☆ 4.3 Review

Emerging Strategies to Improve the Stability and Bioavailability of Insulin: An Update on Formulations and Delivery Approaches

CURRENT DRUG DELIVERY (2023)

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Article Pharmacology & Pharmacy

Development of an Insulin Nano-delivery System through Buccal Administration

Diaa Al-Domi et al.

Summary: The aim of this study was to develop a new nano-delivery system for buccal administration of insulin. Positively charged poly (D, L-lactide-co-glycolide) nanoparticles coated with chitosan were prepared using the water-oil-water microemulsion solvent evaporation technique, and loaded into a buccal film. Evaluation of the nanoparticles' size, charge, and surface morphology, as well as in vitro insulin release experiments, demonstrated controlled and sustained delivery when using the buccal film.

CURRENT DRUG DELIVERY (2022)

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Article Health Care Sciences & Services

Opportunities and counterintuitive challenges for decentralized clinical trials to broaden participant inclusion

Noah Goodson et al.

Summary: Traditional clinical trials often fail to recruit representative participant populations. Decentralized clinical trials (DCTs) have been proposed as a potential solution to reduce barriers and attract a wider range of participants, but their impact on participant inclusivity remains to be seen. Digital studies aiming to address a single element of inclusion may inadvertently lead to unintended consequences in other areas. Implementing DCTs presents new challenges such as the digital divide and the need to build new infrastructure.

NPJ DIGITAL MEDICINE (2022)

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Article Chemistry, Applied

Stabilization of insulin using low molecular weight chitosan carbonate nanocarrier

Mayyas Al-Remawi et al.

Summary: The current study aimed to design a nanoparticulate system for encapsulating insulin and improving its stability. Nanoparticles were successfully formulated through the ionic cross-linking of chitosan with carbonate divalent anions. The findings demonstrated that the chitosan carbonate system not only maintained the stability of insulin conformation but also interacted with insulin.

CARBOHYDRATE POLYMERS (2022)

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Article Nanoscience & Nanotechnology

Photothermal Activatable Mucoadhesive Fiber Mats for On-Demand Delivery of Insulin via Buccal and Corneal Mucosa

Anna Voronova et al.

Summary: Electrospun fiber mats loaded with therapeutics are being used as a versatile tool in the biomedical field, with stimuli-responsive fiber mats offering timely and controlled drug delivery, particularly for on-demand hormone release like insulin. Research has shown that modified poly(acrylic acid) fiber mats can effectively deliver insulin through buccal and corneal routes.

ACS APPLIED BIO MATERIALS (2022)

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Article Chemistry, Medicinal

Design and Investigation of Penetrating Mechanism of Octaarginine-Modified Alginate Nanoparticles for Improving Intestinal Insulin Delivery

Manman Li et al.

Summary: The study aimed to design octaarginine-modified insulin-alginate nanoparticles for oral insulin delivery, which showed improved stability, controlled release, insulin transport capacity, and hypoglycemic effect compared to unmodified nanoparticles. The mechanism of penetration may involve the production of endogenous nitric oxide signal molecule, leading to enhanced insulin intestinal uptake. The cytotoxicity analysis confirmed the safety of orally administrated nanoparticles, indicating their potential for oral delivery of protein drugs.

JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Alginate Calcium Microbeads Containing Chitosan Nanoparticles for Controlled Insulin Release

Jinglei Li et al.

Summary: An effective delivery system for oral insulin administration was developed using alginate microbeads containing chitosan nanoparticles (CNP) for controlled release of insulin. The optimized CNP with a size around 150 nm and encapsulation efficiency of 23.70% showed promising potential for oral insulin delivery. The insulin-loaded alginate microbeads significantly lowered blood glucose level in hyperglycemia model mice in a controlled manner for up to 96 hours, demonstrating the potential for extended release of insulin.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2021)

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Article Engineering, Biomedical

Iontophoresis-driven porous microneedle array patch for active transdermal drug delivery

Yanjun Li et al.

Summary: The study introduced a novel iontophoresis-driven porous MA patch (IDPMAP) and a portable iontophoresis-driven device for active transdermal delivery of charged liquid drugs. IDPMAP showed robust drug delivery ability with more advanced controllability and efficiency compared to pristine MA or iontophoresis, offering a platform technique for effective drug delivery in an active-controlled manner.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Applied

Inclusion complex based on N-acetyl-L-cysteine and arginine modified hydroxypropyl-β-cyclodextrin for oral insulin delivery

Siyi Li et al.

Summary: The novel NAC-HP-β-CD-Arg was successfully synthesized for oral delivery of insulin, showing protective effects against enzymatic degradation and excellent hypoglycemic effects in vivo.

CARBOHYDRATE POLYMERS (2021)

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Article Endocrinology & Metabolism

2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2021

Summary: The American Diabetes Association's Standards of Medical Care in Diabetes provides clinical practice recommendations, treatment goals, guidelines, and tools for evaluating care quality. It is updated annually by a multidisciplinary expert committee, and readers are invited to comment on the standards at professional.diabetes.org/SOC.

