☆ 4.6 Review

The emerging role of epigenetic regulation in the progression of silicosis

CLINICAL EPIGENETICS (2022)

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Article Environmental Sciences

Microcrystalline silica particles induce inflammatory response via pyroptosis in primary human respiratory epithelial cells

Shangya Chen et al.

Summary: The study revealed that silica particles induce significant inflammation and pyroptosis in human primary airway epithelial cells through the NLRP3 inflammasome pathway and NF-kappa B signaling pathway, possibly mediated by miR-455-3p and five lncRNAs. These findings provide insight into the mechanism of toxicity of microcrystalline silica particles to airway epithelial cells.

ENVIRONMENTAL TOXICOLOGY (2022)

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Article Respiratory System

The methyl-CpG-binding domain 2 facilitates pulmonary fibrosis by orchestrating fibroblast to myofibroblast differentiation

Yi Wang et al.

Summary: This study reveals that DNA methylation and overexpression of MBD2 are associated with fibroblast differentiation and pulmonary fibrosis in idiopathic pulmonary fibrosis (IPF) and a mouse model. TGF-β1 induces global DNA hypermethylation and Mbd2 overexpression in a TβRI/Smad3 dependent manner, leading to repression of Erdr1 expression and promotion of fibroblast differentiation into myofibroblasts. Enhancing Erdr1 expression can significantly reverse pulmonary fibrosis.

EUROPEAN RESPIRATORY JOURNAL (2022)

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Article Public, Environmental & Occupational Health

The single nucleotide polymorphism rs1814521 in long non-coding RNA ADGRG3 associates with the susceptibility to silicosis: a multi-stage study

Wei Wang et al.

Summary: The study identified the SNP rs1814521 in lncRNA ADGRG3 as a key factor associated with susceptibility to silicosis. ADGRG3 was found to be lowly expressed in silicosis cases. Further research is needed to explore the biological mechanisms by which lncRNA ADGRG3 and rs1814521 regulate the development of silicosis.

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE (2022)

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Article Biochemistry & Molecular Biology

The Combined Effects of Circular RNA Methylation Promote Pulmonary Fibrosis

Sha Wang et al.

Summary: This study found that m(6)A-modified circRNA plays an important role in pulmonary fibrosis, participating in silica-induced fibroblast dysfunction by targeting specific proteins. The study also revealed the regulatory mechanism of METTL3 in this process.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

ALKBH5 promotes lung fibroblast activation and silica-induced pulmonary fibrosis through miR-320a-3p and FOXM1

Wenqing Sun et al.

Summary: The study finds that ALKBH5 promotes silica-induced lung fibrosis through the miR-320a-3p/FOXM1 axis or direct targeting of FOXM1. Inhibition of ALKBH5 may be effective in treating lung fibrosis.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2022)

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Article Environmental Sciences

Peripheral blood circular RNA hsa_circ_0058493 as a potential novel biomarker for silicosis and idiopathic pulmonary fibrosis

Zhounan Cheng et al.

Summary: Existing studies have shown that certain circular RNAs (circRNAs) play important roles in the development of pulmonary fibrosis. This study aimed to explore the potential of circRNAs as biomarkers for diagnosing silicosis and idiopathic pulmonary fibrosis (IPF) using a population data approach. The results identified hsa_circ_0058493 as a potential novel biomarker for diagnosing silicosis and IPF.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

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Article Integrative & Complementary Medicine

m6A RNA Methylation Regulators Contribute to Predict and as a Therapy Target of Pulmonary Fibrosis

Meng-Sheng Deng et al.

Summary: Finding new biomarkers and drug treatment targets is crucial for the diagnosis and treatment of pulmonary fibrosis. This study explored the potential of m6A methylation regulator METTL3 as a diagnostic marker and drug target for early pulmonary fibrosis. The results showed that METTL3 can predict the occurrence and development of pulmonary fibrosis and has lower expression in fibrotic lungs.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Review Genetics & Heredity

Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation

Ryan L. Kan et al.

