Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier

Review Physiology

NEUROPATHIC PAIN: FROM MECHANISMS TO TREATMENT

Nanna Brix Finnerup et al.

Summary: Neuropathic pain is a common chronic pain condition caused by lesion or disease of the somatosensory nervous system, characterized by ongoing or intermittent spontaneous pain. Evoked pain may spread to neighboring areas and is associated with peripheral and central sensitization processes.

PHYSIOLOGICAL REVIEWS (2021)

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Article Neurosciences

Effects of Cooling Temperatures via Thermal K2P Channels on Regeneration of High-Frequency Action Potentials at Nodes of Ranvier of Rat Aβ-Afferent Nerves

Hirosato Kanda et al.

Summary: The study revealed that cooling temperatures affect the electrophysiological properties and AP regeneration of A beta-afferent nerves, with the effects partially reversed by activation of thermal K2P channels. Interplays among thermal K2P channels, RMPs, and voltage-gated Na+ channels were shown to limit the regeneration of high-frequency AP trains at the NR.

ENEURO (2021)

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Article Biochemistry & Molecular Biology

Targeting Two-Pore-Domain Potassium Channels by Mechanical Stretch Instantaneously Modulates Action Potential Transmission in Mouse Sciatic Nerves

Jia Liu et al.

Summary: Recent reports suggest that TRAAK and TREK-1 channels play important roles in action potential repolarization in mammalian peripheral nerves. A new in vitro approach was developed to study the effects of mechanical stretch on nerve conduction, showing that axial stretch leads to increased conduction delay in both myelinated A-fibers and unmyelinated C-fibers. These results highlight the potential for pharmacological and mechanical activation of K2P channels in modulating peripheral nerve function.

ACS CHEMICAL NEUROSCIENCE (2021)

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Article Biochemical Research Methods

Protocol for pressure-clamped patch-clamp recording at the node of Ranvier of rat myelinated nerves

Hirosato Kanda et al.

Summary: Researchers have developed a pressure-clamped patch-clamp recording method for studying ion channel functions at the node of Ranvier in rat myelinated nerves. This approach can be used to investigate the mechanisms underlying saltatory conduction and information processing in myelinated nerves of mammals.

STAR PROTOCOLS (2021)

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Article Biochemistry & Molecular Biology