Facile fabrication of two-dimensional iodine nanosheets for antibacterial therapy

Herein, we report a facile approach for the preparation of two-dimensional iodine nanosheets (2D iodine NSs) with good stability and high biocompatibility via an aqueous solvent-assisted ultrasonic route. Due to the large specific surface area of the 2D morphology, iodine NSs effectively interact with bacterial membranes and destroy bacterial integrity, as well as further damaging intracellular DNA, showing prominent antibacterial activity against S. aureus in vitro and in vivo.

Automated summary

In this study, a simple method is reported to prepare two-dimensional iodine nanosheets (2D iodine NSs) with good stability and high biocompatibility using an aqueous solvent-assisted ultrasonic route. Due to the large specific surface area of the 2D morphology, iodine NSs effectively interact with bacterial membranes, leading to the destruction of bacterial integrity and further damage to intracellular DNA. Consequently, the iodine NSs exhibit significant antibacterial activity against S. aureus both in vitro and in vivo.