期刊
SCIENTIFIC REPORTS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-022-26426-1
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资金
- Indonesia Endowment Fund for Education (LPDP)
- Australian Research Council [DP180100845]
In this study, antibacterial hydrogels were prepared through the self-assembly of short cationic peptide mimics capped with NaA. The resulting hydrogels exhibited desirable viscoelastic properties and showed potent bactericidal activity against both Gram-positive and Gram-negative bacteria. These hydrogels are non-cytotoxic and have potential applications in areas where bacterial contamination is a problem.
In this study, we prepared antibacterial hydrogels through the self-assembly of naphthyl anthranilamide (NaA) capped amino acid based cationic peptide mimics. These ultra-short cationic peptide mimics were rationally designed with NaA as a capping group, l-phenylalanine, a short aliphatic linker, and a cationic group. The synthesized peptide mimics efficiently formed hydrogels with minimum gel concentrations between 0.1 and 0.3%w/v. The resulting hydrogels exhibited desirable viscoelastic properties which can be tuned by varying the cationic group, electronegative substituent, or counter anion. Importantly, nanofibers from the NaA-capped cationic hydrogels were found to be the source of hydrogels' potent bacteriacidal actvity against both Gram-positive and Gram-negative bacteria while remaining non-cytotoxic. These intrinsically antibacterial hydrogels are ideal candidates for further development in applications where bacterial contamination is problematic.
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