Summary: Epigenetic modifications play a crucial role in gene expression regulation through modifications on genomic DNA, histones, and more recently, mRNA. These modifications, especially the common N6-methyladenosine (m6A) methylation, not only influence RNA stability and translation efficiency, but also interact with histone/DNA epigenetic mechanisms to specify transcriptional outputs and recruit chromatin modifiers. This review focuses on dissecting the feedback circuits orchestrated by m6A, which regulate histone modifications and the activity of regulatory RNAs, such as long noncoding RNA and chromosome-associated regulatory RNA. The evidence suggests that m6A acts as a versatile checkpoint linking different layers of gene regulation.

TRENDS IN GENETICS (2022)

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Article Pharmacology & Pharmacy

LncRNA UCA1 regulates silicosis-related lung epithelial cell-to-mesenchymal transition through competitive adsorption of miR-204-5p

Guo Yang et al.

Summary: This study observed the changes and effects of UCA1 and miR-204-5p in silica-induced mouse silicosis model and in vitro EMT model of A549 cells. It was found that both models showed the presence of EMT process, and UCA1 was upregulated in the in vitro model. Silencing UCA1 inhibited EMT process, while intervention of miR-204-5p regulated EMT.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2022)

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Article Toxicology

Mechanism of LncRNA XIST/miR-101-3p/ZEB1 axis in EMT associated with silicosis

Chao Li et al.

Summary: This study reveals that LncRNA XIST can regulate the expression of miR-101-3p and up-regulate ZEB1, thereby promoting the EMT process of alveolar epithelial cells in silicosis-related pulmonary fibrosis EMT.

TOXICOLOGY LETTERS (2022)

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Article Pharmacology & Pharmacy

Macrophage derived miR-7219-3p-containing exosomes mediate fibroblast trans-differentiation by targeting SPRY1 in silicosis

Zhiyuan Niu et al.

Summary: Silicosis is a serious occupational disease characterized by inflammation, fibroblast activation, and extracellular matrix deposition in the lung. Macrophage-derived exosomes have been found to play a role in the development of silicosis by transferring microRNAs (miRNAs). In this study, the researchers identified the up-regulation of miR-7219-3p in both macrophages and their exosomes after silica exposure, as well as in a silicotic mice model. They found that miR-7219-3p promoted fibroblast to myofibroblast trans-differentiation, cell proliferation, and migration. The target gene of miR-7219-3p, Spouty1 (SPRY1), was confirmed to modulate the Ras/ERK/MAPK signaling pathway, and manipulating SPRY1 expression affected fibroblast to myofibroblast trans-differentiation via this pathway. Inhibition of exosomal miR-7219-3p partially suppressed fibroblast to myofibroblast trans-differentiation and silica-induced pulmonary fibrosis. These findings suggest that exosomal miR-7219-3p could be a potential therapeutic target for silicosis.

TOXICOLOGY (2022)

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Review Oncology

Noncoding RNAs regulate alternative splicing in Cancer

Yunze Liu et al.

Summary: AS and ncRNAs play crucial roles in cancer by influencing the development of various diseases, especially in different aspects of cancer progression. Acting as regulatory molecules, ncRNAs can affect cell signaling pathways by influencing AS, thus impacting cancer progression.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Environmental Sciences

Long non-coding RNA SNHG1 promotes fibroblast-to-myofibroblast transition during the development of pulmonary fibrosis induced by silica particles exposure

Qiuyun Wu et al.

Summary: Inhaling silica dust can lead to pulmonary fibrosis and silicosis, which is the most harmful occupational disease. Long non-coding RNA lnc-SNHG1 was found to be highly expressed in fibrotic lung tissues and TGF-beta 1-treated fibroblasts, promoting fibroblast migration, invasion, and fibrotic molecule secretion. It was discovered that lnc-SNHG1 may regulate pulmonary fibrosis through the miR-326/SP1 axis.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

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Article Toxicology

Long non-coding RNA expression in silicosis and MRAK050699 function in epithelial-mesenchymal transition

Fa-Xuan Wang et al.

Summary: Silicosis is a lung fibrotic disease caused by chronic silica exposure, and differential expression of lncRNAs is related to its development, with MRAK050699 playing a crucial role in epithelial-mesenchymal transition.

