesion heterogeneity in Mycobacterium tuberculosis microenvironment, replication status, and drug efficacy
Richard C. Lavin et al.
PLOS PATHOGENS (2022)
The Iron Response of Mycobacterium tuberculosis and Its Implications for Tuberculosis Pathogenesis and Novel Therapeutics
G. Marcela Rodriguez et al.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)
Interim Guidance: 4-Month Rifapentine-Moxifloxacin Regimen for the Treatment of Drug-Susceptible Pulmonary Tuberculosis — United States, 2022
Wendy Carr et al.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2022)
CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis
Shuqi Li et al.
NATURE MICROBIOLOGY (2022)
Tuberculosis treatment failure associated with evolution of antibiotic resilience
Qingyun Liu et al.
SCIENCE (2022)
Iron limitation in M. tuberculosis has broad impact on central carbon metabolism
Monique E. Theriault et al.
COMMUNICATIONS BIOLOGY (2022)
Moxifloxacin-Mediated Killing of Mycobacterium tuberculosis Involves Respiratory Downshift, Reductive Stress, and Accumulation of Reactive Oxygen Species
Somnath Shee et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2022)
How Mycobacterium tuberculosis drug resistance has shaped anti-tubercular drug discovery
Amala Bhagwat et al.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)
The evolving biology of Mycobacterium tuberculosis drug resistance
Richard M. M. Jones et al.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)
Drug resistant tuberculosis: Implications for transmission, diagnosis, and disease management
Dale Liebenberg et al.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)
Iron deprivation enhances transcriptional responses to in vitro growth arrest of Mycobacterium tuberculosis
Sogol Alebouyeh et al.
FRONTIERS IN MICROBIOLOGY (2022)
Design principles to assemble drug combinations for effective tuberculosis therapy using interpretable pairwise drug response measurements
Jonah Larkins-Ford et al.
CELL REPORTS MEDICINE (2022)
Development of New Tuberculosis Drugs: Translation to Regimen Composition for Drug-Sensitive and Multidrug-Resistant Tuberculosis
Jacqueline P. Ernest et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021 (2021)
Fourteen-day PET/CT imaging to monitor drug combination activity in treated individuals with tuberculosis
Yingda L. Xie et al.
SCIENCE TRANSLATIONAL MEDICINE (2021)
A multi-scale pipeline linking drug transcriptomics with pharmacokinetics predicts in vivo interactions of tuberculosis drugs
Joseph M. Cicchese et al.
SCIENTIFIC REPORTS (2021)
Survival of hypoxia-induced dormancy is not a common feature of all strains of the Mycobacterium tuberculosis complex
Barbara Tizzano et al.
SCIENTIFIC REPORTS (2021)
Four-Month Rifapentine Regimens with or without Moxifloxacin for Tuberculosis
S. E. Dorman et al.
NEW ENGLAND JOURNAL OF MEDICINE (2021)
Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens
Nicholas D. Walter et al.
NATURE COMMUNICATIONS (2021)
Zinc limitation triggers anticipatory adaptations in Mycobacterium tuberculosis
Allexa Dow et al.
PLOS PATHOGENS (2021)
Growth of Mycobacterium tuberculosis at acidic pH depends on lipid assimilation and is accompanied by reduced GAPDH activity
Alexandre Gouzy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery
David J. Wooten et al.
NATURE COMMUNICATIONS (2021)
Systematic measurement of combination-drug landscapes to predict in vivo treatment outcomes for tuberculosis
Jonah Larkins-Ford et al.
CELL SYSTEMS (2021)
Multiform antimicrobial resistance from a metabolic mutation
Sarah M. Schrader et al.
SCIENCE ADVANCES (2021)
IL-10 Impairs Local Immune Response in Lung Granulomas and Lymph Nodes during Early Mycobacterium tuberculosis Infection
Eileen A. Wong et al.
JOURNAL OF IMMUNOLOGY (2020)
Treatment of Highly Drug-Resistant Pulmonary Tuberculosis
Francesca Conradie et al.
