4.8 Article

Distinct reward processing by subregions of the nucleus accumbens

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state

Zhiyuan Liu et al.

Summary: Activation of NAc D1-MSNs projecting to the ventral pallidum (D1(NAc-VP)) induces aversive responses, while activation of those projecting to the ventral mesencephalon (D1(NAc-VM)) leads to reward. The D1(NAc-VP) projection inhibits VM DAergic neurons and reduces DA release, contributing to the balance of dopamine levels in the NAc for maintaining reward-aversion states.

CELL RESEARCH (2022)

Article Multidisciplinary Sciences

NAc-VTA circuit underlies emotional stress-induced anxiety-like behavior in the three-chamber vicarious social defeat stress mouse model

Guangjian Qi et al.

Summary: Emotional stress is a significant factor in psychiatric disorders, but the circuit mechanisms are unclear. This study used a 3C-VSDS mouse model and found that chronic emotional stress induced anxiety-like behavior and transient social interaction changes. Dopaminergic neurons in the VTA play a critical role in controlling this behavioral deficit, with their hyperactivity being involved in the anxiety-like behavior in an innate anxiogenic environment. Bidirectional modulation of the NAc-VTA circuit mimics or reverses the CES-induced anxiety-like behavior.

NATURE COMMUNICATIONS (2022)

Review Biochemistry & Molecular Biology

Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens

Alexander K. Zinsmaier et al.

Summary: Cocaine craving, seeking, and relapse are partially mediated by adaptive changes in the brain reward circuits induced by cocaine. The nucleus accumbens integrates emotional and motivational inputs and prioritizes them for the reward system. Medium spiny neurons in the NAc show complex adaptations following cocaine experience, influenced by various factors such as cocaine regimen, withdrawal time, cell type, location, and input/output projections.

MOLECULAR PSYCHIATRY (2022)

Article Multidisciplinary Sciences

Targeting thalamic circuits rescues motor and mood deficits in PD mice

Ying Zhang et al.

Summary: This study suggests that targeting the neural circuits in the parafascicular thalamus may be an effective strategy for treating both motor and non-motor symptoms in Parkinson's disease.

NATURE (2022)

Article Neurosciences

An inhibitory brainstem input to dopamine neurons encodes nicotine aversion

Christine Liu et al.

Summary: Nicotine stimulates the dopamine system and has aversive effects at high doses. This study found that high doses of nicotine cause inhibitory and excitatory responses in VTA DA neurons, which can be separated by projections to different subregions. The aversive effects involve desensitization of a4b2 receptors and activation of a7 receptors, as well as the activation of upstream GABA neurons in the LDT. Inhibiting these GABA neurons prevents nicotine aversion.

NEURON (2022)

Article Neurosciences

Chloral Hydrate Alters Brain Activation Induced by Methamphetamine-Associated Cue and Prevents Relapse

Chenyu Jiang et al.

Summary: Chloral hydrate has shown promise in inhibiting methamphetamine-seeking behavior and cue-induced relapse by suppressing neuronal activity in specific brain regions, suggesting its potential as a treatment for methamphetamine addiction.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)

Article Multidisciplinary Sciences

Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice

Kuikui Zhou et al.

Summary: This study investigates the afferent-specific circuitry of NAc and its role in controlling reward and aversion. The authors present evidence for two distinct pathways in the NAc that mediate positive reinforcement and aversion, respectively.

NATURE COMMUNICATIONS (2022)

Article Behavioral Sciences

Dopamine D1 receptor signalling in the lateral shell of the nucleus accumbens controls dietary fat intake in male rats

Anil Joshi et al.

Summary: Our study evaluates the effects of D1 or D2 receptor inhibition in the lateral shell of the nucleus accumbens on fcHFHS diet consumption. The results show that infusion of the D1 receptor antagonist SCH23390 promotes dietary fat intake in male Sprague Dawley rats during 2 hours after infusion, while the D2 receptor antagonist raclopride does not have this effect. Anatomical analysis reveals that the rostral region of the lateral shell of the nucleus accumbens is sensitive to D1 receptor inhibition effects on fat consumption.

APPETITE (2021)

Article Neurosciences

Activation of ventral CA1 hippocampal neurons projecting to the lateral septum during feeding

Kenzo Kosugi et al.

Summary: Studies have shown that vCA1(-> LS) neurons are involved in feeding behavior, with activation during food intake and consummatory phases. Reward omission eliminates this activity, indicating a relationship between vCA1(-> LS) activation and food reward.

HIPPOCAMPUS (2021)

Article Neurosciences

Genetically identified amygdala-striatal circuits for valence-specific behaviors

Xian Zhang et al.