HUMAN & EXPERIMENTAL TOXICOLOGY (2021)

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Article Pharmacology & Pharmacy

Long noncoding RNA-SNHG20 promotes silica-induced pulmonary fibrosis by miR-490-3p/TGFBR1 axis

Demin Cheng et al.

Summary: Silicosis is a common occupational disease caused by long-term exposure to crystalline silica. Recent studies have shown the important role of miR-490-3p in silica-induced pulmonary fibrosis by regulating TGFBR1 gene. The results suggest that the SNHG20/miR-490-3p/TGFBR1 axis may serve as a new therapeutic target for pulmonary fibrosis.

TOXICOLOGY (2021)

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Article Oncology

Anti-fibrotic effects and the mechanism of action of miR-29c in silicosis

Lei Huang et al.

Summary: The study revealed that miR-29c plays a significant role in anti-fibrosis in pulmonary silicosis, with its expression levels being downregulated. Exposure to silica increased the expression levels of COL1 alpha 1, COL3 alpha 1, alpha-SMA, and TGF-beta 1. MiR-29c regulates the expression of these fibrosis-related genes to different extents.

MOLECULAR MEDICINE REPORTS (2021)

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Article Environmental Sciences

miR-770-5p inhibits the activation of pulmonary fibroblasts and silica-induced pulmonary fibrosis through targeting TGFBR1

Jiali Yuan et al.

Summary: This study found that miR-770-5p is downregulated in silica-induced pulmonary fibrosis and exerts an anti-fibrotic effect by targeting TGFBR1. Experimental evidence showed that miR-770-5p can reduce fibrotic lesions and control the activation of pulmonary fibroblasts.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

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Article Ophthalmology

The potential role of m6A RNA methylation in diabetic retinopathy

Nidhi Kumari et al.

Summary: Diabetic retinopathy, a major microvascular complication of diabetes affecting most individuals, may potentially involve the modification of RNA through m6A in disease progression mechanisms, although its specific role remains unclear.

EXPERIMENTAL EYE RESEARCH (2021)

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Article Cell Biology

LncRNA-ATB regulates epithelial-mesenchymal transition progression in pulmonary fibrosis via sponging miR-29b-2-5p and miR-34c-3p

Qi Xu et al.

Summary: The dysregulation of non-coding RNAs, particularly lncRNA-ATB and its downstream targets miR-29b-2-5p and miR-34c-3p, plays a crucial role in regulating EMT and fibrosis in pulmonary diseases. Overexpression of miR-29b-2-5p or miR-34c-3p can inhibit EMT progression and counteract the pro-fibrotic effects of lncRNA-ATB, providing potential therapeutic targets for pulmonary fibrosis.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Review Biochemical Research Methods

Transcription factors: Bridge between cell signaling and gene regulation

Paula Weidemuller et al.

Summary: This review discusses the role of transcription factors as a link between signaling pathways and gene regulation. TFs play a crucial role in modulating cell transcriptional programs, but there are technical and conceptual challenges in measuring TF activity. Many TFs are understudied in research, leading to a bias in our knowledge of known TF targets. TFs act as a bridge between the fields of gene regulation and signaling, and separating these fields impedes our understanding of cell functions.

PROTEOMICS (2021)

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Article Biochemistry & Molecular Biology

CircHIPK3 regulates pulmonary fibrosis by facilitating glycolysis in miR-30a-3p/FOXK2-dependent manner

Qi Xu et al.

Summary: Glycolysis is associated with pulmonary fibrosis, and the circHIPK3/miR-30a-3p/FOXK2 regulatory pathway plays a crucial role in promoting fibrosis.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Non-coding RNA regulatory networks

Simona Panni et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2020)

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Review Biochemistry & Molecular Biology

Role of Mammalian DNA Methyltransferases in Development

Zhiyuan Chen et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 89 (2020)

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Article Cardiac & Cardiovascular Systems

Changes in m6A RNA methylation contribute to heart failure progression by modulating translation

Tea Berulava et al.