NEW ENGLAND JOURNAL OF MEDICINE (2020)
One-Year Old Dormant, Non-culturable Mycobacterium tuberculosis Preserves Significantly Diverse Protein Profile
Kseniya A. Trutneva et al.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)
Selective translation by alternative bacterial ribosomes
Yu-Xiang Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Mathematical model and tool to explore shorter multi-drug therapy options for active pulmonary tuberculosis
John Fors et al.
PLOS COMPUTATIONAL BIOLOGY (2020)
Prediction of ultra-high-order antibiotic combinations based on pairwise interactions
Itay Katzir et al.
PLOS COMPUTATIONAL BIOLOGY (2019)
Potassium response and homeostasis in Mycobacterium tuberculosis modulates environmental adaptation and is important for host colonization
Nathan J. MacGilvary et al.
PLOS PATHOGENS (2019)
Definitions and guidelines for research on antibiotic persistence
Nathalie Q. Balaban et al.
NATURE REVIEWS MICROBIOLOGY (2019)
Tuberculosis drugs' distribution and emergence of resistance in patient's lung lesions: A mechanistic model and tool for regimen and dose optimization
Natasha Strydom et al.
PLOS MEDICINE (2019)
Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Daniel J. Greenwood et al.
SCIENCE (2019)
Acid Fasting: Modulation of Mycobacterium tuberculosis Metabolism at Acidic pH
Jacob J. Baker et al.
TRENDS IN MICROBIOLOGY (2019)
A rapid, low pH, nutrient stress, assay to determine the bactericidal activity of compounds against non-replicating Mycobacterium tuberculosis
Julie Early et al.
PLOS ONE (2019)
Transcriptomic Signatures Predict Regulators of Drug Synergy and Clinical Regimen Efficacy against Tuberculosis
Shuyi Ma et al.
MBIO (2019)
Effect of Moxifloxacin plus Pretomanid against Mycobacterium tuberculosis in Log Phase, Acid Phase, and Nonreplicating-Persister Phase in an In Vitro Assay
Carolina de Miranda Silva et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2019)
Identification of Compounds with pH-Dependent Bactericidal Activity against Mycobacterium tuberculosis
Julie Early et al.
ACS INFECTIOUS DISEASES (2019)
Genetic and metabolic regulation of Mycobacterium tuberculosis acid growth arrest
Jacob J. Baker et al.
SCIENTIFIC REPORTS (2018)
Cholesterol and fatty acids grease the wheels of Mycobacterium tuberculosis pathogenesis
Kaley M. Wilburn et al.
PATHOGENS AND DISEASE (2018)
Storage lipid studies in tuberculosis reveal that foam cell biogenesis is disease-specific
Valentina Guerrini et al.
PLoS Pathogens (2018)
Clinically prevalent mutations in Mycobacterium tuberculosis alter propionate metabolism and mediate multidrug tolerance
Nathan D. Hicks et al.
NATURE MICROBIOLOGY (2018)
Rifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpoB transcription
Jun-Hao Zhu et al.
NATURE COMMUNICATIONS (2018)
Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence
Huiqing Zheng et al.
NATURE CHEMICAL BIOLOGY (2017)
Deletion of a mycobacterial divisome factor collapses single-cell phenotypic heterogeneity
E. Hesper Rego et al.
NATURE (2017)
Cholesterol plays a larger role during Mycobacterium tuberculosis in vitro dormancy and reactivation than previously suspected
Maria D. Soto-Ramirez et al.
TUBERCULOSIS (2017)
The Capacity of Mycobacterium tuberculosis To Survive Iron Starvation Might Enable It To Persist in Iron-Deprived Microenvironments of Human Granulomas
Krishna Kurthkoti et al.
MBIO (2017)
Origins of Combination Therapy for Tuberculosis: Lessons for Future Antimicrobial Development and Application
Christopher A. Kerantzas et al.
MBIO (2017)
Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach
Elsje Pienaar et al.
PLOS COMPUTATIONAL BIOLOGY (2017)
Efficient measurement and factorization of high-order drug interactions in Mycobacterium tuberculosis
Murat Cokol et al.