DIABETES CARE (2021)

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Article Biochemistry & Molecular Biology

Exploring protein stabilized multiple emulsion with permeation enhancer for oral delivery of insulin

Ishneet Kaur et al.

Summary: In this study, a novel oral insulin microemulsion was developed with piperine as a permeation enhancer and albumin as a stabilizer. The microemulsion showed small droplet size and good stability, maintaining INS stability in simulated gastrointestinal fluids and showing improved uptake and permeation compared to free INS. Animal studies demonstrated a significantly higher hypoglycemic effect and pharmacokinetic studies revealed higher AUC for the microemulsion with albumin as a stabilizer, suggesting its potential for oral delivery of bio-macromolecules.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Pharmacology & Pharmacy

Design of folic acid decorated virus-mimicking nanoparticles for enhanced oral insulin delivery

Hongbo Cheng et al.

Summary: Combining mucus penetration and active transcellular transport by using folic acid decorated virus-mimicking nanoparticles can improve insulin absorption efficiency. The graft ratio of folic acid affects the properties of nanoparticles in vitro and in vivo, with better effect observed when the ratio is at/over 12.51%.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Chemistry, Physical

Zwitterion-functionalized mesoporous silica nanoparticles for enhancing oral delivery of protein drugs by overcoming multiple gastrointestinal barriers

Yikun Gao et al.

Summary: By modifying meso-porous silica nanoparticles with distinct coatings, the oral delivery of protein drugs was enhanced in terms of permeation and absorption in the gastrointestinal tract. Furthermore, the modified carrier showed reduced chances of entering lysosomes and displayed outstanding hypoglycemic effects in diabetic rats.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Article Pharmacology & Pharmacy

In vitro and in vivo evaluations on nanoparticle and phospholipid hybrid nanoparticles with absorption enhancers for oral insulin delivery

N. Basaran Mutlu-Agardan et al.

Summary: This study successfully developed nanoparticles encapsulating insulin using ionic gelation and thin-film hydration methods, demonstrating ideal stability and drug release performance in vitro. The phospholipid hybrid nanoparticles showed promising therapeutic efficacy and safety through cytotoxicity studies.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2021)

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Article Pharmacology & Pharmacy

Sublingual insulin administration: application of hydroxypropyl beta-cyclodextrin and poloxamer188 as permeation enhancers

Anuja Paprikar et al.

Summary: The study found that the use of HP beta CD/poloxamer 188 can lead to the development of insulin solutions/films for sublingual administration, with enhanced permeation and absorption effects.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Development of an M cell targeted nanocomposite system for effective oral protein delivery: preparation, in vitro and in vivo characterization

Jae Geun Song et al.

Summary: The study aimed at developing an M cell targeted-nanocomposite delivery system for protein drugs to overcome absorption barriers in the GI tract, and showed promising results in improving the bioavailability of orally administered protein drugs in mice.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Multidisciplinary Sciences

Characterization of Insulin Mucoadhesive Buccal Films: Spectroscopic Analysis and In Vivo Evaluation

Maram Diab et al.

Summary: Insulin mucoadhesive buccal films (MBF) are a noninvasive delivery system formulated with chitosan, glycerin, and L-arginine. Stability testing showed retention of insulin structure and in vivo testing revealed a blood glucose-lowering effect in rat models, suggesting MBFs as a promising insulin delivery system.

SYMMETRY-BASEL (2021)

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Article Materials Science, Biomaterials

Self-Assembled, Dilution-Responsive Hydrogels for Enhanced Thermal Stability of Insulin Biopharmaceuticals

Catherine M. Meis et al.

Summary: Hydrogels have the potential to effectively encapsulate and stabilize biotherapeutics, such as insulin, preventing issues caused by harsh conditions during storage and transportation. This supramolecular hydrogel system can maintain the bioactivity of insulin for over 28 days and can be easily recovered for administration at the point of care, showing promise in reducing the dependence of insulin and other biotherapeutics on the cold chain.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Polymer Science

Poly(vinyl alcohol)/poly(hydroxypropyl methacrylate-co-methacrylic acid) as pH-sensitive semi-IPN hydrogels for oral insulin delivery: preparation and characterization

Shunying Li et al.

Summary: A series of pH-sensitive semi-interpenetrating polymer network hydrogels were synthesized and characterized in terms of their physicochemical properties. The hydrogels showed sensitivity to both pH and ionic strength, as well as good biocompatibility. Oral delivery of drug-loaded hydrogels demonstrated potential for reducing blood glucose levels.

IRANIAN POLYMER JOURNAL (2021)

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Article Pharmacology & Pharmacy

In vivo testing of mucus-permeating nanoparticles for oral insulin delivery using Caenorhabditis elegans as a model under hyperglycemic conditions

Ana L. Martinez-Lopez et al.