EUROPEAN JOURNAL OF HEART FAILURE (2020)

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Article Oncology

MiR-411-3p alleviates Silica-induced pulmonary fibrosis by regulating Smurf2/TGF-β signaling

Xuemin Gao et al.

EXPERIMENTAL CELL RESEARCH (2020)

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Article Biochemistry & Molecular Biology

The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation

Tao Liu et al.

NUCLEIC ACIDS RESEARCH (2020)

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Article Medicine, Research & Experimental

Differential expression of lncRNAs during silicosis and the role of LOC103691771 in myofibroblast differentiation induced by TGF-β1

Wenchen Cai et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Medicine, Research & Experimental

Inhibition of miR-155-5p Exerts Anti-Fibrotic Effects in Silicotic Mice by Regulating Meprin α

Yingying Chen et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Cell Biology

HOTAIR/miR-125 axis-mediated Hexokinase 2 expression promotes chemoresistance in human glioblastoma

Jinnan Zhang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Medicine, Research & Experimental

Elk-1 transcriptionally regulates ZC3H4 expression to promote silica-induced epithelial-mesenchymal transition

Rong Jiang et al.

LABORATORY INVESTIGATION (2020)

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Article Public, Environmental & Occupational Health

Trends in global, regional and national incidence of pneumoconiosis caused by different aetiologies: an analysis from the Global Burden of Disease Study 2017

Peng Shi et al.

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2020)

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Review Medicine, Research & Experimental

Role of m6A RNA methylation in cardiovascular disease (Review)

Yuhan Qin et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2020)

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Article Cell Biology

miR-34a-5p Attenuates EMT through targeting SMAD4 in silica-induced pulmonary fibrosis

Yuanmeng Qi et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Review Biology

Beyond the RNA-dependent function of LncRNA genes

Tamer Ali et al.

ELIFE (2020)

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Article Biochemistry & Molecular Biology

A Landscape of lncRNA Expression Profile and the Predictive Value of a Candidate lncRNA for Silica-Induced Pulmonary Fibrosis

Xiaohong Lei et al.

DNA AND CELL BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Circular RNA: metabolism, functions and interactions with proteins

Wei-Yi Zhou et al.

MOLECULAR CANCER (2020)

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Article Biochemistry & Molecular Biology

Epigenetic alterations in cancer

Suganya Ilango et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2020)

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Review Biotechnology & Applied Microbiology

Histone methylation and the DNA damage response

Fade Gong et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2019)

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Article Environmental Sciences

Dust induces lung fibrosis through dysregulated DNA methylation

Na Zhang et al.

ENVIRONMENTAL TOXICOLOGY (2019)

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Article Medicine, Research & Experimental

MicroRNA-29b Mediates Lung Mesenchymal-Epithelial Transition and Prevents Lung Fibrosis in the Silicosis Model

Jingping Sun et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

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Review Medicine, Research & Experimental

The role of m6A RNA methylation in cancer

Ting Sun et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Review Biochemistry & Molecular Biology

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

Hailing Shi et al.

MOLECULAR CELL (2019)

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Review Biochemistry & Molecular Biology

Epidrugs: targeting epigenetic marks in cancer treatment

Cristiana Libardi Miranda Furtado et al.

EPIGENETICS (2019)

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Review Respiratory System

Silica-associated lung disease: An old-world exposure in modern industries

Hayley Barnes et al.

RESPIROLOGY (2019)

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Article Toxicology

Profiling long non-coding RNA changes in silica-induced pulmonary fibrosis in rat

Linlin Sai et al.

TOXICOLOGY LETTERS (2019)

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Article Chemistry, Medicinal

MiR-326 Inhibits Inflammation and Promotes Autophagy in Silica-Induced Pulmonary Fibrosis through Targeting TNFSF14 and PTBP1

Tiantian Xu et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2019)

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Review Rheumatology

Shared and distinct mechanisms of fibrosis

Joerg H. W. Distler et al.

