Mucus-derived exosome-like vesicles from the Spanish slug (Arion vulgaris): taking advantage of invasive pest species in biotechnology

Review Biochemistry & Molecular Biology

Plant-Derived Extracellular Vesicles as Therapeutic Nanocarriers

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Bioactive-Based Cosmeceuticals: An Update on Emerging Trends

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MOLECULES (2022)

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Article Biochemistry & Molecular Biology

Targeted Delivery of Exosomes Armed with Anti-Cancer Therapeutics

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Review Biochemistry & Molecular Biology

Plant Secondary Metabolites as Defense Tools against Herbivores for Sustainable Crop Protection

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Summary: Plants have evolved adaptive strategies to defend against herbivores by synthesizing plant secondary metabolites (PSMs). PSMs play important roles in detecting and responding to herbivore attacks, and have limited adaptability to insects. They cause direct toxicity to pests and indirectly protect plants by attracting herbivore natural enemies. Understanding the molecular regulation of PSM biosynthesis can contribute to improving plant tolerance to herbivores.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biotechnology & Applied Microbiology

Therapeutically harnessing extracellular vesicles

Lesley Cheng et al.

Summary: The field of extracellular vesicle (EV) research has rapidly developed and is now recognized for its potential in the treatment and diagnosis of diseases. This article provides an overview of the characteristics and physiological functions of EVs, their association with diseases, and the strategies for their therapeutic exploitation.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Review Biochemistry & Molecular Biology

Conventional and Nonconventional Sources of Exosomes-Isolation Methods and Influence on Their Downstream Biomedical Application

Olga Janouskova et al.

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FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Review Physiology

Plant Extracellular Vesicles and Their Potential in Human Health Research, the Practical Approach

Michaela Kocholata et al.

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PHYSIOLOGICAL RESEARCH (2022)

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Article Nutrition & Dietetics

Comparative study of the most commonly used methods for total protein determination in milk of different species and their ultrafiltration products

Diego Hueso et al.

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FRONTIERS IN NUTRITION (2022)

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Review Pharmacology & Pharmacy

Clinical applications for exosomes: Are we there yet?

Dany Perocheau et al.

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BRITISH JOURNAL OF PHARMACOLOGY (2021)

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Article Engineering, Biomedical

Bioactive snail mucus-slime extract loaded chitosan scaffolds for hard tissue regeneration: the effect of mucoadhesive and antibacterial extracts on physical characteristics and bioactivity of chitosan matrix

Merve Perpelek et al.

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Article Zoology

Strong, Non-specific Adhesion Using C-Lectin Heterotrimers in a Molluscan Defensive Secretion

A. M. Smith et al.

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INTEGRATIVE AND COMPARATIVE BIOLOGY (2021)

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Review Medicine, Research & Experimental

A comprehensive review on time-tested anticancer drug doxorubicin

Sruthi Sritharan et al.

Summary: Doxorubicin is a widely used chemotherapeutic drug for cancer treatment, inducing cell death through various mechanisms and aiding in immune clearance of tumor cells, but its applicability is limited by the development of chemoresistance and cardiotoxicity. Various formulations and co-treatments are essential in reducing toxicity and combating resistance. Further research into the molecular mechanisms of chemoresistance development is crucial for improving patient survivability and preventing cancer relapse.

LIFE SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Design of Liposomes Carrying HelixComplex Snail Mucus: Preliminary Studies

Andrea Alogna et al.

Summary: Liposomes have been utilized in various fields due to their versatility and easy production. This study evaluated the use of liposomes as a vehicle for delivering active components from snail mucus, showing promising effects on wound healing reconstitution. Specifically, the HC-loaded liposomes demonstrated superior cell monolayer reconstruction compared to untreated and HC-treated samples, indicating a novel delivery strategy for the HelixComplex mucus.

MOLECULES (2021)

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Review Biochemistry & Molecular Biology

Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals

Anca Maria Juncan et al.

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MOLECULES (2021)

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Article Multidisciplinary Sciences

The effect of biologically active compounds in the mucus of slugs Limax maximus and Arion rufus on human skin cells

Anna Leskow et al.

Summary: The study evaluated the properties of biologically active compounds in sterile mucus isolated from slugs Limax maximus and Arion rufus, finding that the mucus decreased metabolic activity and cell numbers in human keratinocytes and melanoma cells, suggesting its potential as a source of biologically active substances with anticancer properties.

SCIENTIFIC REPORTS (2021)

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Review Polymer Science

A Comprehensive Review on the Applications of Exosomes and Liposomes in Regenerative Medicine and Tissue Engineering

Mojtaba Shafiei et al.