Summary: This study demonstrated that PPA-NPs have enhanced mucus permeation ability, allowing them to cross the intestinal barrier and release insulin, resulting in significant therapeutic effects on Caenorhabditis elegans under high glucose conditions.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Pharmacology & Pharmacy

Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery-A Particle Engineering Approach

Dariush Nikjoo et al.

Summary: Hydrogels, particularly those made from hyaluronic acid (HA), show promise as a material for controlled pulmonary drug delivery. In this study, spray-dried microparticles were successfully prepared from crosslinked HA, with superior performance demonstrated by those crosslinked with glutaraldehyde (GA) in terms of aerosolization and swelling.

PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Development, Characterization, and Ex Vivo Assessment of Elastic Liposomes for Enhancing the Buccal Delivery of Insulin

Santosh Bashyal et al.

Summary: The study focused on developing and characterizing elastic liposomes for buccal drug delivery, with sodium-glycodeoxycholate-incorporated elastic liposomes showing the most superior permeability of insulin across porcine buccal tissues. Bioimaging analysis provided further support for the enhanced permeability of insulin by the SGDC-ELs. These findings highlight the potential of nanocarriers in improving buccal drug delivery for insulin management.

PHARMACEUTICS (2021)

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Article Nanoscience & Nanotechnology

Insulin Transdermal Delivery System for Diabetes Treatment Using a Biocompatible Ionic Liquid-Based Microemulsion

Md Rafiqul Islam et al.

Summary: A novel ionic liquid-in-oil microemulsion formulation (MEF) was developed for transdermal insulin delivery, which significantly enhanced the transdermal permeation of insulin via the intercellular route. The experiment results indicate that MEFs have potential application prospects in transdermal insulin delivery.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Applied

Design of biotin decorated enterocyte targeting muco-inert nanocomplexes for enhanced oral insulin delivery

Zhixiang Cui et al.

Summary: A nanocomplex system targeting the intestines was developed using biotin modification and hyaluronic acid coating to enhance penetration efficiency and achieve significant hypoglycemic effects.

CARBOHYDRATE POLYMERS (2021)

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Article Chemistry, Physical

Insulin-loaded liposomes functionalized with cell-penetrating peptides: influence on drug release and permeation through porcine nasal mucosa

Eliete de Souza Von Zuben et al.

Summary: This study developed and characterized insulin-loaded liposomes functionalized with cell-penetrating peptides (CPPs) for nasal delivery. The addition of CPPs improved the stability of liposomes and the permeation of insulin through porcine nasal mucosa.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2021)

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Review Pharmacology & Pharmacy

A Recent Update on Intranasal Delivery of High Molecular Weight Proteins, Peptides, and Hormones

Mayank Sharma et al.

Summary: This review emphasizes the systemic delivery of macromolecules such as proteins and hormones via the nasal route, which has proven beneficial in treating neurological disorders.

CURRENT PHARMACEUTICAL DESIGN (2021)

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Article Endocrinology & Metabolism

Efficacy and safety of 28-day treatment with oral insulin (ORMD-0801) in patients with type 2 diabetes: A randomized, placebo-controlled trial

Roy Eldor et al.

Summary: ORMD-0801 effectively controlled night-time glycemia, 24-hour glucose, and HbA1c levels in patients with T2D without increasing the risk of hypoglycemia or adverse events compared to the placebo group.

DIABETES OBESITY & METABOLISM (2021)

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Article Pharmacology & Pharmacy

Highly cross-linked arabinoxylans microspheres as a microbiota-activated carrier for colon-specific insulin delivery

A. M. Morales-Burgos et al.

Summary: Arabinoxylans microspheres were shown to protect insulin from degradation in the upper gastrointestinal tract and effectively lower blood glucose levels in diabetic rats, while also improving symptoms and increasing the presence of beneficial bacteria.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2021)

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Article Nanoscience & Nanotechnology

Facilitated Buccal Insulin Delivery via Hydrophobic Ion-Pairing Approach: In vitro and ex vivo Evaluation

Santosh Bashyal et al.

Summary: The study successfully demonstrated enhanced permeability of insulin through buccal administration using hydrophobic ion-pairing (HIP) nanocomplexes, providing a promising strategy for the delivery of this life-saving peptide hormone.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Pharmacology & Pharmacy

Accelerating transdermal delivery of insulin by ginsenoside nanoparticles with unique permeability

Jun-Jie Zou et al.

Summary: The combination of insulin and ginsenosides in a nanoformulation has shown to be effective in transdermal delivery for diabetes treatment, reducing side effects while maintaining euglycemic levels for an extended period of time. This green and safe nano-system has the potential to deliver other less permeable drugs and benefit individuals with chronic diseases that require long-term medication.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Polymer Science

Microparticles based on alginate/chitosan/casein three-dimensional system for oral insulin delivery

Zhenyu Xu et al.