NATURE REVIEWS RHEUMATOLOGY (2019)

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Review Biochemistry & Molecular Biology

Deciphering miRNAs' Action through miRNA Editing

Marta Correia de Sousa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

CircRNA-012091/PPP1R13B-mediated Lung Fibrotic Response in Silicosis via Endoplasmic Reticulum Stress and Autophagy

Yusi Chang et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2019)

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Article Pharmacology & Pharmacy

CircHECTD1 mediates pulmonary fibroblast activation via HECTD1

Han Chu et al.

THERAPEUTIC ADVANCES IN CHRONIC DISEASE (2019)

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Article Biochemistry & Molecular Biology

MODOMICS: a database of RNA modification pathways. 2017 update

Pietro Boccaletto et al.

NUCLEIC ACIDS RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Long non-coding RNA-ATB promotes EMT during silica-induced pulmonary fibrosis by competitively binding miR-200c

Yi Liu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

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Article Biochemistry & Molecular Biology

Silica-induced initiation of circular ZC3H4 RNA/ZC3H4 pathway promotes the pulmonary macrophage activation

Xiyue Yang et al.

FASEB JOURNAL (2018)

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Review Oncology

Multiple functions of m(6)A RNA methylation in cancer

Yutian Pan et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

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Article Public, Environmental & Occupational Health

MiRNA-Regulated Changes in Extracellular Matrix Protein Levels Associated With a Severe Decline in Lung Function Induced by Silica Dust

Yi Rong et al.

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2018)

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Review Oncology

Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury

Anubhav Chakraborty et al.

ANALYTICAL CELLULAR PATHOLOGY (2018)

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Article Cell Biology

circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1

Shencun Fang et al.

CELL DEATH & DISEASE (2018)

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Article Medicine, Research & Experimental

circRNA Mediates Silica-Induced Macrophage Activation Via HECTD1/ZC3H12A-Dependent Ubiquitination

Zewei Zhou et al.

THERANOSTICS (2018)

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Article Toxicology

The CDR1as/miR-7/TGFBR2 Axis Modulates EMT in Silica-Induced Pulmonary Fibrosis

Wenxi Yao et al.

TOXICOLOGICAL SCIENCES (2018)

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Article Biochemistry & Molecular Biology

miR-542-5p Attenuates Fibroblast Activation by Targeting Integrin α6 in Silica-Induced Pulmonary Fibrosis

Jiali Yuan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Oncology

Non-coding RNAs as regulators in epigenetics

Jian-Wei Wei et al.

ONCOLOGY REPORTS (2017)

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Article Biochemistry & Molecular Biology

miR-1224-5p Mediates Mitochondrial Damage to Affect Silica-Induced Pulmonary Fibrosis by Targeting BECN1

Qiuyun Wu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Review Biochemistry & Molecular Biology

The RNA modification landscape in human disease

Nicky Jonkhout et al.

RNA (2017)

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Article Cell Biology

circHIPK2-mediated σ-1R promotes endoplasmic reticulum stress in human pulmonary fibroblasts exposed to silica

Zhouli Cao et al.

CELL DEATH & DISEASE (2017)

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Article Multidisciplinary Sciences

MiR-503 modulates epithelial-mesenchymal transition in silica-induced pulmonary fibrosis by targeting PI3K p85 and is sponged by lncRNA MALAT1

Weiwen Yan et al.

SCIENTIFIC REPORTS (2017)

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Article Cell Biology

MALAT1 Modulates TGF-beta 1 nduced Endothelial-to-Mesenchymal Transition through Downregulation of miR-145

Yin Xiang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)

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Article Respiratory System

Genome-wide DNA methylation analysis in lung fibroblasts co-cultured with silica-exposed alveolar macrophages

Juan Li et al.

RESPIRATORY RESEARCH (2017)

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Article Anatomy & Morphology

Down-Regulation of miR-19a as a Biomarker for Early Detection of Silicosis

Zhen Yang et al.

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2016)

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Article Genetics & Heredity

MiR-449a regulates autophagy to inhibit silica-induced pulmonary fibrosis through targeting Bcl2

Ruhui Han et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2016)

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Article Multidisciplinary Sciences

miR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF

Qiuyun Wu et al.

