相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article
Biochemistry & Molecular Biology
Adam Kazberuk et al.
Summary: Nonsteroidal anti-inflammatory drugs (NSAIDs) may induce apoptosis through the activation of PPAR gamma and the proline metabolism enzyme PRODH/POX in breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Junrong Lu et al.
Summary: Cyperi Rhizoma (CR) is an herbal medicine widely used in different healthcare systems, with significant therapeutic effects in promoting qi circulation, regulating menstruation, and alleviating pain. Research shows its significant application in treating qi stagnation symptoms in various countries or regions.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Atanu Chatterjee et al.
Summary: Cyperus tegetum extract, traditionally used in treating skin cancers, was studied for its anti-inflammatory, analgesic, and anticancer properties in mice. The extract showed significant effects on tumor growth, area, and weight in tumorigenesis study, indicating its potential as a promising compound to reduce skin cancer risk.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Feng Xu et al.
Summary: C-2, a derivative of Jaspine B, has been found to exhibit anti-gastric cancer activity by inducing autophagy through the activation of the JNK/ERK pathway. The activation of this pathway leads to the disruption of Beclin-1/Bcl-xL or Beclin-1/Bcl-2 complexes, resulting in autophagy and up-regulation of p62. Furthermore, the release of Nrf2 from the p62/Keap1 complex enhances cell survival. However, JNK/ERK-dependent autophagy antagonizes the growth-inhibiting effect of C-2 on gastric cancer cells through the p62/Keap1/Nrf2 pathway.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yu Tanaka et al.
Summary: Systemic Nrf2 deletion decreases pancreatic cancer progression in a mutant K-ras/p53-expressing mouse model, with pancreatic stellate cells (PSCs) playing a role in this process. Nrf2-deleted PSCs exhibit lower proliferative and migration capacity, and show reduced growth-stimulating effects on pancreatic cancer cells.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Oncology
Jeeyeon Lee et al.
Summary: The study found that the degree of depression and anxiety increased in breast cancer patients during treatment but decreased during the 6-month follow-up period. Although there were no significant statistical differences among the four periods, patients faced problems such as fatigue and insomnia during treatment and follow-up.
Article
Oncology
Hyuna Sung et al.
Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Article
Biochemistry & Molecular Biology
Kuen-Jang Tsai et al.
Summary: Recent studies have shown that luteolin can inhibit the stemness of breast CSCs by downregulating the expression of Nrf2, and enhanced cytotoxicity to breast cancer cells when used in combination with the chemotherapeutic drug Taxol. Luteolin could be a potential agent for cancer stemness-targeted breast cancer treatments.
Article
Plant Sciences
Ruqian Ding et al.
Summary: The study demonstrates the potential of Antrodia camphorata extract (ACE) as an anticancer agent that induces apoptosis in human colon cancer cells through BMP4 and p53-dependent response to ROS.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pelin Telkoparan-Akillilar et al.
Summary: Cancer is a fatal disease with increasing mortality worldwide, and dysregulation of the NRF2/KEAP1 signaling pathway promotes tumor cell survival and metastasis in various cancers.
Article
Plant Sciences
Xiaoye Fan et al.
Summary: The study demonstrates that Daph induces ROS-dependent apoptosis in ovarian cancer cells and triggers cytoprotective autophagy through the modulation of the AMPK/Akt/mTOR pathway. Combination therapy of Daph and an autophagy inhibitor shows synergistic effects on inhibiting cell viability and promoting apoptosis in ovarian cancer cells, suggesting a potential therapeutic strategy.
Review
Biology
Xiaoyi Zhang et al.
Summary: Traditional Chinese medicine, especially Chinese herbal medicines and acupuncture, has been used to effectively alleviate cancer symptoms and treatment-related adverse reactions, improving patients’ quality of life. Current research has focused on the efficacy of herbal medicines and acupuncture, but more rigorously designed trials are needed in the future to further validate their effectiveness.
Article
Biochemistry & Molecular Biology
Alessia Garufi et al.
Summary: The study found that the zinc-curcumin compound can activate NRF2 and decrease the levels of Keap1, increasing cancer cell sensitivity to Zn(II)-curc-induced cell death. The crosstalk between p62/SQSTM1 and NRF2 could be therapeutically exploited to enhance cancer patient response to therapies.
Review
Biochemistry & Molecular Biology
Chit Tam et al.
