4.5 Article

Potential links between COVID-19 and periodontitis: a bioinformatic analysis based on GEO datasets

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Dentistry, Oral Surgery & Medicine

Is There a Causal Link Between Periodontitis and Cardiovascular Disease? A Concise Review of Recent Findings

Maria Febbraio et al.

Summary: This article reviews the association between periodontitis and cardiovascular disease, focusing on the question of causality. Although there is evidence supporting the association, intervention studies fail to determine causality. Issues with surrogate markers and collider bias are highlighted. The article also discusses a new cardiovascular risk factor and the potential impact of periodontal disease on it.

INTERNATIONAL DENTAL JOURNAL (2022)

Article Dentistry, Oral Surgery & Medicine

Normative Approaches for Oral Health: Standards, Specifications, and Guidelines

G. Schmalz et al.

Summary: Normative approaches aim to provide high-quality methods through strict criteria, standards, and guidelines, ensuring reliable results. There is a clear need for the oral health community to actively participate in the development of normative documents to improve oral health outcomes and promote standardization in rapidly advancing research fields.

JOURNAL OF DENTAL RESEARCH (2022)

Article Oncology

Carbonic anhydrase 10 functions as a tumor suppressor in renal cell carcinoma and its methylation is a risk factor for survival outcome

Qinhan Li et al.

Summary: This study reveals that the downregulation of CA10 in renal cell carcinoma is caused by CpG methylation of its promoter, and this methylation status is associated with disease progression and patient survival outcomes.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2022)

Article Dentistry, Oral Surgery & Medicine

Difference in oral microbial composition between chronic periodontitis patients with and without diabetic nephropathy

Dongxue Zhang et al.

Summary: The study revealed significant differences in the structural composition of oral flora between chronic periodontitis patients with and without diabetic nephropathy. The increase in the relative abundance of Selenomonas spp. may be associated with diabetic nephropathy in patients with chronic periodontitis.

BMC ORAL HEALTH (2022)

Article Dentistry, Oral Surgery & Medicine

A case-control study on the association between periodontitis and coronavirus disease (COVID-19)

Pradeep S. Anand et al.

Summary: The study found an association between the severity of periodontitis and COVID-19. Gingival bleeding and dental plaque accumulation are more common among COVID-19 patients. Therefore, maintaining periodontal health and good oral hygiene is vital for COVID-19 prevention and management.

JOURNAL OF PERIODONTOLOGY (2022)

Article Dentistry, Oral Surgery & Medicine

Poor oral health status and adverse COVID-19 outcomes: A preliminary study in hospitalized patients

Camila Alves Costa et al.

Summary: This study found that hospitalized COVID-19 patients with poor oral health, particularly periodontitis, were more likely to experience severe COVID-19 outcomes such as ICU admission and death.

JOURNAL OF PERIODONTOLOGY (2022)

Article Dentistry, Oral Surgery & Medicine

Association of periodontitis, missing teeth, and oral hygiene behaviors with the incidence of hypertension in middle-aged and older adults in Korea: A 10-year follow-up study

Su-Yeon Hwang et al.

Summary: This study investigated the relationship between periodontitis, missing teeth, oral hygiene behaviors, and the incidence of hypertension. The results showed significant associations between periodontitis, the number of missing teeth, dental scaling, toothbrushing frequency, and incident hypertension. Oral inflammation could contribute to the development of hypertension, suggesting that oral health care may be beneficial in the management of hypertension.

JOURNAL OF PERIODONTOLOGY (2022)

Review Virology

Dysregulated Immune Responses in SARS-CoV-2-Infected Patients: A Comprehensive Overview

Igor Kudryavtsev et al.

Summary: This article reviews the pathological changes in T and B cell subsets and their phenotypes during the acute phase of SARS-CoV-2 infection, as well as discusses the implications of this knowledge in early recognition of disease severity and prediction of long-term complications of COVID-19.

VIRUSES-BASEL (2022)

Article Dentistry, Oral Surgery & Medicine

A retrospective study on the effect of the COVID-19 pandemic on dental treatments in adults

Diego Gomez-Costa et al.