Summary: A novel oral delivery system of insulin called NiM, based on a three-dimensional system of biocompatible chitosan/alginate/casein, has been developed to overcome the GI barriers. NiM showed stable hydrodynamic parameters and effectively controlled the release of insulin in gastric and intestinal tracts, demonstrating promising results for diabetic patients.

POLYMERS FOR ADVANCED TECHNOLOGIES (2021)

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Review Pharmacology & Pharmacy

Commemorating insulin's centennial: engineering insulin pharmacology towards physiology

Peter Kurtzhals et al.

Summary: The discovery of insulin in 1921 was a significant achievement in medical history, but optimizing its therapeutic effects has been a challenge for a century. Recent advancements in combining genetic and chemical engineering with pharmaceutical optimization have led to the development of more effective insulin analogs.

TRENDS IN PHARMACOLOGICAL SCIENCES (2021)

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Article Pharmacology & Pharmacy

Dissolving Polymer Microneedles for Transdermal Delivery of Insulin

Na Zhang et al.

Summary: This study developed insulin-loaded dissolving microneedles that can efficiently deliver insulin to the skin to treat diabetes. The fabrication process of microneedles is uniform, controllable, and has the potential for mass production and practical application in the future.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Spray Freeze Dried Lyospheres(R) for Nasal Administration of Insulin

Tugrul Mert Serim et al.

Summary: A new approach using SFD lyospheres(R) for the preparation of fast dissolving porous particles for nasal administration of insulin was proposed in this study, showing promising potential as an effective delivery system. The particles demonstrated low density and high porosity, leading to excellent performance in nasal administration, indicating a highly prospective platform for nasal peptide delivery.

PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Oral Insulin Delivery by Chitosan Coated Solid Lipid Nanoparticles: Ex vivo and in vivo Studies

Rakshitha Bhaskar Anchan et al.

Summary: Chitosan coated insulin-loaded solid lipid nanoparticles show promising potential as an effective oral insulin formulation, with the ability to control blood glucose levels in vivo and significant permeation properties.

JOURNAL OF YOUNG PHARMACISTS (2021)

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Article Medicine, Research & Experimental

Charge-switchable zwitterionic polycarboxybetaine particle as an intestinal permeation enhancer for efficient oral insulin delivery

Yan Li et al.

Summary: The study utilized charge-switchable zwitterionic polycarboxybetaine (PCB) to load insulin and form PCB/insulin (PCB/INS) particles, which showed an opening effect on intestinal epithelium, increasing the intestinal permeability of insulin and enhancing the antidiabetic efficacy after oral administration.

THERANOSTICS (2021)

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Article Chemistry, Multidisciplinary

In vivo oral insulin delivery via covalent organic frameworks

Farah Benyettou et al.

Summary: This study introduces a novel approach using nCOF nanoparticles for oral insulin delivery, which demonstrated protection of insulin and glucose-responsive release in vitro, as well as hyperglycemia-induced release in vivo without toxic effects in diabetic rats. These findings suggest that nCOF-based oral insulin delivery systems could potentially replace traditional subcutaneous injections for insulin therapy.

CHEMICAL SCIENCE (2021)

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Article Materials Science, Biomaterials

Bioinspired zwitterionic polyphosphoester modified porous silicon nanoparticles for efficient oral insulin delivery

Rong Rao et al.

Summary: The study showed that zwitterionic polyphosphoester modified porous silicon nanoparticles play an important role in oral delivery of protein or peptide drugs, enhancing mucus permeability and cellular internalization.

BIOMATERIALS SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Layer-by-layer coated nanoliposomes for oral delivery of insulin

Yiming Zhang et al.

Summary: The study developed a multi-layered insulin loading strategy on an anionic nanoliposome surface based on electrostatic interaction, achieving high insulin loading and protection in simulated gastrointestinal environments. In rat studies, oral administration of the formulation resulted in rapid absorption with peak plasma insulin levels reached at 0.5 hours post oral gavaging, making it promising for potential oral insulin applications.

NANOSCALE (2021)

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Review Pharmacology & Pharmacy

Permeation enhancers in transdermal drug delivery: benefits and limitations

Andrej Kovacik et al.

EXPERT OPINION ON DRUG DELIVERY (2020)

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Article Engineering, Biomedical

Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs

Jicheng Yu et al.

NATURE BIOMEDICAL ENGINEERING (2020)

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Review Chemistry, Multidisciplinary

The ABC of Insulin: The Organic Chemistry of a Small Protein

Mads Ostergaard et al.

