Deciphering the Heterogeneity Landscape of Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles for Precise Selection in Translational Medicine

Review Oncology

Mesenchymal stem cell-derived exosome: A tumor regulator and carrier for targeted tumor therapy

Fusheng Zhang et al.

Summary: MSCs-Exo play a significant role in tumor growth and have the potential to be safe carriers for anti-tumor drugs. Despite the controversial relationship between MSCs-Exo and tumors, they show promise in targeted tumor therapy.

CANCER LETTERS (2022)

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Review Biochemistry & Molecular Biology

Dental Mesenchymal Stem Cell Secretome: An Intriguing Approach for Neuroprotection and Neuroregeneration

Agnese Gugliandolo et al.

Summary: Dental-derived mesenchymal stem cells have a prominent neuroregenerative potential and their secretome, consisting of bioactive molecules, can effectively promote neurite outgrowth and neuroprotective effects.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Dentistry, Oral Surgery & Medicine

Dental stem cell-derived extracellular vesicles as promising therapeutic agents in the treatment of diseases

Ye Li et al.

Summary: Dental stem cells (DSCs) are an important source of mesenchymal stem cells (MSCs) and have been used for the treatment of various diseases. The therapeutic effects of DSCs are attributed to their extracellular vesicles (DSC-EVs), which carry bioactive contents and have therapeutic potential. This review provides insights into the therapeutic effects of DSC-EVs and highlights challenges and future directions for their clinical translation.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2022)

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Article Cell Biology

The impact of storage on extracellular vesicles: A systematic study

Stefano Gelibter et al.

Summary: Storage has a significant impact on extracellular vesicles (EVs) samples, leading to a decrease in concentration, reduction in purity, and generation of artefactual particles. It is recommended to process fresh, non-archival samples for EVs analysis, depending on downstream analyses and experimental settings.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Review Gastroenterology & Hepatology

Extracellular vesicles derived from mesenchymal stem/stromal cells: The regenerative impact in liver diseases

Adriana Psaraki et al.

Summary: Liver dysfunctions are often treated with liver transplantation, but a new concept in therapy involves using extracellular vesicles secreted by mesenchymal stem cells to overcome limitations and promote liver repair. Studies have shown that these vesicles have the potential to ameliorate systemic inflammation and positively impact various pathways associated with liver diseases.

HEPATOLOGY (2022)

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Review Pharmacology & Pharmacy

Effects of BMSC-Derived EVs on Bone Metabolism

Xuchang Zhou et al.

Summary: Extracellular vesicles (EVs) are small membrane vesicles that can be secreted by most cells. EVs, especially BMSC-EVs, have therapeutic effects such as tissue repair, inhibition of macrophage polarization, and promotion of angiogenesis. BMSC-EVs also serve as efficient nanocarriers for drug delivery with advantages such as low immunogenicity, no ethical controversy, good stability, and easy storage.

PHARMACEUTICS (2022)

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Article Dentistry, Oral Surgery & Medicine

Dental stem cell-derived extracellular vesicles transfer miR-330-5p to treat traumatic brain injury by regulating microglia polarization

Ye Li et al.

Summary: This study reveals the potential therapeutic effect of extracellular vesicles (EVs) secreted by stem cells from human exfoliated deciduous teeth (SHED) in treating traumatic brain injury (TBI). By transferring miR-330-5p, SHED-EVs can regulate microglia polarization and alleviate inflammation, thus promoting functional recovery in TBI.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2022)

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Review Biochemistry & Molecular Biology

Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses

Luis A. Costa et al.

Summary: Studies have shown that mesenchymal stem cells (MSC) have therapeutic potential in various organs and tissues. However, their functional heterogeneity poses a challenge in transferring their capabilities to clinical applications. Proper selection of MSC based on their functional potential and improving their features in the artificial niche are essential for personalized and precise medicine.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

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Review Cell & Tissue Engineering

Advances in mesenchymal stem cell exosomes: a review

Yaya Tang et al.

