4.7 Article

The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen

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SCIENTIFIC REPORTS
卷 13, 期 1, 页码 -

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NATURE PORTFOLIO
DOI: 10.1038/s41598-022-27002-3

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Living in risky environments and having a risky occupation can affect risk-tolerance. Despite the involvement of dopamine in reward expectation, genetic studies have not found a conclusive link between dopaminergic genes and risk attitudes. This study explores the possibility that the DRD4-7R allele's effect on risk-taking behavior is influenced by environmental factors. The results show that the increase in risk-tolerance caused by the 7R allele is independent of environmental risk in two populations in Northern Senegal, one of which is exposed to a very high risk due to dangerous fishing.
It has been shown that living in risky environments, as well as having a risky occupation, can moderate risk-tolerance. Despite the involvement of dopamine in the expectation of reward described by neurobiologists, a GWAS study was not able to demonstrate a genetic contribution of genes involved in the dopaminergic pathway in risk attitudes and gene candidate studies gave contrasting results. We test the possibility that a genetic effect of the DRD4-7R allele in risk-taking behavior could be modulated by environmental factors. We show that the increase in risk-tolerance due to the 7R allele is independent of the environmental risk in two populations in Northern Senegal, one of which is exposed to a very high risk due to dangerous fishing.

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