期刊
POLYMERS
卷 14, 期 22, 页码 -出版社
MDPI
DOI: 10.3390/polym14224886
关键词
polylactide; collagen; surface modification; plasma treatment; biocompatibility
资金
- RFBR [18-32-00901]
- Russian Science Foundation [18-15-00401]
- Joint Research Center Materials science and metallurgy of NUST MISiS [075-15-2021-696]
This study compares the effects of different methods of collagen deposition on polylactide films in terms of surface chemical structure, morphology, hydrophilicity, and the ability to support adhesion and growth of human mesenchymal stromal cells.
Enhancement of cell adhesion and growth on surface of the biodegradable materials is one of the important tasks in development of materials for regenerative medicine. This work focuses on comparison of various methods of collagen coating deposition onto polylactide films, aiming to increase their biocompatibility with human mesenchymal stromal cells. The collagen deposition was realized using either preliminary plasma treatment of the polylactide films or pre-swelling in solvent mixture. These techniques were compared in terms of the effect on the surface's chemical structure, morphology, hydrophilicity and ability to support adhesion and growth of human mesenchymal stromal cells.
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