Summary: Stem cells are valuable in regenerative medicine and disease treatment, but face challenges such as storage limitations and cell senescence. Exosomes, as an alternative, have similar effects to stem cells and offer advantages such as targeted delivery, low immunogenicity, and high repairability.

STEM CELL RESEARCH & THERAPY (2021)

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Review Medicine, General & Internal

Stem cell-derived exosomes for wound healing: current status and promising directions

Ngoc B. Vu et al.

Summary: Stem cell therapy plays a significant role in the healing of chronic wounds, however, it is complex, expensive, and time-consuming. Recent studies suggest that stem cell-derived exosomes can be an effective treatment for wounds, inducing positive effects in various stages of wound healing.

MINERVA MEDICA (2021)

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Review Biochemistry & Molecular Biology

Regulation of exosome production and cargo sorting

Hong Wei et al.

Summary: Cellular communication through the exchange of biological information, mainly in the form of proteins and RNAs, is mediated by extracellular vesicles like exosomes. Understanding the molecular mechanisms of exosome secretion and cargo sorting is crucial for shedding light on their physiological and pathological functions, as well as for exploring potential therapeutic opportunities in clinical applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Medicine, Research & Experimental

Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury

Jing-Yuan Cao et al.

Summary: In this study, MSC-exos were found to preferentially target injured kidneys and localize to proximal tubules in ischemic AKI. The researchers demonstrated that MSC-exos ameliorated ischemic AKI and promoted tubular repair by targeting the cell cycle arrest and apoptosis of TECs through the miR-125b-5p/p53 pathway. This study provides new insights into the role of MSC-exos in renal tubule repair and highlights their potential as a promising therapeutic strategy for AKI.

THERANOSTICS (2021)

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Review Biochemistry & Molecular Biology

An Update on the Progress of Isolation, Culture, Storage, and Clinical Application of Human Bone Marrow Mesenchymal Stem/Stromal Cells

Dinh-Toi Chu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Size and surface charge characterization of nanoparticles with a salt gradient

Martin K. Rasmussen et al.

NATURE COMMUNICATIONS (2020)

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Article Cell Biology

Boosting the Biogenesis and Secretion of Mesenchymal Stem Cell-Derived Exosomes

Jinli Wang et al.

CELLS (2020)

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Review Cell Biology

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Challenges in Clinical Applications

Austin Gowen et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Cell & Tissue Engineering

Potential application of mesenchymal stem cells and their exosomes in lung injury: an emerging therapeutic option for COVID-19 patients

Sara Al-Khawaga et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Cell Biology

Adipose-derived mesenchymal stem cells reduce autophagy in stroke mice by extracellular vesicle transfer of miR-25

Yaoyun Kuang et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Letter Cell Biology

Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes

Yirui Cheng et al.

PROTEIN & CELL (2019)

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Article Oncology

Lymphotoxin-α promotes tumor angiogenesis in HNSCC by modulating glycolysis in a PFKFB3-dependent manner

Jie-Gang Yang et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

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Review Medicine, General & Internal

Adipose Tissue Stem Cells for Therapy: An Update on the Progress of Isolation, Culture, Storage, and Clinical Application

Dinh-Toi Chu et al.

JOURNAL OF CLINICAL MEDICINE (2019)

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Review Biophysics

Mesenchymal stem cell-derived exosomes for clinical use

Mayela Mendt et al.

BONE MARROW TRANSPLANTATION (2019)

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Article Cell & Tissue Engineering

Mesenchymal Stem Cells and Induced Bone Marrow-Derived Macrophages Synergistically Improve Liver Fibrosis in Mice

Yusuke Watanabe et al.

STEM CELLS TRANSLATIONAL MEDICINE (2019)

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Article Critical Care Medicine

Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial

Michael A. Matthay et al.

LANCET RESPIRATORY MEDICINE (2019)

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Article Engineering, Biomedical

Mesenchymal stem cell exosomes enhance periodontal ligament cell functions and promote periodontal regeneration

Jacob Ren Jie Chew et al.