SCIENTIFIC REPORTS (2016)

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Article Respiratory System

Global DNA methylation and PTEN hypermethylation alterations in lung tissues from human silicosis

Xianan Zhang et al.

JOURNAL OF THORACIC DISEASE (2016)

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Article Immunology

Silica, Silicosis, and Autoimmunity

Kenneth Michael Pollard

FRONTIERS IN IMMUNOLOGY (2016)

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Article Biochemistry & Molecular Biology

Plasma LncRNA-ATB, a Potential Biomarker for Diagnosis of Patients with Coal Workers' Pneumoconiosis: A Case-Control Study

Jixuan Ma et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Environmental Sciences

Blocking TGF-β expression inhibits silica particle-induced epithelial-mesenchymal transition in human lung epithelial cells

Yi Rong et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2015)

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Review Cell Biology

RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation

Yanan Yue et al.

GENES & DEVELOPMENT (2015)

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Article Oncology

Roles of microRNA-146a and microRNA-181b in regulating the secretion of tumor necrosis factor-α and interleukin-1β in silicon dioxide-induced NR8383 rat macrophages

Yang Zhang et al.

MOLECULAR MEDICINE REPORTS (2015)

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Review Cell Biology

Emerging Concept in DNA Methylation: Role of Transcription Factors in Shaping DNA Methylation Patterns

Claire Marchal et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2015)

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Article Multidisciplinary Sciences

The Anti-fibrotic Effects and Mechanisms of MicroRNA-486-5p in Pulmonary Fibrosis

Xiaoming Ji et al.

SCIENTIFIC REPORTS (2015)

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Review Immunology

Impaired DNA methylation and its mechanisms in CD4+T cells of systemic lupus erythematosus

Yiqun Zhang et al.

JOURNAL OF AUTOIMMUNITY (2013)

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Review Biochemistry & Molecular Biology

Epigenetics: The link between nature and nurture

Stephanie A. Tammen et al.

MOLECULAR ASPECTS OF MEDICINE (2013)

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Article Pathology

Participation of miR-200 in Pulmonary Fibrosis

Shanzhong Yang et al.

AMERICAN JOURNAL OF PATHOLOGY (2012)

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Article Biochemistry & Molecular Biology

被撤回的出版物: miR-31 is a negative regulator of fibrogenesis and pulmonary fibrosis (Retracted article. See vol. 27, pg. 843, 2013)

Shanzhong Yang et al.

FASEB JOURNAL (2012)

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Article Toxicology

Altered microRNAs expression profiling in experimental silicosis rats

Wang Faxuan et al.

JOURNAL OF TOXICOLOGICAL SCIENCES (2012)

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Article Biotechnology & Applied Microbiology

miR-29 Inhibits Bleomycin-induced Pulmonary Fibrosis in Mice

Jun Xiao et al.

MOLECULAR THERAPY (2012)

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Review Genetics & Heredity

Histone methylation: a dynamic mark in health, disease and inheritance

Eric L. Greer et al.

NATURE REVIEWS GENETICS (2012)

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Article Obstetrics & Gynecology

Epigenetics and the placenta

Ewka C. M. Nelissen et al.

HUMAN REPRODUCTION UPDATE (2011)

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Review Genetics & Heredity

Non-coding RNAs in human disease

Manel Esteller

NATURE REVIEWS GENETICS (2011)

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Article Oncology

Aberrant promoter hypermethylation in serum DNA from patients with silicosis

Shigeki Umemura et al.

CARCINOGENESIS (2008)

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Article Respiratory System

An epidemic of silicosis among former denim sandblasters

M. Akgun et al.

EUROPEAN RESPIRATORY JOURNAL (2008)

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Article Medicine, General & Internal

Silicosis: A review

Michael I. Greenberg et al.

DM DISEASE-A-MONTH (2007)

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Article Cell Biology

MicroRNAs - Critical regulators of development, cellular physiology and malignancy

JT Mendell

CELL CYCLE (2005)

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Review Genetics & Heredity

Micrornas: Small RNAs with a big role in gene regulation

L He et al.

NATURE REVIEWS GENETICS (2004)

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