☆ 4.6 Article

The first genetic engineered system for ovothiol biosynthesis in diatoms reveals a mitochondrial localization for the sulfoxide synthase OvoA

OPEN BIOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

The first genetic engineered system for ovothiol biosynthesis in diatoms reveals a mitochondrial localization for the sulfoxide synthase OvoA

Monia Teresa Russo et al.

Summary: Diatoms are abundant microalgae in the ocean and can fix 20% of CO2 on Earth. They have molecular biodiversity and unique metabolic activities, making them potential biofactories. They produce ovothiols, which have antioxidant and anti-inflammatory properties. The functional role of ovothiol biosynthesis in organisms is still largely unknown.

OPEN BIOLOGY (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ovothiol ensures the correct developmental programme of the sea urchin Paracentrotus lividus embryo

Alfonsina Milito et al.

Summary: This study investigates the biological relevance of ovothiol during sea urchin embryogenesis and the inflammatory response. It suggests that ovothiol may regulate cell proliferation in early developing embryos and play a key role in larval skeleton formation and inflammatory processes triggered by bacterial infection.

OPEN BIOLOGY (2022)

添加到收藏夹

Article Chemistry, Medicinal

A Survey on the Distribution of Ovothiol and ovoA Gene Expression in Different Tissues and Cells: A Comparative Analysis in Sea Urchins and Mussels

Carola Murano et al.

Summary: This study compares the biosynthesis of ovothiols in sea urchins and mussels, identifying the tissues and cells that produce the compound and highlighting similarities and differences between the two species. By improving our understanding of the biological roles of ovothiols and identifying sustainable natural sources, this study lays the foundation for future biotechnological investigations on these valuable compounds.

MARINE DRUGS (2022)

添加到收藏夹

Review Engineering, Marine

Microalgae-Based PUFAs for Food and Feed: Current Applications, Future Possibilities, and Constraints

Anna Santin et al.

Summary: Microalgae are considered valuable sources of compounds such as PUFAs for human and animal consumption. Culturing microalgae in open ponds is a common method for production, but it is more susceptible to contamination and lacks reproducibility. Genetic engineering techniques have improved, allowing for modified microalgae to accumulate specific compounds. However, these modified strains should be cultured in closed photobioreactors to minimize contamination and achieve higher yields. This review provides information on microalgae-derived commodities, with a focus on PUFAs, and discusses the challenges and possible solutions for large-scale production.

JOURNAL OF MARINE SCIENCE AND ENGINEERING (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

First evidence of dermo-protective activity of marine sulfur-containing histidine compounds

Mariarita Brancaccio et al.

Summary: The use of ovothiol (ovo) and 5-thiohistidine (5-thio) in skin cells and tissues can reduce inflammation, providing skin protection and preventing inflammatory conditions caused by environmental stress and aging.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Highly Valuable Polyunsaturated Fatty Acids from Microalgae: Strategies to Improve Their Yields and Their Potential Exploitation in Aquaculture

Anna Santin et al.

Summary: Microalgae show great potential in the production of healthy food and feed supplements, with a focus on polyunsaturated fatty acids (PUFAs). Research is centered on improving PUFAs production in microalgae through selecting the best species and strains, optimizing culturing conditions, and utilizing genetic and metabolic engineering techniques. Biotechnological applications of PUFAs from microalgae, such as aquafeed and food ingredients, are discussed, along with techniques for extraction and purification.

MOLECULES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells

Ying Wang et al.

Summary: SLC25A39 is identified as a regulator of GSH transport into mitochondria, and its loss affects mitochondrial GSH import and abundance without impacting cellular GSH levels. Its absence also leads to defects in the activity and stability of proteins containing iron-sulfur clusters, and mitochondrial GSH import is found to be essential for cell proliferation and red blood cell development.

NATURE (2021)

添加到收藏夹

Review Environmental Sciences

Diatoms Biotechnology: Various Industrial Applications for a Greener Tomorrow

Nikunj Sharma et al.