CHEMISTRY-A EUROPEAN JOURNAL (2020)

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Article Pharmacology & Pharmacy

Cell -penetrating peptide enhanced insulin buccal absorption

You Xu et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Chemistry, Medicinal

Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence

Daniel E. K. Kabotso et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Review Pharmacology & Pharmacy

Advances in Oral Drug Delivery for Regional Targeting in the Gastrointestinal Tract-Influence of Physiological, Pathophysiological and Pharmaceutical Factors

Susan Hua

FRONTIERS IN PHARMACOLOGY (2020)

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Article Chemistry, Applied

Pullulan microneedle patches for the efficient transdermal administration of insulin envisioning diabetes treatment

Daniela F. S. Fonseca et al.

CARBOHYDRATE POLYMERS (2020)

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Article Pharmacology & Pharmacy

Optimization of phytic acid-crosslinked chitosan microspheres for oral insulin delivery using response surface methodology

Jeong Un Kim et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Pharmacology & Pharmacy

Transdermal insulin delivery with microwave and fatty acids as permeation enhancers

Nurulaini Harjoh et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Chemistry, Multidisciplinary

Excipient-free pulmonary insulin dry powder: Pharmacokinetic and pharmacodynamics profiles in rats

Eride Quarta et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Pharmacology & Pharmacy

Artificial intelligence in drug discovery and development

Debleena Paul et al.

DRUG DISCOVERY TODAY (2020)

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Article Pharmacology & Pharmacy

Drug-Loaded Lipid-Core Micelles in Mucoadhesive Films as a Novel Dosage Form for Buccal Administration of Poorly Water-Soluble and Biological Drugs

Wai-Houng Chou et al.

PHARMACEUTICS (2020)

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Article Nanoscience & Nanotechnology

Internalization Mechanism of Phenylboronic-Acid-Decorated Nanoplatform for Enhanced Nasal Insulin Delivery

Xiaosong Wei et al.

ACS APPLIED BIO MATERIALS (2020)

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Article Endocrinology & Metabolism

Prevalence, Risk Factors, and Clinical Characteristics of Lipodystrophy in Insulin-Treated Patients with Diabetes: An Old Problem in a New Era of Modern Insulin

Yotsapon Thewjitcharoen et al.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2020)

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Article Chemistry, Multidisciplinary

Ionic liquid-mediated delivery of insulin to buccal mucosa

Amogh Vaidya et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Pharmacology & Pharmacy

Factors affecting the buccal delivery of deformable nanovesicles based on insulin-phospholipid complex: anin vivoinvestigation

Yuqi Yang et al.

DRUG DELIVERY (2020)

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Article Medicine, Research & Experimental

Study Protocol for a Prospective, Multicenter, Randomized, Open-Label, Parallel-Group Clinical Trial Comparing the Efficacy and Safety of a Needle-Free Insulin Injector and a Conventional Insulin Pen in Controlling Blood Glucose Concentrations in Chinese Patients with Type 2 Diabetes Mellitus (The FREE Study)

LiNong Ji et al.

ADVANCES IN THERAPY (2019)

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Article Pharmacology & Pharmacy

Preparation and characterization of insulin chitosan-nanoparticles loaded in buccal films

Nusaiba K. Al-Nemrawi et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2019)

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Review Physiology

Hepatic Insulin Clearance: Mechanism and Physiology

Sonia M. Najjar et al.

PHYSIOLOGY (2019)

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Meeting Abstract Endocrinology & Metabolism

Dance 501 Inhaled Human Insulin (INH): Linear Dose Response, Earlier Onset of Action, and Higher Early Effect than s.c. Insulin Lispro (LIS)

Eric Zijlstra et al.

DIABETES (2019)

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Article Chemistry, Medicinal

Effect of Glyceryl Monocaprylate-Modified Chitosan on the Intranasal Absorption of Insulin in Rats

Mingyue Gao et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

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Article Pharmacology & Pharmacy

Chitosan-Coated Alginate Nanoparticles Enhanced Absorption Profile of Insulin via Oral Administration

Mohd H. M. Jaafar et al.

CURRENT DRUG DELIVERY (2019)

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Article Pharmacology & Pharmacy

Improving the hypoglycemic effect of insulin via the nasal administration of deep eutectic solvents

Yang Li et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Review Pharmacology & Pharmacy

Artificial intelligence in drug development: present status and future prospects

Kit-Kay Mak et al.

DRUG DISCOVERY TODAY (2019)

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Article Materials Science, Biomaterials

Thermal ablation of separable microneedles for transdermal delivery of metformin on diabetic rats

Yang Zhang et al.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2019)

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Article Chemistry, Multidisciplinary

Enhanced intranasal insulin delivery by formulations and tumor protein-derived protein transduction domain as an absorption enhancer

Nam Ah Kim et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Review Biotechnology & Applied Microbiology

Non-invasive delivery strategies for biologics

Aaron C. Anselmo et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Article Engineering, Biomedical

Supercritical Fluid-Assisted Porous Microspheres for Efficient Delivery of Insulin and Inhalation Therapy of Diabetes

Xiao-Fen Lin et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Pharmacology & Pharmacy

Preparation, characterization, and pharmacodynamics of insulin-loaded fumaryl diketopiperazine microparticle dry powder inhalation

Yun Xia et al.

