4.6 Article

Comparative analysis of the DNA methylation landscape in CD4, CD8, and B memory lineages

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling

Lucas A. Salas et al.

Summary: This study presents a deconvolution method for predicting DNA methylation levels in 12 leukocyte subtypes, expanding to include 56 immune profile variables. The accuracy of the method was validated in various applications, showing its potential for standardized investigation of immune profiles in human health and disease.

NATURE COMMUNICATIONS (2022)

Article Immunology

Whole-genome profiling of DNA methylation and hydroxymethylation identifies distinct regulatory programs among innate lymphocytes

Vincent Peng et al.

Summary: This study characterizes the whole-genome distribution of DNA methylation and hydroxymethylation in innate lymphocytes. It identifies differentially methylated and hydroxymethylated regions between NK cells, ILC2s, and ILC3s and correlates them with transcriptional signatures. The study also reveals unique patterns of DNA methylation/hydroxymethylation in relation to open chromatin regions, histone modifications, and TF-binding sites.

NATURE IMMUNOLOGY (2022)

Article Cell Biology

Defining the Molecular Hallmarks of T-Cell Memory

Caitlin C. Zebley et al.

Summary: The pool of memory CD8 T cells consists of highly specialized subpopulations of cells with both shared and distinct functions. Current research on T-cell memory focuses on how these subpopulations arise, how the cells are maintained over the host's lifespan, and how they protect the host against reinfection. However, the use of surface markers to define and study these memory T-cell subsets is proving to be inadequate, and there is a need for an updated definition using the epigenetic state of cells to better characterize the functional capacity of CD8 memory T-cell subsets.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2022)

Article Immunology

DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity

Roshni Roy et al.

Summary: This study identified lineage-specific DNA methylation signatures of six immune cell types from human peripheral blood, with PU.1 transcription factor found to be associated with lineage-specific DNA methylation. The observations suggest that innate and adaptive immune lineages are specified by distinct epigenetic mechanisms.

IMMUNITY (2021)

Article Immunology

An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy

Bassem D. Khalil et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Article Cell Biology

Loss of the orphan nuclear receptor NR2F6 enhances CD8+ T-cell memory via IFN-γ

Bojana Jakic et al.

Summary: The loss of nuclear orphan receptor NR2F6 enhances antigen-specific CD8(+) memory formation and boosts inflammatory cytokine responses in mice after bacterial infection. The enhanced memory formation is intrinsic to CD8(+) T cells and is established early in the antibacterial immune response, mediated by IFN-gamma. Blocking IFN-gamma normalizes the memory precursor cell formation, indicating potential therapeutic benefits of NR2F6 manipulation for memory CD8(+) T cell functionality.

CELL DEATH & DISEASE (2021)

Review Immunology

Transcriptional regulation of memory B cell differentiation

Brian J. Laidlaw et al.

Summary: Memory B cells play a critical role in developing protective immunity and efforts to induce broadly protective MBCs to rapidly mutating pathogens with vaccines have been unsuccessful. Understanding the signals and transcription factors regulating MBC development and function are crucial for overcoming challenges in vaccine development.

NATURE REVIEWS IMMUNOLOGY (2021)

Review Immunology

Epigenetic Regulation of T Cell Memory: Recalling Therapeutic Implications

David F. Tough et al.

TRENDS IN IMMUNOLOGY (2020)

Review Medicine, Research & Experimental

Emerging roles of non-coding RNAs in the pathogenesis of type 1 diabetes mellitus

Mohammad Taheri et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Review Biochemistry & Molecular Biology

The complex relationship between MITF and the immune system: a Melanoma ImmunoTherapy (response) Factor?

Robert Ballotti et al.

MOLECULAR CANCER (2020)

Article Cell Biology

Regulation of Mitochondrial Respiratory Chain Complex Levels, Organization, and Function by Arginyltransferase 1

Chunhua Jiang et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Biochemical Research Methods

eFORGE v2.0: updated analysis of cell type-specific signal in epigenomic data

Charles E. Breeze et al.