Summary: The study found that during the COVID-19 pandemic, conservative and periodontal treatments may have been negatively affected, increasing the risk of tooth loss in adults. Patients most affected ranged in age from 35 to 74 years, and factors such as age, sex, and nationality were not influential in not performing dental treatments.

BMC ORAL HEALTH (2022)

Article Immunology

Control of CDH1/E-Cadherin Gene Expression and Release of a Soluble Form of E-Cadherin in SARS-CoV-2 Infected Caco-2 Intestinal Cells: Physiopathological Consequences for the Intestinal Forms of COVID-19

Ikram Omar Osman et al.

Summary: COVID-19 is the largest pandemic in this century, and it is not only characterized by respiratory damage, but also by gastrointestinal symptoms. This study suggests that SARS-CoV-2 may cause damage to the epithelial barrier of the intestines by disrupting E-cadherin adherens junctions, leading to gastrointestinal symptoms.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Article Immunology

Role of T Regulatory Cells and Myeloid-Derived Suppressor Cells in COVID-19

Alhasan Alsalman et al.

Journal of Immunology Research (2022)

Review Immunology

Adaptive Immune Responses and Immunity to SARS-CoV-2

Dragan Primorac et al.

Summary: Since the COVID-19 pandemic, the medical field has been applying immunology knowledge to understand the immune response to SARS-CoV-2. Cellular immunity has been shown to persist even years after infection, and T cells play a crucial role in both cellular and humoral immune responses. IgA production is important for mucosal immunity. Recent research has also demonstrated the long-lasting cellular immunity in those who have recovered from COVID-19 or received approved vaccines.

FRONTIERS IN IMMUNOLOGY (2022)

Article Immunology

Regulation of Proinflammatory Molecules and Tissue Factor by SARS-CoV-2 Spike Protein in Human Placental Cells: Implications for SARS-CoV-2 Pathogenesis in Pregnant Women

Xiaofang Guo et al.

Summary: SARS-CoV-2 infection in placental cells induces the release of pro-inflammatory cytokines, which may contribute to cytokine storms and placental dysfunction. In addition, the infection increases the risk of thrombosis.

FRONTIERS IN IMMUNOLOGY (2022)

Review Medicine, General & Internal

Oral Manifestations in SARS-CoV-2 Positive Patients: A Systematic Review

Kacper Nijakowski et al.

Summary: The COVID-19 pandemic has had a significant impact on oral health, with a high prevalence of oral symptoms reported in infected individuals, including taste alterations, xerostomia, and ulcerations.

JOURNAL OF CLINICAL MEDICINE (2022)

Review Pharmacology & Pharmacy

Convalescent Plasma Therapy, Therapeutic Formulations of Repurposed Drugs in 20th Century Epidemics against COVID-19: A Systematic Review

Diego Fernandez-Lazaro et al.

Summary: This is a systematic review evaluating the effect and safety of convalescent plasma therapy on hospitalized COVID-19 patients. The results show that convalescent plasma therapy can reduce viral load, symptomatology, the period of infection, and mortality without serious adverse effects.

PHARMACEUTICS (2022)

Article Dentistry, Oral Surgery & Medicine

Periodontitis promotes the expression of gingival transmembrane serine protease 2 (TMPRSS2), a priming protease for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Tomokazu Ohnishi et al.

Summary: Periodontitis increases the expression of TMPRSS2 in gingival keratinocytes, which is responsible for activating the fusion protein of SARS-CoV-2. Analysis of gene expression and experimental models showed increased TMPRSS2 expression in gingiva of periodontitis patients. Further investigation identified transcription factors such as ESR1 that are associated with TMPRSS2 expression.

JOURNAL OF ORAL BIOSCIENCES (2022)

Review Public, Environmental & Occupational Health

The Relationship Between Hepcidin-Mediated Iron Dysmetabolism and COVID-19 Severity: A Meta-Analysis

Denggao Peng et al.

