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Prostate Cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly
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Targeted agents and immunotherapies: optimizing outcomes in melanoma
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SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling
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The Molecular Taxonomy of Primary Prostate Cancer
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Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover
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Androgen Receptor Is the Key Transcriptional Mediator of the Tumor Suppressor SPOP in Prostate Cancer
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CANCER RESEARCH (2014)
Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer
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SCIENCE (2014)
Destruction of Full-Length Androgen Receptor by Wild-Type SPOP, but Not Prostate-Cancer-Associated Mutants
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CELL REPORTS (2014)
Building and remodelling Cullin-RING E3 ubiquitin ligases - 'Ubiquitylation: mechanism and functions' review series
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Ring Finger Protein 149 Is an E3 Ubiquitin Ligase Active on Wild-type v-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF)
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Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes
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NATURE GENETICS (2012)
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
Christopher E. Barbieri et al.
NATURE GENETICS (2012)
Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1
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ONCOGENE (2011)
Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases
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Low frequency of BRAF mutations in endometrial and in cervical carcinomas
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CLINICAL CANCER RESEARCH (2006)
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
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