期刊
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
卷 16, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnbeh.2022.1057251
关键词
claustrum; cerebellar interpositus nucleus; eyelid classical conditioning; facial motoneurons; hippocampus; motor cortex; medial prefrontal cortex; red nucleus
资金
- Spanish MCIN [PID2021-122446NB-I00]
- Spanish Junta de Andalucia [DOC-00309, BIO-122]
Classical conditioning of nictitating membrane/eyelid responses has been used as a model to study how the brain organizes the acquisition, storage, and retrieval of motor abilities. Multiple brain areas have been found to be involved in this type of learning. This study specifically focuses on the functional roles of three brain structures involved in the acquisition and performance of eyelid conditioned responses, as well as three other brain structures related to non-motor aspects of the acquisition process.
For almost a century the classical conditioning of nictitating membrane/eyelid responses has been used as an excellent and feasible experimental model to study how the brain organizes the acquisition, storage, and retrieval of new motor abilities in alert behaving mammals, including humans. Lesional, pharmacological, and electrophysiological approaches, and more recently, genetically manipulated animals have shown the involvement of numerous brain areas in this apparently simple example of associative learning. In this regard, the cerebellum (both cortex and nuclei) has received particular attention as a putative site for the acquisition and storage of eyelid conditioned responses, a proposal not fully accepted by all researchers. Indeed, the acquisition of this type of learning implies the activation of many neural processes dealing with the sensorimotor integration and the kinematics of the acquired ability, as well as with the attentional and cognitive aspects also involved in this process. Here, we address specifically the functional roles of three brain structures (red nucleus, cerebellar interpositus nucleus, and motor cortex) mainly involved in the acquisition and performance of eyelid conditioned responses and three other brain structures (hippocampus, medial prefrontal cortex, and claustrum) related to non-motor aspects of the acquisition process. The main conclusion is that the acquisition of this motor ability results from the contribution of many cortical and subcortical brain structures each one involved in specific (motor and cognitive) aspects of the learning process.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据