Summary: Researchers have discovered two classes of 'hardwired' neurons in the BLA, positive-valence and negative-valence neurons, which express Fezf2 and have distinct connectivity. These neurons drive punishment avoidance and reward seeking behaviors by receiving inputs from separate sensory and limbic areas, and conveying information to the nucleus accumbens and olfactory tubercle.

NATURE NEUROSCIENCE (2021)

Article Neurosciences

Decoding molecular and cellular heterogeneity of mouse nucleus accumbens

Renchao Chen et al.

Summary: The authors utilized single-cell RNA sequencing and multiplexed error-robust FISH to generate a cell census of the mouse nucleus accumbens, revealing a high level of cell heterogeneity. This study demonstrates that the transcriptional and spatial diversity of neuron subtypes underlie the anatomic and functional heterogeneity of the nucleus accumbens.

NATURE NEUROSCIENCE (2021)

Article Neurosciences

Projections from D2 Neurons in Different Subregions of Nucleus Accumbens Shell to Ventral Pallidum Play Distinct Roles in Reward and Aversion

Yun Yao et al.

Summary: The nucleus accumbens shell plays a crucial role in reward and aversion, with D2 neurons having varied effects on behavior based on their location within the NAcSh. Activation of D2 neurons in different regions of the NAcSh can induce different behaviors and affect movement speed. This study sheds light on the controversy surrounding the function of NAcSh D2 neurons and provides new insights into the heterogeneous nature of the NAcSh.

NEUROSCIENCE BULLETIN (2021)

Article Biotechnology & Applied Microbiology

High-throughput mapping of a whole rhesus monkey brain at micrometer resolution

Fang Xu et al.

Summary: This study introduces a new method combining primate-optimized tissue sectioning and clearing with high-speed fluorescence microscopy to achieve high-resolution imaging of the entire rhesus monkey brain. Researchers have also developed an efficient method for tracing sparse axonal fibers in large datasets, enabling connectome-scale mapping of large primate brains.

NATURE BIOTECHNOLOGY (2021)

Article Neurosciences

Pain modulates dopamine neurons via a spinal-parabrachial-mesencephalic circuit

Hongbin Yang et al.

Summary: This study identifies a neural circuit that conveys nociceptive input to DA neurons through a spinal-parabrachial-mesencephalic connection, regulating the activity of dopamine neurons during pain.

NATURE NEUROSCIENCE (2021)

Article Neurosciences

Activation of ventral tegmental area neurotensin Receptor-1 neurons promotes weight loss

Patricia Perez-Bonilla et al.

Summary: Research on activating dopamine neurons in the ventral tegmental area using specific drugs found that activating neurons expressing neurotensin receptor-1 (NtsR1) can promote weight loss behaviors in mice without causing adverse effects.

NEUROPHARMACOLOGY (2021)

Article Neurosciences

Midbrain and Lateral Nucleus Accumbens Dopamine Depletion Affects Free-choice High-fat high-sugar Diet Preference in Male Rats

Anil Joshi et al.

Summary: Dopamine influences food intake behavior, and food intake can also modulate dopamine-related brain circuitries. Experimental findings suggest that midbrain dopamine lesions in rats can result in changes in food preference, particularly an increase in fat intake.

NEUROSCIENCE (2021)

Article Biochemistry & Molecular Biology

Demystifying functional role of cocaine- and amphetamine-related transcript (CART) peptide in control of energy homeostasis: A twenty-five year expedition

Arashdeep Singh et al.

Summary: CART is a neuropeptide with important roles in energy homeostasis and is widely expressed in various mammalian species. Research has shown that CARTp has effects on appetite suppression, energy expenditure, and body weight control, making it a potential target for treating obesity.

PEPTIDES (2021)

Review Neurosciences

Plasticity of the Reward Circuitry After Early-Life Adversity: Mechanisms and Significance

Matthew T. Birnie et al.

BIOLOGICAL PSYCHIATRY (2020)

Article Biochemistry & Molecular Biology

β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors

Lauren M. Slosky et al.

Article Multidisciplinary Sciences

Facial expressions of emotion states and their neuronal correlates in mice

Nejc Dolensek et al.

SCIENCE (2020)

Article Anatomy & Morphology

Reward-related dynamical coupling between basolateral amygdala and nucleus accumbens

Chia-Chun Hsu et al.

BRAIN STRUCTURE & FUNCTION (2020)

Article Neurosciences

Orchestrating Opiate-Associated Memories in Thalamic Circuits

Piper C. Keyes et al.

