4.7 Article

Pan-cancer analysis of the prognostic and immunological role of PAQR4

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

KEGG for taxonomy-based analysis of pathways and genomes

Minoru Kanehisa et al.

Summary: KEGG is a manually curated database resource that integrates various biological objects classified into systems, genomic, chemical, and health information. Through the KEGG identifier and URL links, users can retrieve and browse information for different biological objects, including pathway maps, hierarchy, and genomes. KEGG has also improved KO assignment annotation and included more eukaryotic genomes for better representation of organisms in the taxonomic tree. The taxonomy mapping enables analysis of the conservation of functional and physical links among genes in different organism groups.

NUCLEIC ACIDS RESEARCH (2023)

Article Biochemistry & Molecular Biology

PAQR4 promotes the development of hepatocellular carcinoma by activating PI3K/AKT pathway

Gang Zhao et al.

Summary: PAQR4 is highly expressed in HCC and its knockdown inhibits cell proliferation and promotes apoptosis, while also blocking cell migration and invasion. Knockdown of PAQR4 sensitizes cells to chemotherapy and inhibits tumor growth through blocking the PI3K/AKT pathway activation.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2021)

Article Cell Biology

Circular RNA CircNOLC1, Upregulated by NF-KappaB, Promotes the Progression of Prostate Cancer via miR-647/PAQR4 Axis

Wenbin Chen et al.

Summary: Our study identified that circNOLC1 is overexpressed in prostate cancer cells and tissues, promoting proliferation and migration of tumor cells while activating the PI3K/Akt pathway through the miR-647/PAQR4 axis. We also showed that NF-kappaB upregulates circNOLC1, leading to the progression of prostate cancer.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Oncology

Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies

Hiroyoshi Nishikawa et al.

Summary: With the widespread use of immunotherapies in cancer treatment, understanding the immune landscape in the tumor microenvironment has become crucial. Regulatory T cells (Tregs) play a key role in cancer immunity but also contribute to immune evasion by tumor cells. Targeting Tregs is considered a crucial aspect of cancer immunotherapy, especially in tumors with abundant Treg presence.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Multidisciplinary Sciences

clusterProfiler 4.0: A universal enrichment tool for interpreting omics data

Tianzhi Wu et al.

Summary: The updated version of clusterProfiler 4.0 is a powerful tool for functional enrichment analysis in a wide range of organisms, offering tidy interfaces for data operation and visualization, as well as new features like gene set enrichment analysis and comparison of results from multiple gene lists.

INNOVATION (2021)

Review Oncology

Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion

Suchit Jhunjhunwala et al.

Summary: This review discusses the importance of antigen presentation in the success of immune checkpoint inhibition therapy and mechanisms by which tumors evade immune recognition. Tumors evade immune recognition by modulating antigen expression and altering antigen presentation.

NATURE REVIEWS CANCER (2021)

Article Medicine, Research & Experimental

Breviscapine suppresses the growth and metastasis of prostate cancer through regulating PAQR4-mediated PI3K/Akt pathway

Jiwei Ye et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Article Biotechnology & Applied Microbiology

PAQR4 promotes cell proliferation and metastasis through the CDK4-pRB-E2F1 pathway in non-small-cell lung cancer

Bin Wu et al.

ONCOTARGETS AND THERAPY (2019)

Review Biochemistry & Molecular Biology

Toward understanding the origin and evolution of cellular organisms

Minoru Kanehisa

PROTEIN SCIENCE (2019)

Article Genetics & Heredity

Tumor mutational load predicts survival after immunotherapy across multiple cancer types

Robert M. Samstein et al.

NATURE GENETICS (2019)

Article Immunology

The Immune Landscape of Cancer

Vesteinn Thorsson et al.

IMMUNITY (2018)

Review Pharmacology & Pharmacy

DNA mismatch repair in cancer

Marina Baretti et al.

PHARMACOLOGY & THERAPEUTICS (2018)

Article Pharmacology & Pharmacy

MicroRNA-370 inhibits the proliferation, invasion and EMT of gastric cancer cells by directly targeting PAQR4

Ye Feng et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2018)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Review Oncology

Immune evasion in cancer: Mechanistic basis and therapeutic strategies

Dass S. Vinay et al.

SEMINARS IN CANCER BIOLOGY (2015)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

PAQR proteins: A novel membrane receptor family defined by an ancient 7-transmembrane pass motif

YT Tang et al.

JOURNAL OF MOLECULAR EVOLUTION (2005)

Article Biochemistry & Molecular Biology

KEGG: Kyoto Encyclopedia of Genes and Genomes

M Kanehisa et al.

NUCLEIC ACIDS RESEARCH (2000)