Summary: Gynecological cancers with chemoresistance involve the crosstalk of autophagy, apoptosis, and factors like hypoxia and oxidative stress induced by chemotherapy. Autophagy is regulated by metabolic and survival factors, and its interaction with non-coding RNA contributes to chemoresistance. Comprehensive analysis of autophagic factors is recommended for developing risk models to predict chemotherapy efficacy and guide precision medicine.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Oncology
Fengjiao Wang et al.
Summary: Kaempferol effectively suppresses pancreatic cancer by upregulating ROS levels and inducing apoptosis via TGM2-mediated Akt/mTOR signaling pathway. High TGM2 expression is correlated with poor prognosis in pancreatic cancer patients, and TGM2 may serve as a promising prognostic biomarker for pancreatic cancer.
Article
Medicine, General & Internal
Wei Cao et al.
Summary: This study summarized the recent changing profiles of cancer burden worldwide and in China, revealing that breast cancer became the most diagnosed cancer globally in 2020. China accounted for 24% of newly diagnosed cases and 30% of cancer-related deaths worldwide in 2020, with a high cancer mortality rate.
CHINESE MEDICAL JOURNAL
(2021)
Review
Oncology
Elisabetta Catalani et al.
Summary: This review discusses the impact of oxidative stress and autophagy in melanoma cells, as well as the modulation of melanoma cell fate by drugs and treatments targeting these processes. Understanding the interactions between these events may lead to new approaches in skin cancer biology and treatment.
Article
Plant Sciences
Eden Bruno Sousa da Silva et al.
Summary: The study investigated the chemical composition of volatile compounds in Cyperus articulatus L. and evaluated the antiproliferative activity of the ethanolic extract of solid residues generated by the extraction of the essential oil. Results showed that the extract exerted antiproliferative activity on cancer cells with low toxicity on healthy cells in vitro.
Article
Chemistry, Medicinal
Nitin T. Telang et al.
Summary: Triple-negative breast cancer lacks estrogen receptor-alpha, progesterone receptor, and human epidermal growth factor receptor-2. Current treatment options are limited to chemotherapy and targeted therapy. Research focuses on identifying effective Chinese herbs as alternative therapies for resistant breast cancer.
Retraction
Oncology
Li Wang et al.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Plant Sciences
Jingjing Du et al.
Summary: Shuganning injection (SGNI), a traditional Chinese patent medicine, selectively inhibits the proliferation of TNBC cells through induction of ferroptosis dependent on heme oxygenase 1 (HO-1). HO-1 promotes intracellular labile iron pool accumulation, leading to ferroptotic cell death of TNBC cells.
Article
Oncology
Cody J. Schmidlin et al.
Summary: NRF2 plays a complex role in cancer by regulating genes involved in cell function and survival, and its activation mode determines its effects in cancer. The discovery of pharmacological modulators targeting NRF2 provides potential breakthroughs in cancer treatment.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Giuseppina Barrera et al.
Summary: Chemoresistance poses a significant challenge to cancer treatment by affecting the efficacy of conventional and targeted therapies. Metabolic remodeling, particularly the control of redox status, and the upregulation of antioxidant systems contribute to cancer cell survival post-therapy. The master regulator Nrf2, along with other transcription factors, plays crucial roles in maintaining high antioxidant levels in chemoresistant cancer cells.
Review
Pharmacology & Pharmacy
Zhenwei Su et al.
Summary: Chemotherapy is powerful in eliminating malignant cells, but its efficacy is often hindered by drug resistance. Nanomedicine, focusing on targeted drug delivery to tumor tissues using nano-sized formulations, shows promise in improving treatment outcomes, minimizing adverse effects, and overcoming cancer drug resistance. This approach involves strategies such as passive and active targeted delivery, delivering multidrug combinations, and multimodal combination therapy to pave the way for effective cancer treatment and holds great potential in overcoming drug resistance.
DRUG RESISTANCE UPDATES
(2021)
Review
Biochemistry & Molecular Biology
Junsha An et al.
Summary: Research has shown that drug metabolizing enzymes can catalyze reactions to deactivate chemotherapy drugs, leading to drug resistance; the drug efflux system can reduce drug concentrations in breast cancer cells; while the combination of the glutathione detoxification system and platinum drugs can cause breast cancer cells to become insensitive to drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hannah E Greenwood et al.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Chemistry, Medicinal
Kamel S. Ahmed et al.