Summary: This study re-evaluated the relationship between hepcidin-mediated iron dysmetabolism and the severity of COVID-19. The results showed that severe COVID-19 cases had higher levels of hepcidin and ferritin, and lower serum iron, with no significant differences in transferrin saturation.

FRONTIERS IN PUBLIC HEALTH (2022)

Review Biochemistry & Molecular Biology

CCL5/CCR5 axis in human diseases and related treatments

Zhen Zeng et al.

Summary: This review discusses the role of the CCL5/CCR5 axis in the pathological processes of different diseases, including inflammation, chronic diseases, cancers, and COVID-19. It also highlights the regulation of relevant signaling pathways and research and clinical trials for treating CCR5-related diseases.

GENES & DISEASES (2022)

Letter Dentistry, Oral Surgery & Medicine

Necrotizing periodontal disease: Oral manifestation of COVID-19

Jay Patel et al.

ORAL DISEASES (2021)

Review Dentistry, Oral Surgery & Medicine

Current concepts in the management of periodontitis

TaeHyun Kwon et al.

Summary: Periodontitis is a common disorder that affects a large percentage of adults globally, with a multifactorial etiology and potential for tooth loss and reduced quality of life. Successful management involves careful diagnosis, treatment including non-surgical and surgical therapies, and long-term maintenance to prevent disease progression and tooth loss.

INTERNATIONAL DENTAL JOURNAL (2021)

Review Medicine, General & Internal

Severe COVID-19 Lung Infection in Older People and Periodontitis

Ruben Aquino-Martinez et al.

Summary: Periodontal bacteria dissemination into the lower respiratory tract may increase the risk of severe COVID-19 lung infection in older patients, as bacterial infection can cause permanent damage and senescence in cells, which in turn facilitates SARS-CoV-2 replication.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Dentistry, Oral Surgery & Medicine

COVID-19 Management in Clinical Dental Care. Part I: Epidemiology, Public Health Implications, and Risk Assessment

Paulo Melo et al.

Summary: The COVID-19 pandemic has brought significant changes to global society, and dental care professionals may manage their risks by adopting a risk management model in combination with recommendations from local and international health authorities, thus providing a safe environment for professionals and patients.

INTERNATIONAL DENTAL JOURNAL (2021)

Article Dentistry, Oral Surgery & Medicine

Pro-inflammatory cytokine interleukin-6-induced hepcidin, a key mediator of periodontitis-related anemia of inflammation

Ye Han et al.

Summary: Periodontitis patients may have a tendency towards anemia of inflammation, and systemic inflammation induced by periodontitis could lead to an increased risk of anemia of inflammation. Hepcidin induced by IL-6 may play a key role in the pathogenesis of periodontitis-related anemia of inflammation.

JOURNAL OF PERIODONTAL RESEARCH (2021)

Article Biology

Gingival crevicular fluid infiltrating CD14+monocytes promote inflammation in periodontitis

Hytham N. Fageeh et al.

Summary: This study aimed to characterize monocytes isolated from the gingival crevicular fluid (GCF) in patients with periodontitis, evaluating cytokine levels, gene expression, and secreted cytokines and chemokines. CD14+ monocytes from GCF secreted higher levels of CCL2 and expressed genes responsible for monocyte migration, indicating their role in the inflammatory microenvironment of periodontitis.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Dentistry, Oral Surgery & Medicine

Related factors of periodontal health among Chinese middle school students, findings from a national cross-sectional survey

Jingyu Zhan et al.

Summary: The study investigated the periodontal health status among Chinese middle school students, finding that factors such as gender, age, father's education level, oral health knowledge and behaviors were related to gingival bleeding and calculus. It was noted that there were higher rates of gingival bleeding and calculus among 15-year-olds compared to 12-year-olds, with males showing worse periodontal health than females. The impact of province on periodontal health status should be a point of concern.

BMC ORAL HEALTH (2021)

Article Immunology

B-Cell Deficiency Exacerbates Inflammation and Bone Loss in Ligature-Induced Experimental Periodontitis in Mice

Wenmin Zeng et al.