Summary: Microalgae like diatoms, known for their complex microscopic structure, have recently surprised the scientific community with their industrial potential. Advances in microscopy, metabarcoding, analytical and genetic tools have significantly increased the prospect of using diatoms for various industrial applications such as pharmaceuticals, nanotechnology, and energy sources, leading to a sustainable economy.

FRONTIERS IN MARINE SCIENCE (2021)

添加到收藏夹

Article Evolutionary Biology

Metabolic Adaptations to Marine Environments: Molecular Diversity and Evolution of Ovothiol Biosynthesis in Bacteria

Mariarita Brancaccio et al.

Summary: Research identified the distribution of ovothiol biosynthetic enzymes in bacteria through genomic and metagenomic data mining. These enzymes are mainly found in marine aerobic Proteobacteria, some of which establish relationships with other organisms. A horizontal gene transfer event of ovothiol biosynthetic enzymes was also discovered.

GENOME BIOLOGY AND EVOLUTION (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Kinetic Studies of Antioxidant Properties of Ovothiol A

Nataliya A. Osik et al.

Summary: Ovothiol A (OSH) is identified as a potent natural antioxidant with exceptional properties in neutralizing oxidants and photoprotection. It acts synergistically with glutathione GSH in biological systems. The findings suggest promising prospects for the use of OSH in the treatment of human diseases.

ANTIOXIDANTS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

First evidence of ovothiol biosynthesis in marine diatoms

Alfonsina Milito et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Phaeodactylum tricornutum: A Diatom Cell Factory

Thomas Butler et al.

TRENDS IN BIOTECHNOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Gametogenesis-Related Fluctuations in Ovothiol Levels in the Mantle of Mussels from Different Estuaries: Fighting Oxidative Stress for Spawning in Polluted Waters

Oihane Diaz de Cerio et al.

BIOMOLECULES (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Metabolic Engineering Strategies in Diatoms Reveal Unique Phenotypes and Genetic Configurations With Implications for Algal Genetics and Synthetic Biology

Jestin George et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Comprehensive and Functional Analysis of Horizontal Gene Transfer Events in Diatoms

Emmelien Vancaester et al.

MOLECULAR BIOLOGY AND EVOLUTION (2020)

添加到收藏夹

Article Chemistry, Medicinal

Insights into the Light Response ofSkeletonema marinoi: Involvement of Ovothiol

Alfonsina Milito et al.

MARINE DRUGS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Sulfur-containing histidine compounds inhibit γ-glutamyl transpeptidase activity in human cancer cells

Mariarita Brancaccio et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

添加到收藏夹

Article Biology

The complex evolutionary history of sulfoxide synthase in ovothiol biosynthesis

Marco Gerdol et al.

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Current trends to comprehend lipid metabolism in diatoms

Nodumo Nokulunga Zulu et al.

PROGRESS IN LIPID RESEARCH (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

On ovothiol biosynthesis and biological roles: from life in the ocean to therapeutic potential

Immacolata Castellano et al.

NATURAL PRODUCT REPORTS (2018)

添加到收藏夹

Review Plant Sciences

Genome editing in diatoms: achievements and goals

Peter G. Kroth et al.

PLANT CELL REPORTS (2018)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Enhanced triacylglycerol production in the diatom Phaeodactylum tricornutum by inactivation of a Hotdog-fold thioesterase gene using TALEN-based targeted mutagenesis

Xiahui Hao et al.

BIOTECHNOLOGY FOR BIOFUELS (2018)

添加到收藏夹

Article Cell Biology

Antifibrotic Effect of Marine Ovothiol in an In Vivo Model of Liver Fibrosis

Mariarita Brancaccio et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Oil and eicosapentaenoic acid production by the diatom Phaeodactylum tricornutum cultivated outdoors in Green Wall Panel (GWP®) reactors

Liliana Rodolfi et al.

