期刊
CELL CALCIUM
卷 58, 期 4, 页码 357-367出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2015.07.001
关键词
STIM1; ORAI1; CRAC channel; Store-operated calcium entry; Microdomain; Calcium
类别
资金
- US National Institutes of Health [AI084167, GM110397]
The regulatory protein STIM1 controls gating of the Ca2+ channel ORAI1 by a direct protein-protein interaction. Because STIM1 is anchored in the ER membrane and ORAI1 is in the plasma membrane, the STIM-ORAI pathway can support Ca2+ influx only where the two membranes come into close apposition, effectively demarcating a microdomain for Ca2+ signalling. This review begins with a brief summary of the STIM-ORAI pathway of store-operated Calf influx, then turns to the special geometry of the STIM-ORAI microdomain and the expected characteristics of the microdomain Ca2+ signal. A final section of the review seeks to place the STIM-ORAI microdomain into a broader context of cellular Ca2+ signalling. (C) 2015 Elsevier Ltd. All rights reserved.
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