NEURON (2020)

Article Multidisciplinary Sciences

Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution

Hao Wang et al.

NATIONAL SCIENCE REVIEW (2019)

Article Neurosciences

Insular Cortex Projections to Nucleus Accumbens Core Mediate Social Approach to Stressed Juvenile Rats

Morgan M. Rogers-Carter et al.

JOURNAL OF NEUROSCIENCE (2019)

Review Pharmacology & Pharmacy

Convergent Neuronal Plasticity and Metaplasticity Mechanisms of Stress, Nicotine, and Alcohol

Alexey Ostroumov et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 58 (2018)

Article Biochemical Research Methods

fastp: an ultra-fast all-in-one FASTQ preprocessor

Shifu Chen et al.

BIOINFORMATICS (2018)

Article Multidisciplinary Sciences

The coding of valence and identity in the mammalian taste system

Li Wang et al.

NATURE (2018)

Article Multidisciplinary Sciences

Reward behaviour is regulated by the strength of hippocampus-nucleus accumbens synapses

Tara A. LeGates et al.

NATURE (2018)

Article Multidisciplinary Sciences

Dynamic salience processing in paraventricular thalamus gates associative learning

Yingjie Zhu et al.

SCIENCE (2018)

Article Multidisciplinary Sciences

Homeostatic circuits selectively gate food cue responses in insular cortex

Yoav Livneh et al.

NATURE (2017)

Article Biochemical Research Methods

Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq

Jun Chen et al.

NATURE PROTOCOLS (2017)

Article Biochemistry & Molecular Biology

Distinct Ventral Pallidal Neural Populations Mediate Separate Symptoms of Depression

Daniel Knowland et al.

Review Neurosciences

Insular cortex activity and the evocation of laughter

Elise Wattendorf et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2016)

Review Neurosciences

Reward and Aversion

Hailan Hu

ANNUAL REVIEW OF NEUROSCIENCE, VOL 39 (2016)

Letter Biochemistry & Molecular Biology

Direct and indirect dorsolateral striatum pathways reinforce different action strategies

Ana M. Vicente et al.

CURRENT BIOLOGY (2016)

Review Clinical Neurology

Neurotensin: A role in substance use disorder?

Luca Ferraro et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2016)

Article Multidisciplinary Sciences

A thalamic input to the nucleus accumbens mediates opiate dependence

Yingjie Zhu et al.

NATURE (2016)

Article Multidisciplinary Sciences

A shared neural ensemble links distinct contextual memories encoded close in time

Denise J. Cai et al.

NATURE (2016)

Article Neurosciences

Antagonistic negative and positive neurons of the basolateral amygdala

Joshua Kim et al.

NATURE NEUROSCIENCE (2016)

Article Biochemical Research Methods

Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown

Mihaela Pertea et al.

NATURE PROTOCOLS (2016)

Article Neurosciences

Simultaneous Denoising, Deconvolution, and Demixing of Calcium Imaging Data

Eftychios A. Pnevmatikakis et al.

NEURON (2016)

Article Multidisciplinary Sciences

Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation

Carina Soares-Cunha et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Slitrk1 is localized to excitatory synapses and promotes their development

Francois Beaubien et al.

SCIENTIFIC REPORTS (2016)

Article Multidisciplinary Sciences

Refining deep brain stimulation to emulate optogenetic treatment of synaptic pathology

Meaghan Creed et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression

Rosemary C. Bagot et al.

NATURE COMMUNICATIONS (2015)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Review Behavioral Sciences

Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley

Eric P. Zorrilla et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2013)

Article Behavioral Sciences

Optogenetic dissection of basolateral amygdala projections during cue-induced reinstatement of cocaine seeking

Michael T. Stefanik et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2013)

Article Multidisciplinary Sciences

Input-specific control of reward and aversion in the ventral tegmental area

Stephan Lammel et al.

NATURE (2012)

Article Neurosciences

Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons

Mitsuko Watabe-Uchida et al.

NEURON (2012)

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Review Neurosciences

Modulation of Striatal Projection Systems by Dopamine

Charles R. Gerfen et al.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 34 (2011)

Article Biochemical Research Methods

Miniaturized integration of a fluorescence microscope

Kunal K. Ghosh et al.

NATURE METHODS (2011)

Review Neurosciences

Cortico-Basal Ganglia Reward Network: Microcircuitry

Susan R. Sesack et al.

NEUROPSYCHOPHARMACOLOGY (2010)

Review Neurosciences

Glutamate transmission in addiction

Peter W. Kalivas et al.

NEUROPHARMACOLOGY (2009)