☆ 4.7 Article

Cellular senescence affects energy metabolism, immune infiltration and immunotherapeutic response in hepatocellular carcinoma

SCIENTIFIC REPORTS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Oncology

Senescence and the tumor-immune landscape: Implications for cancer immunotherapy

Loretah Chibaya et al.

Summary: Cancer therapies not only affect tumor cells, but also the tumor-immune microenvironment. Induction of cellular senescence can lead to durable tumor cell arrest and remodeling of the tumor-immune microenvironment through the production of SASP. Depending on the therapy, the SASP can either promote anti-tumor immunity or chronic inflammation, affecting the success of the treatment.

SEMINARS IN CANCER BIOLOGY (2022)

添加到收藏夹

Article Medicine, General & Internal

Clinical Value of EZH2 in Hepatocellular Carcinoma and Its Potential for Target Therapy

An-Na Bae et al.

Summary: This study investigated the clinical and prognostic value of EZH2 in hepatocellular carcinoma (HCC) and found that EZH2 overexpression is associated with poor prognosis in HCC. Additionally, EZH2 was correlated with N stage and alpha-fetoprotein (AFP) levels in HCC. The study also revealed a negative correlation between EZH2 expression and STAT3 expression.

MEDICINA-LITHUANIA (2022)

添加到收藏夹

Article Pathology

Prognostic significance of viable tumor size measurement in hepatocellular carcinomas after preoperative locoregional treatment

Yoon Jung Hwang et al.

Summary: The study suggests that residual viable tumor size (VTS) may be more relevant for predicting prognosis in surgically resected hepatocellular carcinoma (HCC) cases, especially in patients who have undergone preoperative locoregional treatment (LRT). Furthermore, VTS > 2 cm was identified as an independent predictive factor for decreased disease-free survival (DFS).

JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer

Yong Won Choi et al.

Summary: Senescent tumor cells inhibit infiltration of CD8(+) T cells by secreting CXCL12 and enhancing differentiation of monocytes into M2 macrophages, forming a cytokine barrier to protect nonsenescent tumor cells. Targeting CXCL12 in senescent tumor cells could enhance T cell infiltration and reduce tumor size in CRC, providing a new strategy to overcome immunotherapy resistance.

ADVANCED SCIENCE (2021)

添加到收藏夹

Article Medicine, General & Internal

Hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), poses a significant global health challenge with rising incidence projected to exceed 1 million cases by 2025. Infection by hepatitis B and C viruses remains a major risk factor for HCC, while non-alcoholic steatohepatitis is emerging as a more common risk factor in Western countries. Advances in systemic therapies for HCC, including immunotherapies and targeted therapies, are expected to revolutionize the management of this disease.

NATURE REVIEWS DISEASE PRIMERS (2021)

添加到收藏夹

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

添加到收藏夹

Review Gastroenterology & Hepatology

Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Locoregional therapies, including local ablation and transarterial chemoembolization, play a crucial role in the management of hepatocellular carcinoma. Recent studies have shown potential benefits of combining these local therapies with systemic treatments, such as molecular therapies, to enhance therapeutic effects.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

The aging lung: Physiology, disease, and immunity

Jaime L. Schneider et al.

Summary: Human population is aging faster than ever before in history, requiring a deeper understanding of aging biology and its connection to diseases. Aging lungs face various stresses, increasing the risk of lung diseases, respiratory infections, and lung cancer.

CELL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Persistence of Hepatitis C Virus Infection in Hepatocytes Promotes Hepatocellular Carcinoma Progression by Pro-Inflammatory Interluekin-8 Expression

Ciniso Sylvester Shabangu et al.

Summary: Persistent HCV infection affects the interaction between the virus and host cell, leading to cell death or growth through different signaling pathways. It induces inflammatory responses and alters cell adhesion and chemokine signaling, promoting hepatocarcinogenesis.

BIOMEDICINES (2021)

添加到收藏夹

Article Cell Biology

Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy

Xia Liu et al.