BIOTECHNOLOGY AND BIOENGINEERING (2017)

添加到收藏夹

Article Chemistry, Organic

Short protecting-group-free synthesis of 5-acetylsulfanyl-histidines in water: novel precursors of 5-sulfanyl-histidine and its analogues

Sylvain Daunay et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2016)

添加到收藏夹

Review Plant Sciences

Evolution of the diatoms: major steps in their evolution and a review of the supporting molecular and morphological evidence

Linda K. Medlin

PHYCOLOGIA (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Shedding light on ovothiol biosynthesis in marine metazoans

Immacolata Castellano et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Genetics & Heredity

The upstream regulatory sequence of the light harvesting complex Lhcf2 gene of the marine diatom Phaeodactylum tricornutum enhances transcription in an orientation- and distance-independent fashion

Monia Teresa Russo et al.

MARINE GENOMICS (2015)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Genetic improvement of the microalga Phaeodactylum tricornutum for boosting neutral lipid accumulation

Jiao Xue et al.

METABOLIC ENGINEERING (2015)

添加到收藏夹

Article Biochemical Research Methods

MitoFates: Improved Prediction of Mitochondrial Targeting Sequences and Their Cleavage Sites

Yoshinori Fukasawa et al.

MOLECULAR & CELLULAR PROTEOMICS (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

The transcriptome of Euglena gracilis reveals unexpected metabolic capabilities for carbohydrate and natural product biochemistry

Ellis C. O'Neill et al.

MOLECULAR BIOSYSTEMS (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Energetic coupling between plastids and mitochondria drives CO2 assimilation in diatoms

Benjamin Bailleul et al.

NATURE (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Designer diatom episomes delivered by bacterial conjugation

Bogumil J. Karas et al.

NATURE COMMUNICATIONS (2015)

添加到收藏夹

Article Chemistry, Medicinal

Ovothiol Isolated from Sea Urchin Oocytes Induces Autophagy in the Hep-G2 Cell Line

Gian Luigi Russo et al.

MARINE DRUGS (2014)

添加到收藏夹

Article Multidisciplinary Sciences

A New and Improved Host-Independent Plasmid System for RK2-Based Conjugal Transfer

Trine Aakvik Strand et al.

PLOS ONE (2014)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Diatoms: a fossil fuel of the future

Orly Levitan et al.

TRENDS IN BIOTECHNOLOGY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Genome engineering empowers the diatom Phaeodactylum tricornutum for biotechnology

Fayza Daboussi et al.

NATURE COMMUNICATIONS (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Glutathione and γ-glutamylcysteine in the antioxidant and survival functions of mitochondria

Ruben Quintana-Cabrera et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Thiohistidine Biosynthesis

Florian P. Seebeck

CHIMIA (2013)

添加到收藏夹

Article Chemistry, Organic

Regioselectivity of the Oxidative C-S Bond Formation in Ergothioneine and Ovothiol Biosyntheses

Heng Song et al.

ORGANIC LETTERS (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Identification and Characterization of the First Ovothiol Biosynthetic Enzyme

Andrea Braunshausen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

添加到收藏夹

Article Multidisciplinary Sciences

The Phaeodactylum genome reveals the evolutionary history of diatom genomes

Chris Bowler et al.

NATURE (2008)

添加到收藏夹

Article Genetics & Heredity

Molecular toolbox for studying diatom biology in Phaeodactylum tricornutum

Magali Siaut et al.

GENE (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

WoLF PSORT: protein localization predictor

Paul Horton et al.

NUCLEIC ACIDS RESEARCH (2007)

添加到收藏夹

Article Neurosciences

Potent mammalian cerebroprotection and neuronal cell death inhibition are afforded by a synthetic antioxidant analogue of marine invertebrate cell protectant ovothiols

J Vamecq et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2003)

添加到收藏夹

Article Biochemistry & Molecular Biology

Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR -: art. no. e36

MW Pfaffl et al.

NUCLEIC ACIDS RESEARCH (2002)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ovothiol and trypanothione as antioxidants in trypanosomatids

MR Ariyanayagam et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2001)

添加到收藏夹

Article Biochemistry & Molecular Biology

4-Mercaptoimidazoles derived from the naturally occurring antioxidant ovothiols 1. Antioxidant properties

V Zoete et al.

FREE RADICAL RESEARCH (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.