Summary: B-cell deficiency exacerbates inflammation and alveolar bone loss in ligature-induced experimental periodontitis in mice, suggesting a role for B cells in the initiation of periodontitis. This is associated with increased osteoclast activity, upregulated RANKL expression, and a shift in gingiva cytokine expression profiles to Th1 and Th17. Additionally, a reduced CD4(+)/CD8(+) T cell ratio was observed in the B cell-deficient mice.

JOURNAL OF INFLAMMATION RESEARCH (2021)

Article Genetics & Heredity

An epigenome-wide DNA methylation study of patients with COVID-19

Shengyu Zhou et al.

Summary: DNA methylation differences were found between healthy individuals and COVID-19 patients with varying disease severities, with key genes identified that may play a role in disease progression. Specific gene functions and pathways were enriched in signal transduction and the immune system.

ANNALS OF HUMAN GENETICS (2021)

Article Dentistry, Oral Surgery & Medicine

B cell activating factor regulates periodontitis development by suppressing inflammatory responses in macrophages

Lixia Wang et al.

Summary: The study found that BAFF blockade exhibits potent anti-inflammatory properties in mice experimental periodontitis in vivo and in P. gingivalis LPS-treated RAW 264.7 cells in vitro, and macrophage polarization may be responsible for this effect.

BMC ORAL HEALTH (2021)

Article Biochemistry & Molecular Biology

KEGG: integrating viruses and cellular organisms

Minoru Kanehisa et al.

Summary: KEGG is a curated resource integrating eighteen databases categorized into systems, genomic, chemical and health information, providing mapping tools for understanding cellular and organism-level functions from genome sequences and other molecular datasets. The network variation maps in the KEGG database show how different pathogens and environmental factors influence cellular signaling pathways.

NUCLEIC ACIDS RESEARCH (2021)

Article Dentistry, Oral Surgery & Medicine

Extending the vitamin D pathway to vitamin D3 and CYP27A1 in periodontal ligament cells

Churen Zhang et al.

Summary: The vitamin D pathway from vitamin D-3 to hCAP-18/LL-37 exists in human periodontal ligament cells, with potential involvement of CYP27A1 in periodontal immune defense.

JOURNAL OF PERIODONTOLOGY (2021)

Article Dentistry, Oral Surgery & Medicine

Identification of novel key lncRNAs involved in periodontitis by weighted gene co-expression network analysis

Su-Han Jin et al.

JOURNAL OF PERIODONTAL RESEARCH (2020)

Article Biochemistry & Molecular Biology

miRDB: an online database for prediction of functional microRNA targets

Yuhao Chen et al.

NUCLEIC ACIDS RESEARCH (2020)

Review Dentistry, Oral Surgery & Medicine

Recent epidemiologic trends in periodontitis in the USA

Paul I. Eke et al.

PERIODONTOLOGY 2000 (2020)

Review Biotechnology & Applied Microbiology

Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19)

Dae-Gyun Ahn et al.

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2020)

Article Immunology

Single-cell landscape of immunological responses in patients with COVID-19

Ji-Yuan Zhang et al.

NATURE IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

Yingyao Zhou et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

The biochemical basis of microRNA targeting efficacy

Sean E. McGeary et al.

SCIENCE (2019)

Review Dentistry, Oral Surgery & Medicine

T cells, teeth and tissue destruction - what do Tcells do in periodontal disease?

L. Campbell et al.

MOLECULAR ORAL MICROBIOLOGY (2016)

Article Pharmacology & Pharmacy

Adenylyl Cyclase 5 Regulation by Gβγ Involves Isoform-Specific Use of Multiple Interaction Sites

Cameron S. Brand et al.

MOLECULAR PHARMACOLOGY (2015)

Article Biochemical Research Methods

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet et al.

BRIEFINGS IN BIOINFORMATICS (2011)

Article Dentistry, Oral Surgery & Medicine

Aspects of adaptive host response in periodontitis

T Berglundh et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2005)