Summary: The functional state of T cells is critical for effective antitumor immunity. T cell senescence driven by malignant tumor cells and regulatory T cells is a common feature in cancers, characterized by unbalanced lipid metabolism and accumulation of lipid droplets. Inhibition of group IVA phospholipase A(2) can reprogram effector T cell lipid metabolism, prevent T cell senescence, and enhance antitumor immunity and immunotherapy efficacy.

SCIENCE TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Recent Advances in Multi-target Drugs Targeting Protein Kinases and Histone Deacetylases in Cancer Therapy

Yong Ling et al.

CURRENT MEDICINAL CHEMISTRY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

A proteomic atlas of senescence-associated secretomes for aging biomarker development

Nathan Basisty et al.

PLOS BIOLOGY (2020)

添加到收藏夹

Review Biology

The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy

Aaron R. Lim et al.

ELIFE (2020)

添加到收藏夹

Review Oncology

Epidemiology of Microsatellite Instability High (MSI-H) and Deficient Mismatch Repair (dMMR) in Solid Tumors: A Structured Literature Review

Maria Lorenzi et al.

JOURNAL OF ONCOLOGY (2020)

添加到收藏夹

Article Medicine, General & Internal

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

Richard S. Finn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Programmed cell death protein-1 (PD-1)-targeted immunotherapy in advanced hepatocellular carcinoma: efficacy and safety data from an international multicentrereal- world cohort

Bernhard Scheiner et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

The senescence-associated secretory phenotype and its regulation

Stephane Lopes-Paciencia et al.

CYTOKINE (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Building on the anti-PD1/PD-L1 backbone: combination immunotherapy for cancer

Alvaro H. Ingles Garces et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cellular Senescence: Defining a Path Forward

Vassilis Gorgoulis et al.

CELL (2019)

添加到收藏夹

Review Oncology

The immune landscape of esophageal cancer

Tu-Xiong Huang et al.

CANCER COMMUNICATIONS (2019)

添加到收藏夹

Review Immunology

Metabolic Barriers to T Cell Function in Tumors

Ayaka Sugiura et al.

JOURNAL OF IMMUNOLOGY (2018)

添加到收藏夹

Review Cell Biology

Hallmarks of Cellular Senescence

Alejandra Hernandez-Segura et al.

TRENDS IN CELL BIOLOGY (2018)

添加到收藏夹

Review Oncology

Molecular therapies and precision medicine for hepatocellular carcinoma

Josep M. Llovet et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

添加到收藏夹

Article Oncology

Nivolumab for the treatment of hepatocellular carcinoma

Fabian Finkelmeier et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2018)

添加到收藏夹

Review Oncology

Hyperprogressive disease: recognizing a novel pattern to improve patient management

Stephane Champiat et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy

Jinfang Zhang et al.

TRENDS IN BIOCHEMICAL SCIENCES (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Elevated G6PD expression contributes to migration and invasion of hepatocellular carcinoma cells by inducing epithelial-mesenchymal transition

Ming Lu et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2018)

添加到收藏夹

Article Oncology

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

Marco Demaria et al.

CANCER DISCOVERY (2017)

添加到收藏夹

Article Oncology

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

Tobias Eggert et al.

CANCER CELL (2016)

添加到收藏夹

Review Oncology

Opportunities for immunotherapy in microsatellite instable colorectal cancer

Harm Westdorp et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Classification and characterization of microsatellite instability across 18 cancer types

Ronald J. Hanse et al.

NATURE MEDICINE (2016)

添加到收藏夹

Review Oncology

The Immune Biology of Microsatellite-Unstable Cancer

Matthias Kloor et al.

TRENDS IN CANCER (2016)

添加到收藏夹

Review Immunology

Senescence-associated inflammatory responses: aging and cancer perspectives

Audrey Lasry et al.

TRENDS IN IMMUNOLOGY (2015)

添加到收藏夹

Review Physiology

Aging, Cellular Senescence, and Cancer

Judith Campisi

ANNUAL REVIEW OF PHYSIOLOGY, VOL 75 (2013)

添加到收藏夹

Article Multidisciplinary Sciences

ShRNA-Targeted Centromere Protein A Inhibits Hepatocellular Carcinoma Growth

Yongmei Li et al.

PLOS ONE (2011)

添加到收藏夹

Review Pathology

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

Jean -Philippe Coppe et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.