4.5 Review

Efficacy and safety of platelet-rich plasma combined with hyaluronic acid versus platelet-rich plasma alone for knee osteoarthritis: a systematic review and meta-analysis

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Relative Efficacy of Intra-articular Injections in the Treatment of Knee Osteoarthritis: A Systematic Review and Network Meta-analysis

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Summary: In the treatment of knee osteoarthritis, all intra-articular treatments except corticosteroids resulted in statistically significant improvements compared to placebo. Platelet-rich plasma (PRP), hyaluronic acid (HA), and plasma rich in growth factors (PRGF) all showed significant improvements in outcomes. PRP showed the highest probability of efficacy in improving pain, function, and combined outcomes.

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Intra-Articular Platelet-Rich Plasma Combined With Hyaluronic Acid Injection for Knee Osteoarthritis Is Superior to Platelet-Rich Plasma or Hyaluronic Acid Alone in Inhibiting Inflammation and Improving Pain and Function

Zhe Xu et al.

Summary: The combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) was found to be more effective in inhibiting synovial inflammation, improving pain and function, and reducing adverse reactions in knee osteoarthritis (KOA) compared to PRP or HA alone. This combination therapy showed promising results through changes in synovial tissue and cytokine levels.

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Platelet-Rich Plasma Combined With Hyaluronic Acid Improves Pain and Function Compared With Hyaluronic Acid Alone in Knee Osteoarthritis: A Systematic Review and Meta-analysis

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Summary: The study compared the combined PRP-HA injections with HA injections alone for knee osteoarthritis management. Results showed that patients receiving PRP combined with HA had greater improvements in pain and function at 3, 6, and 12 months, as well as 12-month WOMAC physical function and stiffness scores, compared to those receiving HA injections alone.

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Comparing efficacy of intraarticular single crosslinked Hyaluronan (HYAJOINT Plus) and platelet-rich plasma (PRP) versus PRP alone for treating knee osteoarthritis

Shu-Fen Sun et al.

Summary: The study compared the efficacy of combined injections of HYAJOINT Plus and PRP with single PRP injections in patients with knee osteoarthritis. The results showed that the combined injection group achieved better pain reduction on the VAS scale at 6 months.

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The Effect of Platelet-Rich Plasma on the Intra-Articular Microenvironment in Knee Osteoarthritis

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Summary: Knee osteoarthritis (KOA) treatment options include medication, physical therapy, braces, activity modification, and surgery, with intra-articular injections commonly used when non-operative treatment fails. PRP may improve the metabolic function of damaged structures, but its effects on chondrogenesis and stem cell proliferation are still controversial.

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Summary: Osteoarthritis (OA) is the most common form of arthritis in the US, affecting 22.7% of the adult population. Knee is the most commonly affected joint, followed by hands and hips. Treatment modalities include weight control, exercise, anti-inflammatory drugs, intra-articular platelet-rich plasma, corticosteroid injection, viscosupplementation, and surgery.

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Bone Marrow Aspirate Concentrate versus Platelet Rich Plasma or Hyaluronic Acid for the Treatment of Knee Osteoarthritis

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Summary: The study compared three biological treatments for knee osteoarthritis, showing that bone marrow aspirate concentrate may be better than platelet-rich plasma and hyaluronic acid in clinical improvement up to 12 months, with platelet-rich plasma providing better outcomes than hyaluronic acid during the observation period.

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Comparing the efficacy of dual Platelet-Rich Plasma (PRP) and Hyaluronic Acid (HA) therapy with PRP-alone therapy in the treatment of knee osteoarthritis: a systematic review and meta-analysis

Angeline Ai Ling Aw et al.

Summary: This study compared the efficacy of dual therapy with PRP and HA versus PRP-alone therapy for knee osteoarthritis, showing that dual therapy resulted in significant pain reduction, better function improvement, and higher IKDC scores compared to PRP-alone therapy at different time points. Additionally, dual therapy was found to be safer than PRP-alone therapy in terms of adverse events.

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Platelet-Rich Plasma Combined with Hyaluronic Acid versus Leucocyte and Platelet-Rich Plasma in the Conservative Treatment of Knee Osteoarthritis. A Retrospective Study

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Summary: This study retrospectively compared the effectiveness of plasma with high concentration of platelets and leukocytes (L-PRP) with PRP + HA in patients with mild to moderate KO. Results showed that PRP + HA had better outcomes in improving knee mobility and function. Further research is needed to fully describe the clinical effectiveness of these formulations.

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