Summary: The study developed a multifunctional nano-structured liposomal system for co-delivery of doxorubicin and celecoxib to overcome doxorubicin resistance in breast cancer, showing remarkable treatment efficacy. The peptide-modified targeted liposomes exhibited strong cellular entry ability and mitochondrial-targeting effect, effectively inhibiting P-glycoprotein efflux activity.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Tabitha Jenkins et al.
Summary: The article discusses the important role of reactive oxygen species in cell proliferation and differentiation, as well as the mechanisms of maintaining redox balance in cells. The dual role of Nrf2 in cells is emphasized, with its activation preventing tumorigenesis in healthy cells but promoting tumor development and metastasis in cancer with constitutive activation. In addition, Nrf2 is also involved in preventing programmed cell death.
Article
Biochemistry & Molecular Biology
Venugopal R. Bovilla et al.
Summary: The study investigated the expression of Nrf2 in breast cancer tissues and cell lines, finding that silencing or inhibiting Nrf2 could reduce cancer cell proliferation and migration, induce cell cycle arrest and activate apoptosis, as well as sensitize breast cancer cells to cisplatin. Additionally, experimental mouse models showed that pharmacological Nrf2 inhibitor brusatol slowed tumor growth and activated anti-cancer effects in the tumor microenvironment. Further testing is needed to confirm the potential of Nrf2 as a marker and therapeutic target for chemo sensitization in drug resistant and advanced tumors.
Review
Biochemistry & Molecular Biology
Paulina Hennig et al.
Summary: P62 is a highly conserved adaptor protein involved in important cellular processes, regulating tissue homeostasis, inflammation, and diseases like cancer. Through interactions with multiple partners, P62 influences key pathways and acts as a central signaling hub for pro- and anti-inflammatory pathways. Its roles in autophagy, inflammation, and cancer highlight its potential as a target for therapeutic strategies in disease progression.
Article
Physics, Fluids & Plasmas
Y. Ma et al.
Summary: This study uses evolutionary game theory to design adaptive schedules for two drugs in order to mitigate chemotherapeutic resistance and delay tumor recurrence. The key parameter determines whether the drugs interact synergistically, additively, or antagonistically, with antagonistic interactions being more effective in controlling the evolution of resistance. By shaping the fitness landscape of cell populations and altering dosages and timing of drugs, the study shows that antagonistic drug interactions result in slower rates of adaptation of resistant cells, making them more effective in combatting resistance evolution.
Article
Psychology, Multidisciplinary
Abdallah Y. Naser et al.
Summary: This study found a higher prevalence of depressive and anxious symptoms in inpatients and patients in advanced disease stages, with underutilization of antidepressant therapy. Enhanced clinical monitoring and treatment of depression and anxiety among cancer patients are necessary.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ruiran Wei et al.
Summary: Colorectal cancer (CRC) is a common malignant tumor and traditional treatments have limited efficacy. Ferroptosis, a form of regulated cell death dependent on iron and reactive oxygen species (ROS), has been studied as a promising way to fight against resistant cancers. This study explored the mechanism of action of tagitinin C (TC), a natural product, as a novel ferroptosis inducer in CRC cells, showing that TC induces ferroptosis through ER stress-mediated activation of the PERK-Nrf2-HO-1 signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Medicine, Research & Experimental
Yawei Wang et al.
Summary: Reactive oxygen species (ROS) act as cell signaling molecules generated in oxidative metabolism and are associated with various human diseases. Abnormal accumulation of ROS in cancer cells leads to tumor progression and metastasis. Understanding the dual roles of ROS in tumor growth, metastasis, and apoptosis, as well as related signal transduction networks and anticancer therapies is crucial in conquering cancer.
Article
Biochemistry & Molecular Biology
Marie Angele Cucci et al.
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Oncology
Cecilia Munguti et al.
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Mateus L. Nogueira et al.
Article
Integrative & Complementary Medicine
Shuangshuang Ma et al.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2020)
Article
Biochemistry & Molecular Biology
Fukai Wang et al.
BIOSCIENCE REPORTS
(2019)
Review
Oncology
Montserrat Rojo de la Vega et al.
Article
Medicine, Research & Experimental
Prabu Mannarreddy et al.
BIOMEDICINE & PHARMACOTHERAPY
(2017)
Article
Oncology
Yingze Wei et al.
Article
Oncology
Meihui Xia et al.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2014)