BIOINFORMATICS (2019)

Article Multidisciplinary Sciences

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

Yingyao Zhou et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Developmental Origin Governs CD8(+) T Cell Fate Decisions during Infection

Norah L. Smith et al.

Review Immunology

Understanding Subset Diversity in T Cell Memory

Stephen C. Jameson et al.

IMMUNITY (2018)

Review Immunology

Control of Immune Cell Homeostasis and Function by lncRNAs

Walter K. Mowel et al.

TRENDS IN IMMUNOLOGY (2018)

Review Immunology

Defining Memory CD8 T Cell

Matthew D. Martin et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

Priming of transcriptional memory responses via the chromatin accessibility landscape in T cells

Wen Juan Tu et al.

SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

Maturation-dependent expression of AIM2 in human B-cells

Alexandra Svensson et al.

PLOS ONE (2017)

Article Biotechnology & Applied Microbiology

An evaluation of processing methods for HumanMethylation450 BeadChip data

Jie Liu et al.

BMC GENOMICS (2016)

Review Multidisciplinary Sciences

Trained immunity: A program of innate immune memory in health and disease

Mihai G. Netea et al.

SCIENCE (2016)

Article Immunology

Defining CD4 T Cell Memory by the Epigenetic Landscape of CpG DNA Methylation

H. Kiyomi Komori et al.

JOURNAL OF IMMUNOLOGY (2015)

Article Genetics & Heredity

Whole-genome fingerprint of the DNA methylome during human B cell differentiation

Marta Kulis et al.

NATURE GENETICS (2015)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Review Immunology

Memory B cells

Tomohiro Kurosaki et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Article Immunology

CD4 T-Cell Memory Generation and Maintenance

David J. Gasper et al.

CRITICAL REVIEWS IN IMMUNOLOGY (2014)

Review Cell Biology

The Regulatory Role of Activating Transcription Factor 2 in Inflammation

Tao Yu et al.

MEDIATORS OF INFLAMMATION (2014)

Article Biochemistry & Molecular Biology

RAD23A negatively regulates RIG-I/MDA5 signaling through promoting TRAF2 polyubiquitination and degradation

Di-Feng Fang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Review Oncology

Review of processing and analysis methods for DNA methylation array data

C. S. Wilhelm-Benartzi et al.

BRITISH JOURNAL OF CANCER (2013)

Review Immunology

NF-κB: roles and regulation in different CD4+ T-cell subsets

Hyunju Oh et al.

IMMUNOLOGICAL REVIEWS (2013)

Article Biochemistry & Molecular Biology

Low-level processing of Illumina Infinium DNA Methylation BeadArrays

Timothy J. Triche et al.

NUCLEIC ACIDS RESEARCH (2013)

Article Neurosciences

Upregulation of CREB-Mediated Transcription Enhances Both Short- and Long-Term Memory

Akinobu Suzuki et al.

JOURNAL OF NEUROSCIENCE (2011)

Article Multidisciplinary Sciences

Accumulation of NFAT mediates IL-2 expression in memory, but not naive, CD4+ T cells

Oliver Dienz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Immunology

Notch signalling during peripheral T-cell activation and differentiation

Barbara A. Osborne et al.

NATURE REVIEWS IMMUNOLOGY (2007)

Article Multidisciplinary Sciences

Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells

CJ Luckey et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis

E Levantini et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Neurosciences

CREB required for the stability of new and reactivated fear memories

S Kida et al.

NATURE NEUROSCIENCE (2002)

Review Immunology

Effector and memory T-cell differentiation: Implications for vaccine development

SM Kaech et al.

NATURE REVIEWS IMMUNOLOGY (2002)

Review Biochemistry & Molecular Biology

The virtuoso of versatility: POU proteins that flex to fit

K Phillips et al.

JOURNAL OF MOLECULAR BIOLOGY (2000)