SCIENCE ADVANCES (2017)
Heterogeneity in tuberculosis
Anthony M. Cadena et al.
NATURE REVIEWS IMMUNOLOGY (2017)
Defining the Optimal Dose of Rifapentine for Pulmonary Tuberculosis: Exposure-Response Relations From Two Phase II Clinical Trials
R. M. Savic et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2017)
Lung Tissue Concentrations of Pyrazinamide among Patients with Drug-Resistant Pulmonary Tuberculosis
Russell R. Kempker et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2017)
Selective Inactivity of Pyrazinamide against Tuberculosis in C3HeB/FeJ Mice Is Best Explained by Neutral pH of Caseum
Jean-Philippe Lanoix et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)
Oxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosis
Julie V. Early et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)
Multiscale Model of Mycobacterium tuberculosis Infection Maps Metabolite and Gene Perturbations to Granuloma Sterilization Predictions
Elsje Pienaar et al.
INFECTION AND IMMUNITY (2016)
Chemogenomics and orthology-based design of antibiotic combination therapies
Sriram Chandrasekaran et al.
MOLECULAR SYSTEMS BIOLOGY (2016)
Distinguishing between resistance, tolerance and persistence to antibiotic treatment
Asher Brauner et al.
NATURE REVIEWS MICROBIOLOGY (2016)
Prediction of multidimensional drug dose responses based on measurements of drug pairs
Anat Zimmer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Prediction of Drug Penetration in Tuberculosis Lesions
Jansy P. Sarathy et al.
ACS INFECTIOUS DISEASES (2016)
Network analysis identifies Rv0324 and Rv0880 as regulators of bedaquiline tolerance in Mycobacterium tuberculosis
Eliza J. R. Peterson et al.
NATURE MICROBIOLOGY (2016)
Rapid, Semiquantitative Assay To Discriminate among Compounds with Activity against Replicating or Nonreplicating Mycobacterium tuberculosis
Ben Gold et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
A Sterilizing Tuberculosis Treatment Regimen Is Associated with Faster Clearance of Bacteria in Cavitary Lesions in Marmosets
Laura E. Via et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Stress and Host Immunity Amplify Mycobacterium tuberculosis Phenotypic Heterogeneity and Induce Nongrowing Metabolically Active Forms
Giulia Manina et al.
CELL HOST & MICROBE (2015)
Forecasting Accuracy of the Hollow Fiber Model of Tuberculosis for Clinical Therapeutic Outcomes
Tawanda Gumbo et al.
CLINICAL INFECTIOUS DISEASES (2015)
Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses
Anne Lenaerts et al.
IMMUNOLOGICAL REVIEWS (2015)
Mycobacteria, metals, and the macrophage
Olivier Neyrolles et al.
IMMUNOLOGICAL REVIEWS (2015)
Zinc regulates a switch between primary and alternative S18 ribosomal proteins in Mycobacterium tuberculosis
Sladjana Prisic et al.
MOLECULAR MICROBIOLOGY (2015)
The association between sterilizing activity and drug distribution into tuberculosis lesions
Brendan Prideaux et al.
NATURE MEDICINE (2015)
Limited Activity of Clofazimine as a Single Drug in a Mouse Model of Tuberculosis Exhibiting Caseous Necrotic Granulomas
Scott M. Irwin et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
Slow growth of Mycobacterium tuberculosis at acidic pH is regulated by phoPR and host-associated carbon sources
Jacob J. Baker et al.
MOLECULAR MICROBIOLOGY (2014)
Global Adaptation to a Lipid Environment Triggers the Dormancy-Related Phenotype of Mycobacterium tuberculosis
Juan G. Rodriguez et al.
MBIO (2014)
Identification of Novel Inhibitors of Nonreplicating Mycobacterium tuberculosis Using a Carbon Starvation Model
Sarah Schmidt Grant et al.
ACS CHEMICAL BIOLOGY (2013)
Intracellular Mycobacterium tuberculosis Exploits Host-derived Fatty Acids to Limit Metabolic Stress
Wonsik Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Dynamic Persistence of Antibiotic-Stressed Mycobacteria
Yuichi Wakamoto et al.
