期刊
ANNUAL REVIEW OF ANIMAL BIOSCIENCES
卷 11, 期 -, 页码 93-114出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-animal-080522-093311
关键词
deleterious mutations; conservation biology; genetic load; inbreeding depression; simulations
Deleterious mutations decrease reproductive fitness and are widespread in genomes. Understanding the impact of such mutations on extinction risk is important for conservation management strategies. This article discusses quantifying deleterious variation, the effect of population history on such variation, and provides guidance on studying deleterious variation in nonmodel populations of conservation concern.
Deleterious mutations decrease reproductive fitness and are ubiquitous in genomes. Given that many organisms face ongoing threats of extinction, there is interest in elucidating the impact of deleterious variation on extinction risk and optimizing management strategies accounting for such mutations. Quantifying deleterious variation and understanding the effects of population history on deleterious variation are complex endeavors because we do not know the strength of selection acting on each mutation. Further, the effect of demographic history on deleterious mutations depends on the strength of selection against the mutation and the degree of dominance. Here we clarify how deleterious variation can be quantified and studied in natural populations. We then discuss how different demographic factors, such as small population size, nonequilibrium population size changes, inbreeding, and gene flow, affect deleterious variation. Lastly, we provide guidance on studying deleterious variation in nonmodel populations of conservation concern.
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