DRUG DELIVERY (2019)

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Article Pharmacology & Pharmacy

Development and characterization of lipid-polymeric nanoparticles for oral insulin delivery

Debora Sgorla et al.

EXPERT OPINION ON DRUG DELIVERY (2018)

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Article Medicine, Research & Experimental

Clinical Benefits Over Time Associated with Use of V-Go Wearable Insulin Delivery Device in Adult Patients with Diabetes: A Retrospective Analysis

David Sutton et al.

ADVANCES IN THERAPY (2018)

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Article Multidisciplinary Sciences

Ionic liquids for oral insulin delivery

Amrita Banerjee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Chemistry, Multidisciplinary

Bioresponsive Microneedles with a Sheath Structure for H2O2 and pH Cascade-Triggered Insulin Delivery

Yuqi Zhang et al.

SMALL (2018)

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Article Pharmacology & Pharmacy

Examining Insulin Adsorption onto Mesoporous Silica Microparticles for Oral Delivery

Sarah Y. Eilleia et al.

CURRENT DRUG DELIVERY (2018)

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Review Endocrinology & Metabolism

Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability

A. K. J. Gradel et al.

JOURNAL OF DIABETES RESEARCH (2018)

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Article Nanoscience & Nanotechnology

Facilitated permeation of insulin across TR146 cells by cholic acid derivatives-modified elastic bilosomes

Santosh Bashyal et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Biotechnology & Applied Microbiology

Oral insulin delivery by carboxymethyl-beta-cyclodextrin-grafted chitosan nanoparticles for improving diabetic treatment

Mingming Song et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

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Review Pharmacology & Pharmacy

Considerations in the use of microneedles: pain, convenience, anxiety and safety

Hye-Rin Jeong et al.

JOURNAL OF DRUG TARGETING (2017)

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Review Pharmacology & Pharmacy

Novel strategies in the oral delivery of antidiabetic peptide drugs - Insulin, GLP 1 and its analogs

Ruba Ismail et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2017)

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Article Chemistry, Multidisciplinary

Safety and efficacy of self-assembling bubble carriers stabilized with sodium dodecyl sulfate for oral delivery of therapeutic proteins

Po-Yen Lin et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Materials Science, Biomaterials

Transdermal delivery of insulin with bioceramic composite microneedles fabricated by gelatin and hydroxyapatite

Weijiang Yu et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Article Engineering, Biomedical

Transdermal Protein Delivery Using Choline and Geranate (CAGE) Deep Eutectic Solvent

Amrita Banerjee et al.

ADVANCED HEALTHCARE MATERIALS (2017)

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Article Chemistry, Multidisciplinary

Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery

Yanqi Ye et al.

ADVANCED MATERIALS (2016)

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Article Endocrinology & Metabolism

Improved Insulin Pharmacokinetics Using a Novel Microneedle Device for Intradermal Delivery in Patients with Type 2 Diabetes

Efrat Kochba et al.

DIABETES TECHNOLOGY & THERAPEUTICS (2016)

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Article Engineering, Biomedical

Choline and Geranate Deep Eutectic Solvent as a Broad-Spectrum Antiseptic Agent for Preventive and Therapeutic Applications

Michael Zakrewsky et al.

ADVANCED HEALTHCARE MATERIALS (2016)

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Review Biotechnology & Applied Microbiology

Polymer-based nanoparticles for oral insulin delivery: Revisited approaches

Pedro Fonte et al.

BIOTECHNOLOGY ADVANCES (2015)

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Article Endocrinology & Metabolism

Inhaled Technosphere Insulin Compared With Injected Prandial Insulin in Type 1 Diabetes: A Randomized 24-Week Trial

Bruce W. Bode et al.

DIABETES CARE (2015)

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Article Endocrinology & Metabolism

Inhaled Technosphere Insulin Versus Inhaled Technosphere Placebo in Insulin-Naive Subjects With Type 2 Diabetes Inadequately Controlled on Oral Antidiabetes Agents

Julio Rosenstock et al.

DIABETES CARE (2015)

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Review Pharmacology & Pharmacy

AFREZZA® (insulin human) Inhalation Powder: A Review in Diabetes Mellitus

Esther S. Kim et al.

DRUGS (2015)

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Article Multidisciplinary Sciences

Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery

Jicheng Yu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Multidisciplinary Sciences

Ionic liquids as a class of materials for transdermal delivery and pathogen neutralization

Michael Zakrewsky et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Acoustics

Sonophoresis in transdermal drug deliverys

Donghee Park et al.