SCIENCE (2013)
Mycobacterium tuberculosis Responds to Chloride and pH as Synergistic Cues to the Immune Status of its Host Cell
Shumin Tan et al.
PLOS PATHOGENS (2013)
Importance of Confirming Data on the In Vivo Efficacy of Novel Antibacterial Drug Regimens against Various Strains of Mycobacterium tuberculosis
Mary A. De Groote et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Pharmacokinetic Evaluation of the Penetration of Antituberculosis Agents in Rabbit Pulmonary Lesions
Maria C. Kjellsson et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Mouse Model of Necrotic Tuberculosis Granulomas Develops Hypoxic Lesions
Jamie Harper et al.
JOURNAL OF INFECTIOUS DISEASES (2012)
Asymmetry and Aging of Mycobacterial Cells Lead to Variable Growth and Antibiotic Susceptibility
Bree B. Aldridge et al.
SCIENCE (2012)
Sterilizing Activity of Novel TMC207-and PA-824-Containing Regimens in a Murine Model of Tuberculosis
Rokeya Tasneen et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Multiscale Computational Modeling Reveals a Critical Role for TNF-α Receptor 1 Dynamics in Tuberculosis Granuloma Formation
Mohammad Fallahi-Sichani et al.
JOURNAL OF IMMUNOLOGY (2011)
Mycobacterium tuberculosis Uses Host Triacylglycerol to Accumulate Lipid Droplets and Acquires a Dormancy-Like Phenotype in Lipid-Loaded Macrophages
Jaiyanth Daniel et al.
PLOS PATHOGENS (2011)
Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection
Joeli Marrero et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy
Kevin Pethe et al.
NATURE COMMUNICATIONS (2010)
Foamy macrophages and the progression of the human tuberculosis granuloma
David G. Russell et al.
NATURE IMMUNOLOGY (2009)
The spectrum of latent tuberculosis: rethinking the biology and intervention strategies
Clifton E. Barry et al.
NATURE REVIEWS MICROBIOLOGY (2009)
A Novel In Vitro Multiple-Stress Dormancy Model for Mycobacterium tuberculosis Generates a Lipid-Loaded, Drug-Tolerant, Dormant Pathogen
Chirajyoti Deb et al.
PLOS ONE (2009)
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates
Laura E. Via et al.
INFECTION AND IMMUNITY (2008)
Nitrate enhances the survival of Mycobacterium tuberculosis during inhibition of respiration
Charles D. Sohaskey
JOURNAL OF BACTERIOLOGY (2008)
Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis
Anil Koul et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis
Srinivasa P. S. Rao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Mycobacterial persistance requires the utilization of host cholesterol
Amit K. Pandey et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M-tuberculosis Persistence
Pascale Peyron et al.
PLOS PATHOGENS (2008)
Location of persisting mycobacteria in a guinea pig model of tuberculosis revealed by R207910
Anne J. Lenaerts et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis
Sang Hyun Cho et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
Moxifloxacin-containing regimen greatly reduces time to culture conversion in murine tuberculosis
EL Nuermberger et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2004)
Selection of a moxifloxacin dose that suppresses drug resistance in Mycobacterium tuberculosis, by use of an in vitro pharmacodynamic infection model and mathematical modeling
T Gumbo et al.
JOURNAL OF INFECTIOUS DISEASES (2004)
Gene expression profile of Mycobacterium tuberculosis in a non-replicating state
DGN Muttucumaru et al.
TUBERCULOSIS (2004)
Transcriptional adaptation of Mycobacterium tuberculosis within macrophages:: Insights into the phagosomal environment
D Schnappinger et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling
JC Betts et al.
MOLECULAR MICROBIOLOGY (2002)
Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding α-crystallin
DR Sherman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Growth of Mycobacterium tuberculosis in a defined medium is very restricted by acid pH and Mg2+ levels
DL Piddington et al.
INFECTION AND IMMUNITY (2000)