ACTA BIOMATERIALIA (2019)

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Article Nanoscience & Nanotechnology

Surface Functionalization of Polymeric Nanoparticles with Umbilical Cord-Derived Mesenchymal Stem Cell Membrane for Tumor-Targeted Therapy

Na Yang et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Review Chemistry, Multidisciplinary

New Technologies for Analysis of Extracellular Vesicles

Huilin Shao et al.

CHEMICAL REVIEWS (2018)

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Review Biochemistry & Molecular Biology

Exosomes and Ectosomes in Intercellular Communication

Jacopo Meldolesi

CURRENT BIOLOGY (2018)

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Article Cell Biology

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

Haiying Zhang et al.

NATURE CELL BIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379

K. P. O'Brien et al.

ONCOGENE (2018)

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Article Cell Biology

The Fas/Fap-1/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing

Xiaoxing Kou et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Article Cell & Tissue Engineering

Therapeutic effect of human umbilical cord-derived mesenchymal stem cells on injured rat endometrium during its chronic phase

Lu Zhang et al.

STEM CELL RESEARCH & THERAPY (2018)

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Article Biochemistry & Molecular Biology

Exosomes Secreted from Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Accelerate Skin Cell Proliferation

Soo Kim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Cell Biology

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Thery et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Pharmacology & Pharmacy

Downregulation of miR-145 in venous malformations: Its association with disorganized vessels and sclerotherapy

Hou-fu Xia et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

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Review Biochemistry & Molecular Biology

Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine

Francisco J. Vizoso et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Review Biochemistry & Molecular Biology

Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases

Guohua Lou et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2017)

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Review Cell & Tissue Engineering

Mesenchymal stem cells in cardiac regeneration: a detailed progress report of the last 6 years (2010-2015)

Aastha Singh et al.

STEM CELL RESEARCH & THERAPY (2016)

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Article Multidisciplinary Sciences

Tumour exosome integrins determine organotropic metastasis

Ayuko Hoshino et al.

NATURE (2015)

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Article Cell & Tissue Engineering

Secretion of Shh by a Neurovascular Bundle Niche Supports Mesenchymal Stem Cell Homeostasis in the Adult Mouse Incisor

Hu Zhao et al.

CELL STEM CELL (2014)

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Article Multidisciplinary Sciences

Glial origin of mesenchymal stem cells in a tooth model system

Nina Kaukua et al.

NATURE (2014)

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Article Cell & Tissue Engineering

Protein synthesis and secretion in human mesenchymal cells derived from bone marrow, adipose tissue and Wharton's jelly

Paola Romina Amable et al.

STEM CELL RESEARCH & THERAPY (2014)

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Article Genetics & Heredity

MicroRNA expression profiling of human bone marrow mesenchymal stem cells during osteogenic differentiation reveals Osterix regulation by miR-31

Serena Rubina Baglio et al.

GENE (2013)

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Article Biotechnology & Applied Microbiology

Extracellular vesicles: biology and emerging therapeutic opportunities

Samir EL Andaloussi et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

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Article Cell & Tissue Engineering

Adipose-Tissue-Derived and Wharton's Jelly-Derived Mesenchymal Stromal Cells Suppress Lymphocyte Responses by Secreting Leukemia Inhibitory Factor

Mehdi Najar et al.

TISSUE ENGINEERING PART A (2010)

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Article Cell & Tissue Engineering

Implanted Adult Human Dental Pulp Stem Cells Induce Endogenous Axon Guidance

Agnieszka Arthur et al.

STEM CELLS (2009)

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Review Immunology

Mesenchymal stem cells in health and disease

Antonio Uccelli et al.

NATURE REVIEWS IMMUNOLOGY (2008)

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Article Cell & Tissue Engineering

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement

M. Dominici et al.

CYTOTHERAPY (2006)

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Article Multidisciplinary Sciences

Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo

S Gronthos et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

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Deciphering the Heterogeneity Landscape of Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles for Precise Selection in Translational Medicine

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