ULTRASONICS (2014)

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Review Pharmacology & Pharmacy

Devices for overcoming biological barriers: The use of physical forces to disrupt the barriers

Samir Mitragotri

ADVANCED DRUG DELIVERY REVIEWS (2013)

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Review Pharmacology & Pharmacy

Microneedles for intradermal and transdermal drug delivery

Tuan-Mazlelaa Tuan-Mahmood et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2013)

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Review Pharmacology & Pharmacy

Approaches for enhancing oral bioavailability of peptides and proteins

Jwala Renukuntla et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

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Article Multidisciplinary Sciences

Design, Synthesis of Novel Lipids as Chemical Permeation Enhancers and Development of Nanoparticle System for Transdermal Drug Delivery

Srujan Marepally et al.

PLOS ONE (2013)

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Review Pharmacology & Pharmacy

Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers

Laura M. Ensign et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

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Article Endocrinology & Metabolism

Transdermal Insulin Application System with Dissolving Microneedles

Yukako Ito et al.

DIABETES TECHNOLOGY & THERAPEUTICS (2012)

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Review Pharmacology & Pharmacy

Novel non- invasive methods of insulin delivery

Sandra Soares et al.

EXPERT OPINION ON DRUG DELIVERY (2012)

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Review Chemistry, Multidisciplinary

Recent advances in nanocarrier-based mucosal delivery of biomolecules

Olga Kammona et al.

JOURNAL OF CONTROLLED RELEASE (2012)

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Review Pharmacology & Pharmacy

Microneedles: an emerging transdermal drug delivery system

Shital H. Bariya et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2012)

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Review Cell Biology

Regulation of glucose transport by insulin: traffic control of GLUT4

Dara Leto et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

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Article Biochemistry & Molecular Biology

Transdermal delivery of insulin using a solid-in-oil nanodispersion enhanced by arginine-rich peptides

Yoshiro Tahara et al.

MEDCHEMCOMM (2012)

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Article Endocrinology & Metabolism

Rapid Pharmacokinetics of Intradermal Insulin Administered Using Microneedles in Type 1 Diabetes Subjects

Jyoti Gupta et al.

DIABETES TECHNOLOGY & THERAPEUTICS (2011)

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Article Pharmacology & Pharmacy

Preparation and evaluation of alginate-chitosan microspheres for oral delivery of insulin

Yueling Zhang et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2011)

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Article Chemistry, Multidisciplinary

Microsecond thermal ablation of skin for transdermal drug delivery

Jeong Woo Lee et al.

JOURNAL OF CONTROLLED RELEASE (2011)

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Article Dermatology

Anatomy and Physiology of the Skin

Paul A. J. Kolarsick et al.

JOURNAL OF THE DERMATOLOGY NURSES ASSOCIATION (2011)

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Article Endocrinology & Metabolism

Open-label study to assess the safety and pharmacodynamics of five oral insulin formulations in healthy subjects

R. Eldor et al.

DIABETES OBESITY & METABOLISM (2010)

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Article Endocrinology & Metabolism

A dose range finding study of novel oral insulin (IN-105) under fed conditions in type 2 diabetes mellitus subjects

A. Khedkar et al.

DIABETES OBESITY & METABOLISM (2010)

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Review Endocrinology & Metabolism

Oral insulin - a review of current status

Harish Iyer et al.

DIABETES OBESITY & METABOLISM (2010)

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Review Pharmacology & Pharmacy

Current status and the future of buccal drug delivery systems

S. Indiran Pather et al.

EXPERT OPINION ON DRUG DELIVERY (2008)

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Review Pharmacology & Pharmacy

Micro-scale devices for transdermal drug delivery

Anubhav Arora et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2008)

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Review Biotechnology & Applied Microbiology

Transdermal drug delivery

Mark R. Prausnitz et al.

NATURE BIOTECHNOLOGY (2008)

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Article Endocrinology & Metabolism

The design and performance of the Exubera® pulmonary insulin delivery system

Nancy J. Harper et al.

DIABETES TECHNOLOGY & THERAPEUTICS (2007)

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Article Pharmacology & Pharmacy

Nasal Drug Delivery System-Factors Affecting and Applications

Kisan R. Jadhav et al.

CURRENT DRUG THERAPY (2007)

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Review Biotechnology & Applied Microbiology

Inhaling medicines: delivering drugs to the body through the lungs

John S. Patton et al.

NATURE REVIEWS DRUG DISCOVERY (2007)

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Review Biochemistry & Molecular Biology

The skin barrier in healthy and diseased state

Joke A. Bouwstra et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2006)

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Article Endocrinology & Metabolism

Transdermal delivery of CaCO3-nanoparticles containing insulin

Megumu Higaki et al.

DIABETES TECHNOLOGY & THERAPEUTICS (2006)

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Review Pharmacology & Pharmacy

The use of mucoadhesive polymers in buccal drug delivery

N Salamat-Miller et al.

ADVANCED DRUG DELIVERY REVIEWS (2005)

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Article Biochemistry & Molecular Biology

Thermal dissociation and unfolding of insulin

K Huus et al.

