期刊
WILEY INTERDISCIPLINARY REVIEWS-RNA
卷 14, 期 4, 页码 -出版社
WILEY
DOI: 10.1002/wrna.1767
关键词
cardiovascular diseases; endoplasmic reticulum stress; non-coding RNA; unfolded protein response
类别
In this review, the interplay regulation of endoplasmic reticulum stress and non-coding RNAs in cardiovascular disease is discussed, providing further insights into the understanding and therapeutic strategies of cardiovascular disease.
Cells are exposed to various pathological stimulus within the cardiovascular system that challenge cells to adapt and survive. Several of these pathological stimulus alter the normal function of the endoplasmic reticulum (ER), leading to the accumulation of unfolded and misfolded proteins, thus triggering the unfolded protein response (UPR) to cope with the stress or trigger apoptosis of damaged cells. Downstream components of the UPR regulate transcription and translation reprogramming to ensure selective gene expression in response to pathological stimulus, including the expression of non-coding RNAs (ncRNAs). The ncRNAs play crucial roles in regulating transcription and translation, and their aberrant expression is associated with the development of cardiovascular disease (CVD). Notably, ncRNAs and ER stress can modulate each other and synergistically affect the development of CVD. Therefore, studying the interaction between ER stress and ncRNAs is necessary for effective prevention and treatment of CVD. In this review, we discuss the UPR signaling pathway and ncRNAs followed by the interplay regulation of ER stress and ncRNAs in CVD, which provides further insights into the understanding of the pathogenesis of CVD and therapeutic strategies.This article is categorized under:RNA in Disease and Development > RNA in Disease
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据