Summary: Liposomes and exosomes play crucial roles in drug delivery systems and disease treatments in nanomedicine. Exosomes, with higher bioactivity and stability compared to liposomes, have significant potential in disease therapy and prognosis.

POLYMERS (2021)

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Article Cell Biology

Activated fibroblasts enhance cancer cell migration by microvesicles-mediated transfer of Galectin-1

Alessandra Toti et al.

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Review Biochemistry & Molecular Biology

Bioactives from Bee Products and Accompanying Extracellular Vesicles as Novel Bioactive Components for Wound Healing

Zeljka Persuric et al.

Summary: Recent research has focused on identifying health-promoting compounds in bee products such as honey, royal jelly, propolis, and bee pollen. Mass spectrometry techniques have revealed the diversity in chemical composition of bee products, influenced by factors like botanical sources and geographical origin. Extracellular vesicles from bee products show promise as a novel bioactive nutraceutical component, with potential applications in wound healing and tissue regeneration.

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Article Biology

Snail mucus from the mantle and foot of two land snails, Lissachatina fulica and Hemiplecta distincta, exhibits different protein profile and biological activity

Nattaphop Noothuan et al.

Summary: The protein composition and biological activities of snail slime differ between the mantle and foot secretions of two snail species, with the mantle secretion showing higher antibacterial activity. The slime from Hemiplecta distincta also displayed antibacterial properties, but to a lesser extent compared to Lissachatina fulica. Both foot and mantle slime exhibited anti-tyrosinase and antioxidant activity without significant differences. These findings suggest potential variations in protein compositions and activities for medical applications.

BMC RESEARCH NOTES (2021)

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Article Biochemistry & Molecular Biology

Functional properties of chitosan films modified by snail mucus extract

Maria Francesca Di Filippo et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Multidisciplinary Sciences

HelixComplex snail mucus as a potential technology against O3 induced skin damage

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PLOS ONE (2020)

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Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

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Review Immunology

Extracellular Vesicles in Fungi: Past, Present, and Future Perspectives

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FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Review Engineering, Biomedical

Exosomes as a next-generation drug delivery system: An update on drug loading approaches, characterization, and clinical application challenges

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Characterization of the Anion vulgaris pedal gland system

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Galectins in Intra- and Extracellular Vesicles

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Neuroprotective effect of placenta-derived mesenchymal stromal cells: role of exosomes

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Exosomes on the border of species and kingdom intercommunication

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Efficacy of chemical and biological slug control measures in response to watering and earthworms

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Research progress on the composition and function of parasite-derived exosomes

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Exosome-like vesicles in Apis mellifera bee pollen, honey and royal jelly contribute to their antibacterial and pro-regenerative activity

Christina M. A. P. Schuh et al.

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Internalization of Exosomes through Receptor-Mediated Endocytosis

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Extracellular Vesicle-Mediated Communication Within Host-Parasite Interactions

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Distinct pathways for zinc metabolism in the terrestrial slug Arion vulgaris

Martin Dvorak et al.

SCIENTIFIC REPORTS (2019)

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Review Food Science & Technology

Naturally Occurring Exosome Vesicles as Potential Delivery Vehicle for Bioactive Compounds

Precious Akuma et al.

FRONTIERS IN SUSTAINABLE FOOD SYSTEMS (2019)

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Snake Venom Extracellular vesicles (SVEVs) reveal wide molecular and functional proteome diversity

Victor Corassolla Carregari et al.

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HelixComplex snail mucus exhibits pro-survival, proliferative and pro-migration effects on mammalian fibroblasts

Claudio Trapella et al.

SCIENTIFIC REPORTS (2018)

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Snail mucus - glandular origin and composition in Helix pomatia

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ZOOLOGY (2017)

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Different diversity-dependent declines in speciation rate unbalances species richness in terrestrial slugs

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Tumor-derived exosomes induce CD8+ T cell suppressors

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JOURNAL FOR IMMUNOTHERAPY OF CANCER (2017)

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Introgressive replacement of natives by invading Arion pest slugs

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Characterization of gelatin/chitosan scaffold blended with aloe vera and snail mucus for biomedical purpose

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Phylogeographic past and invasive presence of Arion pest slugs in Europe

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Mucus of Achatina fulica stimulates mineralization and inflammatory response in dental pulp cells

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Bidirectional cross-kingdom RNAi and fungal uptake of external RNAs confer plant protection

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Article Biotechnology & Applied Microbiology

Invading slugs (Arion vulgaris) can be vectors for Listeria monocytogenes

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Invasive slug populations (Arion vulgaris) as potential vectors for Clostridium botulinum

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Mucus-derived exosome-like vesicles from the Spanish slug (Arion vulgaris): taking advantage of invasive pest species in biotechnology

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