期刊
ELIFE
卷 11, 期 -, 页码 -出版社
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.74929
关键词
dorsal striatum; reward; action sequence; waiting time; impulsivity; adolescence; Rat
类别
资金
- Agencia Nacional de Promocion Cientifica y Tecnologica [PICT 2016-0396, PICT 2017-0520, PICT 2017-2465]
- Secretaria de Ciencia y Tecnica, Universidad de Buenos Aires UBACYT [2018-2020 305BA]
The activity of the striatum plays a role in the timing of action sequence initiation and is linked to impulsivity. This modulation is more pronounced in adolescent rats, potentially reflecting age-related differences in reward expectation and temporal discounting.
The automatic initiation of actions can be highly functional. But occasionally these actions cannot be withheld and are released at inappropriate times, impulsively. Striatal activity has been shown to participate in the timing of action sequence initiation and it has been linked to impulsivity. Using a self-initiated task, we trained adult male rats to withhold a rewarded action sequence until a waiting time interval has elapsed. By analyzing neuronal activity we show that the striatal response preceding the initiation of the learned sequence is strongly modulated by the time subjects wait before eliciting the sequence. Interestingly, the modulation is steeper in adolescent rats, which show a strong prevalence of impulsive responses compared to adults. We hypothesize this anticipatory striatal activity reflects the animals' subjective reward expectation, based on the elapsed waiting time, while the steeper waiting modulation in adolescence reflects age-related differences in temporal discounting, internal urgency states, or explore-exploit balance.
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