BIOCHEMISTRY (2005)

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Article Biochemistry & Molecular Biology

Zinc-ligand interactions modulate assembly and stability of the insulin hexamer - a review

MF Dunn

BIOMETALS (2005)

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Article Endocrinology & Metabolism

Time-action profile of inhaled insulin in comparison with subcutaneously injected insulin lispro and regular human insulin

K Rave et al.

DIABETES CARE (2005)

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Article Engineering, Biomedical

Hollow metal microneedles for insulin delivery to diabetic rats

SP Davis et al.

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING (2005)

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Article Endocrinology & Metabolism

A novel per-oral insulin formulation: proof of concept study in non-diabetic subjects

M Kidron et al.

DIABETIC MEDICINE (2004)

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Review Pharmacology & Pharmacy

Iontophoretic drug delivery

YN Kalia et al.

ADVANCED DRUG DELIVERY REVIEWS (2004)

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Review Biotechnology & Applied Microbiology

Current status and future potential of transdermal drug delivery

MR Prausnitz et al.

NATURE REVIEWS DRUG DISCOVERY (2004)

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Article Pharmacology & Pharmacy

Transdermal iontophoresis of insulin: IV. Influence of chemical enhancers

O Pillai et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2004)

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Article Endocrinology & Metabolism

Efficacy and safety of inhaled insulin (Exubera) compared with subcutaneous insulin therapy in patients with type 2 diabetes - Results of a 6-month, randomized, comparative trial

PA Hollander et al.

DIABETES CARE (2004)

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Article Chemistry, Multidisciplinary

Transdermal delivery of macromolecules by erbium:YAG laser

JY Fang et al.

JOURNAL OF CONTROLLED RELEASE (2004)

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Article Endocrinology & Metabolism

Efficacy and safety of inhaled insulin (exubera) compared with subcutaneous insulin therapy in patients with type 1 diabetes -: Results of a 6-month, randomized, comparative trial

T Quattrin et al.

DIABETES CARE (2004)

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Article Chemistry, Multidisciplinary

Transdermal delivery of insulin using microneedles in vivo

W Martanto et al.

PHARMACEUTICAL RESEARCH (2004)

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Article Acoustics

Ultrasound-mediated transdermal in vivo transport of insulin with low-profile cymbal arrays

NB Smith et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2003)

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Review Chemistry, Multidisciplinary

Chitosan-based gastrointestinal delivery systems

R Hejazi et al.

JOURNAL OF CONTROLLED RELEASE (2003)

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Review Biotechnology & Applied Microbiology

Challenges for the oral delivery of macromolecules

M Goldberg et al.

NATURE REVIEWS DRUG DISCOVERY (2003)

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Article Chemistry, Multidisciplinary

Nasal drug delivery - possibilities, problems and solutions

L Illum

JOURNAL OF CONTROLLED RELEASE (2003)

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Review Pharmacology & Pharmacy

Pulmonary drug delivery. Part I: Physiological factors affecting therapeutic effectiveness of aerosolized medications

NR Labiris et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2003)

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Review Pharmacology & Pharmacy

Absorption enhancers for nasal drug delivery

SS Davis et al.

CLINICAL PHARMACOKINETICS (2003)

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Review Chemistry, Medicinal

Buccal delivery systems

JS Hao et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2003)

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Article Endocrinology & Metabolism

Technosphere (TM)/Insulin - proof of concept study with a new insulin formulation for pulmonary delivery

S Steiner et al.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2002)

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Article Chemistry, Multidisciplinary

Drug permeation enhancement via buccal route: possibilities and limitations

S Senel et al.

JOURNAL OF CONTROLLED RELEASE (2001)

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Review Pharmacology & Pharmacy

Factors and strategies for improving buccal absorption of peptides

F Veuillez et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2001)

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Article Chemistry, Multidisciplinary

Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance

C Bosquillon et al.

JOURNAL OF CONTROLLED RELEASE (2001)

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Article Medicine, General & Internal

Inhaled human insulin treatment in patients with type 2 diabetes mellitus

WT Cefalu et al.

ANNALS OF INTERNAL MEDICINE (2001)

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Review Pharmacology & Pharmacy

The biopharmaceutical aspects of nasal mucoadhesive drug delivery

MI Ugwoke et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2001)

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Article Pharmacology & Pharmacy

TR146 cells grown on filters as a model of human buccal epithelium: V. Enzyme activity of the TR146 cell culture model, human buccal epithelium and porcine buccal epithelium, and permeability of leu-enkephalin

HM Nielsen et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2000)

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Review Chemistry, Medicinal

Permeation enhancers for transdermal drug delivery

VR Sinha et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2000)

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Article Endocrinology & Metabolism

The HLA class II locus DPB1 can influence susceptibility to type 1 diabetes

JA Noble et al.

DIABETES (2000)

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