Engineered biomembrane-derived nanoparticles for nanoscale theranostics

Currently, biological membrane-derived nanoparticles (NPs) have shown enormous potential as drug delivery vehicles due to their outstanding biomimetic properties. To make these NPs more adaptive to complex biological systems, some methods have been developed to modify biomembranes and endow them with more functions while preserving their inherent natures. In this review, we introduce five common approaches used for biomembrane decoration: membrane hybridization, the postinsertion method, chemical methods, metabolism engineering and gene engineering. These methods can functionalize a series of biomembranes derived from red blood cells, white blood cells, tumor cells, platelets, exosomes and so on. Biomembrane engineering could markedly facilitate the targeted drug delivery, treatment and diagnosis of cancer, inflammation, immunological diseases, bone diseases and Alzheimer's disease. It is anticipated that these membrane modification techniques will advance biomembrane-derived NPs into broader applications in the future.

Automated summary

Biological membrane engineering methods can enhance the functionality of biomembrane-derived nanoparticles for improved drug delivery and treatment. These methods can be applied to various biomembranes and are expected to play a significant role in the treatment and diagnosis of cancer, inflammation, immunological diseases, bone diseases, and Alzheimer's disease.